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ATE398110T1 - 3-aminochinazolin-2,4-dione als antibakterielle mittel - Google Patents

3-aminochinazolin-2,4-dione als antibakterielle mittel

Info

Publication number
ATE398110T1
ATE398110T1 AT00984246T AT00984246T ATE398110T1 AT E398110 T1 ATE398110 T1 AT E398110T1 AT 00984246 T AT00984246 T AT 00984246T AT 00984246 T AT00984246 T AT 00984246T AT E398110 T1 ATE398110 T1 AT E398110T1
Authority
AT
Austria
Prior art keywords
aminoquinazoline
dione
antibacterial agent
antibacterial
agent
Prior art date
Application number
AT00984246T
Other languages
English (en)
Inventor
Paul Bird
Edmund Ellsworth
Dai Nguyen
Joseph SANCHEZ
Howard Showalter
Rajeshwar Singh
Michael STIER
Tuan Tran
Brian Watson
Judy Yip
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE398110T1 publication Critical patent/ATE398110T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Paper (AREA)
AT00984246T 2000-01-24 2000-12-12 3-aminochinazolin-2,4-dione als antibakterielle mittel ATE398110T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17825200P 2000-01-24 2000-01-24
US24126700P 2000-10-18 2000-10-18

Publications (1)

Publication Number Publication Date
ATE398110T1 true ATE398110T1 (de) 2008-07-15

Family

ID=26874138

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00984246T ATE398110T1 (de) 2000-01-24 2000-12-12 3-aminochinazolin-2,4-dione als antibakterielle mittel

Country Status (38)

