HRP20031000A2 - Benzoylsulfonamides and sulfonylbenzamidines as antitumour agents - Google Patents

Benzoylsulfonamides and sulfonylbenzamidines as antitumour agents

Info

Publication number: HRP20031000A2
Authority: HR; Croatia
Prior art keywords: sulfonylbenzamidines; benzoylsulfonamides; antitumour agents; antitumour; agents
Prior art date: 2001-06-06

Application number

HR20031000A

Other languages

English (en)

Inventor

Thomas Hughes Corbett

Cora Sue Grossman

Karen Lynn Lobb

Chuan Shih

Philip Arthur Hipskind

Ho-Shen Lin

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-06

Filing date

2002-05-24

Publication date

2004-04-30

2002-05-24 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2004-04-30 Publication of HRP20031000A2 publication Critical patent/HRP20031000A2/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/51—Y being a hydrogen or a carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
- C07D213/34—Sulfur atoms to which a second hetero atom is attached
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/18—Radicals substituted by singly bound hetero atoms other than halogen by sulfur atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Quinoline Compounds (AREA)
Furan Compounds (AREA)

HR20031000A 2001-06-06 2002-05-24 Benzoylsulfonamides and sulfonylbenzamidines as antitumour agents HRP20031000A2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US29635001P	2001-06-06	2001-06-06
PCT/US2002/015142 WO2002098848A1 (fr)	2001-06-06	2002-05-24	Benzoylsulfonamides et sulfonylbenzamidines en tant qu'agents antitumoraux

Publications (1)

Publication Number	Publication Date
HRP20031000A2 true HRP20031000A2 (en)	2004-04-30

Family

ID=23141662

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20031000A HRP20031000A2 (en)	2001-06-06	2002-05-24	Benzoylsulfonamides and sulfonylbenzamidines as antitumour agents

Country Status (35)

Country	Link
US (1)	US7183320B2 (fr)
EP (1)	EP1401806B1 (fr)
JP (1)	JP4167173B2 (fr)
KR (1)	KR100880760B1 (fr)
CN (1)	CN100475787C (fr)
AR (1)	AR036079A1 (fr)
AT (1)	ATE335722T1 (fr)
AU (1)	AU2002259204B2 (fr)
BR (1)	BR0210078A (fr)
CA (1)	CA2446719A1 (fr)
CR (1)	CR7182A (fr)
CY (1)	CY1105386T1 (fr)
CZ (1)	CZ20033296A3 (fr)
DE (1)	DE60213810T2 (fr)
DK (1)	DK1401806T3 (fr)
EA (1)	EA005810B1 (fr)
EC (1)	ECSP034874A (fr)
EG (1)	EG24356A (fr)
ES (1)	ES2269688T3 (fr)
HR (1)	HRP20031000A2 (fr)
HU (1)	HUP0400114A3 (fr)
IL (1)	IL158985A0 (fr)
MX (1)	MXPA03011197A (fr)
MY (1)	MY136855A (fr)
NO (1)	NO20035366L (fr)
NZ (1)	NZ529098A (fr)
PE (1)	PE20030199A1 (fr)
PL (1)	PL367188A1 (fr)
PT (1)	PT1401806E (fr)
SK (1)	SK14642003A3 (fr)
SV (1)	SV2003001076A (fr)
TW (1)	TWI266761B (fr)
UA (1)	UA74889C2 (fr)
WO (1)	WO2002098848A1 (fr)
ZA (1)	ZA200308644B (fr)

