HRP20010903A2 - Pyrazinone thrombin inhibitors - Google Patents

Pyrazinone thrombin inhibitors Download PDF

Info

Publication number: HRP20010903A2
Authority: HR; Croatia
Prior art keywords: alkyl; ring; image; halogen; cycloalkyl
Prior art date: 1999-06-04

Application number

HR20010903A

Other languages

English (en)

Croatian (hr)

Inventor

S Christopher Burgey

A Kyle Robinson

D Peter Williams

A Craig Coburna

Terry A Lyle

Philip E Sanderson

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-06-04

Filing date

2000-06-01

Publication date

2003-04-30

2000-06-01 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2003-04-30 Publication of HRP20010903A2 publication Critical patent/HRP20010903A2/hr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/18—Oxygen or sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/16—Halogen atoms; Nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Diabetes (AREA)
Ophthalmology & Optometry (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

HR20010903A 1999-06-04 2000-06-01 Pyrazinone thrombin inhibitors HRP20010903A2 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US13753899P	1999-06-04	1999-06-04
US14429199P	1999-07-16	1999-07-16
PCT/US2000/015140 WO2000075134A1 (en)	1999-06-04	2000-06-01	Pyrazinone thrombin inhibitors

Publications (1)

Publication Number	Publication Date
HRP20010903A2 true HRP20010903A2 (en)	2003-04-30

Family

ID=26835338

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20010903A HRP20010903A2 (en)	1999-06-04	2000-06-01	Pyrazinone thrombin inhibitors

Country Status (31)

Country	Link
US (1)	US6455532B1 (uk)
EP (1)	EP1189899B1 (uk)
JP (2)	JP4495377B2 (uk)
KR (1)	KR20020029653A (uk)
CN (1)	CN1353705A (uk)
AT (1)	ATE232527T1 (uk)
AU (1)	AU761982B2 (uk)
BG (1)	BG106263A (uk)
BR (1)	BR0011260A (uk)
CA (1)	CA2373999C (uk)
CZ (1)	CZ20014343A3 (uk)
DE (1)	DE60001414T2 (uk)
DK (1)	DK1189899T3 (uk)
DZ (1)	DZ3264A1 (uk)
EA (1)	EA004372B1 (uk)
EE (1)	EE200100641A (uk)
ES (1)	ES2190417T3 (uk)
HK (1)	HK1047277A1 (uk)
HR (1)	HRP20010903A2 (uk)
HU (1)	HUP0202366A3 (uk)
IL (1)	IL146393A0 (uk)
IS (1)	IS6158A (uk)
MX (1)	MXPA01012505A (uk)
NO (1)	NO20015887L (uk)
NZ (1)	NZ515454A (uk)
PL (1)	PL352558A1 (uk)
SK (1)	SK17532001A3 (uk)
TR (1)	TR200103491T2 (uk)
UA (1)	UA58636C2 (uk)
WO (1)	WO2000075134A1 (uk)
YU (1)	YU84301A (uk)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2001265094A1 (en)	2000-06-01	2001-12-11	Merck And Co., Inc.	Pyrazinone thrombin inhibitors
FR2818277B1 (fr) *	2000-12-14	2003-01-24	Servier Lab	Nouveaux derives bicycliques d'amino-pyrazinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2002230836A1 (en)	2000-12-18	2002-07-01	Merck & Co., Inc.	Benzylamine derivatives and their use as thrombin inhibitors
US6528503B2 (en)	2000-12-18	2003-03-04	Merck & Co., Inc.	Thrombin inhibitors
JP2005504003A (ja)	2001-02-09	2005-02-10	メルク　エンド　カムパニー　インコーポレーテッド	トロンビン阻害剤
US7262211B2 (en)	2001-12-04	2007-08-28	Dendreon Corporation	Aromatic heterocyclic non-covalent inhibitors of urokinase and blood vessel formation
FR2867780B1 (fr) *	2004-03-19	2006-05-19	Servier Lab	Nouveaux derives de 4-oxo-4,6,7,8-tetrahydropyrrolo (1,2-a) pyrazine-6-carboxamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE102004022897A1 (de) *	2004-05-10	2005-12-08	Bayer Cropscience Ag	Azinyl-imidazoazine
GB0507577D0 (en)	2005-04-14	2005-05-18	Novartis Ag	Organic compounds
DE102008041214A1 (de)	2008-08-13	2010-02-18	Bayer Cropscience Ag	N-substituierte Azinylakyl-azincarboxamide und deren Analoge
US8541580B2 (en) *	2009-11-03	2013-09-24	Diakron Pharmaceuticals, Inc.	Process for the preparation of pyrazinone thrombin inhibitor and its intermediates
CA2857953A1 (en) *	2011-11-07	2013-05-16	Diakron Pharmaceuticals Inc.	An extended release formulation of a direct thrombin inhibitor
CN115677511B (zh) *	2022-10-26	2024-06-21	南通华祥医药科技有限公司	一种2,2-二氟丙胺盐酸盐的合成方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0262096B1 (de)	1986-09-26	1992-01-02	Ciba-Geigy Ag	Aminopyrazinone und Aminotriazinone
TW201303B (uk)	1990-07-05	1993-03-01	Hoffmann La Roche
GB9207145D0 (en)	1991-04-18	1992-05-13	Ici Plc	Heterocyclic amides
JP2599665B2 (ja)	1991-05-01	1997-04-09	大塚製薬株式会社	ピラジン誘導体
DE4127404A1 (de)	1991-08-19	1993-02-25	Thomae Gmbh Dr K	Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
TW223629B (uk)	1992-03-06	1994-05-11	Hoffmann La Roche
AU670381B2 (en)	1993-04-30	1996-07-11	Merck & Co., Inc.	Thrombin inhibitors
US5672582A (en)	1993-04-30	1997-09-30	Merck & Co., Inc.	Thrombin inhibitors
US5510369A (en)	1994-07-22	1996-04-23	Merck & Co., Inc.	Pyrrolidine thrombin inhibitors
AU698911B2 (en)	1995-04-04	1998-11-12	Merck & Co., Inc.	Thrombin inhibitors
US5629324A (en)	1995-04-10	1997-05-13	Merck & Co., Inc.	Thrombin inhibitors
WO1997001338A1 (en)	1995-06-27	1997-01-16	Merck & Co., Inc.	Pyridinone-thrombin inhibitors
JP3140790B2 (ja)	1996-04-23	2001-03-05	メルクエンドカンパニーインコーポレーテッド	ピラジノン系トロンビン阻害薬
US5668289A (en)	1996-06-24	1997-09-16	Merck & Co., Inc.	Pyridinone thrombin inhibitors
US5981546A (en)	1996-08-29	1999-11-09	Merck & Co., Inc.	Integrin antagonists
CA2277929A1 (en)	1997-01-22	1998-07-23	Merck & Co., Inc.	Thrombin inhibitors
CA2283704A1 (en) *	1997-03-24	1998-10-01	Merck & Co., Inc.	Thrombin inhibitors
US5866573A (en)	1997-04-21	1999-02-02	Merck & Co., Inc.	Pyrazinone thrombin inhibitors
JP2001514227A (ja) *	1997-09-05	2001-09-11	メルクエンドカムパニーインコーポレーテッド	ピラジノン系トロンビン阻害薬
CA2329914A1 (en) *	1998-05-19	1999-11-25	Merck & Co., Inc.	Pyrazinone thrombin inhibitors
IL146245A0 (en)	1999-05-19	2002-07-25	Pharmacia Corp	Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade

