HK91692A - Bicyclic carboxylic acids and their alkyl and aralkyl esters - Google Patents

Bicyclic carboxylic acids and their alkyl and aralkyl esters

Info

Publication number: HK91692A
Authority: HK; Hong Kong
Prior art keywords: signifies; formula; diazepine; dioxo; pyridazo
Prior art date: 1982-05-12

Application number

HK916/92A

Other languages

German (de)

English (en)

French (fr)

Inventor

Michael Richard Attwood

Cedric Herbert Hassall

Robert Wilson Lambert

Geoffrey Lawton

Sally Redshaw

Original Assignee

F. Hoffmann-La Roche Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-05-12

Filing date

1992-11-19

Publication date

1992-11-27

1992-11-19 Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag

1992-11-27 Publication of HK91692A publication Critical patent/HK91692A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3886—Acids containing the structure -C(=X)-P(=X)(XH)2 or NC-P(=X)(XH)2, (X = O, S, Se)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/409—Compounds containing the structure P(=X)-X-acyl, P(=X) -X-heteroatom, P(=X)-X-CN (X = O, S, Se)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
- C07F9/650947—Six-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Crystallography & Structural Chemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)

HK916/92A 1982-05-12 1992-11-19 Bicyclic carboxylic acids and their alkyl and aralkyl esters HK91692A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8213850		1982-05-12
GB08305505A GB2128984B (en)	1982-05-12	1983-02-28	Diaza-bicyclic compounds

Publications (1)

Publication Number	Publication Date
HK91692A true HK91692A (en)	1992-11-27

Family

ID=26282820

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK916/92A HK91692A (en)	1982-05-12	1992-11-19	Bicyclic carboxylic acids and their alkyl and aralkyl esters

Country Status (32)

