HRP20020696A2 - 3-aminoquinazolin-2,4-dione antibakterial agents - Google Patents
3-aminoquinazolin-2,4-dione antibakterial agents Download PDFInfo
- Publication number
- HRP20020696A2 HRP20020696A2 HR20020696A HRP20020696A HRP20020696A2 HR P20020696 A2 HRP20020696 A2 HR P20020696A2 HR 20020696 A HR20020696 A HR 20020696A HR P20020696 A HRP20020696 A HR P20020696A HR P20020696 A2 HRP20020696 A2 HR P20020696A2
- Authority
- HR
- Croatia
- Prior art keywords
- amino
- cyclopropyl
- dione
- fluoro
- quinazoline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Paper (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17825200P | 2000-01-24 | 2000-01-24 | |
| US24126700P | 2000-10-18 | 2000-10-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20020696A2 true HRP20020696A2 (en) | 2003-12-31 |
Family
ID=26874138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20020696A HRP20020696A2 (en) | 2000-01-24 | 2000-12-12 | 3-aminoquinazolin-2,4-dione antibakterial agents |
Country Status (38)
| Country | Link |
|---|---|
| US (2) | US7094780B1 (es) |
| EP (1) | EP1255739B1 (es) |
| JP (1) | JP4811978B2 (es) |
| KR (1) | KR20020067701A (es) |
| CN (1) | CN1425008A (es) |
| AP (1) | AP2002002603A0 (es) |
| AR (1) | AR030186A1 (es) |
| AT (1) | ATE398110T1 (es) |
| AU (1) | AU783078B2 (es) |
| BG (1) | BG107023A (es) |
| BR (1) | BR0017010A (es) |
| CA (1) | CA2393802C (es) |
| CO (1) | CO5320600A1 (es) |
| CR (1) | CR6709A (es) |
| DE (1) | DE60039194D1 (es) |
| EA (1) | EA005585B1 (es) |
| EE (1) | EE200200412A (es) |
| ES (1) | ES2304992T3 (es) |
| GE (1) | GEP20053429B (es) |
| HK (1) | HK1054237A1 (es) |
| HN (1) | HN2001000009A (es) |
| HR (1) | HRP20020696A2 (es) |
| HU (1) | HUP0204101A3 (es) |
| IL (1) | IL150393A0 (es) |
| IS (1) | IS6448A (es) |
| MA (1) | MA26866A1 (es) |
| MX (1) | MXPA02005989A (es) |
| NO (1) | NO20023516L (es) |
| OA (1) | OA12316A (es) |
| PA (1) | PA8510101A1 (es) |
| PE (1) | PE20011060A1 (es) |
| PL (1) | PL356837A1 (es) |
| SK (1) | SK10572002A3 (es) |
| SV (1) | SV2001000288A (es) |
| TN (1) | TNSN01011A1 (es) |
| UY (1) | UY26551A1 (es) |
| WO (1) | WO2001053273A1 (es) |
| YU (1) | YU55902A (es) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2193558C2 (ru) | 1997-09-15 | 2002-11-27 | Дзе Проктер Энд Гэмбл Компани | Производные хинолона и фармацевтическая композиция на их основе |
| MXPA03010799A (es) | 2001-05-30 | 2005-07-25 | Warner Lambert Co | Agentes antibacterianos. |
| JP2005501021A (ja) * | 2001-06-19 | 2005-01-13 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 抗細菌剤 |
| US6900224B2 (en) * | 2002-07-31 | 2005-05-31 | The Procter & Gamble Company | Antimicrobial quinolones, their compositions and uses |
| WO2005026153A1 (en) * | 2003-09-12 | 2005-03-24 | Warner-Lambert Company Llc | Quinazoline-2, 4-diones as antibacterial agents |
| EP1667994A1 (en) * | 2003-09-12 | 2006-06-14 | Warner-Lambert Company LLC | Quinolone antibacterial agents |
| JP2007511597A (ja) * | 2003-11-18 | 2007-05-10 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 抗菌アミノキナゾリヂンヂオン誘導体 |
| WO2006019965A2 (en) * | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| GB0416730D0 (en) | 2004-07-27 | 2004-09-01 | Novartis Ag | Organic compounds |
| KR100915472B1 (ko) * | 2005-01-26 | 2009-09-03 | 에프. 호프만-라 로슈 아게 | 페닐 메탄온 유도체 및 그의 글라이신 트랜스포터 1억제제로서의 용도 |
| GB0507298D0 (en) * | 2005-04-11 | 2005-05-18 | Novartis Ag | Organic compounds |
| US7977346B2 (en) | 2006-01-17 | 2011-07-12 | Guoqing Paul Chen | Spiro compounds and methods of use |
