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EA200400006A1 - Бензоилсульфонамиды и сульфонилбензамидины для применения в качестве противоопухолевых агентов - Google Patents

Бензоилсульфонамиды и сульфонилбензамидины для применения в качестве противоопухолевых агентов

Info

Publication number
EA200400006A1
EA200400006A1 EA200400006A EA200400006A EA200400006A1 EA 200400006 A1 EA200400006 A1 EA 200400006A1 EA 200400006 A EA200400006 A EA 200400006A EA 200400006 A EA200400006 A EA 200400006A EA 200400006 A1 EA200400006 A1 EA 200400006A1
Authority
EA
Eurasian Patent Office
Prior art keywords
sulfonylbenzamidines
benzoylsulfonamides
tumor agents
formula
methods
Prior art date
Application number
EA200400006A
Other languages
English (en)
Other versions
EA005810B1 (ru
Inventor
Томас Хьюз Корбетт
Кора Сью Гроссмэн
Карен Линн Лобб
Чуан Ших
Филип Артур Хипскинд
Хо-Шен Лин
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200400006A1 publication Critical patent/EA200400006A1/ru
Publication of EA005810B1 publication Critical patent/EA005810B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/51—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C07D213/34—Sulfur atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/18—Radicals substituted by singly bound hetero atoms other than halogen by sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

Настоящее изобретение относится к противоопухолевым соединениям формулы Iи способам лечения опухолей.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200400006A 2001-06-06 2002-05-24 Бензоилсульфонамиды и сульфонилбензамидины для применения в качестве противоопухолевых агентов EA005810B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29635001P 2001-06-06 2001-06-06
PCT/US2002/015142 WO2002098848A1 (en) 2001-06-06 2002-05-24 Benzoylsulfonamides and sulfonylbenzamidines for use as antitumour agents

Publications (2)

Publication Number Publication Date
EA200400006A1 true EA200400006A1 (ru) 2004-06-24
EA005810B1 EA005810B1 (ru) 2005-06-30

Family

ID=23141662

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400006A EA005810B1 (ru) 2001-06-06 2002-05-24 Бензоилсульфонамиды и сульфонилбензамидины для применения в качестве противоопухолевых агентов

Country Status (35)

Country Link
US (1) US7183320B2 (ru)
EP (1) EP1401806B1 (ru)
JP (1) JP4167173B2 (ru)
KR (1) KR100880760B1 (ru)
CN (1) CN100475787C (ru)
AR (1) AR036079A1 (ru)
AT (1) ATE335722T1 (ru)
AU (1) AU2002259204B2 (ru)
BR (1) BR0210078A (ru)
CA (1) CA2446719A1 (ru)
CR (1) CR7182A (ru)
CY (1) CY1105386T1 (ru)
CZ (1) CZ20033296A3 (ru)
DE (1) DE60213810T2 (ru)
DK (1) DK1401806T3 (ru)
EA (1) EA005810B1 (ru)
EC (1) ECSP034874A (ru)
EG (1) EG24356A (ru)
ES (1) ES2269688T3 (ru)
HR (1) HRP20031000A2 (ru)
HU (1) HUP0400114A3 (ru)
IL (1) IL158985A0 (ru)
MX (1) MXPA03011197A (ru)
MY (1) MY136855A (ru)
NO (1) NO20035366L (ru)
NZ (1) NZ529098A (ru)
PE (1) PE20030199A1 (ru)
PL (1) PL367188A1 (ru)
PT (1) PT1401806E (ru)
SK (1) SK14642003A3 (ru)
SV (1) SV2003001076A (ru)
TW (1) TWI266761B (ru)
UA (1) UA74889C2 (ru)
WO (1) WO2002098848A1 (ru)
ZA (1) ZA200308644B (ru)