Country	Link
US (3)	US4512924A (pt)
EP (1)	EP0094095B1 (pt)
KR (1)	KR890002106B1 (pt)
AR (1)	AR240940A1 (pt)
AU (1)	AU567873B2 (pt)
BG (1)	BG61123B2 (pt)
CA (1)	CA1234568A (pt)
CS (2)	CS249128B2 (pt)
CU (1)	CU21532A3 (pt)
DE (2)	DE3317290A1 (pt)
DK (1)	DK160612C (pt)
DO (1)	DOP1983004163A (pt)
DZ (1)	DZ540A1 (pt)
ES (6)	ES522291A0 (pt)
FI (1)	FI77244C (pt)
FR (1)	FR2531956B1 (pt)
GB (1)	GB2128984B (pt)
GR (1)	GR77462B (pt)
HK (1)	HK91692A (pt)
HU (3)	HU199842B (pt)
IE (1)	IE56480B1 (pt)
IL (1)	IL68620A (pt)
IT (1)	IT1212738B (pt)
LU (2)	LU84803A1 (pt)
MC (1)	MC1515A1 (pt)
MY (1)	MY102889A (pt)
NL (2)	NL8301640A (pt)
NO (1)	NO160368C (pt)
PT (1)	PT76681B (pt)
SE (1)	SE461792B (pt)
SG (1)	SG81192G (pt)
ZW (1)	ZW9883A1 (pt)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2128984B (en) *	1982-05-12	1985-05-22	Hoffmann La Roche	Diaza-bicyclic compounds
NZ204130A (en) *	1982-05-12	1986-03-14	Hoffmann La Roche	Bicyclic heterocyclic compounds and pharmaceutical compositions
DE3315464A1 (de) *	1983-04-28	1984-10-31	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
US4801721A (en) *	1984-08-16	1989-01-31	Ryan James W	Stereospecific synthesis of carboxyalkyl peptides
US4692438A (en) *	1984-08-24	1987-09-08	Hoffmann-La Roche Inc.	Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
US4902707A (en) *	1985-04-30	1990-02-20	Eli Lilly And Company	Bicyclic pyrazolidinones, compositions and use
ES8801833A1 (es) *	1985-04-30	1988-02-16	Lilly Co Eli	Un procedimiento para la preparacion de un compuesto.
US4826992A (en) *	1985-04-30	1989-05-02	Eli Lilly And Company	2,3-(Dihydro) bicyclic pyrazolidinones
US4940718A (en) *	1985-04-30	1990-07-10	Eli Lilly And Company	7-substituted bicyclic pyrazolidinones, pharmaceutical compositions and use
ZW11586A1 (en) *	1985-07-01	1987-12-30	Hoffmann La Roche	Bicyclic compounds
US4832763A (en) *	1985-10-15	1989-05-23	Westinghouse Electric Corp.	Method of stress-relief annealing a magnetic core containing amorphous material
DE3542794A1 (de) *	1985-12-04	1987-06-11	Bayer Ag	Antihypertensives kombinationspraeparat
EP0254032A3 (en)	1986-06-20	1990-09-05	Schering Corporation	Neutral metalloendopeptidase inhibitors in the treatment of hypertension
EP0566157A1 (en)	1986-06-20	1993-10-20	Schering Corporation	Neutral metalloendopeptidase inhibitors in the treatment of hypertension
GB8629875D0 (en) *	1986-12-15	1987-01-28	Hoffmann La Roche	Pyridazodiazepine derivatives
US5262436A (en) *	1987-03-27	1993-11-16	Schering Corporation	Acylamino acid antihypertensives in the treatment of congestive heart failure
US4956490A (en) *	1989-03-09	1990-09-11	Merck & Co., Inc.	Process for preparing benzylpyruvic acids and esters
ZA902661B (en) *	1989-04-10	1991-01-30	Schering Corp	Mercapto-acyl amino acids
DE3917255A1 (de) *	1989-05-26	1990-11-29	Schopf Masch	Verfahren und vorrichtung zum aufnehmen eines flugzeugbugfahrwerks durch einen flugzeugschlepper
US5011938A (en) *	1989-10-02	1991-04-30	Eli Lilly And Company	7-substituted bicyclic pyrazolidinones
US5389610A (en) *	1989-11-21	1995-02-14	Schering Corporation	Carboxyalkylcarbonyl aminoacid endopeptidase inhibitors
WO1991009840A1 (en) *	1989-12-22	1991-07-11	Schering Corporation	Mercaptocycloacyl aminoacid endopeptidase inhibitors
US5075302A (en) *	1990-03-09	1991-12-24	Schering Corporation	Mercaptoacyl aminolactam endopeptidase inhibitors
US5173506A (en) *	1990-08-16	1992-12-22	Schering Corporation	N-(mercaptoalkyl)ureas and carbamates
EP0487453B1 (de) *	1990-11-21	1996-05-22	Ciba-Geigy Ag	Silylierte Acylphosphinoxide