| WO2007110835A2 (en) | 2006-03-28 | 2007-10-04 | The Procter & Gamble Company | A coupling process for preparing quinolone intermediates |
| MY148393A (en) | 2006-03-28 | 2013-04-15 | Taigen Biotechnology Co Ltd | Malate salts, and polymorphs of (3s, 5s)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid |
| US20080139574A1 (en) | 2006-11-30 | 2008-06-12 | Cadila Healthcare Limited | Novel quinoline derivatives |
| CN101925585B (zh) * | 2008-01-30 | 2013-04-17 | 新丰制药株式会社 | 喹唑啉-2,4-二酮衍生物及含有所述衍生物的用于预防和治疗脑神经疾病的药物组合物 |
| WO2011031745A1 (en) | 2009-09-09 | 2011-03-17 | Achaogen, Inc. | Antibacterial fluoroquinolone analogs |
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| EP2686320B1 (en) | 2011-03-15 | 2016-05-18 | Merck Sharp & Dohme Corp. | Tricyclic gyrase inhibitors |
| SI2796460T1 (sl) * | 2011-12-21 | 2018-10-30 | Jiangsu Hengrui Medicine Co. Ltd | Pirolni šestčlenski derivat heteroarilnega obroča, postopek priprave zanj in medicinske uporabe le-tega |
| SI2861595T1 (sl) | 2012-06-13 | 2017-04-26 | Incyte Holdings Corporation | Substituirane triciklične spojine kot inhibitorji fgfr |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| TWI639602B (zh) | 2012-09-12 | 2018-11-01 | 默沙東藥廠 | 三環旋轉酶抑制劑 |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| ES2657451T3 (es) | 2013-04-19 | 2018-03-05 | Incyte Holdings Corporation | Heterocíclicos bicíclicos como inhibidores del FGFR |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
| CA2976790C (en) | 2015-02-20 | 2024-02-27 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| CN108530448A (zh) * | 2017-03-02 | 2018-09-14 | 浙江司太立制药股份有限公司 | 含有碱性氮杂螺环片段的苯并噻嗪-4-酮类化合物及其制备方法 |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| KR20210018265A (ko) | 2018-05-04 | 2021-02-17 | 인사이트 코포레이션 | Fgfr 억제제의 고체 형태 및 이의 제조 방법 |
| MX2020011639A (es) | 2018-05-04 | 2021-02-15 | Incyte Corp | Sales de un inhibidor de receptores de factor de crecimiento de fibroblastos (fgfr). |
| CN111620866A (zh) * | 2019-02-27 | 2020-09-04 | 南京药石科技股份有限公司 | 一种顺式-7,7-二氟-六氢-1H 吡咯并[3,4-c]吡啶衍生物及其制备方法 |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| JP7675711B2 (ja) | 2019-10-14 | 2025-05-13 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤としての二環式複素環 |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021113479A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| CR20220285A (es) | 2019-12-04 | 2022-10-27 | Incyte Corp | Derivados de un inhibidor de fgfr |
| WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| CN111499513B (zh) * | 2020-04-24 | 2023-03-14 | 上海毕得医药科技股份有限公司 | 一种2,3,4,5-四溴苯甲酸酯的合成方法 |
| JP2024513575A (ja) | 2021-04-12 | 2024-03-26 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤及びネクチン－４標的化剤を含む併用療法 |
| AR126102A1 (es) | 2021-06-09 | 2023-09-13 | Incyte Corp | Heterociclos tricíclicos como inhibidores de fgfr |
| EP4352060A1 (en) | 2021-06-09 | 2024-04-17 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1068263B (es) * | 1959-11-05 | |||
| FR1203542A (fr) * | 1958-02-25 | 1960-01-19 | Rhone Poulenc Sa | Nouveaux dérivés de la phénothiazine comportant en position 10 une chaîne pipérazinique et leurs procédés de préparation |
| ATE8626T1 (de) * | 1980-03-10 | 1984-08-15 | Berri-Balzac Societe Dite: | 3-amino-(1h,3h)-2,4-chinazolindionderivate. |
| GB2097784A (en) * | 1981-04-28 | 1982-11-10 | Davidson Dr John Stirton | Dihydrobenzotriazepine diones; aminoquinazoline diones |
| WO1994014809A1 (de) | 1992-12-23 | 1994-07-07 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Anellierte uracilderivate |