Country Link
US (2) US7094780B1 (de)
EP (1) EP1255739B1 (de)
JP (1) JP4811978B2 (de)
KR (1) KR20020067701A (de)
CN (1) CN1425008A (de)
AP (1) AP2002002603A0 (de)
AR (1) AR030186A1 (de)
AT (1) ATE398110T1 (de)
AU (1) AU783078B2 (de)
BG (1) BG107023A (de)
BR (1) BR0017010A (de)
CA (1) CA2393802C (de)
CO (1) CO5320600A1 (de)
CR (1) CR6709A (de)
DE (1) DE60039194D1 (de)
EA (1) EA005585B1 (de)
EE (1) EE200200412A (de)
ES (1) ES2304992T3 (de)
GE (1) GEP20053429B (de)
HK (1) HK1054237A1 (de)
HN (1) HN2001000009A (de)
HR (1) HRP20020696A2 (de)
HU (1) HUP0204101A3 (de)
IL (1) IL150393A0 (de)
IS (1) IS6448A (de)
MA (1) MA26866A1 (de)
MX (1) MXPA02005989A (de)
NO (1) NO20023516D0 (de)
OA (1) OA12316A (de)
PA (1) PA8510101A1 (de)
PE (1) PE20011060A1 (de)
PL (1) PL356837A1 (de)
SK (1) SK10572002A3 (de)
SV (1) SV2001000288A (de)
TN (1) TNSN01011A1 (de)
UY (1) UY26551A1 (de)
WO (1) WO2001053273A1 (de)
YU (1) YU55902A (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4669607B2 (ja) 1997-09-15 2011-04-13 ザ プロクター アンド ギャンブル カンパニー 抗微生物キノロン類、その組成物およびその使用
ATE315038T1 (de) 2001-05-30 2006-02-15 Warner Lambert Co Antibakterielle mittel
MXPA03009894A (es) * 2001-06-19 2004-02-17 Warner Lambert Co Agentes antibacterianos.
US6900224B2 (en) * 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
WO2005026153A1 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinazoline-2, 4-diones as antibacterial agents
WO2005026154A1 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinolone antibacterial agents
WO2005049605A1 (en) * 2003-11-18 2005-06-02 Warner-Lambert Company Llc Antibacterial aminoquinazolidinedione derivatives
WO2006019965A2 (en) * 2004-07-16 2006-02-23 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
GB0416730D0 (en) 2004-07-27 2004-09-01 Novartis Ag Organic compounds
DE602006010175D1 (de) * 2005-01-26 2009-12-17 Hoffmann La Roche Phenylmethanonderivate und ihre verwendung als glycin-transporter-1-hemmer
GB0507298D0 (en) * 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7977346B2 (en) 2006-01-17 2011-07-12 Guoqing Paul Chen Spiro compounds and methods of use
HRP20110558T1 (hr) 2006-03-28 2011-09-30 Warner Chilcott Company Malatne soli i polimorfi od (3s, 5s)-7-[3-amino-5-metil-piperidinil]-1-ciklopropil-1, 4-dihidro-8-metoksi-4-okso-3-kinolinkarboksilne kiseline
US7456279B2 (en) 2006-03-28 2008-11-25 The Procter & Gamble Company Coupling process for preparing quinolone intermediates
US20080139574A1 (en) 2006-11-30 2008-06-12 Cadila Healthcare Limited Novel quinoline derivatives
PL2239257T3 (pl) * 2008-01-30 2012-10-31 Shin Poong Pharmaceutical Co Ltd Nowe pochodne chinazolino-2,4-dionu oraz zawierające je farmaceutyczne kompozycje do profilaktyki i leczenia chorób nerwów czaszkowych
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
CN103562208B (zh) 2011-03-15 2016-08-31 默沙东公司 三环促旋酶抑制剂
ES2682755T3 (es) * 2011-12-21 2018-09-21 Jiangsu Hengrui Medicine Co. Ltd. Derivado del anillo heteroarilo de seis miembros de pirrol, método de preparación del mismo y sus usos medicinales
NZ702747A (en) 2012-06-13 2017-03-31 Incyte Holdings Corp Substituted tricyclic compounds as fgfr inhibitors
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
US10865216B2 (en) 2012-09-12 2020-12-15 Merck Sharp & Dohme Corp. Tricyclic Gyrase inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
LT2986610T (lt) 2013-04-19 2018-04-10 Incyte Holdings Corporation Bicikliniai heterociklai, kaip fgfr inhibitoriai
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
SG10201913036RA (en) 2015-02-20 2020-02-27 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
CN108530448A (zh) * 2017-03-02 2018-09-14 浙江司太立制药股份有限公司 含有碱性氮杂螺环片段的苯并噻嗪-4-酮类化合物及其制备方法
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
EP4309737A3 (de) 2018-05-04 2024-03-27 Incyte Corporation Feste formen eines fgfr-inhibitors und verfahren zur herstellung davon
EP3788046B1 (de) 2018-05-04 2025-12-10 Incyte Corporation Salze eines fgfr-hemmers
CN111620866A (zh) * 2019-02-27 2020-09-04 南京药石科技股份有限公司 一种顺式-7,7-二氟-六氢-1H 吡咯并[3,4-c]吡啶衍生物及其制备方法
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
WO2021067374A1 (en) 2019-10-01 2021-04-08 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
CR20220169A (es) 2019-10-14 2022-10-27 Incyte Corp Heterociclos bicíclicos como inhibidores de fgfr
WO2021076728A1 (en) 2019-10-16 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
CA3163875A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
KR20220131900A (ko) 2019-12-04 2022-09-29 인사이트 코포레이션 Fgfr 억제제의 유도체
US12012409B2 (en) 2020-01-15 2024-06-18 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
CN111499513B (zh) * 2020-04-24 2023-03-14 上海毕得医药科技股份有限公司 一种2,3,4,5-四溴苯甲酸酯的合成方法
US12065494B2 (en) 2021-04-12 2024-08-20 Incyte Corporation Combination therapy comprising an FGFR inhibitor and a Nectin-4 targeting agent
AR126101A1 (es) 2021-06-09 2023-09-13 Incyte Corp Heterociclos tricíclicos como inhibidores de fgfr
AR126102A1 (es) 2021-06-09 2023-09-13 Incyte Corp Heterociclos tricíclicos como inhibidores de fgfr