US5208230A (en) *	1990-12-21	1993-05-04	Merrell Dow Pharmaceuticals	Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
DK0577629T3 (da) *	1991-03-19	1996-07-29	Ciba Geigy Ag	Nye herbicidt, acaricidt og insekticidt aktive forbindelser
TW216770B (pt) *	1991-07-23	1993-12-01	Hoffmann La Roche
CA2078759C (en) *	1991-09-27	2003-09-16	Alan M. Warshawsky	Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
US5455242A (en) *	1991-09-27	1995-10-03	Merrell Dow Pharmaceuticals Inc.	Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
US5457196A (en) *	1991-09-27	1995-10-10	Merrell Dow Pharmaceuticals Inc.	2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
JPH06107661A (ja) *	1991-10-24	1994-04-19	Upjohn Co:The	イミダゾール誘導体およびこれを有効成分とする医薬組成物
US5442062A (en) *	1991-10-24	1995-08-15	The Upjohn Company	Imidazole derivatives and pharmaceutical compositions containing the same
US5972990A (en) *	1992-04-10	1999-10-26	Brigham And Women's Hospital, Inc.	Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
US5977160A (en) *	1992-04-10	1999-11-02	Brigham And Women's Hospital, Inc.	Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
US5552397A (en) *	1992-05-18	1996-09-03	E. R. Squibb & Sons, Inc.	Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
HU223663B1 (hu) *	1992-05-15	2004-11-29	Merrel Dow Pharmaceuticals Inc.	Enkefalináz és ACE gátló hatású 9-[(2-acetil-tio-3-fenil)-propanoil-amino]-piridazo[1,2-a][1,2]diazepin-származékok, eljárás előállításukra, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények
EP0570764B1 (de) *	1992-05-18	2001-07-18	F.Hoffmann-La Roche & Co. Aktiengesellschaft	Asymmetrische Hydrierung
US5238932A (en) *	1992-05-20	1993-08-24	Merrell Dow Pharmaceuticals Inc.	Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
CA2146238C (en) *	1992-10-30	2001-03-13	Gary A. Flynn	Novel mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ace
JPH072859A (ja) *	1993-01-28	1995-01-06	Upjohn Co:The	ピラゾール誘導体およびこれを有効成分とする医薬組成物
US5476395A (en) *	1993-03-01	1995-12-19	Methode Electronics, Inc.	Planar fuse panel
US5654294A (en) *	1993-05-13	1997-08-05	Bristol-Myers Squibb	Spiro lactam dual action inhibitors
DK0634175T3 (da) *	1993-07-15	2001-04-30	Hoffmann La Roche	Farmaceutisk kombination, der indeholder en hæmmer af renin-angiotensin-systemet og en endothelin-antagonist
EP0746566A1 (en) *	1994-02-14	1996-12-11	Merrell Pharmaceuticals Inc.	Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
CA2183320C (en) *	1994-02-14	1999-10-26	Gary A. Flynn	Novel mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
KR100364947B1 (ko) *	1994-02-14	2003-03-06	메렐 파마슈티칼스 인크.	엔케팔리나제및ace의억제제로서유용한신규의머캅토아세틸아미도1,3,4,5-테트라히드로-벤조[c]아제핀-3-온디술파이드유도체
DE69524064T2 (de) *	1994-02-14	2002-07-11	Merrell Pharmaceuticals Inc., Cincinnati	Indan-2-mercaptoacetylamid disulfidderivate als enkephalinase inhibitoren
US5530013A (en) *	1994-02-14	1996-06-25	American Home Products Corporation	Venlafaxine in the inducement of cognition enhancement
US5484783A (en) *	1994-03-24	1996-01-16	Merrell Dow Pharmaceuticals Inc.	Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
WO1995025532A1 (en) *	1994-03-24	1995-09-28	Merrell Pharmaceuticals Inc.	Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic aminoacetylmercapto derivatives
EP0751774B1 (en) *	1994-03-24	2003-08-13	Merrell Pharmaceuticals Inc.	Hypocholesterolemic mercaptoacetylamide disulfide derivatives
US5756466A (en)	1994-06-17	1998-05-26	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1β converting enzyme