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JP2012136435A (ja) * 2009-03-30 2012-07-19 Eisai R & D Management Co Ltd 腫瘍組織の感受性を検査する方法
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US20220315555A1 (en) 2009-05-26 2022-10-06 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
EP2944638A1 (en) 2009-05-26 2015-11-18 AbbVie Bahamas Limited Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US9034875B2 (en) 2009-05-26 2015-05-19 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
ES2553143T3 (es) * 2010-03-25 2015-12-04 Abbvie Inc. Agentes inductores de apoptosis para el tratamiento del cáncer y de enfermedades inmunitarias y autoinmunitarias
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
JP6068352B2 (ja) 2010-10-29 2017-01-25 アッヴィ・インコーポレイテッド アポトーシス誘発剤を含む固体分散体
CA2817629C (en) 2010-11-23 2019-08-13 Abbvie Inc. Salts and crystalline forms of an apoptosis-inducing agent
ES2603129T3 (es) 2010-11-23 2017-02-23 Abbvie Ireland Unlimited Company Métodos de tratamiento utilizando inhibidores selectivos de Bcl-2
CN103159650B (zh) * 2011-12-19 2016-04-20 天津市国际生物医药联合研究院 芳香杂环磺酰胺类化合物的制备及其应用
CN103159649B (zh) * 2011-12-19 2016-03-09 天津市国际生物医药联合研究院 磺酰胺类化合物的制备及其应用
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CN105712925B (zh) * 2014-12-05 2019-01-04 沈阳中化农药化工研发有限公司 一种取代的磺酰胺基(硫代)羰基化合物及其用途
MA41542A (fr) 2015-02-13 2021-04-14 Oxford Drug Design Ltd Nouveaux dérivés de n-acyl-arylsulfonamide utilisés en tant qu'inhibiteurs d'aminoacyl-arnt synthétase
CN105753748B (zh) * 2016-02-15 2018-05-29 南京励合化学新材料有限公司 一种医药中间体磺酰类化合物的合成方法
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Also Published As

Publication number Publication date
EA005810B1 (ru) 2005-06-30
DE60213810T2 (de) 2007-02-01
BR0210078A (pt) 2004-06-22
CA2446719A1 (en) 2002-12-12
DK1401806T3 (da) 2006-11-27
US20040157741A1 (en) 2004-08-12
CY1105386T1 (el) 2010-04-28
SK14642003A3 (sk) 2004-12-01
PT1401806E (pt) 2006-11-30
WO2002098848A1 (en) 2002-12-12
MY136855A (en) 2008-11-28
CR7182A (es) 2004-06-08
ZA200308644B (en) 2005-02-07
PE20030199A1 (es) 2003-03-12
EP1401806A1 (en) 2004-03-31
DE60213810D1 (de) 2006-09-21
AR036079A1 (es) 2004-08-11
SV2003001076A (es) 2003-07-29
CN1514824A (zh) 2004-07-21
EG24356A (en) 2009-03-04
US7183320B2 (en) 2007-02-27
JP4167173B2 (ja) 2008-10-15
ECSP034874A (es) 2004-01-28
UA74889C2 (en) 2006-02-15
EP1401806B1 (en) 2006-08-09
HUP0400114A3 (en) 2007-05-02
NZ529098A (en) 2005-08-26
KR20040007656A (ko) 2004-01-24
CZ20033296A3 (cs) 2004-04-14
ES2269688T3 (es) 2007-04-01
HUP0400114A2 (hu) 2005-04-28
PL367188A1 (en) 2005-02-21
ATE335722T1 (de) 2006-09-15
TWI266761B (en) 2006-11-21
HRP20031000A2 (en) 2004-04-30
CN100475787C (zh) 2009-04-08
KR100880760B1 (ko) 2009-02-02
IL158985A0 (en) 2004-05-12
NO20035366D0 (no) 2003-12-02
JP2004530709A (ja) 2004-10-07
HK1064360A1 (en) 2005-01-28
NO20035366L (no) 2004-02-06
MXPA03011197A (es) 2004-02-26
AU2002259204B2 (en) 2008-01-17

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