| AU6908398A (en) | 1996-10-28 | 1998-05-22 | Versicor Inc | Fused 2,4-pyrimidinedione combinatorial libraries and biologically active fused 2,4-pyramidinediones |
| ATE239000T1 (de) * | 1997-10-28 | 2003-05-15 | Warner Lambert Co | 7-substituierte chinazolin-2,4-dionen verwendbar als antibakterielle mittel |
| EA003640B1 (ru) | 1998-05-26 | 2003-08-28 | Варнер-Ламберт Компани | Бициклические пиримидины и бициклические 3,4-дигидропиримидины как ингибиторы клеточной пролиферации |
| WO2000035885A1 (en) * | 1998-12-11 | 2000-06-22 | F. Hoffmann-La Roche Ag | Cyclic hydrazine derivatives as tnf-alpha inhibitors |
-
2000
- 2000-12-12 HR HR20020696A patent/HRP20020696A2/hr not_active Application Discontinuation
- 2000-12-12 IL IL15039300A patent/IL150393A0/xx unknown
- 2000-12-12 JP JP2001553275A patent/JP4811978B2/ja not_active Expired - Fee Related
- 2000-12-12 EP EP00984246A patent/EP1255739B1/en not_active Expired - Lifetime
- 2000-12-12 SK SK1057-2002A patent/SK10572002A3/sk unknown
- 2000-12-12 EE EEP200200412A patent/EE200200412A/xx unknown
- 2000-12-12 HU HU0204101A patent/HUP0204101A3/hu unknown
- 2000-12-12 EA EA200200661A patent/EA005585B1/ru not_active IP Right Cessation
- 2000-12-12 CN CN00818578A patent/CN1425008A/zh active Pending
- 2000-12-12 MX MXPA02005989A patent/MXPA02005989A/es active IP Right Grant
- 2000-12-12 KR KR1020027009515A patent/KR20020067701A/ko not_active Withdrawn
- 2000-12-12 PL PL00356837A patent/PL356837A1/xx not_active Application Discontinuation
- 2000-12-12 AP APAP/P/2002/002603A patent/AP2002002603A0/en unknown
- 2000-12-12 AT AT00984246T patent/ATE398110T1/de not_active IP Right Cessation
- 2000-12-12 OA OA1200200210A patent/OA12316A/en unknown
- 2000-12-12 DE DE60039194T patent/DE60039194D1/de not_active Expired - Lifetime
- 2000-12-12 CA CA2393802A patent/CA2393802C/en not_active Expired - Fee Related
- 2000-12-12 HK HK03106519.6A patent/HK1054237A1/zh unknown
- 2000-12-12 US US10/182,221 patent/US7094780B1/en not_active Expired - Fee Related
- 2000-12-12 WO PCT/US2000/033656 patent/WO2001053273A1/en not_active Ceased
- 2000-12-12 YU YU55902A patent/YU55902A/sh unknown
- 2000-12-12 AU AU20899/01A patent/AU783078B2/en not_active Ceased
- 2000-12-12 GE GE4912A patent/GEP20053429B/en unknown
- 2000-12-12 ES ES00984246T patent/ES2304992T3/es not_active Expired - Lifetime
- 2000-12-12 BR BR0017010-0A patent/BR0017010A/pt not_active Application Discontinuation
-
2001
- 2001-01-19 PA PA20018510101A patent/PA8510101A1/es unknown
- 2001-01-22 TN TNTNSN01011A patent/TNSN01011A1/en unknown
- 2001-01-22 SV SV2001000288A patent/SV2001000288A/es not_active Application Discontinuation
- 2001-01-22 UY UY26551A patent/UY26551A1/es not_active Application Discontinuation
- 2001-01-22 HN HN2001000009A patent/HN2001000009A/es unknown
- 2001-01-22 CO CO01004183A patent/CO5320600A1/es not_active Application Discontinuation
- 2001-01-22 PE PE2001000066A patent/PE20011060A1/es not_active Application Discontinuation
- 2001-01-23 AR ARP010100278A patent/AR030186A1/es unknown
-
2002
- 2002-06-27 IS IS6448A patent/IS6448A/is unknown
- 2002-07-19 CR CR6709A patent/CR6709A/es not_active Application Discontinuation
- 2002-07-22 MA MA26734A patent/MA26866A1/fr unknown
- 2002-07-23 NO NO20023516A patent/NO20023516L/no not_active Application Discontinuation
- 2002-08-22 BG BG107023A patent/BG107023A/xx unknown
-
2006
- 2006-06-13 US US11/452,121 patent/US7582627B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
| OBST | Application withdrawn |