US5587375A (en) *	1995-02-17	1996-12-24	Bristol-Myers Squibb Company	Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en) *	1995-05-17	1999-03-02	Bristol-Myers Squibb	Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5635504A (en) *	1995-06-07	1997-06-03	Bristol-Myers Squibb Co.	Diazepine containing dual action inhibitors
US5650408A (en) *	1995-06-07	1997-07-22	Karanewsky; Donald S.	Thiazolo benzazepine containing dual action inhibitors
AU2003200034B2 (en) *	1998-04-27	2006-07-20	Aventis Pharma S.A.	New derivatives of octahydro-6, 10-dioxo-6H-pyridazino [1,2-A][1,2]diazepine-1-carboxylic acid, their preparation process and their use in the preparation of therapeutically active compounds
FR2777889B1 (fr) *	1998-04-27	2004-07-09	Hoechst Marion Roussel Inc	Nouveaux derives de l'acide octahydro-6,10-dioxo-6h- pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de composes therapeutiquement actifs
FR2777888B1 (fr)	1998-04-27	2004-07-16	Hoechst Marion Roussel Inc	Nouveaux derives de l'acide (3,4,7,8,9,10-hexahydro-6,10- dioxo-6h-pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de medicaments
US6177565B1 (en) *	1998-08-19	2001-01-23	Vertex Pharmaceuticals Inc.	Process for synthesizing piperazic acid
US6703500B2 (en)	1998-08-19	2004-03-09	Vertex Pharmaceuticals, Incorporated	Method of preparing bicyclic intermediates from piperazic acid or an ester thereof useful in the manufacture of caspase inhibitors
US6559304B1 (en)	1998-08-19	2003-05-06	Vertex Pharmaceuticals Incorporated	Method for synthesizing caspase inhibitors
FR2788276B1 (fr) *	1999-01-12	2001-02-16	Hoechst Marion Roussel Inc	NOUVEAU PROCEDE DE PREPARATION DE COMPOSES BICYCLIQUES ET L'APPLICATION DE CE PROCEDE COMME ETAPE INTERMEDIAIRE POUR LA PREPARATION D'UN COMPOSE INHIBITEUR DE L'ENZYME DE CONVERSION DE L'INTERLEUKINE 1-BETA (ice)
WO2001021163A2 (en) *	1999-09-21	2001-03-29	Emory University	Methods and compositions for treating platelet-related disorders using mpl pathway inhibitory agents
US20030113330A1 (en) *	1999-11-08	2003-06-19	Uhal Bruce D.	Methods for treating pulmonary fibrosis
US8101363B2 (en)	2000-12-14	2012-01-24	The Brigham And Women's Hospital, Inc.	Inflammatory markers as tools in the detection and prevention of diabetes mellitus and as tools to aid in the selection of agents to be used for the prevention and treatment of diabetes
GB0119305D0 (en)	2001-04-12	2001-10-03	Aventis Pharma Gmbh	Mercaptoacetylamide derivatives,a process for their preparation and their use
WO2003094856A2 (en)	2002-05-09	2003-11-20	The Brigham And Women's Hospital, Inc.	1l1rl-1 as a cardiovascular disease marker and therapeutic target
US20040110241A1 (en) *	2002-12-06	2004-06-10	Segal Mark S.	Materials and methods for monitoring vascular endothelial function
CA2510320C (en)	2002-12-20	2012-10-09	St. James Associates Llc/Faber Research Series	Coated particles for sustained-release pharmaceutical administration
EP1603916A1 (en) *	2003-03-06	2005-12-14	Ranbaxy Laboratories, Ltd.	Enantiomerically pure cilazapril, process for preparation
WO2005003134A1 (en) *	2003-07-07	2005-01-13	Hetero Drugs Limited	A novel process for the preparation of cilazapril
EP3081214A3 (en)	2003-08-29	2016-11-16	The Brigham And Women's Hospital, Inc.	Inhibitors of cellular necrosis
EP1697746B1 (en)	2003-12-05	2012-02-22	The Cleveland Clinic Foundation	Risk markers for cardiovascular disease
US7803838B2 (en) *	2004-06-04	2010-09-28	Forest Laboratories Holdings Limited	Compositions comprising nebivolol