2000
- 2000-01-06 UA UA2002010007A patent/UA58636C2/uk unknown
- 2000-06-01 SK SK1753-2001A patent/SK17532001A3/sk unknown
- 2000-06-01 TR TR2001/03491T patent/TR200103491T2/xx unknown
- 2000-06-01 AT AT00939492T patent/ATE232527T1/de active
- 2000-06-01 IL IL14639300A patent/IL146393A0/xx unknown
- 2000-06-01 WO PCT/US2000/015140 patent/WO2000075134A1/en not_active Ceased
- 2000-06-01 JP JP2001502417A patent/JP4495377B2/ja not_active Expired - Fee Related
- 2000-06-01 DE DE60001414T patent/DE60001414T2/de not_active Expired - Lifetime
- 2000-06-01 YU YU84301A patent/YU84301A/sh unknown
- 2000-06-01 CN CN00808497A patent/CN1353705A/zh active Pending
- 2000-06-01 ES ES00939492T patent/ES2190417T3/es not_active Expired - Lifetime
- 2000-06-01 CZ CZ20014343A patent/CZ20014343A3/cs unknown
- 2000-06-01 BR BR0011260-7A patent/BR0011260A/pt not_active IP Right Cessation
- 2000-06-01 EP EP00939492A patent/EP1189899B1/en not_active Expired - Lifetime
- 2000-06-01 DZ DZ003264A patent/DZ3264A1/fr active
- 2000-06-01 NZ NZ515454A patent/NZ515454A/xx not_active Application Discontinuation
- 2000-06-01 MX MXPA01012505A patent/MXPA01012505A/es unknown
- 2000-06-01 AU AU54571/00A patent/AU761982B2/en not_active Expired
- 2000-06-01 US US09/585,112 patent/US6455532B1/en not_active Expired - Lifetime
- 2000-06-01 HU HU0202366A patent/HUP0202366A3/hu unknown
- 2000-06-01 KR KR1020017015562A patent/KR20020029653A/ko not_active Ceased
- 2000-06-01 EE EEP200100641A patent/EE200100641A/xx unknown
- 2000-06-01 DK DK00939492T patent/DK1189899T3/da active
- 2000-06-01 PL PL00352558A patent/PL352558A1/xx not_active Application Discontinuation
- 2000-06-01 EA EA200200005A patent/EA004372B1/ru not_active IP Right Cessation
- 2000-06-01 HR HR20010903A patent/HRP20010903A2/hr not_active Application Discontinuation
- 2000-06-01 HK HK02108849.4A patent/HK1047277A1/zh unknown
- 2000-06-01 CA CA002373999A patent/CA2373999C/en not_active Expired - Lifetime
2001
- 2001-11-13 IS IS6158A patent/IS6158A/is unknown
- 2001-12-03 NO NO20015887A patent/NO20015887L/no not_active Application Discontinuation
- 2001-12-21 BG BG106263A patent/BG106263A/xx unknown
2010
- 2010-02-24 JP JP2010038280A patent/JP2010150275A/ja active Pending

