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HN2010000202A - Anticuarpos humanos contra cd20 humano y metodo para utilizarlos - Google Patents

Anticuarpos humanos contra cd20 humano y metodo para utilizarlos

Info

Publication number
HN2010000202A
HN2010000202A HN2010000202A HN2010000202A HN2010000202A HN 2010000202 A HN2010000202 A HN 2010000202A HN 2010000202 A HN2010000202 A HN 2010000202A HN 2010000202 A HN2010000202 A HN 2010000202A HN 2010000202 A HN2010000202 A HN 2010000202A
Authority
HN
Honduras
Prior art keywords
human
antibody
union
antigen
fragment
Prior art date
Application number
HN2010000202A
Other languages
English (en)
Inventor
H Martin Joel
Wang Li-Hsien
Stevens Sean
M Allison Erin
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of HN2010000202A publication Critical patent/HN2010000202A/es

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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10S530/866—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10S530/867—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody produced via recombinant dna technology

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Public Health (AREA)
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  • Diabetes (AREA)
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  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)

Abstract

ESTA INVENCION SE REFIERE A UN ANTICUERPO HUMANO O UN FRAGMENTO DE UNION AL ANTIGENO DE UN ANTICUERPO QUE SE UNE ESPECIFICAMENTE AL DC20 HUMANO Y QUE ES CAPAZ DE INDUCIR UNA CITOTOXIDAD DEPENDIENTE DEL COMPLEMENTO (CDC) Y QUE ES CAPAZ DE AUMENTAR EL TIEMPO DE SUPERVIVENCIA SIN SINTOMAS ENTRE APROXIMADAMENTE 2 VECEA A APROXIMADAMENTE 9 VECES MAS O MAYOR , CON RELACION A ANIMALES CONTROL TRATADOS EN UN MODELO DE RATON DEL LIMFOMA HUMANO. EL ANTICUERPO O SU FRAGMENTO DE UNION AL ANTIGENO ES UTIL ES UN METODO TERAPEUTICO PARA TRATAR UNA ENFERMEDAD O UN TRASTORNO MEDIADO PO CD20 COMO POR EJEMPLO EL LIMFOMA NO HOGKINIANO, LA ARTRITIS REUMATOIDE EL LUPUS ERITEMATOSO SISTEMATIO LA ENFERMEDAD DE CROHN, LA LEUCEMIA LINFOCITICA CRONICA Y LAS ENFERMEDADE INFLAMATORIAS
HN2010000202A 2007-07-31 2010-01-29 Anticuarpos humanos contra cd20 humano y metodo para utilizarlos HN2010000202A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96281107P 2007-07-31 2007-07-31
US6799408P 2008-03-03 2008-03-03

Publications (1)

Publication Number Publication Date
HN2010000202A true HN2010000202A (es) 2012-08-15

Family

ID=40010730

Family Applications (1)

Application Number Title Priority Date Filing Date
HN2010000202A HN2010000202A (es) 2007-07-31 2010-01-29 Anticuarpos humanos contra cd20 humano y metodo para utilizarlos

Country Status (28)

Country Link
US (3) US7879984B2 (es)
EP (1) EP2178916B1 (es)
JP (1) JP5588865B2 (es)
KR (1) KR101561020B1 (es)
CN (1) CN101809037B (es)
AU (1) AU2008282152B2 (es)
BR (1) BRPI0813985B1 (es)
CA (1) CA2695199C (es)
CO (1) CO6260105A2 (es)
CR (1) CR11243A (es)
DK (1) DK2178916T3 (es)
DO (1) DOP2010000037A (es)
EC (1) ECSP10010005A (es)
ES (1) ES2527297T3 (es)
GT (1) GT201000026A (es)
HN (1) HN2010000202A (es)
MA (1) MA31634B1 (es)
ME (1) ME00973B (es)
MX (1) MX2010000970A (es)
MY (1) MY147651A (es)
NI (1) NI201000016A (es)
NZ (1) NZ583019A (es)
PL (1) PL2178916T3 (es)
RU (1) RU2486205C2 (es)
SV (1) SV2010003468A (es)
TN (2) TN2010000054A1 (es)
WO (1) WO2009018411A1 (es)
ZA (1) ZA201000545B (es)

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