HRP20030675A2 - Imidazolyl derivatives as corticotropin relasing factor inhibitors - Google Patents

Imidazolyl derivatives as corticotropin relasing factor inhibitors Download PDF

Info

Publication number: HRP20030675A2
Authority: HR; Croatia
Prior art keywords: phenyl; image; alkyl; ethyl; scheme
Prior art date: 2001-01-26

Application number

HR20030675A

Other languages

English (en)

Croatian (hr)

Inventor

Gene

Xiaojun Han

Vivekananda

Dmitry Zuev

Bireshwar Dasgupta

Jodi

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-01-26

Filing date

2002-01-11

Publication date

2004-08-31

2002-01-11 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2004-08-31 Publication of HRP20030675A2 publication Critical patent/HRP20030675A2/hr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
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- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

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Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Addiction (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Pregnancy & Childbirth (AREA)
Gynecology & Obstetrics (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Anesthesiology (AREA)
Hematology (AREA)
Child & Adolescent Psychology (AREA)
Urology & Nephrology (AREA)
Nutrition Science (AREA)

HR20030675A 2001-01-26 2002-01-11 Imidazolyl derivatives as corticotropin relasing factor inhibitors HRP20030675A2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US26457001P	2001-01-26	2001-01-26
PCT/US2002/000841 WO2002058704A1 (en)	2001-01-26	2002-01-11	Imidazolyl derivatives as corticotropin releasing factor inhibitors

Publications (1)

Publication Number	Publication Date
HRP20030675A2 true HRP20030675A2 (en)	2004-08-31

Family

ID=23006646

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20030675A HRP20030675A2 (en)	2001-01-26	2002-01-11	Imidazolyl derivatives as corticotropin relasing factor inhibitors

Country Status (22)

Country	Link
US (5)	US6888004B2 (is)
EP (1)	EP1359916A4 (is)
JP (1)	JP2004531475A (is)
KR (1)	KR20040034594A (is)
CN (1)	CN1499972A (is)
BG (1)	BG107999A (is)
BR (1)	BR0206698A (is)
CA (1)	CA2434558A1 (is)
CZ (1)	CZ20032044A3 (is)
EE (1)	EE200300342A (is)
HR (1)	HRP20030675A2 (is)
HU (1)	HUP0303721A2 (is)
IL (1)	IL156813A0 (is)
IS (1)	IS6889A (is)
MX (1)	MXPA03006484A (is)
NO (1)	NO20033350L (is)
PE (1)	PE20020844A1 (is)
PL (1)	PL368555A1 (is)
RU (1)	RU2003126188A (is)
SK (1)	SK9222003A3 (is)
WO (1)	WO2002058704A1 (is)
ZA (1)	ZA200305531B (is)

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BR0206698A (pt) *	2001-01-26	2004-04-20	Bristol Myers Squibb Co	Derivados de imidazolila como inibidores de fator de liberação de corticotropina.
TWI312347B (en)	2001-02-08	2009-07-21	Eisai R&D Man Co Ltd	Bicyclic nitrogen-containing condensed ring compounds
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US7176216B2 (en)	2002-10-22	2007-02-13	Eisai Co., Ltd.	7-phenylpyrazolopyridine compounds
BRPI0313976B8 (pt)	2002-10-22	2021-05-25	Eisai Co Ltd	compostos de 7-fenilpirazolopiridina e uso dos mesmos na preparação de agente terapêutico ou profilático para doenças associadas com o crf ou seus receptores
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US7815905B2 (en) *	2006-01-27	2010-10-19	Research Development Foundation	Methods of increasing insulin sensitivity or decreasing insulin secretion by administering corticotropin releasing factor receptor-2 inhibitors
EP2522351B1 (en)	2007-06-13	2017-09-06	Research Development Foundation	Treatment and prevention of tauopathies and amyloid beta amyloidosis by modulating CRF receptor signaling
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PL2266990T3 (pl)	2008-04-15	2013-03-29	Eisai R&D Man Co Ltd	ZWIĄZEK 3-FENYLOPIRAZOLO[5,1-b] TIAZOLOWY
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EP2531510B1 (en) *	2010-02-01	2014-07-23	Novartis AG	Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists
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CN108299439B (zh)	2011-11-10	2021-02-09	Udc 爱尔兰有限责任公司	用于电子应用的4H-咪唑并[1,2-a]咪唑
TWI644888B (zh)	2012-02-07	2018-12-21	拜耳智慧財產有限公司	用於製備經取代之鄰胺苯甲酸衍生物之方法
IN2014DN10229A (is)	2012-05-25	2015-08-07	Nutech Ventures
CN108191870A (zh)	2012-07-10	2018-06-22	Udc 爱尔兰有限责任公司	用于电子应用的苯并咪唑并[1,2-a]苯并咪唑衍生物
RU2696278C2 (ru) *	2012-07-18	2019-08-01	Юниверсити Оф Нотр Дам Дю Лак	5,5-гетероароматические противоинфекционные соединения
US20140206667A1 (en)	2012-11-14	2014-07-24	Michela Gallagher	Methods and compositions for treating schizophrenia
CN105384691B (zh) *	2015-10-26	2018-06-29	深圳大学	一种谷氨酰胺酰基环化酶抑制剂的制备方法及应用
US11214550B2 (en) *	2017-07-24	2022-01-04	University Of South Florida	Bis-cyclic guanidines as antibacterial agents
WO2019169113A1 (en) *	2018-03-02	2019-09-06	Ponce Medical School Foundation, Inc.	Compositions and methods for the treatment of endometriosis

