GT200600478A - Compuestos utiles en terapia - Google Patents
Compuestos utiles en terapiaInfo
- Publication number
- GT200600478A GT200600478A GT200600478A GT200600478A GT200600478A GT 200600478 A GT200600478 A GT 200600478A GT 200600478 A GT200600478 A GT 200600478A GT 200600478 A GT200600478 A GT 200600478A GT 200600478 A GT200600478 A GT 200600478A
- Authority
- GT
- Guatemala
- Prior art keywords
- rent
- chronic
- represent
- independently
- present
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 206010013935 Dysmenorrhoea Diseases 0.000 abstract 2
- 230000001684 chronic effect Effects 0.000 abstract 2
- 201000009273 Endometriosis Diseases 0.000 abstract 1
- 230000035620 dolor Effects 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LA PRESENTE INVENCIÓN SE REFIERE A LOS COMPUESTOS DE FÓRMULA (I), O UNO DE SUS DERIVADOS FARMACÉUTICAMENTE ACEPTABLES, EN DONDE R1 Y R3 REPRESENTAN, DE MODO INDEPENDIENTE, H, ALQUILO C1-6, CICLOALQUILO C3-8 O HALÓGENO; R2 REPRESENTA ALQUILO C1-6, CF3 O ARILO; A REPRESNTA 1 Ó 2; R4, R5, R7 Y R8 REPRESENTAN, DE MODO INDEPENDIENTE, H, ALQUILO C1-6, ALQUIL C1-6 OXI, CN O HALÓGENO, O R4 Y R5, O R7 Y R8, JUNTO CON EL ANILLO AL QUE ESTÁN UNIDOS, FORMAN UN ARILO O SISTEMA DE ANILLOS HETEROCÍCLICOS FUSIONADOS; M REPRESENTA C O N; Y REPRESENTA CH2 U O; R6 REPRESENTA H, CN O HALO, PERO CUANDO X REPRESENTA N, ENTONCES R6 NO ESTÁ PRESENTE; PUEDEN SER DE UTILIDAD PARA TRATAR ENDOMETRIOSIS, FIBROIDES UTERINOS (LEIOMIOMAS), MENORRAGIA, ADENOMIOSIS, DISMENORREA PRIMARIA Y SECUNDARIA (INCLUYENDO LOS SÍNTOMAS DE DISPAREUNIA, DISQUEXIA Y DOLOR PÉLVICO CRÓNICO), O SÍNDROME DE DOLOR PÉLVICO CRÓNICO. T2006
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73509105P | 2005-11-08 | 2005-11-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GT200600478A true GT200600478A (es) | 2007-06-08 |
Family
ID=37909834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GT200600478A GT200600478A (es) | 2005-11-08 | 2006-11-07 | Compuestos utiles en terapia |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US7309712B2 (es) |
| EP (1) | EP1948615B1 (es) |
| JP (1) | JP4234786B1 (es) |
| KR (1) | KR100997595B1 (es) |
| CN (1) | CN101304974A (es) |
| AP (1) | AP2008004463A0 (es) |
| AR (1) | AR056780A1 (es) |
| AT (1) | ATE537150T1 (es) |
| AU (1) | AU2006313478A1 (es) |
| BR (1) | BRPI0618630A2 (es) |
| CA (1) | CA2628844C (es) |
| CR (1) | CR9959A (es) |
| CY (1) | CY1112286T1 (es) |
| DK (1) | DK1948615T3 (es) |
| DO (1) | DOP2006000245A (es) |
| EA (1) | EA014693B1 (es) |
| EC (1) | ECSP088431A (es) |
| ES (1) | ES2376252T3 (es) |
| GT (1) | GT200600478A (es) |
| HN (1) | HN2006037713A (es) |
| IL (1) | IL190806A0 (es) |
| MA (1) | MA29940B1 (es) |
| NL (1) | NL2000299C2 (es) |
| NO (1) | NO20082504L (es) |
| PE (1) | PE20070642A1 (es) |
| PL (1) | PL1948615T3 (es) |
| PT (1) | PT1948615E (es) |
| RS (1) | RS20080191A (es) |
| SI (1) | SI1948615T1 (es) |
| TN (1) | TNSN08202A1 (es) |
| TW (1) | TWI321563B (es) |
| UA (1) | UA90763C2 (es) |
| UY (1) | UY29904A1 (es) |
| WO (1) | WO2007054770A2 (es) |
| ZA (1) | ZA200803670B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1094757C (zh) | 1996-07-24 | 2002-11-27 | 沃尼尔·朗伯公司 | 用于治疗疼痛的异丁基γ－氨基丁酸及其衍生物 |