WO2005122682A2 (en)	2004-06-18	2005-12-29	Ranbaxy Laboratories Limited	Process for the preparation of esters of piperazic acid
CA2624601C (en)	2004-10-06	2018-07-03	The Brigham And Women's Hospital, Inc.	Relevance of achieved levels of markers of systemic inflammation following treatment
EP1846380A4 (en) *	2005-01-21	2010-02-17	Nicox Sa	HETEROCYCLIC NITROGEN MONOXIDE DONOR COMPOSITIONS CONTAINING CARDIOVASCULAR COMPOUNDS, AND METHODS OF USING THE SAME
CA2596426A1 (en) *	2005-01-31	2006-08-10	Mylan Laboratories, Inc.	Pharmaceutical composition comprising hydroxylated nebivolol
CA2610694A1 (en)	2005-05-31	2006-12-07	Mylan Laboratories, Inc.	Compositions comrising nebivolol
US8119358B2 (en)	2005-10-11	2012-02-21	Tethys Bioscience, Inc.	Diabetes-related biomarkers and methods of use thereof
US20070281000A1 (en) *	2006-06-02	2007-12-06	Michael Fox	Stable formulation comprising moisture sensitive drug/s and manufacturing procedure thereof
ES2299157T3 (es)	2006-06-02	2008-05-16	Teva Pharmaceutical Industries Ltd	Formulacion estable que comprende un farmaco sensible a la humedad y procedimiento de preparacion del mismo.
CA2659082A1 (en) *	2006-06-07	2007-12-21	Tethys Bioscience, Inc.	Markers associated with arteriovascular events and methods of use thereof
US20080008751A1 (en) *	2006-07-10	2008-01-10	Michael Fox	Stable formulation comprising a combination of a moisture sensitive drug and a second drug and manufacturing procedure thereof
DK2147315T3 (da)	2007-04-18	2013-09-23	Tethys Bioscience Inc	Diabetesrelaterede biomarkører og fremgangsmåder til anvendelse deraf
US7828840B2 (en) *	2007-11-15	2010-11-09	Med Institute, Inc.	Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists
GB2462022B (en) *	2008-06-16	2011-05-25	Biovascular Inc	Controlled release compositions of agents that reduce circulating levels of platelets and methods thereof
EP2221299A3 (en)	2009-02-11	2010-11-03	Dr. Reddy's Laboratories Ltd.	Preparation of cilazapril intermediates
JP2013518618A (ja)	2010-02-01	2013-05-23	ザ・ホスピタル・フォー・シック・チルドレン	再狭窄を治療および予防するための遠隔虚血コンディショニング
WO2011121402A2 (en)	2010-03-31	2011-10-06	The Hospital For Sick Children	Use of remote ischemic conditioning to improve outcome after myocardial infarction
TWI621420B (zh)	2010-04-08	2018-04-21	病童醫院	遠距缺血處理於創傷性傷害的用途
WO2012049646A1 (en)	2010-10-12	2012-04-19	Ranbaxy Laboratories Limited	Process for the preparation of an intermediate of cilazapril
EP2537534B1 (en)	2011-06-22	2014-12-17	Hexal AG	Esters of (1S,9S)-9-[[(1S)-1-carboxy-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid and their therapeutic use.
EP2734222B1 (en)	2011-07-18	2016-10-19	Critical Care Diagnostics, Inc.	Methods of treating cardiovascular diseases and predicting the efficacy of exercise therapy
CN104640856B (zh)	2012-05-11	2017-09-15	复位治疗公司	作为隐花色素调节剂的含有咔唑的磺酰胺类
CA2881563C (en)	2012-08-01	2021-07-20	Zahra TAVAKOLI	Free flowing, frozen compositions comprising a therapeutic agent
EP2968276A4 (en)	2013-03-15	2017-02-15	President and Fellows of Harvard College	Hybrid necroptosis inhibitors
EP3981388A1 (en)	2013-03-21	2022-04-13	Eupraxia Pharmaceuticals USA LLC	Injectable sustained release composition and method of using the same for treating inflammation in joints and pain associated therewith
TWI690521B (zh)	2014-04-07	2020-04-11	美商同步製藥公司	作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類
ES2672993T3 (es)	2015-10-27	2018-06-19	Eupraxia Pharmaceuticals Inc.	Formulaciones de liberación sostenida de anestésicos locales

