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HN1997000039A - Complejo de inclusion de sales de aril heterociclicos - Google Patents

Complejo de inclusion de sales de aril heterociclicos

Info

Publication number
HN1997000039A
HN1997000039A HN1997000039A HN1997000039A HN1997000039A HN 1997000039 A HN1997000039 A HN 1997000039A HN 1997000039 A HN1997000039 A HN 1997000039A HN 1997000039 A HN1997000039 A HN 1997000039A HN 1997000039 A HN1997000039 A HN 1997000039A
Authority
HN
Honduras
Prior art keywords
complex
inclusion
salts
ziprasidone
heterociclicos
Prior art date
Application number
HN1997000039A
Other languages
English (en)
Inventor
Johnson Kevin Charles
Kim Yesook
Shanker Ravi Mysore
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of HN1997000039A publication Critical patent/HN1997000039A/es

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/724Cyclodextrins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Psychiatry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Seasonings (AREA)
  • Machine Translation (AREA)
  • Soil Conditioners And Soil-Stabilizing Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Composiciones de materia que comprende una sal farmacéuticamente aceptable de un compuesto aril HETEROCÍCLICOS, COMO ziprasidona en una ciclodextrina. CICLODEXTRINAS preferidos son SBECD Y HPBCD. La composición puede comprender una mezcla seca, un complejo de inclusión DRY o una solución acuosa. LA INCLUSIÓN complejo de sal / CICLODEXTRINA proporciona preferiblemente una cantidad de ZIPRASIDONA DE AL MENOS 2.5MGA/ML cuando el complejo se disuelve en agua a 40 W / V. Una variedad de sales de ziprasidona se prefieren, INCLUYENDO LA mesilato, esilato, besilato, tartrato, napsilato Y tosilato.
HN1997000039A 1996-05-07 1997-04-02 Complejo de inclusion de sales de aril heterociclicos HN1997000039A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1920496P 1996-05-07 1996-05-07

Publications (1)

Publication Number Publication Date
HN1997000039A true HN1997000039A (es) 1997-06-26

Family

ID=21791976

Family Applications (1)

Application Number Title Priority Date Filing Date
HN1997000039A HN1997000039A (es) 1996-05-07 1997-04-02 Complejo de inclusion de sales de aril heterociclicos

Country Status (47)

Country Link
US (2) US6232304B1 (es)
EP (1) EP0900088B1 (es)
JP (1) JP3579060B2 (es)
KR (1) KR20000010823A (es)
CN (1) CN1216923A (es)
AP (1) AP796A (es)
AR (2) AR007002A1 (es)
AT (1) ATE257714T1 (es)
AU (1) AU713711B2 (es)
BG (3) BG64474B1 (es)
BR (1) BR9709213A (es)
CA (1) CA2251912C (es)
CO (1) CO4600677A1 (es)
CZ (1) CZ297847B6 (es)
DE (1) DE69727218T2 (es)
DK (1) DK0900088T3 (es)
DZ (1) DZ2220A1 (es)
EA (1) EA001731B1 (es)
EG (1) EG24135A (es)
ES (1) ES2212809T3 (es)
GE (1) GEP20074185B (es)
GT (1) GT199700044A (es)
HN (1) HN1997000039A (es)
HR (1) HRP970237B1 (es)
HU (1) HU222451B1 (es)
ID (1) ID16866A (es)
IL (1) IL126546A (es)
IS (1) IS2524B (es)
MA (1) MA24172A1 (es)
ME (1) ME00880B (es)
MY (1) MY121999A (es)
NO (1) NO324373B1 (es)
NZ (1) NZ332220A (es)
OA (1) OA10907A (es)
PL (1) PL189324B1 (es)
PT (1) PT900088E (es)
RS (1) RS49532B (es)
SA (1) SA97180024B1 (es)
SI (1) SI0900088T1 (es)
SK (1) SK282032B6 (es)
TN (1) TNSN97075A1 (es)
TR (1) TR199802231T2 (es)
TW (1) TW514529B (es)
UA (1) UA57734C2 (es)
UY (1) UY24544A1 (es)
WO (1) WO1997041896A2 (es)
ZA (1) ZA973874B (es)