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ATE375978T1 (de) *	2002-11-22	2007-11-15	Lilly Co Eli	Benzoylsulfonamide als antitumor-mittel
WO2005049593A2 (fr) *	2003-11-13	2005-06-02	Abbott Laboratories	Promoteurs de l'apoptose contenant n-acylsulfonamide
US8614318B2 (en)	2003-11-13	2013-12-24	Abbvie Inc.	Apoptosis promoters
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US7973161B2 (en)	2003-11-13	2011-07-05	Abbott Laboratories	Apoptosis promoters
ES2380345T3 (es) *	2004-05-26	2012-05-10	Abbott Laboratories	Promotores de la apoptosis de N-sulfonilcarboximidamida
JP5134247B2 (ja) *	2004-09-13	2013-01-30	エーザイ・アール・アンド・ディー・マネジメント株式会社	スルホンアミド含有化合物の血管新生阻害物質との併用
US8772269B2 (en)	2004-09-13	2014-07-08	Eisai R&D Management Co., Ltd.	Use of sulfonamide-including compounds in combination with angiogenesis inhibitors
WO2006030947A1 (fr) *	2004-09-13	2006-03-23	Eisai R & D Management Co., Ltd.	Utilisation conjointe d’un compose a base de sulfonamide et d'un inhibiteur d’angiogenese
WO2006090921A1 (fr) *	2005-02-28	2006-08-31	Eisai R & D Management Co., Ltd.	Effet d’inhibition d’un composé de sulfamide sur l’activation de lymphocytes
KR20070114774A (ko) *	2005-02-28	2007-12-04	에자이 알앤드디 매니지먼트 가부시키가이샤	술폰아미드 화합물의 혈관 신생 저해 물질과의 신규 병용
WO2006090930A1 (fr) *	2005-02-28	2006-08-31	Eisai R & D Management Co., Ltd.	Nouvelle utilisation combinee d'un compose de sulfonamide
DK1888550T3 (da)	2005-05-12	2014-09-29	Abbvie Bahamas Ltd	Apoptosepromotorer
US8624027B2 (en)	2005-05-12	2014-01-07	Abbvie Inc.	Combination therapy for treating cancer and diagnostic assays for use therein
US7208526B2 (en)	2005-05-20	2007-04-24	Hoffmann-La Roche Inc.	Styrylsulfonamides
US7208506B2 (en)	2005-07-07	2007-04-24	Hoffmann-La Roche Inc.	Heteroarylethenyl derivatives, their manufacture and use as pharmaceutical agents
US7625896B2 (en) *	2005-11-25	2009-12-01	Hoffman-La Roche Inc.	Pyridylsulfonamide derivatives
EP2015070A4 (fr)	2006-04-20	2010-04-21	Eisai R&D Man Co Ltd	Nouveau marqueur contre la sensibilité à un composé de sulfonamide
CN101534904B (zh)	2006-09-05	2013-11-06	Abbvie公司	治疗血小板过量的bcl抑制剂
US7939532B2 (en) *	2006-10-26	2011-05-10	Hoffmann-La Roche Inc.	Heterocyclyl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents
CA2686768A1 (fr) *	2007-05-16	2008-11-20	F. Hoffmann-La Roche Ag	Derives d'aryl pyridyl sulfonamide, leur fabrication et leur utilisation en tant qu'agents pharmaceutiques
US8557983B2 (en)	2008-12-04	2013-10-15	Abbvie Inc.	Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US20100160322A1 (en)	2008-12-04	2010-06-24	Abbott Laboratories	Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8586754B2 (en)	2008-12-05	2013-11-19	Abbvie Inc.	BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
US8563735B2 (en)	2008-12-05	2013-10-22	Abbvie Inc.	Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
NZ593593A (en) *	2009-01-19	2013-11-29	Abbvie Inc	Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
JP2012136435A (ja) *	2009-03-30	2012-07-19	Eisai R & D Management Co Ltd	腫瘍組織の感受性を検査する方法
KR200457823Y1 (ko) *	2009-05-08	2012-01-05	황정용	쭈꾸미 포획용 어구
US20220315555A1 (en)	2009-05-26	2022-10-06	Abbvie Inc.	Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US9034875B2 (en)	2009-05-26	2015-05-19	Abbvie Inc.	Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
CN104906100A (zh)	2009-05-26	2015-09-16	艾伯维巴哈马有限公司	用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂
US8546399B2 (en)	2009-05-26	2013-10-01	Abbvie Inc.	Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
RU2568611C2 (ru) *	2010-03-25	2015-11-20	Эббви Инк.	Средства, индуцирующие апоптоз, для лечения рака, иммунных и аутоиммунных заболеваний
SG10201801794WA (en)	2010-10-29	2018-04-27	Abbvie Inc	Solid dispersions containing an apoptosis-inducing agent
UA113500C2 (xx)	2010-10-29	2017-02-10		Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
SG190361A1 (en)	2010-11-23	2013-06-28	Abbvie Inc	Salts and crystalline forms of an apoptosis-inducing agent