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL58849A (en) *	1978-12-11	1983-03-31	Merck & Co Inc	Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
IL60617A0 (en) *	1979-07-23	1980-09-16	Sparamedica Ag	Triazolopyridazine derivative,their preparation and pharmaceutical compositions containing them
EP0025941B1 (de) *	1979-09-19	1983-05-04	F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft	Pyridazopyridazinderivate, Verfahren zu deren Herstellung und Arzneimittel enthaltend solche Pyridazopyridazinderivate
EP0042100A1 (de) *	1980-06-13	1981-12-23	F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft	Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel
EP0047620B1 (en) *	1980-09-10	1985-03-13	Beecham Group Plc	Aryl diazabicyclyl amides, a process for their preparation and use
GB2128984B (en) *	1982-05-12	1985-05-22	Hoffmann La Roche	Diaza-bicyclic compounds

1983
- 1983-02-28 GB GB08305505A patent/GB2128984B/en not_active Expired
- 1983-04-29 ZW ZW98/83A patent/ZW9883A1/xx unknown
- 1983-04-29 CA CA000427095A patent/CA1234568A/en not_active Expired
- 1983-05-02 DK DK194783A patent/DK160612C/da not_active IP Right Cessation
- 1983-05-06 IL IL68620A patent/IL68620A/xx not_active IP Right Cessation
- 1983-05-09 IT IT8321000A patent/IT1212738B/it active
- 1983-05-09 HU HU875409A patent/HU199842B/hu not_active IP Right Cessation
- 1983-05-09 CU CU8335899A patent/CU21532A3/xx unknown
- 1983-05-09 HU HU831589A patent/HU195965B/hu unknown
- 1983-05-09 HU HU875410A patent/HU198935B/hu unknown
- 1983-05-09 AU AU14364/83A patent/AU567873B2/en not_active Expired
- 1983-05-09 NL NL8301640A patent/NL8301640A/nl not_active Application Discontinuation
- 1983-05-10 FR FR8307785A patent/FR2531956B1/fr not_active Expired
- 1983-05-10 DZ DZ836846A patent/DZ540A1/fr active
- 1983-05-10 MC MC821633A patent/MC1515A1/fr unknown
- 1983-05-11 KR KR1019830002033A patent/KR890002106B1/ko not_active Expired
- 1983-05-11 ES ES522291A patent/ES522291A0/es active Granted
- 1983-05-11 EP EP83104668A patent/EP0094095B1/de not_active Expired - Lifetime
- 1983-05-11 NO NO831675A patent/NO160368C/no not_active IP Right Cessation
- 1983-05-11 LU LU84803A patent/LU84803A1/de unknown
- 1983-05-11 AR AR292991A patent/AR240940A1/es active
- 1983-05-11 DE DE19833317290 patent/DE3317290A1/de not_active Ceased
- 1983-05-11 SE SE8302716A patent/SE461792B/sv not_active IP Right Cessation
- 1983-05-11 IE IE1084/83A patent/IE56480B1/en not_active IP Right Cessation
- 1983-05-11 DE DE8383104668T patent/DE3381884D1/de not_active Expired - Lifetime
- 1983-05-11 CS CS833303A patent/CS249128B2/cs unknown
- 1983-05-12 PT PT76681A patent/PT76681B/pt unknown
- 1983-05-12 DO DO1983004163A patent/DOP1983004163A/es unknown
- 1983-05-12 US US06/493,876 patent/US4512924A/en not_active Expired - Lifetime
- 1983-05-12 GR GR71331A patent/GR77462B/el unknown
- 1983-05-12 FI FI831661A patent/FI77244C/fi not_active IP Right Cessation
1984
- 1984-01-02 ES ES528628A patent/ES8706672A1/es not_active Expired
- 1984-01-02 ES ES528627A patent/ES528627A0/es active Granted
- 1984-01-02 ES ES528630A patent/ES8607970A1/es not_active Expired
- 1984-01-02 ES ES528625A patent/ES528625A0/es active Granted
1985
- 1985-02-01 US US06/697,559 patent/US4658024A/en not_active Expired - Lifetime
1986
- 1986-05-14 ES ES554935A patent/ES8800170A1/es not_active Expired
- 1986-11-28 US US06/936,003 patent/US4772701A/en not_active Expired - Lifetime
1987
- 1987-09-08 MY MYPI87001597A patent/MY102889A/en unknown
1991
- 1991-12-23 CS CS914021A patent/CS402191A3/cs unknown
1992
- 1992-08-12 SG SG811/92A patent/SG81192G/en unknown
- 1992-11-19 HK HK916/92A patent/HK91692A/xx not_active IP Right Cessation
1993
- 1993-06-09 LU LU88299C patent/LU88299I2/fr unknown
- 1993-06-11 NL NL930055C patent/NL930055I2/nl unknown
1994
- 1994-02-21 BG BG098502A patent/BG61123B2/bg unknown

