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HRP960008A2 - Proline derivatives - Google Patents

Proline derivatives Download PDF

Info

Publication number
HRP960008A2
HRP960008A2 HR9502152.3A HRP960008A HRP960008A2 HR P960008 A2 HRP960008 A2 HR P960008A2 HR P960008 A HRP960008 A HR P960008A HR P960008 A2 HRP960008 A2 HR P960008A2
Authority
HR
Croatia
Prior art keywords
hexane
mixture
compound
methyl
formula
Prior art date
Application number
HR9502152.3A
Other languages
English (en)
Croatian (hr)
Inventor
Peter Robert Bernstein
Chris Allan Veale
Elwyn Peter Davies
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of HRP960008A2 publication Critical patent/HRP960008A2/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
HR9502152.3A 1995-02-03 1996-01-08 Proline derivatives HRP960008A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9502152.3A GB9502152D0 (en) 1995-02-03 1995-02-03 Proline derivatives

Publications (1)

Publication Number Publication Date
HRP960008A2 true HRP960008A2 (en) 1998-04-30

Family

ID=10769064

Family Applications (1)

Application Number Title Priority Date Filing Date
HR9502152.3A HRP960008A2 (en) 1995-02-03 1996-01-08 Proline derivatives

Country Status (23)

Country Link
US (4) US5686628A (es)
EP (1) EP0808327A1 (es)
JP (1) JPH10513173A (es)
KR (1) KR19980701869A (es)
CN (1) CN1172486A (es)
AR (1) AR003922A1 (es)
AU (1) AU704704B2 (es)
BR (1) BR9607095A (es)
CA (1) CA2209675A1 (es)
CZ (1) CZ246697A3 (es)
FI (1) FI973211A7 (es)
GB (1) GB9502152D0 (es)
HR (1) HRP960008A2 (es)
HU (1) HUP9801991A3 (es)
IL (1) IL117013A0 (es)
NO (1) NO973539L (es)
NZ (1) NZ300256A (es)
PL (1) PL321680A1 (es)
RU (1) RU2159249C2 (es)
SK (1) SK105497A3 (es)
TR (1) TR199700732T1 (es)
WO (1) WO1996023812A1 (es)
ZA (1) ZA96851B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6375926B1 (en) 1996-09-16 2002-04-23 Amersham International Plc Labelled elastase inhibitors
HUP0100669A3 (en) * 1996-12-06 2001-12-28 Cortech Inc Denver Peptide derivatives as serine protease inhibitors, their use and pharmaceutical compositions comprising thereof
US5773430A (en) * 1997-03-13 1998-06-30 Research Foundation Of State University Of New York Serine proteinase inhibitory activity by hydrophobic tetracycline
US6362341B1 (en) 1997-07-31 2002-03-26 Athena Neurosciences, Inc. Benzyl compounds which inhibit leukocyte adhesion mediated by VLA-4
US6583139B1 (en) 1997-07-31 2003-06-24 Eugene D. Thorsett Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6559127B1 (en) 1997-07-31 2003-05-06 Athena Neurosciences, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6423688B1 (en) 1997-07-31 2002-07-23 Athena Neurosciences, Inc. Dipeptide and related compounds which inhibit leukocyte adhesion mediated by VLA-4
US7030114B1 (en) 1997-07-31 2006-04-18 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6489300B1 (en) 1997-07-31 2002-12-03 Eugene D. Thorsett Carbamyloxy compounds which inhibit leukocyte adhesion mediated by VLA-4
US6492421B1 (en) 1997-07-31 2002-12-10 Athena Neurosciences, Inc. Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4
US7232918B2 (en) * 2001-11-06 2007-06-19 Shell Oil Company Catalyst composition
US6544732B1 (en) * 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
WO2001044165A1 (en) 1999-12-16 2001-06-21 Dainippon Pharmaceutical Co., Ltd. Processes for producing (aminomethyl)trifluorocarbinol derivatives
US7294722B2 (en) * 2002-12-12 2007-11-13 Novartis Ag Process for the synthesis of peptides containing a 4-hydroxy-proline substructure
WO2006016720A1 (ja) * 2004-08-11 2006-02-16 Dainippon Sumitomo Pharma Co., Ltd. 医薬化合物
WO2006025216A1 (ja) * 2004-08-31 2006-03-09 Dainippon Sumitomo Pharma Co., Ltd. 医薬結晶化合物
US7533740B2 (en) * 2005-02-08 2009-05-19 Smith International Inc. Thermally stable polycrystalline diamond cutting elements and bits incorporating the same
JP6934012B2 (ja) * 2016-09-23 2021-09-08 科研製薬株式会社 （ｒ）‐５‐（３，４‐ジフルオロフェニル）‐５‐［（３‐メチル‐２‐オキソピリジン‐１（２ｈ）‐イル）メチル］イミダゾリジン‐２，４‐ジオンの製造方法およびその製造のための中間体
EP4031138A1 (en) 2019-09-17 2022-07-27 Mereo Biopharma 4 Limited Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
AU2021256835A1 (en) 2020-04-16 2022-10-13 Mereo Biopharma 4 Limited Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency
AU2022373971A1 (en) 2021-10-20 2024-04-04 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4277395A (en) * 1980-06-16 1981-07-07 Richardson-Merrell Inc. Novel enzyme inhibitors
DE3481913D1 (de) * 1983-04-27 1990-05-17 Ici America Inc Prolin-derivate.
US4518528A (en) * 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
US4643991A (en) * 1984-12-18 1987-02-17 The University Of Kentucky Research Foundation Peptide elastase inhibitors and methods
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
US5194588A (en) * 1985-01-22 1993-03-16 Ici Americas Inc. Aminoalcohol intermediates for peptide derivatives
US5055450A (en) * 1985-01-22 1991-10-08 Ici Americas Inc. Peptide derivatives
CA1341029C (en) * 1985-02-04 2000-06-20 Michael Kolb Peptidase inhibitors
CH672792A5 (es) * 1985-02-19 1989-12-29 Sandoz Ag
IT1203971B (it) * 1987-04-24 1989-02-23 Roussel Maestretti Spa Derivati di 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro applicazione come medicamenti
GB9402680D0 (en) * 1994-02-11 1994-04-06 Zeneca Ltd Pyrrolidine derivatives

