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ES8407049A1 - Un procedimiento para la preparacion de compuestos biciclicos. - Google Patents

Un procedimiento para la preparacion de compuestos biciclicos.

Info

Publication number
ES8407049A1
ES8407049A1 ES522291A ES522291A ES8407049A1 ES 8407049 A1 ES8407049 A1 ES 8407049A1 ES 522291 A ES522291 A ES 522291A ES 522291 A ES522291 A ES 522291A ES 8407049 A1 ES8407049 A1 ES 8407049A1
Authority
ES
Spain
Prior art keywords
procedure
preparation
formula
bicycle compounds
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES522291A
Other languages
English (en)
Other versions
ES522291A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES8407049A1 publication Critical patent/ES8407049A1/es
Publication of ES522291A0 publication Critical patent/ES522291A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3886—Acids containing the structure -C(=X)-P(=X)(XH)2 or NC-P(=X)(XH)2, (X = O, S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/409—Compounds containing the structure P(=X)-X-acyl, P(=X) -X-heteroatom, P(=X)-X-CN (X = O, S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
    • C07F9/650947—Six-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS BICICLICOS, DE FORMULA GENERAL (I), Y SUS SALES FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), CON UN COMPUESTO DE FORMULA (III), EN UN DISOLVENTE ORGANICO INERTE Y EN PRESENCIA DE UN AGENTE ACEPTOR DE ACIDO.DE APLICACION EN MEDICINA COMO AGENTES ANTIHIPERTENSIVOS.
ES522291A 1982-05-12 1983-05-11 Un procedimiento para la preparacion de compuestos biciclicos. Granted ES522291A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8213850 1982-05-12
GB08305505A GB2128984B (en) 1982-05-12 1983-02-28 Diaza-bicyclic compounds

Publications (2)

Publication Number Publication Date
ES8407049A1 true ES8407049A1 (es) 1984-08-16
ES522291A0 ES522291A0 (es) 1984-08-16

Family

ID=26282820

Family Applications (6)

Application Number Title Priority Date Filing Date
ES522291A Granted ES522291A0 (es) 1982-05-12 1983-05-11 Un procedimiento para la preparacion de compuestos biciclicos.
ES528628A Expired ES8706672A1 (es) 1982-05-12 1984-01-02 Un procedimiento para la preparacion de pirazolo y piridazo-pirazolinas, piridazinas y diazepinas.
ES528627A Granted ES528627A0 (es) 1982-05-12 1984-01-02 Un procedimiento para la preparacion de pirazolo-y piridazo-pirazolinas,-piridazinas y-diazepinas.
ES528630A Expired ES8607970A1 (es) 1982-05-12 1984-01-02 Un procedimiento para la obtencion de derivados de hexahidro-3-oxo-piridinas.
ES528625A Granted ES528625A0 (es) 1982-05-12 1984-01-02 Un procedimiento para la preparacion de compuestos biciclicos
ES554935A Expired ES8800170A1 (es) 1982-05-12 1986-05-14 Un procedimiento para la preparacion de pirazolo- y piridazo-pirazolinas, -piridazinas y -diacepinas

Family Applications After (5)

Application Number Title Priority Date Filing Date
ES528628A Expired ES8706672A1 (es) 1982-05-12 1984-01-02 Un procedimiento para la preparacion de pirazolo y piridazo-pirazolinas, piridazinas y diazepinas.
ES528627A Granted ES528627A0 (es) 1982-05-12 1984-01-02 Un procedimiento para la preparacion de pirazolo-y piridazo-pirazolinas,-piridazinas y-diazepinas.
ES528630A Expired ES8607970A1 (es) 1982-05-12 1984-01-02 Un procedimiento para la obtencion de derivados de hexahidro-3-oxo-piridinas.
ES528625A Granted ES528625A0 (es) 1982-05-12 1984-01-02 Un procedimiento para la preparacion de compuestos biciclicos
ES554935A Expired ES8800170A1 (es) 1982-05-12 1986-05-14 Un procedimiento para la preparacion de pirazolo- y piridazo-pirazolinas, -piridazinas y -diacepinas

Country Status (32)

