BRPI0923368A2 - derivados bicíclicos de morfina-6-glicuronida, o respectivo preparo e a respectiva aplicação em terapêutica. - Google Patents

derivados bicíclicos de morfina-6-glicuronida, o respectivo preparo e a respectiva aplicação em terapêutica.

Info

Publication number: BRPI0923368A2
Authority: BR; Brazil
Prior art keywords: morphine; bicyclic; preparation; therapeutic application; glucuronide derivatives
Prior art date: 2008-12-11

Application number

BRPI0923368A

Other languages

English (en)

Inventor

Dlubala Alain

Trecant Claire

Ripoche Isabelle

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-12-11

Filing date

2009-12-08

Publication date

2019-09-24

2009-12-08 Application filed by Sanofi Sa filed Critical Sanofi Sa

2019-09-24 Publication of BRPI0923368A2 publication Critical patent/BRPI0923368A2/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/06—Heterocyclic radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Pain & Pain Management (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Rheumatology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)

BRPI0923368A 2008-12-11 2009-12-08 derivados bicíclicos de morfina-6-glicuronida, o respectivo preparo e a respectiva aplicação em terapêutica. BRPI0923368A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0806974A FR2939796B1 (fr)	2008-12-11	2008-12-11	Derives bicycliques de morphine-6-glucuronide, leur preparation et leur application en therapeutique
PCT/FR2009/052446 WO2010067008A2 (fr)	2008-12-11	2009-12-08	Derives bicycliques de morphine-6-glucuronide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number	Publication Date
BRPI0923368A2 true BRPI0923368A2 (pt)	2019-09-24

Family

ID=41037668

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0923368A BRPI0923368A2 (pt)	2008-12-11	2009-12-08	derivados bicíclicos de morfina-6-glicuronida, o respectivo preparo e a respectiva aplicação em terapêutica.

Country Status (32)

Country	Link
US (1)	US8440634B2 (pt)
EP (1)	EP2376511B1 (pt)
JP (1)	JP5616355B2 (pt)
KR (1)	KR20110091536A (pt)
CN (1)	CN102317302B (pt)
AR (1)	AR074578A1 (pt)
AU (1)	AU2009326907B2 (pt)
BR (1)	BRPI0923368A2 (pt)
CA (1)	CA2746701A1 (pt)
CL (1)	CL2011001401A1 (pt)
CO (1)	CO6382159A2 (pt)
CR (1)	CR20110317A (pt)
EA (1)	EA201170791A1 (pt)
EC (1)	ECSP11011107A (pt)
ES (1)	ES2470684T3 (pt)
FR (1)	FR2939796B1 (pt)
HN (1)	HN2011001614A (pt)
IL (1)	IL213380A (pt)
MA (1)	MA32954B1 (pt)
ME (1)	ME01147B (pt)
MX (1)	MX2011006251A (pt)
MY (1)	MY153779A (pt)
NI (1)	NI201100113A (pt)
NZ (1)	NZ593340A (pt)
PE (1)	PE20120231A1 (pt)
SG (1)	SG172070A1 (pt)
SV (1)	SV2011003937A (pt)
TN (1)	TN2011000277A1 (pt)
TW (1)	TW201026313A (pt)
UA (1)	UA104445C2 (pt)
WO (1)	WO2010067008A2 (pt)
ZA (1)	ZA201104389B (pt)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3766188A (en)	1971-06-28	1973-10-16	Yamanouchi Pharma Co Ltd	Carbonyldioxymorphinan derivatives
GB9116909D0 (en)	1991-08-06	1991-09-18	Salford Ultrafine Chem & Res	Morphine derivatives
GB2282758A (en)	1993-08-23	1995-04-19	Euro Celtique Sa	Oral morphine-6-glucuronide compositions
JP2001518912A (ja) *	1997-04-14	2001-10-16	ソルフォード、ウルトラファイン、ケミカルズ、アンド、リサーチ、リミテッド	モルヒネ誘導体
HUP0100841A3 (en) *	1998-02-02	2003-03-28	Cenes Ltd Cambridge	Glycosidation of 4,5-epoxymorphinan-6-ols
CA2332974C (en)	1998-06-06	2009-03-10	Cenes Limited	Morphine-6-glucuronide synthesis
DE10161963A1 (de) *	2001-12-17	2003-07-03	Johannes Schuetz	6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung
DE10229842A1 (de) *	2002-07-03	2004-02-05	Helmut Prof. Dr. Schmidhammer	Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung
GB0218811D0 (en) *	2002-08-14	2002-09-18	Cenes Ltd	Salts of morphine-6-glucuronide
FR2864082B1 (fr) *	2003-12-22	2006-03-10	Synt Em	Nouveau derive de la morphine-6-glucuronide, composition pharmaceutique le contenant et son utilisation pour le traitement de la douleur
JP5266492B2 (ja) *	2004-05-28	2013-08-21	ヒューマンバイオモレキュラルリサーチインスティテュート	代謝安定性鎮痛薬、疼痛薬物療法及び他の物質の合成
FR2907121B1 (fr) *	2006-10-12	2012-05-04	Neorphys	Nouveaux derives morphiniques

