[go: up one dir, main page]

HN2011001614A - Derivados biciclicos de morfina -6-glucuronido, su preparacion y su aplicacion en terapeutica - Google Patents

Derivados biciclicos de morfina -6-glucuronido, su preparacion y su aplicacion en terapeutica

Info

Publication number
HN2011001614A
HN2011001614A HN2011001614A HN2011001614A HN2011001614A HN 2011001614 A HN2011001614 A HN 2011001614A HN 2011001614 A HN2011001614 A HN 2011001614A HN 2011001614 A HN2011001614 A HN 2011001614A HN 2011001614 A HN2011001614 A HN 2011001614A
Authority
HN
Honduras
Prior art keywords
group
therapeutics
application
preparation
morfina
Prior art date
Application number
HN2011001614A
Other languages
English (en)
Inventor
Alain Dlubala
Isabelle Ripoche
Claire Trecant
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of HN2011001614A publication Critical patent/HN2011001614A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06—Heterocyclic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

LA PRESENTE INVENCION TIENE POR OBJETO LOS COMPUESTOS QUE RESPONDEN A LA FORMULA (I) EN LA QUE R1: REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO (C1-C4), R2 REPRESENTA UN GRUPO HIDROXILO, UN GRUPO TIOL, UNN GRUPO ALQUILOXI (C1-C4) O UN GRUPO TIOALQUILO (C1-C4) Y N ES UN NUMERO ENTERO IGUAL A 1 0 2 EN EL ESTADO DE BASE O DE SAL DE ADICION A UN ACIDO ASI COMO EN EL ESTADO DE HIDRATO O DE SOLVATO. LA PRESENTE INVENCION PRETENDE IGUALMENTE SU PROCEDIMIENTO DE PREPARACION Y SU APLICACION EN TERAPEUTICA
HN2011001614A 2008-12-11 2011-06-10 Derivados biciclicos de morfina -6-glucuronido, su preparacion y su aplicacion en terapeutica HN2011001614A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0806974A FR2939796B1 (fr) 2008-12-11 2008-12-11 Derives bicycliques de morphine-6-glucuronide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
HN2011001614A true HN2011001614A (es) 2014-03-03

Family

ID=41037668

Family Applications (1)

Application Number Title Priority Date Filing Date
HN2011001614A HN2011001614A (es) 2008-12-11 2011-06-10 Derivados biciclicos de morfina -6-glucuronido, su preparacion y su aplicacion en terapeutica

Country Status (32)

Country Link
US (1) US8440634B2 (es)
EP (1) EP2376511B1 (es)
JP (1) JP5616355B2 (es)
KR (1) KR20110091536A (es)
CN (1) CN102317302B (es)
AR (1) AR074578A1 (es)
AU (1) AU2009326907B2 (es)
BR (1) BRPI0923368A2 (es)
CA (1) CA2746701A1 (es)
CL (1) CL2011001401A1 (es)
CO (1) CO6382159A2 (es)
CR (1) CR20110317A (es)
EA (1) EA201170791A1 (es)
EC (1) ECSP11011107A (es)
ES (1) ES2470684T3 (es)
FR (1) FR2939796B1 (es)
HN (1) HN2011001614A (es)
IL (1) IL213380A (es)
MA (1) MA32954B1 (es)
ME (1) ME01147B (es)
MX (1) MX2011006251A (es)
MY (1) MY153779A (es)
NI (1) NI201100113A (es)
NZ (1) NZ593340A (es)
PE (1) PE20120231A1 (es)
SG (1) SG172070A1 (es)
SV (1) SV2011003937A (es)
TN (1) TN2011000277A1 (es)
TW (1) TW201026313A (es)
UA (1) UA104445C2 (es)
WO (1) WO2010067008A2 (es)
ZA (1) ZA201104389B (es)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766188A (en) 1971-06-28 1973-10-16 Yamanouchi Pharma Co Ltd Carbonyldioxymorphinan derivatives
GB9116909D0 (en) 1991-08-06 1991-09-18 Salford Ultrafine Chem & Res Morphine derivatives
GB2282758A (en) 1993-08-23 1995-04-19 Euro Celtique Sa Oral morphine-6-glucuronide compositions
JP2001518912A (ja) * 1997-04-14 2001-10-16 ソルフォード、ウルトラファイン、ケミカルズ、アンド、リサーチ、リミテッド モルヒネ誘導体
JP2002506002A (ja) * 1998-02-02 2002-02-26 セネス リミティド ４，５−エポキシモルフィナン−６−オール類のグリコシド化
DE69903291T2 (de) 1998-06-06 2003-06-26 Cenes Ltd., Cambridge Synthese von morphin-6-glucuronid
DE10161963A1 (de) * 2001-12-17 2003-07-03 Johannes Schuetz 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung
DE10229842A1 (de) * 2002-07-03 2004-02-05 Helmut Prof. Dr. Schmidhammer Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung
GB0218811D0 (en) * 2002-08-14 2002-09-18 Cenes Ltd Salts of morphine-6-glucuronide
FR2864082B1 (fr) * 2003-12-22 2006-03-10 Synt Em Nouveau derive de la morphine-6-glucuronide, composition pharmaceutique le contenant et son utilisation pour le traitement de la douleur
CA2568249C (en) * 2004-05-28 2014-12-09 Human Biomolecular Research Institute Synthesis of metabolically stable analgesics, pain medications and other agents
FR2907121B1 (fr) * 2006-10-12 2012-05-04 Neorphys Nouveaux derives morphiniques

