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HRP20000415B1 - Kappa receptor opioid peptides - Google Patents

Kappa receptor opioid peptides

Info

Publication number
HRP20000415B1
HRP20000415B1 HR20000415A HRP20000415A HRP20000415B1 HR P20000415 B1 HRP20000415 B1 HR P20000415B1 HR 20000415 A HR20000415 A HR 20000415A HR P20000415 A HRP20000415 A HR P20000415A HR P20000415 B1 HRP20000415 B1 HR P20000415B1
Authority
HR
Croatia
Prior art keywords
opioid peptides
kappa receptor
receptor opioid
kappa
peptides
Prior art date
Application number
HR20000415A
Other languages
English (en)
Inventor
Junien Jean Louis
Pierre J M Riviere
Claudio D Schteingart
Javier Sueiras Diaz
Jerzy A Trojnar
Todd W Vanderah
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring Bv filed Critical Ferring Bv
Publication of HRP20000415A2 publication Critical patent/HRP20000415A2/hr
Publication of HRP20000415B1 publication Critical patent/HRP20000415B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nutrition Science (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HR20000415A 1997-12-23 1998-12-22 Kappa receptor opioid peptides HRP20000415B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/997,208 US5965701A (en) 1997-12-23 1997-12-23 Kappa receptor opioid peptides
PCT/US1998/027282 WO1999032510A1 (en) 1997-12-23 1998-12-22 Kappa receptor opioid peptides

Publications (2)

Publication Number Publication Date
HRP20000415A2 HRP20000415A2 (en) 2000-12-31
HRP20000415B1 true HRP20000415B1 (en) 2004-06-30

Family

ID=25543752

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20000415A HRP20000415B1 (en) 1997-12-23 1998-12-22 Kappa receptor opioid peptides

Country Status (32)

Country Link
US (1) US5965701A (es)
EP (1) EP1042359B1 (es)
JP (1) JP4275852B2 (es)
KR (1) KR100629548B1 (es)
CN (1) CN1154655C (es)
AR (1) AR014167A1 (es)
AT (1) ATE301670T1 (es)
AU (1) AU747806B2 (es)
BR (2) BR9814499B1 (es)
CA (1) CA2315878C (es)
CR (1) CR5936A (es)
CZ (1) CZ297281B6 (es)
DE (1) DE69831176T2 (es)
DK (1) DK1042359T3 (es)
EE (1) EE04440B1 (es)
ES (1) ES2247735T3 (es)
HR (1) HRP20000415B1 (es)
HU (1) HU227640B1 (es)
IL (3) IL136742A0 (es)
MY (1) MY117542A (es)
NO (1) NO327080B1 (es)
NZ (1) NZ505183A (es)
PL (1) PL195842B1 (es)
PT (1) PT1042359E (es)
RU (1) RU2217437C2 (es)
SK (1) SK286135B6 (es)
TR (1) TR200001985T2 (es)
TW (1) TW580502B (es)
UA (1) UA68366C2 (es)
UY (1) UY25327A1 (es)
WO (1) WO1999032510A1 (es)
ZA (1) ZA9811801B (es)