2008
- 2008-12-11 FR FR0806974A patent/FR2939796B1/fr not_active Expired - Fee Related
2009
- 2009-12-08 ES ES09801747.8T patent/ES2470684T3/es active Active
- 2009-12-08 AU AU2009326907A patent/AU2009326907B2/en not_active Ceased
- 2009-12-08 JP JP2011540162A patent/JP5616355B2/ja not_active Expired - Fee Related
- 2009-12-08 MA MA34001A patent/MA32954B1/fr unknown
- 2009-12-08 MX MX2011006251A patent/MX2011006251A/es active IP Right Grant
- 2009-12-08 ME MEP-2011-104A patent/ME01147B/me unknown
- 2009-12-08 BR BRPI0923368A patent/BRPI0923368A2/pt not_active IP Right Cessation
- 2009-12-08 EP EP09801747.8A patent/EP2376511B1/fr active Active
- 2009-12-08 CN CN200980156458.3A patent/CN102317302B/zh not_active Expired - Fee Related
- 2009-12-08 WO PCT/FR2009/052446 patent/WO2010067008A2/fr not_active Ceased
- 2009-12-08 KR KR1020117013251A patent/KR20110091536A/ko not_active Abandoned
- 2009-12-08 UA UAA201108555A patent/UA104445C2/uk unknown
- 2009-12-08 NZ NZ593340A patent/NZ593340A/xx not_active IP Right Cessation
- 2009-12-08 CA CA2746701A patent/CA2746701A1/fr not_active Abandoned
- 2009-12-08 PE PE2011001206A patent/PE20120231A1/es not_active Application Discontinuation
- 2009-12-08 SG SG2011042330A patent/SG172070A1/en unknown
- 2009-12-08 EA EA201170791A patent/EA201170791A1/ru unknown
- 2009-12-08 MY MYPI2011002645A patent/MY153779A/en unknown
- 2009-12-10 AR ARP090104785A patent/AR074578A1/es unknown
- 2009-12-11 TW TW098142583A patent/TW201026313A/zh unknown
2011
- 2011-05-30 TN TN2011000277A patent/TN2011000277A1/fr unknown
- 2011-06-03 EC EC2011011107A patent/ECSP11011107A/es unknown
- 2011-06-05 IL IL213380A patent/IL213380A/en not_active IP Right Cessation
- 2011-06-07 CR CR20110317A patent/CR20110317A/es unknown
- 2011-06-08 SV SV2011003937A patent/SV2011003937A/es unknown
- 2011-06-08 NI NI201100113A patent/NI201100113A/es unknown
- 2011-06-08 US US13/155,727 patent/US8440634B2/en not_active Expired - Fee Related
- 2011-06-09 CL CL2011001401A patent/CL2011001401A1/es unknown
- 2011-06-10 CO CO11072131A patent/CO6382159A2/es not_active Application Discontinuation
- 2011-06-10 HN HN2011001614A patent/HN2011001614A/es unknown
- 2011-06-13 ZA ZA2011/04389A patent/ZA201104389B/en unknown