Also Published As

Publication number Publication date
ZA96851B (en) 1996-08-05
GB9502152D0 (en) 1995-03-29
AU704704B2 (en) 1999-04-29
NO973539D0 (no) 1997-08-01
NO973539L (no) 1997-10-01
SK105497A3 (en) 1997-12-10
FI973211L (fi) 1997-08-01
HUP9801991A3 (en) 1999-06-28
WO1996023812A1 (en) 1996-08-08
AR003922A1 (es) 1998-09-30
CA2209675A1 (en) 1996-08-08
NZ300256A (en) 2000-01-28
EP0808327A1 (en) 1997-11-26
FI973211A0 (fi) 1997-08-01
JPH10513173A (ja) 1998-12-15
CZ246697A3 (en) 1997-11-12
KR19980701869A (ko) 1998-06-25
FI973211A7 (fi) 1997-08-01
US5808097A (en) 1998-09-15
RU2159249C2 (ru) 2000-11-20
US6054593A (en) 2000-04-25
TR199700732T1 (xx) 1998-02-21
CN1172486A (zh) 1998-02-04
US6048889A (en) 2000-04-11
MX9705231A (es) 1997-10-31
PL321680A1 (en) 1997-12-22
US5686628A (en) 1997-11-11
BR9607095A (pt) 1997-11-11
AU4494396A (en) 1996-08-21
HUP9801991A2 (hu) 1999-02-01
IL117013A0 (en) 1996-06-18

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
ODBC Application rejected