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GT200600116A - Derivados de aril 1,4-pirazina sustituidos - Google Patents

Derivados de aril 1,4-pirazina sustituidos

Info

Publication number
GT200600116A
GT200600116A GT200600116A GT200600116A GT200600116A GT 200600116 A GT200600116 A GT 200600116A GT 200600116 A GT200600116 A GT 200600116A GT 200600116 A GT200600116 A GT 200600116A GT 200600116 A GT200600116 A GT 200600116A
Authority
GT
Guatemala
Prior art keywords
pirazina
aril
derivatives
substituted
compounds
Prior art date
Application number
GT200600116A
Other languages
English (en)
Inventor
Patrick Robert Verhoest
Robert Louis Hoffman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200600116A publication Critical patent/GT200600116A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P25/36—Opioid-abuse
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A COMPUESTOS DE LA FÓRMULA GENERAL I EN LA QUE R1,R2,R3,R4,R22, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR CFR POR LO QUE SON DE UTILIDAD EN TRASTORNOS DE ANSIEDAD, DEPRESIÓN Y ESTRÉS.
GT200600116A 2005-03-17 2006-03-16 Derivados de aril 1,4-pirazina sustituidos GT200600116A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66291705P 2005-03-17 2005-03-17

Publications (1)

Publication Number Publication Date
GT200600116A true GT200600116A (es) 2006-11-09

Family

ID=36617394

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200600116A GT200600116A (es) 2005-03-17 2006-03-16 Derivados de aril 1,4-pirazina sustituidos

Country Status (26)

Country Link
US (1) US20060211710A1 (es)
EP (1) EP1871763A1 (es)
JP (1) JP2008533124A (es)
KR (1) KR20070113294A (es)
CN (1) CN101160304A (es)
AP (1) AP2007004174A0 (es)
AR (1) AR056279A1 (es)
AU (1) AU2006238976A1 (es)
BR (1) BRPI0606284A2 (es)
CA (1) CA2601600C (es)
CR (1) CR9436A (es)
DO (1) DOP2006000056A (es)
EA (1) EA012874B1 (es)
GT (1) GT200600116A (es)
IL (1) IL185997A0 (es)
MA (1) MA29336B1 (es)
MX (1) MX2007011423A (es)
NL (1) NL1031384C2 (es)
NO (1) NO20075209L (es)
PE (1) PE20061108A1 (es)
TN (1) TNSN07355A1 (es)
TW (1) TWI315670B (es)
UA (1) UA86873C2 (es)
UY (1) UY29418A1 (es)
WO (1) WO2006114666A1 (es)
ZA (1) ZA200707933B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0525068D0 (en) 2005-12-08 2006-01-18 Novartis Ag Organic compounds
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
US8183371B2 (en) * 2009-10-30 2012-05-22 Janssen Pharmaceutica Nv Pyrazines as delta opioid receptor modulators
WO2011092293A2 (en) 2010-02-01 2011-08-04 Novartis Ag Cyclohexyl amide derivatives as crf receptor antagonists
EP2531510B1 (en) 2010-02-01 2014-07-23 Novartis AG Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists
US8835444B2 (en) 2010-02-02 2014-09-16 Novartis Ag Cyclohexyl amide derivatives as CRF receptor antagonists
JP2022062287A (ja) * 2019-02-27 2022-04-20 住友化学株式会社 ピリジルピラジン化合物の製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5872136A (en) * 1996-04-03 1999-02-16 Merck & Co., Inc. Arylheteroaryl inhibitors of farnesyl-protein transferase
US5883105A (en) * 1996-04-03 1999-03-16 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5880140A (en) * 1996-04-03 1999-03-09 Merck & Co., Inc. Biheteroaryl inhibitors of farnesyl-protein transferase
PA8467401A1 (es) * 1998-02-17 2000-09-29 Pfizer Prod Inc Procedimiento para tratar la insuficiencia cardiaca
AU770600B2 (en) * 1999-10-07 2004-02-26 Amgen, Inc. Triazine kinase inhibitors
IL139197A0 (en) * 1999-10-29 2001-11-25 Pfizer Prod Inc Use of corticotropin releasing factor antagonists and related compositions
AU783915B2 (en) * 2000-02-16 2005-12-22 Neurogen Corporation Substituted arylpyrazines
AU2002343557A1 (en) * 2001-11-21 2003-06-10 Pharmacia And Upjohn Company Substituted aryl 1,4-pyrazine derivatives
US6992087B2 (en) * 2001-11-21 2006-01-31 Pfizer Inc Substituted aryl 1,4-pyrazine derivatives
WO2003091225A1 (en) * 2002-04-26 2003-11-06 Pharmacia & Upjohn Company Substituted pyrazine derivatives
WO2004024719A1 (en) * 2002-09-12 2004-03-25 Pharmacia & Upjohn Company Llc Substituted 1,4-pyrazine derivatives

Also Published As

Publication number Publication date
WO2006114666A8 (en) 2008-04-03
UY29418A1 (es) 2006-10-31
CA2601600C (en) 2010-09-14
PE20061108A1 (es) 2006-10-13
AP2007004174A0 (en) 2007-10-31
MA29336B1 (fr) 2008-03-03
CR9436A (es) 2007-11-23
EA200701758A1 (ru) 2008-02-28
NL1031384C2 (nl) 2007-01-23
UA86873C2 (en) 2009-05-25
AR056279A1 (es) 2007-10-03
BRPI0606284A2 (pt) 2009-06-09
ZA200707933B (en) 2009-08-26
AU2006238976A1 (en) 2006-11-02
IL185997A0 (en) 2008-01-20
NL1031384A1 (nl) 2006-09-20
KR20070113294A (ko) 2007-11-28
TWI315670B (en) 2009-10-11
TNSN07355A1 (fr) 2008-12-31
CN101160304A (zh) 2008-04-09
WO2006114666A1 (en) 2006-11-02
US20060211710A1 (en) 2006-09-21
TW200700067A (en) 2007-01-01
NO20075209L (no) 2007-10-11
DOP2006000056A (es) 2006-08-30
MX2007011423A (es) 2007-10-12
JP2008533124A (ja) 2008-08-21
EA012874B1 (ru) 2009-12-30
CA2601600A1 (en) 2006-11-02
EP1871763A1 (en) 2008-01-02

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