Also Published As

Publication number	Publication date
EA201170791A1 (ru)	2012-01-30
CL2011001401A1 (es)	2011-10-28
MX2011006251A (es)	2011-11-18
CA2746701A1 (fr)	2010-06-17
AR074578A1 (es)	2011-01-26
JP2012511552A (ja)	2012-05-24
ME01147B (me)	2012-12-20
US8440634B2 (en)	2013-05-14
NZ593340A (en)	2012-12-21
FR2939796B1 (fr)	2010-12-17
SG172070A1 (en)	2011-07-28
ECSP11011107A (es)	2011-07-29
EP2376511B1 (fr)	2014-03-12
CN102317302A (zh)	2012-01-11
CN102317302B (zh)	2014-02-12
MA32954B1 (fr)	2012-01-02
AU2009326907B2 (en)	2016-05-26
US20110275580A1 (en)	2011-11-10
AU2009326907A1 (en)	2011-06-30
TN2011000277A1 (fr)	2012-12-17
IL213380A0 (en)	2011-07-31
HK1163109A1 (en)	2012-09-07
PE20120231A1 (es)	2012-04-04
IL213380A (en)	2014-02-27
WO2010067008A3 (fr)	2011-07-07
CR20110317A (es)	2011-10-18
FR2939796A1 (fr)	2010-06-18
ES2470684T3 (es)	2014-06-24
MY153779A (en)	2015-03-13
TW201026313A (en)	2010-07-16
SV2011003937A (es)	2012-01-20
ZA201104389B (en)	2012-09-26
KR20110091536A (ko)	2011-08-11
HN2011001614A (es)	2014-03-03
WO2010067008A2 (fr)	2010-06-17
JP5616355B2 (ja)	2014-10-29
NI201100113A (es)	2011-12-15
CO6382159A2 (es)	2012-02-15
EP2376511A2 (fr)	2011-10-19
UA104445C2 (uk)	2014-02-10

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BRPI0907381A2 (pt)	2015-07-14	Derivados de carboxamidas azabicíclicos, o respectivo preparo e a respectiva aplicação em terapêutica.
BRPI0810412A2 (pt)	2014-10-14	Derivados de triazolo piridina-carboxamidas e triazolo pirimidina - carboxamidas, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI1012857A2 (pt)	2019-09-24	derivados de ciclopenta[c]pirrol-2-carboxilatos, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI0906567A2 (pt)	2015-07-07	Derivados de ureia de tetra-hidroquinoxalina, o respectivo preparo e a respectiva aplicação em terapêutica j
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BRPI0810430A2 (pt)	2014-10-14	Derivados de triazolo piridina - carboxamidas, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI1008955A2 (pt)	2015-09-01	Terapia de combinação com derivados de tiocolchicina.
BRPI0810202A2 (pt)	2014-10-21	Derivados de piridina
BRPI1010881A2 (pt)	2016-05-31	derivados de triazina e suas aplicações terapêuticas.
BRPI1010882A2 (pt)	2019-09-24	derivados de triazina e suas aplicações terapêuticas.
BRPI1011527A2 (pt)	2016-07-26	derivados de triazina substituídos com ureidofenil e suas aplicações terapêuticas.
BRPI0908999A8 (pt)	2016-07-12	derivados poli-substituídos de 2-aril-6-fenil-imidazo[1,2-a]piridinas, o respectivo preparo e respectiva aplicação em terapêutica
AP2011005695A0 (en)	2011-06-30	Therapeutic antiviral poptides.
BRPI1016117A8 (pt)	2018-01-02	derivados de isoxazol-isoxazol e isoxazol-isotiazol.
BRPI0917464A2 (pt)	2015-12-01	compostos de azetidinas polissubstituídas, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI1013553A2 (pt)	2016-04-12	derivados de nicotinamida, o respectivo preparo e a respectiva aplicação em terapêutica como anticancerígenos
BRPI0917446A2 (pt)	2015-12-22	derivados de acilaminobenzamida.
EP2160385A4 (en)	2010-10-27	2-SUBSTITUTED ISOFLAVONOID COMPOUNDS AND MEDICAMENTS THEREOF AND APPLICATIONS THEREOF
BRPI0921407A2 (pt)	2019-09-24	terapia de combinação seletiva de erbb-3 (her3)
BRPI0907578A2 (pt)	2019-09-24	derivados de 3-aminoalquil-1,3-di-hidro-2h-indol-2-ona, o respectivo preparo e a respectiva aplicação em terapêutica
BR112012000104A2 (pt)	2016-03-15	derivados de pirazóis, o respectivo preparo e a respectiva aplicação em terapêutica
BRPI1015943A2 (pt)	2016-04-19	derivados de 1,2,3,4-tetra - hidro - pirimido [1,2-a] pirimidin-6-ona, o respectivo preparo e a respectiva utilização farmacêutica.
BRPI1016192A2 (pt)	2016-04-19	derivados de soxazol.

Legal Events

Date	Code	Title	Description
2019-10-01	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
2020-01-21	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.
2020-03-17	B15G	Petition not considered as such [chapter 15.7 patent gazette]	Free format text: NAO DEVE SER CONHECIDA A PETICAO NO 870160077814 DE 21/12/2016, EM VIRTUDE DO DISPOSTO NO ARTIGO 219 INCISO II DA LPI NO9.279/96, UMA VEZ QUE NAO TEM FUNDAMENTACAO LEGAL.