Also Published As

Publication number	Publication date
PL352558A1 (en)	2003-08-25
EA200200005A1 (ru)	2002-06-27
CA2373999A1 (en)	2000-12-14
JP2003501426A (ja)	2003-01-14
BG106263A (en)	2002-06-28
HUP0202366A2 (en)	2002-10-28
DZ3264A1 (fr)	2000-12-14
EE200100641A (et)	2003-02-17
CN1353705A (zh)	2002-06-12
NZ515454A (en)	2004-02-27
IL146393A0 (en)	2002-07-25
NO20015887D0 (no)	2001-12-03
HK1047277A1 (zh)	2003-02-14
WO2000075134A1 (en)	2000-12-14
CA2373999C (en)	2007-01-02
SK17532001A3 (sk)	2002-05-09
DE60001414D1 (en)	2003-03-20
NO20015887L (no)	2002-01-23
HUP0202366A3 (en)	2005-07-28
BR0011260A (pt)	2002-03-19
EP1189899B1 (en)	2003-02-12
AU761982B2 (en)	2003-06-12
TR200103491T2 (tr)	2002-12-23
DE60001414T2 (de)	2003-11-06
MXPA01012505A (es)	2002-07-02
ES2190417T3 (es)	2003-08-01
UA58636C2 (uk)	2003-08-15
CZ20014343A3 (cs)	2002-03-13
JP4495377B2 (ja)	2010-07-07
EP1189899A1 (en)	2002-03-27
JP2010150275A (ja)	2010-07-08
EA004372B1 (ru)	2004-04-29
YU84301A (sh)	2004-07-15
US6455532B1 (en)	2002-09-24
KR20020029653A (ko)	2002-04-19
ATE232527T1 (de)	2003-02-15
DK1189899T3 (da)	2003-03-10
AU5457100A (en)	2000-12-28
IS6158A (is)	2001-11-13

Publication	Publication Date	Title
CZ340898A3 (cs)	1999-02-17	Sloučenina, způsob její výroby a farmaceutický prostředek
JP2010150275A (ja)	2010-07-08	ピラジノントロンビン阻害剤
EP1082324A1 (en)	2001-03-14	Imidazopyridine thrombin inhibitors
WO2002064211A1 (en)	2002-08-22	Thrombin inhibitors
TW201245177A (en)	2012-11-16	Quinolyl amines as kinase inhibitors
JP2002525370A (ja)	2002-08-13	トロンビン阻害剤
US6387911B1 (en)	2002-05-14	Pyrazinone thrombin inhibitors
US6610701B2 (en)	2003-08-26	Thrombin inhibitors
US6462050B1 (en)	2002-10-08	Thrombin inhibitors
US6521625B2 (en)	2003-02-18	Pyrazinone thrombin inhibitors
US7026324B2 (en)	2006-04-11	Thrombin inhibitors
AU1539599A (en)	1999-06-16	Thrombin inhibitors
JP2003501389A (ja)	2003-01-14	トロンビン阻害物質
US7084134B2 (en)	2006-08-01	Thrombin inhibitors
WO1999016750A1 (en)	1999-04-08	Thrombin inhibitors

Legal Events

Date	Code	Title
2003-04-30	A1OB	Publication of a patent application
2003-10-31	ARAI	Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
2004-05-03	OBST	Application withdrawn