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1068263B (de) * 1959-11-05
FR1203542A (fr) * 1958-02-25 1960-01-19 Rhone Poulenc Sa Nouveaux dérivés de la phénothiazine comportant en position 10 une chaîne pipérazinique et leurs procédés de préparation
ATE8626T1 (de) 1980-03-10 1984-08-15 Berri-Balzac Societe Dite: 3-amino-(1h,3h)-2,4-chinazolindionderivate.
GB2097784A (en) 1981-04-28 1982-11-10 Davidson Dr John Stirton Dihydrobenzotriazepine diones; aminoquinazoline diones
AU5813394A (en) 1992-12-23 1994-07-19 Byk Gulden Lomberg Chemische Fabrik Gmbh Anellated uracil derivates
AU6908398A (en) 1996-10-28 1998-05-22 Versicor Inc Fused 2,4-pyrimidinedione combinatorial libraries and biologically active fused 2,4-pyramidinediones
DE69814135T2 (de) * 1997-10-28 2004-04-01 Warner-Lambert Co. Llc 7-substituierte chinazolin-2,4-dionen verwendbar als antibakterielle mittel
AU763839B2 (en) 1998-05-26 2003-07-31 Warner-Lambert Company Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation
CA2353924A1 (en) * 1998-12-11 2000-06-22 F. Hoffmann-La Roche Ag Cyclic hydrazine derivatives as tnf-alpha inhibitors

Also Published As

Publication number Publication date
JP2003520277A (ja) 2003-07-02
PE20011060A1 (es) 2001-10-12
KR20020067701A (ko) 2002-08-23
CA2393802A1 (en) 2001-07-26
IL150393A0 (en) 2002-12-01
IS6448A (is) 2002-06-27
AP2002002603A0 (en) 2002-09-30
AU2089901A (en) 2001-07-31
SK10572002A3 (sk) 2003-10-07
UY26551A1 (es) 2001-04-30
EP1255739A1 (de) 2002-11-13
CR6709A (es) 2003-11-25
BR0017010A (pt) 2002-11-05
WO2001053273A1 (en) 2001-07-26
US20060183762A1 (en) 2006-08-17
BG107023A (en) 2003-04-30
EE200200412A (et) 2003-10-15
US20060287308A1 (en) 2006-12-21
TNSN01011A1 (en) 2005-11-10
MA26866A1 (fr) 2004-12-20
HUP0204101A3 (en) 2004-05-28
SV2001000288A (es) 2001-11-30
GEP20053429B (en) 2005-01-25
JP4811978B2 (ja) 2011-11-09
CN1425008A (zh) 2003-06-18
PA8510101A1 (es) 2003-06-30
HUP0204101A2 (hu) 2003-04-28
PL356837A1 (en) 2004-07-12
AR030186A1 (es) 2003-08-13
CO5320600A1 (es) 2003-09-30
HN2001000009A (es) 2001-06-13
US7094780B1 (en) 2006-08-22
EP1255739B1 (de) 2008-06-11
US7582627B2 (en) 2009-09-01
HRP20020696A2 (en) 2003-12-31
DE60039194D1 (de) 2008-07-24
ES2304992T3 (es) 2008-11-01
EA005585B1 (ru) 2005-04-28
EA200200661A1 (ru) 2003-02-27
NO20023516L (no) 2002-07-23
OA12316A (en) 2006-05-15
NO20023516D0 (no) 2002-07-23
AU783078B2 (en) 2005-09-22
HK1054237A1 (zh) 2003-11-21
MXPA02005989A (es) 2002-10-23
YU55902A (sh) 2006-01-16
CA2393802C (en) 2011-04-19

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