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GT200800203A - Derivados de sulfonil-3-heterociclilindazol como ligandos de 58-hidroxitriptamina-6 - Google Patents

Derivados de sulfonil-3-heterociclilindazol como ligandos de 58-hidroxitriptamina-6

Info

Publication number
GT200800203A
GT200800203A GT200800203A GT200800203A GT200800203A GT 200800203 A GT200800203 A GT 200800203A GT 200800203 A GT200800203 A GT 200800203A GT 200800203 A GT200800203 A GT 200800203A GT 200800203 A GT200800203 A GT 200800203A
Authority
GT
Guatemala
Prior art keywords
hydroxitriptamine
heterociclilindazol
ligandos
sulfonil
derivatives
Prior art date
Application number
GT200800203A
Other languages
English (en)
Inventor
Kevin Liu
Albert Jean Robichaud
Jennifer Rebecca Lo
Hassan Mahmoud Elokdah
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200800203A publication Critical patent/GT200800203A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A COMPUESTOS DE LA FÓRMULA GENERAL I EN LA QUE R,R1,R2,R3,R4,R5,N, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS ACTÚAN COMO LIGANDOS DE LOS RECEPTORES DE 5-HIDROXITRIPTAMINA (5-HT) POR LO QUE SON DE UTILIDAD EN CUADROS DE ALZHEIMER Y PARA EL MEJORAMIENTO DE LA COGNICIÓN.
GT200800203A 2006-04-05 2008-10-02 Derivados de sulfonil-3-heterociclilindazol como ligandos de 58-hidroxitriptamina-6 GT200800203A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78953606P 2006-04-05 2006-04-05

Publications (1)

Publication Number Publication Date
GT200800203A true GT200800203A (es) 2008-12-04

Family

ID=38283536

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200800203A GT200800203A (es) 2006-04-05 2008-10-02 Derivados de sulfonil-3-heterociclilindazol como ligandos de 58-hidroxitriptamina-6

Country Status (17)

Country Link
US (2) US7482461B2 (es)
EP (1) EP2001865A1 (es)
JP (1) JP2009532471A (es)
KR (1) KR20090006148A (es)
CN (1) CN101432274A (es)
AU (1) AU2007235499A1 (es)
BR (1) BRPI0709718A2 (es)
CA (1) CA2648055A1 (es)
CR (1) CR10339A (es)
EC (1) ECSP088789A (es)
GT (1) GT200800203A (es)
IL (1) IL194365A0 (es)
MX (1) MX2008012824A (es)
NO (1) NO20084206L (es)
RU (1) RU2008139078A (es)
WO (1) WO2007117413A1 (es)
ZA (1) ZA200808462B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015026380A8 (pt) * 2013-04-17 2019-12-31 Sage Therapeutics Inc esteróides de c21-n-pirazolil 19-nor c3,3-dissubstituídos e métodos de uso destes
CN113121564A (zh) * 2019-12-31 2021-07-16 韩国科学技术研究院 具有抗肿瘤效果的咪唑并恶唑衍生物及包括其的药物组合物

Family Cites Families (27)