Also Published As

Publication number Publication date
JP5616355B2 (ja) 2014-10-29
KR20110091536A (ko) 2011-08-11
BRPI0923368A2 (pt) 2019-09-24
AU2009326907A1 (en) 2011-06-30
MA32954B1 (fr) 2012-01-02
ZA201104389B (en) 2012-09-26
ECSP11011107A (es) 2011-07-29
AR074578A1 (es) 2011-01-26
EP2376511B1 (fr) 2014-03-12
CO6382159A2 (es) 2012-02-15
CA2746701A1 (fr) 2010-06-17
MX2011006251A (es) 2011-11-18
EA201170791A1 (ru) 2012-01-30
PE20120231A1 (es) 2012-04-04
IL213380A0 (en) 2011-07-31
FR2939796B1 (fr) 2010-12-17
TN2011000277A1 (fr) 2012-12-17
UA104445C2 (uk) 2014-02-10
US8440634B2 (en) 2013-05-14
CN102317302B (zh) 2014-02-12
EP2376511A2 (fr) 2011-10-19
SG172070A1 (en) 2011-07-28
HK1163109A1 (en) 2012-09-07
IL213380A (en) 2014-02-27
NI201100113A (es) 2011-12-15
FR2939796A1 (fr) 2010-06-18
ME01147B (me) 2012-12-20
WO2010067008A2 (fr) 2010-06-17
ES2470684T3 (es) 2014-06-24
WO2010067008A3 (fr) 2011-07-07
CL2011001401A1 (es) 2011-10-28
AU2009326907B2 (en) 2016-05-26
JP2012511552A (ja) 2012-05-24
MY153779A (en) 2015-03-13
TW201026313A (en) 2010-07-16
NZ593340A (en) 2012-12-21
US20110275580A1 (en) 2011-11-10
CN102317302A (zh) 2012-01-11
CR20110317A (es) 2011-10-18
SV2011003937A (es) 2012-01-20

Similar Documents

Publication Publication Date Title
HN2009000502A (es) DERIVADOS DE 2- ARIL-6-FENIL-IMIDAZO[ 1,2-a] PIRIDINAS SU PREPARACION Y SU APLICACION EN TERAPEUTICA
HN2010001460A (es) Derivados biciclicos de carboxamidas aza-biciclicas, su preparacion y su aplicacion terapeutica
BR112014017749A8 (pt) Composto alquinilbenzeno 3,5-dissubstituído e sal do mesmo
CR11327A (es) Derivados de quinazolinadiona, su preparacion y sus aplicaciones terapeuticas
BR112014001018A2 (pt) derivado de azabenzimidazol tendo atividade de ativação de ampk
HN2010001459A (es) Derivados de carboxamidas azabiciclicas, su preparacion y su preparacion en terapeutica.
ES2571483T3 (es) Producto intermedio para producir un éster de ácido sulfónico cíclico
DOP2007000014A (es) Derivados de sulfonamidas, su preparacion y su aplicacion en terapeutica
UY29047A1 (es) Derivados de sulfonamidas, su preparación y su aplicación en terapéutica
CO6362007A2 (es) Derivados de azaspiranil-alquilcarbamatos de heterociclos de 5 eslabones, su preparación y su aplicación en terapeútica
CO6351789A2 (es) Derivados de carbamatos de alquiltiazoles, su preparacion y su aplicacion en terapeutica
CO6361851A2 (es) Derivados de n-(2-fenoxietil)carboxamida fungicidas y sus analogos aza, tia y sila
BRPI1009212B8 (pt) Composto de piperazina capaz de inibir a prostaglandina d sintase, seus usos e composição farmacêutica
ECSP099216A (es) Nuevos derivados de diosmetina, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
CO6361849A2 (es) Derivados de n-cicloalquil-nbifenilmetil-carboxamida fungicidas
BR112015008912A2 (pt) composições solidificáveis compreendendo volastonita e pedra-pomes e métodos de uso
BR112013024223A2 (pt) composto de poliéter, agente de cura usando o composto de poliéter, e método de produção do composto de poliéter
CO6251235A2 (es) Compuestos derivados de azetidinas su preparacion y su aplicacion en terapeutica
HN2010000330A (es) DERIVADOS DE INDOL-2-ONA DISUSTITUIDOS EN 3 y SU PREPARACION
CR9499A (es) Nuevos derivados de fenilpiridinilpiperazina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
CR9565A (es) Derivados del 4,5-diarilpirrol, su preparacion y su aplicacion en terapeutica
CO6341633A2 (es) Composicion farmaceutica solida
BR112016011778A2 (pt) Pirazol fluorofenila, seus usos, e composição farmacêutica
HN2011001614A (es) Derivados biciclicos de morfina -6-glucuronido, su preparacion y su aplicacion en terapeutica
BR112014018985A8 (pt) Método para preparar um composto