Country Link
US (3) US4512924A (es)
EP (1) EP0094095B1 (es)
KR (1) KR890002106B1 (es)
AR (1) AR240940A1 (es)
AU (1) AU567873B2 (es)
BG (1) BG61123B2 (es)
CA (1) CA1234568A (es)
CS (2) CS249128B2 (es)
CU (1) CU21532A3 (es)
DE (2) DE3317290A1 (es)
DK (1) DK160612C (es)
DO (1) DOP1983004163A (es)
DZ (1) DZ540A1 (es)
ES (6) ES522291A0 (es)
FI (1) FI77244C (es)
FR (1) FR2531956B1 (es)
GB (1) GB2128984B (es)
GR (1) GR77462B (es)
HK (1) HK91692A (es)
HU (3) HU199842B (es)
IE (1) IE56480B1 (es)
IL (1) IL68620A (es)
IT (1) IT1212738B (es)
LU (2) LU84803A1 (es)
MC (1) MC1515A1 (es)
MY (1) MY102889A (es)
NL (2) NL8301640A (es)
NO (1) NO160368C (es)
PT (1) PT76681B (es)
SE (1) SE461792B (es)
SG (1) SG81192G (es)
ZW (1) ZW9883A1 (es)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
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US4801721A (en) * 1984-08-16 1989-01-31 Ryan James W Stereospecific synthesis of carboxyalkyl peptides
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US4826992A (en) * 1985-04-30 1989-05-02 Eli Lilly And Company 2,3-(Dihydro) bicyclic pyrazolidinones
US4940718A (en) * 1985-04-30 1990-07-10 Eli Lilly And Company 7-substituted bicyclic pyrazolidinones, pharmaceutical compositions and use
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GB2128984B (en) 1985-05-22
ZW9883A1 (en) 1984-11-21
IL68620A (en) 1987-11-30
IL68620A0 (en) 1983-09-30
SE8302716D0 (sv) 1983-05-11
SE8302716L (sv) 1983-11-13
DK160612B (da) 1991-04-02
IE831084L (en) 1983-11-12
BG61123B2 (bg) 1996-11-29
NO831675L (no) 1983-11-14
ES8601994A1 (es) 1985-11-16
NO160368C (no) 1989-04-12
DK194783D0 (da) 1983-05-02
DK160612C (da) 1991-09-23
FI77244C (fi) 1989-02-10
ES8505173A1 (es) 1985-05-16
HU195965B (en) 1988-08-29
HK91692A (en) 1992-11-27
EP0094095A3 (en) 1984-11-21
AR240940A1 (es) 1991-03-27
NL930055I1 (nl) 1993-09-01
PT76681A (en) 1983-06-01
ES522291A0 (es) 1984-08-16
KR840004754A (ko) 1984-10-24
MY102889A (en) 1993-03-31
FI77244B (fi) 1988-10-31
ES554935A0 (es) 1987-11-01
MC1515A1 (fr) 1984-02-10
GB8305505D0 (en) 1983-03-30
LU88299I2 (fr) 1994-09-09
CS402191A3 (en) 1992-10-14
FI831661A0 (fi) 1983-05-12
SE461792B (sv) 1990-03-26
ES528630A0 (es) 1986-06-16
CS249128B2 (en) 1987-03-12
IT1212738B (it) 1989-11-30
FR2531956B1 (fr) 1987-02-20
IT8321000A0 (it) 1983-05-09
DOP1983004163A (es) 1988-09-20
HU198935B (en) 1989-12-28
GR77462B (es) 1984-09-24
ES8607970A1 (es) 1986-06-16
AR240940A2 (es) 1991-03-27
US4658024A (en) 1987-04-14
DK194783A (da) 1983-11-13
FR2531956A1 (fr) 1984-02-24
AU567873B2 (en) 1987-12-10
CU21532A3 (en) 1987-06-09
SG81192G (en) 1993-01-29
CA1234568A (en) 1988-03-29
DE3317290A1 (de) 1983-11-17
EP0094095A2 (de) 1983-11-16
NO160368B (no) 1989-01-02
PT76681B (en) 1986-05-20
EP0094095B1 (de) 1990-09-19
ES528628A0 (es) 1987-07-16
ES528627A0 (es) 1985-11-16
IE56480B1 (en) 1991-08-14
ES8706672A1 (es) 1987-07-16
US4772701A (en) 1988-09-20
NL8301640A (nl) 1983-12-01
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ES528625A0 (es) 1985-05-16
HU199842B (en) 1990-03-28
DE3381884D1 (de) 1990-10-25
KR890002106B1 (ko) 1989-06-19
LU84803A1 (fr) 1985-03-21
US4512924A (en) 1985-04-23
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