| ATE537150T1 (de) * | 2005-11-08 | 2011-12-15 | Pfizer Ltd | Zur behandlung gynäkologischer erkrankungen geeignete pyrazolderivate |
| US7935715B2 (en) | 2006-07-28 | 2011-05-03 | Boehringer Ingelheim International Gmbh | Compounds which modulate the CB2 receptor |
| MX2009002888A (es) | 2006-09-25 | 2009-03-31 | Boehringer Ingelheim Int | Compuestos que modulan el receptor cb2. |
| WO2008135824A1 (en) * | 2007-05-02 | 2008-11-13 | Pfizer Limited | Oxyalkylpyrazole compounds useful in therapy |
| CA2704684A1 (en) | 2007-11-07 | 2009-05-14 | Boehringer Ingelheim International Gmbh | Compounds which modulate the cb2 receptor |
| EP2116618A1 (en) | 2008-05-09 | 2009-11-11 | Agency for Science, Technology And Research | Diagnosis and treatment of Kawasaki disease |
| JP2011520884A (ja) * | 2008-05-13 | 2011-07-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を変調するスルホン化合物 |
| CA2730037A1 (en) | 2008-07-10 | 2010-01-14 | Boehringer Ingelheim International Gmbh | Sulfone compounds which modulate the cb2 receptor |
| PE20110397A1 (es) | 2008-09-25 | 2011-07-01 | Boehringer Ingelheim Int | Compuestos que modulan selectivamente el receptor cb2 |
| US8299103B2 (en) | 2009-06-15 | 2012-10-30 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the CB2 receptor |
| JP5756800B2 (ja) | 2009-06-16 | 2015-07-29 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を調節するアゼチジン２−カルボキサミド誘導体 |
| EP2480544A1 (en) | 2009-09-22 | 2012-08-01 | Boehringer Ingelheim International GmbH | Compounds which selectively modulate the cb2 receptor |
| US20110136815A1 (en) * | 2009-12-08 | 2011-06-09 | Horst Zerbe | Solid oral film dosage forms and methods for making same |
| US10610528B2 (en) | 2009-12-08 | 2020-04-07 | Intelgenx Corp. | Solid oral film dosage forms and methods for making same |
| EP2523936A1 (en) | 2010-01-15 | 2012-11-21 | Boehringer Ingelheim International GmbH | Compounds which modulate the cb2 receptor |
| US8329735B2 (en) | 2010-03-05 | 2012-12-11 | Boehringer Ingelheim International Gmbh | Tetrazole compounds which selectively modulate the CB2 receptor |
| US20110263606A1 (en) * | 2010-04-26 | 2011-10-27 | Horst Zerbe | Solid oral dosage forms comprising tadalafil |
| WO2012012307A1 (en) | 2010-07-22 | 2012-01-26 | Boehringer Ingelheim International Gmbh | Sulfonyl compounds which modulate the cb2 rece |
| EP2803668A1 (en) | 2013-05-17 | 2014-11-19 | Boehringer Ingelheim International Gmbh | Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles |
| CN112839941B (zh) * | 2018-10-18 | 2022-06-07 | 南京圣和药业股份有限公司 | 作为TGF-βR1抑制剂的化合物及其应用 |
| RU2711615C1 (ru) * | 2019-09-12 | 2020-01-17 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт акушерства, гинекологии и репродуктологии имени Д.О. Отта" | Способ лечения эндометриоза на основании экспериментальной модели у крыс |
| CN111269097B (zh) * | 2020-04-02 | 2023-02-17 | 苏州爱玛特生物科技有限公司 | 一种多元环双取代的1,3-丙二酮类化合物的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6281638A (ja) * | 1985-10-07 | 1987-04-15 | Fuji Photo Film Co Ltd | ハロゲン化銀カラ−写真感光材料 |
| JPS63313784A (ja) * | 1987-03-12 | 1988-12-21 | Zeria Shinyaku Kogyo Kk | 新規ピラゾール誘導体およびその製造法ならびにこれを有効成分とする抗潰瘍剤 |