* Cited by examiner, † Cited by third party
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US3539573A (en) * 1967-03-22 1970-11-10 Jean Schmutz 11-basic substituted dibenzodiazepines and dibenzothiazepines
US4670447A (en) * 1983-08-22 1987-06-02 Hoechst-Roussel Pharmaceuticals Inc. Antipsychotic 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles
GB9523250D0 (en) * 1995-11-14 1996-01-17 Merck Sharp & Dohme Therapeutic agents
GB9523583D0 (en) * 1995-11-17 1996-01-17 Merck Sharp & Dohme Therapeutic agents
AR008245A1 (es) 1996-06-21 1999-12-29 Glaxo Group Ltd Derivados de acido acetico, uso de los mismos en la fabricacion de un agente terapeutico y proceso para preparar dichos derivados
BR9813926A (pt) * 1997-11-04 2000-09-19 Pfizer Prod Inc Substituição de bioisóstero de catecol por indazol em compostos terapeuticamente ativos
AU2005102A (en) * 2000-11-02 2002-05-15 Wyeth Corp 1-aryl- or 1-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands
US6890938B2 (en) * 2000-11-20 2005-05-10 Scios, Inc. Indole-type inhibitors of p38 kinase
WO2002051832A2 (en) * 2000-12-22 2002-07-04 Wyeth Heterocyclylalkylindole or -azaindole compounds as 5-hydroxytryptamine-6 ligands
JP4307073B2 (ja) * 2000-12-22 2009-08-05 ワイス ５−ヒドロキシトリプトアミン−６リガンドとしてのヘテロサイクルインダゾールおよびアザインダゾール化合物
TW593278B (en) * 2001-01-23 2004-06-21 Wyeth Corp 1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands
EA200301143A1 (ru) * 2001-04-20 2004-02-26 Уайт Производные гетероциклилалкокси-, алкилтио- и -алкиламинобензазола в качестве лигандов 5-гидрокситриптамина-6
BR0209056A (pt) * 2001-04-20 2004-08-10 Wyeth Corp Derivados de heterociclilóxi-, -tióxi- e -aminobenzazol como ligantes de 5-hidroxitriptamina-6
WO2002100833A1 (en) * 2001-06-12 2002-12-19 Sumitomo Pharmaceuticals Company, Limited Rho KINASE INHIBITORS
US20040242589A1 (en) 2001-08-07 2004-12-02 Bromidge Steven Mark 3-arylsulfonyl-7-piperzinyl-indoles-benzofurans and -benzothiophenes with 5-ht6 receptor affinity for treating cns disorders
US20050113283A1 (en) * 2002-01-18 2005-05-26 David Solow-Cordero Methods of treating conditions associated with an EDG-4 receptor
SI1497266T1 (sl) 2002-03-27 2008-10-31 Glaxo Group Ltd Derivati kinolina in njihova uporaba kot ligandi 5-ht6
ATE346068T1 (de) 2002-03-27 2006-12-15 Glaxo Group Ltd Chinolin- und aza-indolderivate und deren verwendung als 5-ht6 liganden
TW200400177A (en) * 2002-06-04 2004-01-01 Wyeth Corp 1-(Aminoalkyl)-3-sulfonylindole and-indazole derivatives as 5-hydroxytryptamine-6 ligands
US7943639B2 (en) * 2002-06-20 2011-05-17 Proximagen Limited Compounds
TW200401641A (en) * 2002-07-18 2004-02-01 Wyeth Corp 1-Heterocyclylalkyl-3-sulfonylindole or-indazole derivatives as 5-hydroxytryptamine-6 ligands
TW200403243A (en) * 2002-07-18 2004-03-01 Wyeth Corp 1-Heterocyclylalkyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands
WO2004069828A1 (ja) 2003-02-04 2004-08-19 Mitsubishi Pharma Corporation ピペリジン化合物およびその医薬用途
CN100482662C (zh) * 2003-02-14 2009-04-29 惠氏公司 作为5-羟基色胺-6配体的杂环基-3-磺酰基氮杂吲哚或-氮杂吲唑衍生物
KR20050101551A (ko) * 2003-02-14 2005-10-24 와이어쓰 5-하이드록시트립타민-6 리간드로서의헤테로사이클릴-3-설포닐인다졸
GB0422263D0 (en) * 2004-10-07 2004-11-10 Glaxo Group Ltd Novel compounds
EP1676841A1 (en) * 2004-12-30 2006-07-05 Esteve Laboratorios Dr. Esteve S.A. Substitited indazolyl sulfonamide and 2,3-dihydro-indolyl sulfonamide compounds, their prepartion and use in medicaments

Also Published As

Publication number Publication date
US7482461B2 (en) 2009-01-27
EP2001865A1 (en) 2008-12-17
RU2008139078A (ru) 2010-05-10
IL194365A0 (en) 2009-08-03
JP2009532471A (ja) 2009-09-10
AU2007235499A1 (en) 2007-10-18
NO20084206L (no) 2008-10-29
CA2648055A1 (en) 2007-10-18
US20070238724A1 (en) 2007-10-11
CR10339A (es) 2008-11-18
US20090105303A1 (en) 2009-04-23
MX2008012824A (es) 2008-10-15
ECSP088789A (es) 2008-11-27
KR20090006148A (ko) 2009-01-14
WO2007117413A1 (en) 2007-10-18
ZA200808462B (en) 2010-01-27
CN101432274A (zh) 2009-05-13
BRPI0709718A2 (pt) 2011-03-29

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