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AR074578A1 - Derivados biciclicos de morfina-6-glucuronido, su preparacion y su aplicacion en terapeutica - Google Patents

Derivados biciclicos de morfina-6-glucuronido, su preparacion y su aplicacion en terapeutica

Info

Publication number
AR074578A1
AR074578A1 ARP090104785A ARP090104785A AR074578A1 AR 074578 A1 AR074578 A1 AR 074578A1 AR P090104785 A ARP090104785 A AR P090104785A AR P090104785 A ARP090104785 A AR P090104785A AR 074578 A1 AR074578 A1 AR 074578A1
Authority
AR
Argentina
Prior art keywords
therapeutics
application
preparation
morfina
glucuronido
Prior art date
Application number
ARP090104785A
Other languages
English (en)
Inventor
Alain Dlubala
Isabelle Ripoche
Claire Trecant
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR074578A1 publication Critical patent/AR074578A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06—Heterocyclic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente solicitud tiene por objeto los compuestos que responden a la fórmula (1) en la que R1 representa un átomo de H o un grupo alquilo C1-4; R2 representa un grupo hidroxilo, tiol, alquiloxi C14 o tioalquilo C1-4, y n es un número entero igual a 1 o 2; en el estado de base o de sal de adición a un ácido así como en el estado de hidrato o de solvato. La presente pretende igualmente su procedimiento de preparación y su aplicación en terapéutica, para la prevención o tratamiento del dolor.
ARP090104785A 2008-12-11 2009-12-10 Derivados biciclicos de morfina-6-glucuronido, su preparacion y su aplicacion en terapeutica AR074578A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0806974A FR2939796B1 (fr) 2008-12-11 2008-12-11 Derives bicycliques de morphine-6-glucuronide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
AR074578A1 true AR074578A1 (es) 2011-01-26

Family

ID=41037668

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090104785A AR074578A1 (es) 2008-12-11 2009-12-10 Derivados biciclicos de morfina-6-glucuronido, su preparacion y su aplicacion en terapeutica

Country Status (32)

Country Link
US (1) US8440634B2 (es)
EP (1) EP2376511B1 (es)
JP (1) JP5616355B2 (es)
KR (1) KR20110091536A (es)
CN (1) CN102317302B (es)
AR (1) AR074578A1 (es)
AU (1) AU2009326907B2 (es)
BR (1) BRPI0923368A2 (es)
CA (1) CA2746701A1 (es)
CL (1) CL2011001401A1 (es)
CO (1) CO6382159A2 (es)
CR (1) CR20110317A (es)
EA (1) EA201170791A1 (es)
EC (1) ECSP11011107A (es)
ES (1) ES2470684T3 (es)
FR (1) FR2939796B1 (es)
HN (1) HN2011001614A (es)
IL (1) IL213380A (es)
MA (1) MA32954B1 (es)
ME (1) ME01147B (es)
MX (1) MX2011006251A (es)
MY (1) MY153779A (es)
NI (1) NI201100113A (es)
NZ (1) NZ593340A (es)
PE (1) PE20120231A1 (es)
SG (1) SG172070A1 (es)
SV (1) SV2011003937A (es)
TN (1) TN2011000277A1 (es)
TW (1) TW201026313A (es)
UA (1) UA104445C2 (es)
WO (1) WO2010067008A2 (es)
ZA (1) ZA201104389B (es)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766188A (en) 1971-06-28 1973-10-16 Yamanouchi Pharma Co Ltd Carbonyldioxymorphinan derivatives
GB9116909D0 (en) 1991-08-06 1991-09-18 Salford Ultrafine Chem & Res Morphine derivatives
GB2282758A (en) 1993-08-23 1995-04-19 Euro Celtique Sa Oral morphine-6-glucuronide compositions
JP2001518912A (ja) * 1997-04-14 2001-10-16 ソルフォード、ウルトラファイン、ケミカルズ、アンド、リサーチ、リミテッド モルヒネ誘導体
JP2002506002A (ja) * 1998-02-02 2002-02-26 セネス リミティド ４，５−エポキシモルフィナン−６−オール類のグリコシド化
DE69903291T2 (de) 1998-06-06 2003-06-26 Cenes Ltd., Cambridge Synthese von morphin-6-glucuronid
DE10161963A1 (de) * 2001-12-17 2003-07-03 Johannes Schuetz 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung
DE10229842A1 (de) * 2002-07-03 2004-02-05 Helmut Prof. Dr. Schmidhammer Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung
GB0218811D0 (en) * 2002-08-14 2002-09-18 Cenes Ltd Salts of morphine-6-glucuronide
FR2864082B1 (fr) * 2003-12-22 2006-03-10 Synt Em Nouveau derive de la morphine-6-glucuronide, composition pharmaceutique le contenant et son utilisation pour le traitement de la douleur
CA2568249C (en) * 2004-05-28 2014-12-09 Human Biomolecular Research Institute Synthesis of metabolically stable analgesics, pain medications and other agents
FR2907121B1 (fr) * 2006-10-12 2012-05-04 Neorphys Nouveaux derives morphiniques

Also Published As

Publication number Publication date
JP5616355B2 (ja) 2014-10-29
KR20110091536A (ko) 2011-08-11
BRPI0923368A2 (pt) 2019-09-24
HN2011001614A (es) 2014-03-03
AU2009326907A1 (en) 2011-06-30
MA32954B1 (fr) 2012-01-02
ZA201104389B (en) 2012-09-26
ECSP11011107A (es) 2011-07-29
EP2376511B1 (fr) 2014-03-12
CO6382159A2 (es) 2012-02-15
CA2746701A1 (fr) 2010-06-17
MX2011006251A (es) 2011-11-18
EA201170791A1 (ru) 2012-01-30
PE20120231A1 (es) 2012-04-04
IL213380A0 (en) 2011-07-31
FR2939796B1 (fr) 2010-12-17
TN2011000277A1 (fr) 2012-12-17
UA104445C2 (uk) 2014-02-10
US8440634B2 (en) 2013-05-14
CN102317302B (zh) 2014-02-12
EP2376511A2 (fr) 2011-10-19
SG172070A1 (en) 2011-07-28
HK1163109A1 (en) 2012-09-07
IL213380A (en) 2014-02-27
NI201100113A (es) 2011-12-15
FR2939796A1 (fr) 2010-06-18
ME01147B (me) 2012-12-20
WO2010067008A2 (fr) 2010-06-17
ES2470684T3 (es) 2014-06-24
WO2010067008A3 (fr) 2011-07-07
CL2011001401A1 (es) 2011-10-28
AU2009326907B2 (en) 2016-05-26
JP2012511552A (ja) 2012-05-24
MY153779A (en) 2015-03-13
TW201026313A (en) 2010-07-16
NZ593340A (en) 2012-12-21
US20110275580A1 (en) 2011-11-10
CN102317302A (zh) 2012-01-11
CR20110317A (es) 2011-10-18
SV2011003937A (es) 2012-01-20

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