SI2642999T1 (sl)	2010-11-23	2017-01-31	Abbvie Ireland Unlimited Company	Postopki zdravljenja z uporabo selektivnih Bcl-2 inhibitorjev
CN103159649B (zh) *	2011-12-19	2016-03-09	天津市国际生物医药联合研究院	磺酰胺类化合物的制备及其应用
CN103159650B (zh) *	2011-12-19	2016-04-20	天津市国际生物医药联合研究院	芳香杂环磺酰胺类化合物的制备及其应用
US20140275082A1 (en)	2013-03-14	2014-09-18	Abbvie Inc.	Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
CN105712925B (zh) *	2014-12-05	2019-01-04	沈阳中化农药化工研发有限公司	一种取代的磺酰胺基(硫代)羰基化合物及其用途
ES3038757T3 (en)	2015-02-13	2025-10-14	Oxford Drug Design Ltd	Novel n-acyl-arylsulfonamide derivatives as aminoacyl-trna synthetase inhibitors
CN105753748B (zh) *	2016-02-15	2018-05-29	南京励合化学新材料有限公司	一种医药中间体磺酰类化合物的合成方法
GB201617064D0 (en)	2016-10-07	2016-11-23	Inhibox Limited And Latvian Institute Of Organic Synthesis The	Compounds and their therapeutic use
MX391501B (es)	2017-04-18	2025-03-21	Fochon Pharmaceuticals Ltd	Agentes inductores de apoptosis
WO2018237163A1 (fr) *	2017-06-23	2018-12-27	Roman Manetsch	Inhibiteurs de 5-aminolévulinate synthase et leurs méthodes d'utilisation
WO2019133797A1 (fr) *	2017-12-29	2019-07-04	Wu, Lester J.	Dérivés de benzènesulfonamide et procédé de modulation d'un radeau lipidique
CN114790149B (zh) *	2021-01-26	2024-11-19	江苏中旗科技股份有限公司	一种以2-氯-4-氟苯胺为原料合成2-氯-4-氟苯甲酸的方法
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2002
- 2002-05-24 SK SK1464-2003A patent/SK14642003A3/sk unknown
- 2002-05-24 DK DK02729196T patent/DK1401806T3/da active
- 2002-05-24 MX MXPA03011197A patent/MXPA03011197A/es active IP Right Grant
- 2002-05-24 JP JP2003501838A patent/JP4167173B2/ja not_active Expired - Fee Related
- 2002-05-24 UA UA20031211105A patent/UA74889C2/uk unknown
- 2002-05-24 CZ CZ20033296A patent/CZ20033296A3/cs unknown
- 2002-05-24 CA CA002446719A patent/CA2446719A1/fr not_active Abandoned
- 2002-05-24 HU HU0400114A patent/HUP0400114A3/hu unknown
- 2002-05-24 AT AT02729196T patent/ATE335722T1/de not_active IP Right Cessation
- 2002-05-24 ES ES02729196T patent/ES2269688T3/es not_active Expired - Lifetime
- 2002-05-24 WO PCT/US2002/015142 patent/WO2002098848A1/fr not_active Ceased
- 2002-05-24 PL PL02367188A patent/PL367188A1/xx not_active Application Discontinuation
- 2002-05-24 NZ NZ529098A patent/NZ529098A/en unknown
- 2002-05-24 IL IL15898502A patent/IL158985A0/xx unknown
- 2002-05-24 DE DE60213810T patent/DE60213810T2/de not_active Expired - Fee Related
- 2002-05-24 EP EP02729196A patent/EP1401806B1/fr not_active Expired - Lifetime
- 2002-05-24 BR BR0210078-9A patent/BR0210078A/pt not_active IP Right Cessation
- 2002-05-24 PT PT02729196T patent/PT1401806E/pt unknown
- 2002-05-24 AU AU2002259204A patent/AU2002259204B2/en not_active Ceased
- 2002-05-24 KR KR1020037015958A patent/KR100880760B1/ko not_active Expired - Fee Related
- 2002-05-24 EA EA200400006A patent/EA005810B1/ru not_active IP Right Cessation
- 2002-05-24 HR HR20031000A patent/HRP20031000A2/xx not_active Application Discontinuation
- 2002-05-24 CN CNB028115104A patent/CN100475787C/zh not_active Expired - Fee Related
- 2002-05-24 US US10/478,389 patent/US7183320B2/en not_active Expired - Fee Related
- 2002-06-03 TW TWPHENYLSULA patent/TWI266761B/zh not_active IP Right Cessation
- 2002-06-04 EG EG2002060594A patent/EG24356A/xx active
- 2002-06-04 AR ARP020102075A patent/AR036079A1/es unknown
- 2002-06-05 SV SV2002001076A patent/SV2003001076A/es not_active Application Discontinuation
- 2002-06-05 MY MYPI20022075A patent/MY136855A/en unknown
- 2002-06-07 PE PE2002000494A patent/PE20030199A1/es not_active Application Discontinuation
2003
- 2003-11-05 ZA ZA200308644A patent/ZA200308644B/en unknown
- 2003-12-02 NO NO20035366A patent/NO20035366L/no not_active Application Discontinuation
- 2003-12-02 EC EC2003004874A patent/ECSP034874A/es unknown
- 2003-12-05 CR CR7182A patent/CR7182A/es unknown
2006
- 2006-09-27 CY CY20061101396T patent/CY1105386T1/el unknown