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DE10116978A1 (de) * 2001-04-05 2002-10-10 Merck Patent Gmbh Kappa-Opiatagonisten für die Behandlung von Erkrankungen der Blase
CA2451133C (en) * 2001-05-08 2012-09-18 Toray Industries, Inc. Therapeutic agent for sepsis
SI1494732T1 (sl) 2002-03-20 2008-08-31 Mannking Corp Inhalacijski aparat
AU2005277208B2 (en) 2004-08-20 2011-11-24 Mannkind Corporation Catalysis of diketopiperazine synthesis
DK1791542T3 (en) 2004-08-23 2015-06-15 Mannkind Corp Diketopiperazinsalte for pharmaceutical delivery
KR101486397B1 (ko) 2005-09-14 2015-01-28 맨카인드 코포레이션 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법
AU2007216966C1 (en) 2006-02-22 2014-03-20 Mannkind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
CN101454338A (zh) * 2006-05-26 2009-06-10 卡拉治疗学股份有限公司 κ阿片样受体肽的N-氧化物
CN101454017A (zh) * 2006-05-26 2009-06-10 卡拉治疗学股份有限公司 提升哺乳动物催乳素的方法
US7713937B2 (en) * 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
US8906859B2 (en) * 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
US8236766B2 (en) * 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
RU2500685C2 (ru) 2006-11-10 2013-12-10 Кара Терапеутикс, Инк Синтетические пептидные амиды
US7842662B2 (en) 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
WO2008077194A1 (en) * 2006-12-22 2008-07-03 Xenome Ltd Receptor agonists
CN109568740B (zh) 2008-06-13 2022-05-27 曼金德公司 干粉吸入器和用于药物输送的系统
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
BRPI0914308B8 (pt) 2008-06-20 2021-06-22 Mannkind Corp sistema de inalação
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2405963B1 (en) 2009-03-11 2013-11-06 MannKind Corporation Apparatus, system and method for measuring resistance of an inhaler
MY186975A (en) 2009-06-12 2021-08-26 Mannkind Corp Diketopiperazine microparticles with defined specific surface areas
EP2496295A1 (en) 2009-11-03 2012-09-12 MannKind Corporation An apparatus and method for simulating inhalation efforts
IL223742A (en) 2010-06-21 2016-06-30 Mannkind Corp A dry powder inhaler and preparation for it
DK2694402T3 (en) 2011-04-01 2017-07-03 Mannkind Corp BLISTER PACKAGE FOR PHARMACEUTICAL CYLINDER AMPULS
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
HK1201475A1 (en) * 2011-10-24 2015-09-04 Mannkind Corporation Methods and compositions for treating pain
SG11201500218VA (en) 2012-07-12 2015-03-30 Mannkind Corp Dry powder drug delivery systems and methods
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
ES2754388T3 (es) 2013-03-15 2020-04-17 Mannkind Corp Composiciones y métodos de dicetopiperazina microcristalina
EP3021834A1 (en) 2013-07-18 2016-05-25 MannKind Corporation Heat-stable dry powder pharmaceutical compositions and methods
JP2016530930A (ja) 2013-08-05 2016-10-06 マンカインド コーポレイション 通気装置及び方法
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
TR201902611T4 (tr) * 2014-06-26 2019-03-21 Maruishi Pharma Sentetik pentapeptit üretme metodu.
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
WO2016181408A2 (en) 2015-05-11 2016-11-17 Cadila Healthcare Limited NOVEL SHORT-CHAIN PEPTIDES AS KAPPA (κ) OPIOID RECEPTORS (KOR) AGONIST
CN107098876B (zh) * 2016-02-23 2021-04-06 江苏恒瑞医药股份有限公司 苯基丙酰胺类衍生物、其制备方法及其在医药上的应用
US11084847B2 (en) 2016-09-27 2021-08-10 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Polyamide compound and use thereof
BR112020001157A2 (pt) * 2017-07-21 2020-07-21 Sichuan Haisco Pharmaceutical Co., Ltd. compostos de peptídeo amida, método de preparação dos mesmos e uso em medicina
BR112020011191A2 (pt) 2017-12-06 2020-11-17 Jiangsu Hengrui Medicine Co., Ltd. sal de derivado de fenilpropionamida, métodos para preparar o mesmo, bem como sua composição farmacêutica e uso dos mesmos
UA126835C2 (uk) 2018-05-16 2023-02-08 Джянгсу Хенгруй Медісін Ко., Лтд. Фармацевтична композиція агоніста рецептора kor
CN114127085B (zh) * 2019-07-25 2024-08-13 西藏海思科制药有限公司 一种肽酰胺盐及其制备方法和在医药上的用途
WO2021013086A1 (zh) * 2019-07-25 2021-01-28 四川海思科制药有限公司 氘代肽酰胺类化合物及其制备方法和在医药上的用途
WO2021026492A1 (en) * 2019-08-07 2021-02-11 Humanwell Pharmaceutical US Kappa opioid receptor peptide amide agonists
WO2021262173A1 (en) 2020-06-25 2021-12-30 Humanwell Pharmaceutical US Peptides for treatment of medical disorders
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US5610271A (en) * 1995-06-07 1997-03-11 Torrey Pines Institute For Molecular Studies Kappa receptor selective opioid peptides

Also Published As

Publication number Publication date
UY25327A1 (es) 2000-12-29
CA2315878C (en) 2010-11-16
DE69831176T2 (de) 2006-04-20
DK1042359T3 (da) 2005-11-28
KR100629548B1 (ko) 2006-09-27
JP2001526295A (ja) 2001-12-18
ZA9811801B (en) 1999-06-22
DE69831176D1 (de) 2005-09-15
HUP0100626A3 (en) 2001-12-28
AU1940299A (en) 1999-07-12
NO327080B1 (no) 2009-04-20
SK286135B6 (sk) 2008-04-07
NZ505183A (en) 2001-09-28
EE200000370A (et) 2001-10-15
US5965701A (en) 1999-10-12
CZ297281B6 (cs) 2006-10-11
HUP0100626A2 (hu) 2001-08-28
ES2247735T3 (es) 2006-03-01
SK9602000A3 (en) 2001-01-18
RU2217437C2 (ru) 2003-11-27
TW580502B (en) 2004-03-21
BRPI9814499A (pt) 2000-10-10
PL341308A1 (en) 2001-04-09
EP1042359B1 (en) 2005-08-10
KR20010033450A (ko) 2001-04-25
HRP20000415A2 (en) 2000-12-31
MY117542A (en) 2004-07-31
CZ20002382A3 (cs) 2000-12-13
EE04440B1 (et) 2005-02-15
AR014167A1 (es) 2001-02-07
IL136742A0 (en) 2001-06-14
CN1283201A (zh) 2001-02-07
BR9814499B1 (pt) 2014-10-21
PT1042359E (pt) 2005-11-30
EP1042359A1 (en) 2000-10-11
WO1999032510A1 (en) 1999-07-01
CR5936A (es) 2006-08-18
UA68366C2 (en) 2004-08-16
CA2315878A1 (en) 1999-07-01
NO20003245L (no) 2000-08-23
BRPI9814499B8 (pt) 2021-11-09
PL195842B1 (pl) 2007-10-31
BRPI9814499B1 (pt) 2014-10-21
ATE301670T1 (de) 2005-08-15
IL178471A0 (en) 2007-02-11
NO20003245D0 (no) 2000-06-21
CN1154655C (zh) 2004-06-23
WO1999032510A9 (en) 1999-09-23
AU747806B2 (en) 2002-05-23
JP4275852B2 (ja) 2009-06-10
IL136742A (en) 2006-12-31
BR9814499A (pt) 2000-10-10
TR200001985T2 (tr) 2000-11-21
HU227640B1 (en) 2011-10-28
HK1029349A1 (en) 2001-03-30

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Owner name: CARA THERAPEUTICS, INC., US

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Payment date: 20111213

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Effective date: 20121223