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US6696441B1 (en) *	2000-08-11	2004-02-24	The Regents Of The University Of California	Inhibition of p53-induced stress response
CA2423156A1 (en) *	2000-09-21	2002-03-28	Bristol-Myers Squibb Company	Substituted azole derivatives as inhibitors of corticotropin releasing factor
BR0206698A (pt) *	2001-01-26	2004-04-20	Bristol Myers Squibb Co	Derivados de imidazolila como inibidores de fator de liberação de corticotropina.

2002
- 2002-01-11 BR BR0206698-0A patent/BR0206698A/pt not_active IP Right Cessation
- 2002-01-11 WO PCT/US2002/000841 patent/WO2002058704A1/en not_active Ceased
- 2002-01-11 RU RU2003126188/04A patent/RU2003126188A/ru not_active Application Discontinuation
- 2002-01-11 MX MXPA03006484A patent/MXPA03006484A/es unknown
- 2002-01-11 PL PL02368555A patent/PL368555A1/xx unknown
- 2002-01-11 EP EP02705754A patent/EP1359916A4/en not_active Withdrawn
- 2002-01-11 CA CA002434558A patent/CA2434558A1/en not_active Abandoned
- 2002-01-11 JP JP2002559038A patent/JP2004531475A/ja active Pending
- 2002-01-11 CZ CZ20032044A patent/CZ20032044A3/cs unknown
- 2002-01-11 SK SK922-2003A patent/SK9222003A3/sk unknown
- 2002-01-11 HU HU0303721A patent/HUP0303721A2/hu unknown
- 2002-01-11 US US10/044,183 patent/US6888004B2/en not_active Expired - Lifetime
- 2002-01-11 HR HR20030675A patent/HRP20030675A2/hr not_active Application Discontinuation
- 2002-01-11 IL IL15681302A patent/IL156813A0/xx unknown
- 2002-01-11 CN CNA028071352A patent/CN1499972A/zh active Pending
- 2002-01-11 KR KR10-2003-7009883A patent/KR20040034594A/ko not_active Withdrawn
- 2002-01-11 EE EEP200300342A patent/EE200300342A/xx unknown
- 2002-01-25 PE PE2002000063A patent/PE20020844A1/es not_active Application Discontinuation
2003
- 2003-07-17 ZA ZA200305531A patent/ZA200305531B/en unknown
- 2003-07-17 BG BG107999A patent/BG107999A/xx unknown
- 2003-07-24 IS IS6889A patent/IS6889A/is unknown
- 2003-07-25 NO NO20033350A patent/NO20033350L/no not_active Application Discontinuation
2004
- 2004-01-29 US US10/767,645 patent/US7211669B2/en not_active Expired - Lifetime
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Publication number	Publication date
IL156813A0 (en)	2004-02-08
US20040235924A1 (en)	2004-11-25
US20040225001A1 (en)	2004-11-11
CN1499972A (zh)	2004-05-26
MXPA03006484A (es)	2003-09-22
EE200300342A (et)	2003-12-15
CZ20032044A3 (cs)	2003-12-17
HUP0303721A2 (hu)	2004-03-01
KR20040034594A (ko)	2004-04-28
BG107999A (en)	2004-08-31
NO20033350L (no)	2003-09-22
CA2434558A1 (en)	2002-08-01
US20040225130A1 (en)	2004-11-11
WO2002058704A1 (en)	2002-08-01
ZA200305531B (en)	2004-07-27
US20020183375A1 (en)	2002-12-05
US7125990B2 (en)	2006-10-24
PL368555A1 (en)	2005-04-04
JP2004531475A (ja)	2004-10-14
IS6889A (is)	2003-07-24
NO20033350D0 (no)	2003-07-25
US7244746B2 (en)	2007-07-17
US6888004B2 (en)	2005-05-03
PE20020844A1 (es)	2002-09-27
SK9222003A3 (en)	2004-05-04
EP1359916A1 (en)	2003-11-12
RU2003126188A (ru)	2005-03-27
BR0206698A (pt)	2004-04-20
US20040254382A1 (en)	2004-12-16
US7238699B2 (en)	2007-07-03
US7211669B2 (en)	2007-05-01
EP1359916A4 (en)	2004-04-07

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