| DE4414792A1 (de) * | 1993-08-11 | 1995-02-16 | Bayer Ag | Arzneimittel enthaltend 1-Thiocarbamoyl-5-hydroxypyrazolen und deren Verwendung als Mittel zur Bekämpfung des septischen Schocks |
| BRPI0208811B8 (pt) | 2001-04-10 | 2021-05-25 | Pfizer | derivados de pirazol, seu uso e processo de preparação, bem como composição farmacêutica compreendendo os mesmos |
| GB0229618D0 (en) * | 2002-12-19 | 2003-01-22 | Cancer Rec Tech Ltd | Pyrazole compounds |
| ATE537150T1 (de) * | 2005-11-08 | 2011-12-15 | Pfizer Ltd | Zur behandlung gynäkologischer erkrankungen geeignete pyrazolderivate |
-
2006
- 2006-10-26 AT AT06809167T patent/ATE537150T1/de active
- 2006-10-26 ES ES06809167T patent/ES2376252T3/es active Active
- 2006-10-26 AP AP2008004463A patent/AP2008004463A0/xx unknown
- 2006-10-26 JP JP2008539519A patent/JP4234786B1/ja not_active Expired - Fee Related
- 2006-10-26 PT PT06809167T patent/PT1948615E/pt unknown
- 2006-10-26 WO PCT/IB2006/003080 patent/WO2007054770A2/en not_active Ceased
- 2006-10-26 RS RSP-2008/0191A patent/RS20080191A/sr unknown
- 2006-10-26 CA CA2628844A patent/CA2628844C/en not_active Expired - Fee Related
- 2006-10-26 UA UAA200805973A patent/UA90763C2/ru unknown
- 2006-10-26 DK DK06809167.7T patent/DK1948615T3/da active
- 2006-10-26 CN CNA2006800416684A patent/CN101304974A/zh active Pending
- 2006-10-26 EP EP06809167A patent/EP1948615B1/en active Active
- 2006-10-26 AU AU2006313478A patent/AU2006313478A1/en not_active Abandoned
- 2006-10-26 KR KR1020087010982A patent/KR100997595B1/ko not_active Expired - Fee Related
- 2006-10-26 EA EA200801053A patent/EA014693B1/ru not_active IP Right Cessation
- 2006-10-26 PL PL06809167T patent/PL1948615T3/pl unknown
- 2006-10-26 BR BRPI0618630-0A patent/BRPI0618630A2/pt not_active IP Right Cessation
- 2006-10-26 SI SI200631237T patent/SI1948615T1/sl unknown
- 2006-11-02 NL NL2000299A patent/NL2000299C2/nl not_active IP Right Cessation
- 2006-11-03 US US11/592,574 patent/US7309712B2/en not_active Expired - Fee Related
- 2006-11-06 PE PE2006001366A patent/PE20070642A1/es not_active Application Discontinuation
- 2006-11-07 GT GT200600478A patent/GT200600478A/es unknown
- 2006-11-07 TW TW095141158A patent/TWI321563B/zh active
- 2006-11-07 HN HN2006037713A patent/HN2006037713A/es unknown
- 2006-11-07 AR ARP060104881A patent/AR056780A1/es unknown
- 2006-11-08 UY UY29904A patent/UY29904A1/es not_active Application Discontinuation
- 2006-11-08 DO DO2006000245A patent/DOP2006000245A/es unknown
-
2007
- 2007-10-11 US US11/870,451 patent/US7425569B2/en not_active Expired - Fee Related
-
2008
- 2008-04-10 IL IL190806A patent/IL190806A0/en unknown
- 2008-04-25 ZA ZA200803670A patent/ZA200803670B/xx unknown
- 2008-05-06 EC EC2008008431A patent/ECSP088431A/es unknown
- 2008-05-07 TN TNP2008000202A patent/TNSN08202A1/fr unknown
- 2008-05-08 CR CR9959A patent/CR9959A/es not_active Application Discontinuation
- 2008-05-08 MA MA30910A patent/MA29940B1/fr unknown
- 2008-06-05 NO NO20082504A patent/NO20082504L/no not_active Application Discontinuation
-
2012
- 2012-01-27 CY CY20121100096T patent/CY1112286T1/el unknown
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