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BRPI9814499A - Peptídeo amida opióide sintético ou um sal farmaceuticamente aceitavel do mesmo, e, composição farmacêutica - Google Patents

Peptídeo amida opióide sintético ou um sal farmaceuticamente aceitavel do mesmo, e, composição farmacêutica

Info

Publication number
BRPI9814499A
BRPI9814499A BRPI9814499A BRPI9814499A BR PI9814499 A BRPI9814499 A BR PI9814499A BR PI9814499 A BRPI9814499 A BR PI9814499A BR PI9814499 A BRPI9814499 A BR PI9814499A
Authority
BR
Brazil
Prior art keywords
pharmaceutically acceptable
pharmaceutical composition
acceptable salt
amide peptide
synthetic opioid
Prior art date
Application number
Other languages
English (en)
Inventor
D Schteingart Claudio
Sueiras Diaz Javier
Louis Junien Jean
A Trojnar Jerzy
J M Riviere Pierre
W Vanderah Todd
Original Assignee
Cara Therapeutics Inc
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cara Therapeutics Inc, Ferring Bv filed Critical Cara Therapeutics Inc
Publication of BRPI9814499A publication Critical patent/BRPI9814499A/pt
Publication of BRPI9814499B1 publication Critical patent/BRPI9814499B1/pt
Publication of BRPI9814499B8 publication Critical patent/BRPI9814499B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BRPI9814499A 1997-12-23 1998-12-22 Peptídeo amida opióide sintético ou um sal farmaceuticamente aceitavel do mesmo, e, composição farmacêutica BRPI9814499B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/997,208 US5965701A (en) 1997-12-23 1997-12-23 Kappa receptor opioid peptides
PCT/US1998/027282 WO1999032510A1 (en) 1997-12-23 1998-12-22 Kappa receptor opioid peptides

Publications (3)

Publication Number Publication Date
BRPI9814499A true BRPI9814499A (pt) 2000-10-10
BRPI9814499B1 BRPI9814499B1 (pt) 2014-10-21
BRPI9814499B8 BRPI9814499B8 (pt) 2021-11-09

Family

ID=25543752

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI9814499-5A BR9814499B1 (pt) 1997-12-23 1998-12-22 Peptídeo amida opióide sintético ou um sal farmaceuticamente aceitavel do mesmo, e, composição farmacêutica
BRPI9814499A BRPI9814499B8 (pt) 1997-12-23 1998-12-22 Peptídeo amida opióide sintético ou um sal farmaceuticamente aceitavel do mesmo, e, composição farmacêutica

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI9814499-5A BR9814499B1 (pt) 1997-12-23 1998-12-22 Peptídeo amida opióide sintético ou um sal farmaceuticamente aceitavel do mesmo, e, composição farmacêutica

Country Status (32)

Country Link
US (1) US5965701A (pt)
EP (1) EP1042359B1 (pt)
JP (1) JP4275852B2 (pt)
KR (1) KR100629548B1 (pt)
CN (1) CN1154655C (pt)
AR (1) AR014167A1 (pt)
AT (1) ATE301670T1 (pt)
AU (1) AU747806B2 (pt)
BR (2) BR9814499B1 (pt)
CA (1) CA2315878C (pt)
CR (1) CR5936A (pt)
CZ (1) CZ297281B6 (pt)
DE (1) DE69831176T2 (pt)
DK (1) DK1042359T3 (pt)
EE (1) EE04440B1 (pt)
ES (1) ES2247735T3 (pt)
HR (1) HRP20000415B1 (pt)
HU (1) HU227640B1 (pt)
IL (3) IL136742A0 (pt)
MY (1) MY117542A (pt)
NO (1) NO327080B1 (pt)
NZ (1) NZ505183A (pt)
PL (1) PL195842B1 (pt)
PT (1) PT1042359E (pt)
RU (1) RU2217437C2 (pt)
SK (1) SK286135B6 (pt)
TR (1) TR200001985T2 (pt)
TW (1) TW580502B (pt)
UA (1) UA68366C2 (pt)
UY (1) UY25327A1 (pt)
WO (1) WO1999032510A1 (pt)
ZA (1) ZA9811801B (pt)