Also Published As

Publication number	Publication date
KR100880760B1 (ko)	2009-02-02
PE20030199A1 (es)	2003-03-12
KR20040007656A (ko)	2004-01-24
UA74889C2 (en)	2006-02-15
MY136855A (en)	2008-11-28
AR036079A1 (es)	2004-08-11
BR0210078A (pt)	2004-06-22
DE60213810D1 (de)	2006-09-21
NO20035366D0 (no)	2003-12-02
ES2269688T3 (es)	2007-04-01
JP4167173B2 (ja)	2008-10-15
US7183320B2 (en)	2007-02-27
MXPA03011197A (es)	2004-02-26
US20040157741A1 (en)	2004-08-12
PL367188A1 (en)	2005-02-21
EP1401806B1 (fr)	2006-08-09
SK14642003A3 (sk)	2004-12-01
ECSP034874A (es)	2004-01-28
EP1401806A1 (fr)	2004-03-31
IL158985A0 (en)	2004-05-12
CN100475787C (zh)	2009-04-08
NZ529098A (en)	2005-08-26
EA200400006A1 (ru)	2004-06-24
CY1105386T1 (el)	2010-04-28
HUP0400114A3 (en)	2007-05-02
CA2446719A1 (fr)	2002-12-12
PT1401806E (pt)	2006-11-30
AU2002259204B2 (en)	2008-01-17
CZ20033296A3 (cs)	2004-04-14
WO2002098848A1 (fr)	2002-12-12
ATE335722T1 (de)	2006-09-15
CN1514824A (zh)	2004-07-21
NO20035366L (no)	2004-02-06
ZA200308644B (en)	2005-02-07
SV2003001076A (es)	2003-07-29
EG24356A (en)	2009-03-04
TWI266761B (en)	2006-11-21
CR7182A (es)	2004-06-08
JP2004530709A (ja)	2004-10-07
DE60213810T2 (de)	2007-02-01
HUP0400114A2 (hu)	2005-04-28
DK1401806T3 (da)	2006-11-27
HK1064360A1 (en)	2005-01-28
EA005810B1 (ru)	2005-06-30

Publication	Publication Date	Title
HRP20031000A2 (en)	2004-04-30	Benzoylsulfonamides and sulfonylbenzamidines as antitumour agents
DE60237965D1 (en)	2010-11-25	Metalloproteinaseinhibitoren
EP1463742A4 (fr)	2006-05-10	Nouvelles pyrazolo-pyrimidines et pyrrolo-pyrimidines et leur utilisation
DE60231477D1 (en)	2009-04-23	Imidazolderivate
IL159918A0 (en)	2004-06-20	Secretion-monitoring article
EP1408978A4 (fr)	2005-07-13	Nouvelles phenylamino-pyrimidines et leur utilisation
IL157845A0 (en)	2004-03-28	Anti-epileptogenic agents
IL154553A0 (en)	2003-09-17	Urocortin-iii and uses thereof
PT1419268E (pt)	2013-03-04	Artigo de monitorização de secreção
GB0126889D0 (en)	2002-01-02	Compounds and their uses
GB0123657D0 (en)	2001-11-21	Worktool
GB2376928B (en)	2003-04-30	Personal hoverplane having four tiltmotors
IL160539A0 (en)	2004-07-25	Anti-influenzal agents
DE60231872D1 (en)	2009-05-20	Echinocandinverfahren
EP1408985A4 (fr)	2006-03-22	Nouveaux pyridopyrimidones et leurs utilisations
DE60206072D1 (en)	2005-10-13	Aroylpyridinone
EP1367123A4 (fr)	2005-10-12	Neurotonine et utilisation
GB0100862D0 (en)	2001-02-21	Reflactron
AU2002313943A8 (en)	2008-01-03	Electromobile
GB0106031D0 (en)	2001-05-02	Use
GB0106987D0 (en)	2001-05-09	Immunotherapeuitic agent
GB0122162D0 (en)	2001-10-31	Agent
GB0106600D0 (en)	2001-05-09	Addition circuitry
GB0003629D0 (en)	2000-04-05	Antitumour agent
CA93126S (en)	2001-07-31	Titlt-latch

Legal Events

Date	Code	Title
2004-04-30	A1OB	Publication of a patent application
2004-07-08	ARAI	Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
2012-01-13	ODBC	Application rejected