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HUP0004896A1 - HIV-1 Tat és/vagy Nef fehérjéket tartalmazó fúziós fehérjék - Google Patents

HIV-1 Tat és/vagy Nef fehérjéket tartalmazó fúziós fehérjék

Info

Publication number
HUP0004896A1
HUP0004896A1 HU0004896A HUP0004896A HUP0004896A1 HU P0004896 A1 HUP0004896 A1 HU P0004896A1 HU 0004896 A HU0004896 A HU 0004896A HU P0004896 A HUP0004896 A HU P0004896A HU P0004896 A1 HUP0004896 A1 HU P0004896A1
Authority
HU
Hungary
Prior art keywords
protein
derivative
hiv
proteins
tat
Prior art date
Application number
HU0004896A
Other languages
English (en)
Inventor
Claudine Bruck
Stephane Andre Georges Godart
Martine Marchand
Original Assignee
Smithkline Beecham Biologicals S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10819735&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0004896(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Biologicals S.A. filed Critical Smithkline Beecham Biologicals S.A.
Publication of HUP0004896A1 publication Critical patent/HUP0004896A1/hu
Publication of HUP0004896A3 publication Critical patent/HUP0004896A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A találmány tárgya az alábbi fehérjék bármelyikét tartalmazóoltóanyag-készítmény: (a) HIV Tat fehérje vagy egy származéka, amivagy (i) egy fúziós partnerhez, vagy (ii) egy HIV Nef fehérjéhez vagyannak egy származékához van kapcsolva; vagy (b) HIV Nef fehérje vagyegy származéka, ami vagy (i) egy fúziós partnerhez, vagy (ii) egy HIVTat fehérjéhez vagy annak egy származékához van kapcsolva; vagy (c)HIV Nef fehérje vagy egy származéka, ami egy HIV Tat fehérjéhez vagyannak egy származékához és egy fúziós partnerhez van kapcsolva. Atalálmány tárgyát képezi továbbá az ilyen fehérjét kódoló nukleinsavés egy, az említett nukleinsavval transzformált olyan gazdasejt,például a Pichia Pastoris<>, továbbá eljárások a fehérjeelőállítására. A találmány szerinti megoldás alkalmas HIV-fertőzéselleni védekezésre. Ó
HU0004896A 1997-09-26 1998-09-17 Fusion proteins comprising hiv-1 tat and/or nef proteins HUP0004896A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9720585.0A GB9720585D0 (en) 1997-09-26 1997-09-26 Vaccine
PCT/EP1998/006040 WO1999016884A1 (en) 1997-09-26 1998-09-17 Fusion proteins comprising hiv-1 tat and/or nef proteins

Publications (2)

Publication Number Publication Date
HUP0004896A1 true HUP0004896A1 (hu) 2001-04-28
HUP0004896A3 HUP0004896A3 (en) 2003-05-28

Family

ID=10819735

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004896A HUP0004896A3 (en) 1997-09-26 1998-09-17 Fusion proteins comprising hiv-1 tat and/or nef proteins

Country Status (27)

Country Link
EP (1) EP1015596B2 (hu)
JP (2) JP2001518300A (hu)
KR (1) KR100554487B1 (hu)
CN (1) CN1188519C (hu)
AR (2) AR017147A1 (hu)
AT (1) ATE338128T1 (hu)
AU (1) AU746564B2 (hu)
BR (1) BR9812547A (hu)
CA (1) CA2305013C (hu)
CO (1) CO4810339A1 (hu)
CZ (1) CZ302878B6 (hu)
DE (1) DE69835756T3 (hu)
DK (1) DK1015596T4 (hu)
ES (1) ES2272012T5 (hu)
GB (1) GB9720585D0 (hu)
HU (1) HUP0004896A3 (hu)
IL (1) IL135102A0 (hu)
NO (2) NO328824B1 (hu)
NZ (1) NZ503482A (hu)
PL (1) PL195243B1 (hu)
PT (1) PT1015596E (hu)
SA (1) SA98190877B1 (hu)
SI (1) SI1015596T2 (hu)
TR (1) TR200000864T2 (hu)
TW (1) TW499436B (hu)
WO (1) WO1999016884A1 (hu)
ZA (1) ZA988789B (hu)