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DE10116978A1 (de) 2001-04-05 2002-10-10 Merck Patent Gmbh Kappa-Opiatagonisten für die Behandlung von Erkrankungen der Blase
EP1402899A4 (en) * 2001-05-08 2009-03-11 Toray Industries MEANS FOR THE TREATMENT OF SEPSIS
PT1494732E (pt) 2002-03-20 2008-03-20 Mannkind Corp Aparelho de inalação
MX2007001903A (es) 2004-08-20 2007-08-02 Mannkind Corp Catalisis de sintesis de dicetopiperazina.
KR20130066695A (ko) 2004-08-23 2013-06-20 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염
KR101486397B1 (ko) 2005-09-14 2015-01-28 맨카인드 코포레이션 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법
BRPI0707991B8 (pt) 2006-02-22 2021-05-25 Mannkind Corp métodos de preparação de um medicamento em pó seco com uma propriedade farmacêutica melhorada, dito pó seco e uso de uma quantidade efetiva do pó seco
CN101454017A (zh) * 2006-05-26 2009-06-10 卡拉治疗学股份有限公司 提升哺乳动物催乳素的方法
US20100029575A1 (en) * 2006-05-26 2010-02-04 Jean-Louis Junien N-Oxides of Kappa Receptor Peptides
US7713937B2 (en) * 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
US8236766B2 (en) * 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
JP5244810B2 (ja) * 2006-11-10 2013-07-24 カラ セラピューティクス インコーポレイテッド 合成ペプチドアミド
US8906859B2 (en) * 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
US7842662B2 (en) * 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
WO2008077194A1 (en) * 2006-12-22 2008-07-03 Xenome Ltd Receptor agonists
RU2608439C2 (ru) 2008-06-13 2017-01-18 Маннкайнд Корпорейшн Ингалятор для сухого порошка и система для доставки лекарственных средств
US9358352B2 (en) 2008-06-13 2016-06-07 Mannkind Corporation Dry powder drug delivery system and methods
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
EP2609954B1 (en) 2008-06-20 2021-12-29 MannKind Corporation An interactive apparatus for real-time profiling of inhalation efforts
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2676695A3 (en) 2009-03-11 2017-03-01 MannKind Corporation Apparatus, system and method for measuring resistance of an inhaler
CN102647979B (zh) 2009-06-12 2015-03-04 曼金德公司 具有确定比表面积的二酮哌嗪颗粒
EP2496295A1 (en) 2009-11-03 2012-09-12 MannKind Corporation An apparatus and method for simulating inhalation efforts
EP2694402B1 (en) 2011-04-01 2017-03-22 MannKind Corporation Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
WO2013063160A1 (en) * 2011-10-24 2013-05-02 Mannkind Corporation Methods and compositions for treating pain
CA2878457C (en) 2012-07-12 2021-01-19 Mannkind Corporation Dry powder drug delivery systems and methods
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
EP3587404B1 (en) 2013-03-15 2022-07-13 MannKind Corporation Microcrystalline diketopiperazine compositions, methods for preparation and use thereof
CA2918369C (en) 2013-07-18 2021-06-29 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
EP3030294B1 (en) 2013-08-05 2020-10-07 MannKind Corporation Insufflation apparatus
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
KR102303092B1 (ko) * 2014-06-26 2021-09-15 마루이시세이야쿠가부시키가이샤 합성 펜타펩티드의 제조법
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
WO2016181408A2 (en) 2015-05-11 2016-11-17 Cadila Healthcare Limited NOVEL SHORT-CHAIN PEPTIDES AS KAPPA (κ) OPIOID RECEPTORS (KOR) AGONIST
CN107098876B (zh) * 2016-02-23 2021-04-06 江苏恒瑞医药股份有限公司 苯基丙酰胺类衍生物、其制备方法及其在医药上的应用
EP3521301B1 (en) * 2016-09-27 2024-03-06 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Polyamide compound and use thereof
PT3656782T (pt) 2017-07-21 2022-02-08 Sichuan Haisco Pharmaceutical Co Ltd Composto amida peptídica e o seu método de preparação e utilização médica
MX2020005932A (es) 2017-12-06 2020-08-24 Jiangsu Hengrui Medicine Co Sal de derivado de fenilpropionamida y su metodo de preparacion.
TW202015716A (zh) 2018-05-16 2020-05-01 大陸商江蘇恆瑞醫藥股份有限公司 一種ｋｏｒ受體激動劑醫藥組成物
WO2021013085A1 (zh) * 2019-07-25 2021-01-28 四川海思科制药有限公司 一种肽酰胺盐及其制备方法和在医药上的用途
WO2021013086A1 (zh) * 2019-07-25 2021-01-28 四川海思科制药有限公司 氘代肽酰胺类化合物及其制备方法和在医药上的用途
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Also Published As

Publication number Publication date
BR9814499B1 (pt) 2014-10-21
CR5936A (es) 2006-08-18
SK286135B6 (sk) 2008-04-07
ZA9811801B (en) 1999-06-22
BR9814499A (pt) 2000-10-10
HRP20000415A2 (en) 2000-12-31
DE69831176T2 (de) 2006-04-20
TR200001985T2 (tr) 2000-11-21
JP4275852B2 (ja) 2009-06-10
CN1154655C (zh) 2004-06-23
MY117542A (en) 2004-07-31
AR014167A1 (es) 2001-02-07
EP1042359A1 (en) 2000-10-11
PT1042359E (pt) 2005-11-30
EE04440B1 (et) 2005-02-15
KR100629548B1 (ko) 2006-09-27
CZ20002382A3 (cs) 2000-12-13
HRP20000415B1 (en) 2004-06-30
BRPI9814499B8 (pt) 2021-11-09
BRPI9814499B1 (pt) 2014-10-21
ES2247735T3 (es) 2006-03-01
CZ297281B6 (cs) 2006-10-11
RU2217437C2 (ru) 2003-11-27
CN1283201A (zh) 2001-02-07
WO1999032510A1 (en) 1999-07-01
UA68366C2 (en) 2004-08-16
HU227640B1 (en) 2011-10-28
IL178471A0 (en) 2007-02-11
IL136742A (en) 2006-12-31
HUP0100626A3 (en) 2001-12-28
TW580502B (en) 2004-03-21
EE200000370A (et) 2001-10-15
JP2001526295A (ja) 2001-12-18
HK1029349A1 (en) 2001-03-30
CA2315878A1 (en) 1999-07-01
NO327080B1 (no) 2009-04-20
EP1042359B1 (en) 2005-08-10
NO20003245L (no) 2000-08-23
NO20003245D0 (no) 2000-06-21
AU747806B2 (en) 2002-05-23
HUP0100626A2 (hu) 2001-08-28
UY25327A1 (es) 2000-12-29
IL136742A0 (en) 2001-06-14
CA2315878C (en) 2010-11-16
AU1940299A (en) 1999-07-12
DK1042359T3 (da) 2005-11-28
PL341308A1 (en) 2001-04-09
WO1999032510A9 (en) 1999-09-23
PL195842B1 (pl) 2007-10-31
DE69831176D1 (de) 2005-09-15
US5965701A (en) 1999-10-12
SK9602000A3 (en) 2001-01-18
KR20010033450A (ko) 2001-04-25
ATE301670T1 (de) 2005-08-15
NZ505183A (en) 2001-09-28

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