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HN2003000062A - USEFUL NICOTINAMIDE DERIVATIVES AS PDE4 INHIBITORS - Google Patents

USEFUL NICOTINAMIDE DERIVATIVES AS PDE4 INHIBITORS

Info

Publication number
HN2003000062A
HN2003000062A HN2003000062A HN2003000062A HN2003000062A HN 2003000062 A HN2003000062 A HN 2003000062A HN 2003000062 A HN2003000062 A HN 2003000062A HN 2003000062 A HN2003000062 A HN 2003000062A HN 2003000062 A HN2003000062 A HN 2003000062A
Authority
HN
Honduras
Prior art keywords
useful
derivatives
pde4 inhibitors
nicotinamide derivatives
nicotinamide
Prior art date
Application number
HN2003000062A
Other languages
Spanish (es)
Inventor
Thomas Victor Magee
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of HN2003000062A publication Critical patent/HN2003000062A/en

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
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    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

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Abstract

LA PRESENTE INVENCION SE REFIERE A DERIVADOS DE NICOTINAMIDA Y A PROCEDIMIENTOS PARA LA PREPARACION DE DICHOS DERIVADOS, A LOS INTERMEDIOS UTILIZADOS EN LA PREPARACIÓN DE DICHOS DERIVADOS, A COMPOSICIONES QUE CONTIENEN DICHOS DERIVADOS Y A LOS USOS DE DICHOS DERIVADOS.THE PRESENT INVENTION REFERS TO NICOTINAMIDE DERIVATIVES AND TO PROCEDURES FOR THE PREPARATION OF SAID DERIVATIVES, TO THE INTERMEDIATES USED IN THE PREPARATION OF SAID DERIVATIVES, TO COMPOSITIONS CONTAINING SAID DERIVATIVES AND TO THE USES OF SAID DERIVATIVES.

HN2003000062A 2002-02-11 2003-02-10 USEFUL NICOTINAMIDE DERIVATIVES AS PDE4 INHIBITORS HN2003000062A (en)

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US7102009B2 (en) 2001-01-12 2006-09-05 Amgen Inc. Substituted amine derivatives and methods of use
US6878714B2 (en) 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
PL372756A1 (en) 2002-02-11 2005-08-08 Pfizer Inc. Nicotinamide derivatives useful as pde4 inhibitors
US7307088B2 (en) 2002-07-09 2007-12-11 Amgen Inc. Substituted anthranilic amide derivatives and methods of use
GB0317509D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as PDE4 inhibitors
GB0317516D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as PDE4 inhibitors
GB0317482D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
US7153870B2 (en) 2003-07-25 2006-12-26 Pfizer Inc. Nicotinamide derivatives useful as PDE4 inhibitors
GB0317484D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
WO2005026132A1 (en) * 2003-09-17 2005-03-24 Nippon Shinyaku Co., Ltd. cAMP-SPECIFIC PHOSPHODIESTERASE INHIBITOR
ES2342468T3 (en) 2003-11-03 2010-07-07 Boehringer Ingelheim International Gmbh PROCEDURE FOR THE PREPARATION OF TIOTROPE SALTS.
JP2007517820A (en) * 2004-01-09 2007-07-05 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Novel pharmaceutical compositions based on scopine esters and nicotinamide derivatives
US7829585B2 (en) * 2005-03-30 2010-11-09 Eisai R&D Management Co., Ltd. Antifungal agent containing pyridine derivative
EP1915152A2 (en) * 2005-08-08 2008-04-30 Boehringer Ingelheim International GmbH Method for the protection against the risk of cardiac disorders comprising administration of tiotropium salts
DE102005049429A1 (en) 2005-10-15 2007-04-19 Cognis Ip Management Gmbh Process for finishing textiles
CA2626628A1 (en) * 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Compositions of phosphodiesterase type iv inhibitors
US8247556B2 (en) 2005-10-21 2012-08-21 Amgen Inc. Method for preparing 6-substituted-7-aza-indoles
TWI385169B (en) 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd Heterocyclic substituted pyridine derivatives and antifungal agent containing same
DK2068873T3 (en) * 2006-09-14 2012-02-27 Bridge Biores Rights Jersey Ltd Isoniazid-mediated healing of wounds and ulcers
US8513287B2 (en) 2007-12-27 2013-08-20 Eisai R&D Management Co., Ltd. Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
CN109020825B (en) * 2017-06-12 2021-03-19 重庆医科大学 Anti-influenza virus compound and preparation method thereof
EP4262797B1 (en) * 2020-12-18 2025-10-08 Merck Sharp & Dohme LLC Amido-substituted pyridyl compounds and methods of use thereof for the treatment of herpesviruses

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