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MXPA03009945A (es) 2002-11-05 2007-04-16 Lg Electronics Inc Montaje para montar una pantalla de toque para un monitor con pantalla de cristal liquido.
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KR20080093464A (ko) * 2003-09-02 2008-10-21 화이자 프로덕츠 인크. 지프라시돈 나노입자
CA2548491A1 (en) * 2003-12-08 2005-06-23 The Arizona Board Of Regents On Behalf Of The University Of Arizona Synergistic anti-cancer compositions
WO2005065660A2 (en) * 2003-12-31 2005-07-21 Alpharma, Inc. Ziprasidone formulations
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Also Published As

Publication number Publication date
EA199800910A1 (ru) 1999-04-29
JPH11509866A (ja) 1999-08-31
AU713711B2 (en) 1999-12-09
UA57734C2 (uk) 2003-07-15
DE69727218T2 (de) 2004-11-18
ME00880B (me) 2006-12-15
AU1937297A (en) 1997-11-26
EP0900088B1 (en) 2004-01-14
DE69727218D1 (de) 2004-02-19
IL126546A0 (en) 1999-08-17
IS4880A (is) 1998-10-27
CZ297847B6 (cs) 2007-04-11
ES2212809T3 (es) 2004-08-01
EP0900088A2 (en) 1999-03-10
BG64474B1 (bg) 2005-04-30
GT199700044A (es) 1998-10-02
NZ332220A (en) 2000-03-27
NO985192L (no) 1998-11-06
HU222451B1 (hu) 2003-07-28
YU17297A (sh) 1999-12-27
AP796A (en) 1999-12-24
BG102894A (en) 1999-09-30
AR045528A2 (es) 2005-11-02
JP3579060B2 (ja) 2004-10-20
ZA973874B (en) 1998-11-06
NO324373B1 (no) 2007-10-01
BG64475B2 (bg) 2005-04-30
DZ2220A1 (fr) 2002-12-03
BR9709213A (pt) 1999-08-10
HRP970237B1 (en) 2002-04-30
CA2251912A1 (en) 1997-11-13
HUP9902799A3 (en) 2000-12-28
IS2524B (is) 2009-07-15
IL126546A (en) 2001-01-28
MY121999A (en) 2006-03-31
CA2251912C (en) 2003-06-03
TNSN97075A1 (fr) 2005-03-15
TR199802231T2 (xx) 1999-02-22
HRP970237A2 (en) 1998-12-31
SK150498A3 (en) 2000-01-18
UY24544A1 (es) 2000-09-29
US20010031756A1 (en) 2001-10-18
OA10907A (en) 2001-10-26
BG64475B1 (bg) 2005-04-30
SI0900088T1 (en) 2004-04-30
ATE257714T1 (de) 2004-01-15
AP9700977A0 (en) 1997-07-31
CZ346198A3 (cs) 1999-09-15
PT900088E (pt) 2004-04-30
GEP20074185B (en) 2007-08-10
WO1997041896A3 (en) 1998-01-08
PL329928A1 (en) 1999-04-26
DK0900088T3 (da) 2004-04-19
WO1997041896A2 (en) 1997-11-13
SK282032B6 (sk) 2001-10-08
EA001731B1 (ru) 2001-08-27
SA97180024B1 (ar) 2005-12-24
HUP9902799A2 (hu) 1999-12-28
KR20000010823A (ko) 2000-02-25
US6399777B2 (en) 2002-06-04
US6232304B1 (en) 2001-05-15
TW514529B (en) 2002-12-21
AR007002A1 (es) 1999-10-13
MA24172A1 (fr) 1997-12-31
PL189324B1 (pl) 2005-07-29
CN1216923A (zh) 1999-05-19
EG24135A (en) 2008-08-06
CO4600677A1 (es) 1998-05-08
ID16866A (id) 1997-11-20
RS49532B (sr) 2006-12-15
NO985192D0 (no) 1998-11-06

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