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GB9706957D0 (en) 1997-04-05 1997-05-21 Smithkline Beecham Plc Formulation
GB9720585D0 (en) * 1997-09-26 1997-11-26 Smithkline Beecham Biolog Vaccine
GB9820525D0 (en) 1998-09-21 1998-11-11 Allergy Therapeutics Ltd Formulation
EP1156825A2 (en) * 1999-02-25 2001-11-28 SMITHKLINE BEECHAM BIOLOGICALS s.a. Immunogens comprising a peptide and a carrier derived from h.influenzae protein d
AU4342900A (en) * 1999-04-12 2000-11-14 Modex Therapeutiques, S.A. Transiently immortalized cells for use in gene therapy
DE60023300T2 (de) * 1999-06-29 2006-07-06 Glaxosmithkline Biologicals S.A. Verwendung von cpg als adjuvans für hivimpstoff
GB0000891D0 (en) 2000-01-14 2000-03-08 Allergy Therapeutics Ltd Formulation
CN1326873C (zh) * 2000-01-31 2007-07-18 史密丝克莱恩比彻姆生物有限公司 用于hiv预防或治疗性免疫的疫苗
US6472176B2 (en) 2000-12-14 2002-10-29 Genvec, Inc. Polynucleotide encoding chimeric protein and related vector, cell, and method of expression thereof
GB0110431D0 (en) * 2001-04-27 2001-06-20 Glaxosmithkline Biolog Sa Novel compounds
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GB0118367D0 (en) * 2001-07-27 2001-09-19 Glaxosmithkline Biolog Sa Novel use
HU230488B1 (hu) 2001-11-21 2016-08-29 The Trustees Of The University Of Pennsylvania Simian adenovírus nukleinsav és aminosav-szekvencia, azt tartalmazó vektorok, és eljárások annak alkalmazására
EP1944043A1 (en) 2001-11-21 2008-07-16 The Trustees of the University of Pennsylvania Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use
KR100466382B1 (ko) * 2002-01-08 2005-01-14 주식회사 엘지생명과학 인간 면역 결핍 바이러스-1, -2 타입의 단백질이 융합된 재조합 콤보 단백질, 이의 생산방법, 이를 포함하는 벡터, 형질전환된 대장균 및 진단키트
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NZ556144A (en) 2002-05-16 2008-04-30 Bavarian Nordic As Fusion protein comprising the amino acid sequence of at least three different HIV proteins selected from Vif, Vpr, Vpu, Vpx, Rev and Tat, wherein the fusion protein does not contain specific clevage sequences for cellular proteases
GB0225788D0 (en) 2002-11-05 2002-12-11 Glaxo Group Ltd Vaccine
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GB0417494D0 (en) 2004-08-05 2004-09-08 Glaxosmithkline Biolog Sa Vaccine
GB0507003D0 (en) * 2005-04-06 2005-05-11 Molmed Spa Therapeutic
ATE491022T1 (de) * 2005-10-18 2010-12-15 Nat Jewish Health Konditionell immortalisierte adulte langzeit- stammzellen und verfahren zur herstellung und verwendung von solchen zellen
BRPI0819774A2 (pt) 2007-11-28 2014-10-14 Univ Pennsylvania Subfamília c de adenovírus sadv-40, -31 e -34 de símio e seus usos
ES2607029T3 (es) 2007-11-28 2017-03-28 The Trustees Of The University Of Pennsylvania Adenovirus que comprende una proteína hexónica de la cápside del adenovirus E de simio SAdV-39 y usos de la misma
JP5661476B2 (ja) 2008-03-04 2015-01-28 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア サルアデノウイルスＳＡｄＶ−３６、−４２．１、−４２．２および−４４ならびにそれらの用途
EP2285832B1 (en) 2008-05-16 2020-08-26 Taiga Biotechnologies, Inc. Antibodies and processes for preparing the same
DK2313496T3 (en) 2008-07-21 2014-12-15 Taiga Biotechnologies Inc Anukleære differentiated cells, and method for preparation thereof
ES2879225T3 (es) 2008-08-28 2021-11-22 Taiga Biotechnologies Inc Moduladores de MYC, métodos de uso de los mismos, y métodos para identificar agentes que modulan MYC
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Also Published As

Publication number Publication date
JP2001518300A (ja) 2001-10-16
TW499436B (en) 2002-08-21
ES2272012T5 (es) 2010-07-06
NO20001508D0 (no) 2000-03-23
PT1015596E (pt) 2006-12-29
HK1030431A1 (en) 2001-05-04
CZ20001091A3 (cs) 2000-09-13
CA2305013C (en) 2008-04-08
CN1188519C (zh) 2005-02-09
SA98190877B1 (ar) 2006-09-10
JP2009213492A (ja) 2009-09-24
SI1015596T1 (sl) 2007-02-28
GB9720585D0 (en) 1997-11-26
EP1015596B2 (en) 2010-04-14
EP1015596A1 (en) 2000-07-05
CO4810339A1 (es) 1999-06-30
NO20076467L (no) 2000-05-18
TR200000864T2 (tr) 2000-08-21
DE69835756T2 (de) 2007-09-13
AU746564B2 (en) 2002-05-02
CZ302878B6 (cs) 2012-01-04
NO20001508L (no) 2000-05-18
WO1999016884A1 (en) 1999-04-08
CA2305013A1 (en) 1999-04-08
KR100554487B1 (ko) 2006-03-03
DK1015596T4 (da) 2010-07-12
AR017147A1 (es) 2001-08-22
HUP0004896A3 (en) 2003-05-28
SI1015596T2 (sl) 2010-07-30
DK1015596T3 (da) 2007-01-02
PL339432A1 (en) 2000-12-18
EP1015596B1 (en) 2006-08-30
CN1279718A (zh) 2001-01-10
ZA988789B (en) 2000-03-29
PL195243B1 (pl) 2007-08-31
NZ503482A (en) 2001-09-28
DE69835756D1 (de) 2006-10-12
DE69835756T3 (de) 2010-09-30
NO328824B1 (no) 2010-05-25
KR20010024287A (ko) 2001-03-26
ES2272012T3 (es) 2007-04-16
AU1025599A (en) 1999-04-23
AR080331A2 (es) 2012-03-28
ATE338128T1 (de) 2006-09-15
BR9812547A (pt) 2000-07-25
IL135102A0 (en) 2001-05-20

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