Also Published As

Publication number	Publication date
GB2128984B (en)	1985-05-22
ZW9883A1 (en)	1984-11-21
IL68620A (en)	1987-11-30
IL68620A0 (en)	1983-09-30
SE8302716D0 (sv)	1983-05-11
SE8302716L (sv)	1983-11-13
DK160612B (da)	1991-04-02
IE831084L (en)	1983-11-12
BG61123B2 (bg)	1996-11-29
NO831675L (no)	1983-11-14
ES8601994A1 (es)	1985-11-16
NO160368C (no)	1989-04-12
DK194783D0 (da)	1983-05-02
ES8407049A1 (es)	1984-08-16
DK160612C (da)	1991-09-23
FI77244C (fi)	1989-02-10
ES8505173A1 (es)	1985-05-16
HU195965B (en)	1988-08-29
EP0094095A3 (en)	1984-11-21
AR240940A1 (es)	1991-03-27
NL930055I1 (nl)	1993-09-01
PT76681A (en)	1983-06-01
ES522291A0 (es)	1984-08-16
KR840004754A (ko)	1984-10-24
MY102889A (en)	1993-03-31
FI77244B (fi)	1988-10-31
ES554935A0 (es)	1987-11-01
MC1515A1 (fr)	1984-02-10
GB8305505D0 (en)	1983-03-30
LU88299I2 (fr)	1994-09-09
CS402191A3 (en)	1992-10-14
FI831661A0 (fi)	1983-05-12
SE461792B (sv)	1990-03-26
ES528630A0 (es)	1986-06-16
CS249128B2 (en)	1987-03-12
IT1212738B (it)	1989-11-30
FR2531956B1 (fr)	1987-02-20
IT8321000A0 (it)	1983-05-09
DOP1983004163A (es)	1988-09-20
HU198935B (en)	1989-12-28
GR77462B (pt)	1984-09-24
ES8607970A1 (es)	1986-06-16
AR240940A2 (es)	1991-03-27
US4658024A (en)	1987-04-14
DK194783A (da)	1983-11-13
FR2531956A1 (fr)	1984-02-24
AU567873B2 (en)	1987-12-10
CU21532A3 (en)	1987-06-09
SG81192G (en)	1993-01-29
CA1234568A (en)	1988-03-29
DE3317290A1 (de)	1983-11-17
EP0094095A2 (de)	1983-11-16
NO160368B (no)	1989-01-02
PT76681B (en)	1986-05-20
EP0094095B1 (de)	1990-09-19
ES528628A0 (es)	1987-07-16
ES528627A0 (es)	1985-11-16
IE56480B1 (en)	1991-08-14
ES8706672A1 (es)	1987-07-16
US4772701A (en)	1988-09-20
NL8301640A (nl)	1983-12-01
DZ540A1 (fr)	2004-09-13
ES528625A0 (es)	1985-05-16
HU199842B (en)	1990-03-28
DE3381884D1 (de)	1990-10-25
KR890002106B1 (ko)	1989-06-19
LU84803A1 (fr)	1985-03-21
US4512924A (en)	1985-04-23
GB2128984A (en)	1984-05-10
NL930055I2 (nl)	1993-10-01
ES8800170A1 (es)	1987-11-01
FI831661L (fi)	1983-11-13
AU1436483A (en)	1983-11-17

Publication	Publication Date	Title
HK91692A (en)	1992-11-27	Bicyclic carboxylic acids and their alkyl and aralkyl esters
US4808713A (en)	1989-02-28	Anthypertensive pyridazo [1,2-a][1,2]diazepines
RU2194037C2 (ru)	2002-12-10	Нитрат асе-ингибитора
CA1322076C (en)	1993-09-07	Phosphorus containing peptides
US5098892A (en)	1992-03-24	Process for preparation of bicyclic compounds
US4668797A (en)	1987-05-26	Bicyclic aminoacids as intermediates and processes for their preparation
MC1881A1 (fr)	1989-01-24	Derives de l'acide phosphinique
CS20192A3 (en)	1992-08-12	Amino acid derivatives, process of their preparation and use
EP0037231A2 (en)	1981-10-07	Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
NZ213130A (en)	1988-05-30	Bicyclic compounds with two common nitrogen atoms; pharmaceutical composition
AU602546B2 (en)	1990-10-18	Pyridazodiazepine derivatives
EP0018104A2 (en)	1980-10-29	Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension
US3586683A (en)	1971-06-22	2,5(5) - di(tri)substituted - 10b-hydroxy-3,6 - dioxo-octahydro-oxazolo(3,2-a) pyrrolo(2,1-c)pyrazine derivatives of lysergic acid
JPH0559105B2 (pt)	1993-08-30
EP0206729B1 (en)	1991-02-06	Pharmacologically active compounds
EP0057998B1 (en)	1984-08-08	Alicyclic compounds, their production and use
HU194278B (en)	1988-01-28	Process for production of medical compounds containing as active substance bicyclic dipeptides and of the active substance
PT97281A (pt)	1992-01-31	Processo para a preparacao de novos derivados contendo fosforo
FR2610322A1 (fr)	1988-08-05	Nouveaux derives de la pilocarpine, leur preparation et leur utilisation comme medicaments
RU2051916C1 (ru)	1996-01-10	Оптически активные производные индолбензохинолина или их фармацевтически приемлемые соли
KR880001007B1 (ko)	1988-06-13	비사이클릭 화합물의 제조 방법
JPH01301656A (ja)	1989-12-05	ヒドロキシプロリンのカルバメート誘導体
EP0279750A2 (en)	1988-08-24	Aminoacid derivatives as antihypertensives
uS	1977	eDS×(l)
JPH01110695A (ja)	1989-04-27	アミノ酸誘導体その製造方法及び血圧降下剤

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2004-12-15	PE	Patent expired