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GT200000011A - USE OF SUBSTITUTED AND DERIVATIVE ISOXAZOLCARBOXILIC ACIDS AND NEW MATERIALS. - Google Patents

USE OF SUBSTITUTED AND DERIVATIVE ISOXAZOLCARBOXILIC ACIDS AND NEW MATERIALS.

Info

Publication number
GT200000011A
GT200000011A GT200000011A GT200000011A GT200000011A GT 200000011 A GT200000011 A GT 200000011A GT 200000011 A GT200000011 A GT 200000011A GT 200000011 A GT200000011 A GT 200000011A GT 200000011 A GT200000011 A GT 200000011A
Authority
GT
Guatemala
Prior art keywords
acids
salts
derivatives
isoxazolcarboxilic
derivative
Prior art date
Application number
GT200000011A
Other languages
Spanish (es)
Inventor
Jurgen Stoltefuss
Gabriele Braunlich
Berthold Hinzen
Thomas Studemann
Thomas Kramer
Michael Sperzel
Ulrich Nielsch
Martin Bechem
Josef Pernerstorfer
Emanuel Lohrmann
Christoph Gerdes
Klemens Lustig
Lorenz Mayr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200000011A publication Critical patent/GT200000011A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

LA INVENCION SE REFIERE AL USO DE ESTOS COMPUESTOS Y DERIVADOS PARA LA OBTENCION DE MEDICAMENTOS PARA LA PROFILAXIS Y/O TRATAMIENTO DE ANEMIAS, NUEVOS ACIDOS ISOXAZOLCARBOXILICOS Y DERIVADOS DE FORMULA GENERAL (I), [EN LA QUE "A,D, E, Y G " REPRESENTAN HIDROGENO, HALOGENO, TRIFLUOROMETILO, HIDROXILO O ALQUILOALCOXI (C1C6) Y "R# " DIFERENTES POSIBILIDADES DE GRUPOS FUNCIONALES QUE PUEDEN FORMAR PARTE DE LA MOLECULA, EL LISTADO DE SUS NOMBRES ESPECIFICOS SE HALLA EN EL DOCUMENTO ORIGINAL], ASI COMO A PROCEDIMIENTOS PARA SU OBTENCION. SEGUN LA INVENCION, LAS SALES FISIOLOGICAMENTE ACEPTABLES DE LOS COMPUESTOS PUEDEN SER SALES DE SUSTANCIAS, SEGUN LA INVENCION, CON ACIDOS MINERALES, ACIDOS CARBOXILICOS O ACIDOS SULFONICOS. COMO SALES, PUEDEN INDICARSE SALES DE BASES CONVENCIONALES, COMO POR EJEMPLO SALES DE METALES ALCALINOS O SALES DE AMONIO, DERIVADOS DE AMONIACO O AMINAS ORGANICAS.THE INVENTION REFERS TO THE USE OF THESE COMPOUNDS AND DERIVATIVES FOR THE OBTAINING OF MEDICINES FOR THE PROFILAXIS AND / OR TREATMENT OF ANEMIAS, NEW ISOXAZOLCARBOXILIC ACIDS AND DERIVATIVES OF GENERAL FORMULA (I), [IN WHICH "A, D, E, YG "THEY REPRESENT HYDROGEN, HALOGEN, TRIFLUOROMETILO, HYDROXYL OR ALQUILOALCOXI (C1C6) AND" R # "DIFFERENT POSSIBILITIES OF FUNCTIONAL GROUPS THAT CAN BE PART OF THE MOLECULA, THE LISTING OF ITS NUMBER IS SPECIFIED ORIGINAL PROCEDURE FOR YOUR OBTAINING. ACCORDING TO THE INVENTION, THE PHYSIOLOGICALLY ACCEPTABLE SALTS OF THE COMPOUNDS MAY BE SUBSTANCE SALTS, ACCORDING TO THE INVENTION, WITH MINERAL ACIDS, CARBOXYLIC ACIDS OR SULPHONIC ACIDS. AS SALTS, CONVENTIONAL BASED SALTS MAY BE INDICATED, AS FOR EXAMPLE OF ALKALINE METALS OR AMMONIAL SALTS, DERIVATIVES OF AMMONIA OR ORGANIC AMINES.

GT200000011A 1999-02-04 2000-02-03 USE OF SUBSTITUTED AND DERIVATIVE ISOXAZOLCARBOXILIC ACIDS AND NEW MATERIALS. GT200000011A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19904389A DE19904389A1 (en) 1999-02-04 1999-02-04 Use of substituted isoxazolecarboxylic acids and derivatives and new substances

Publications (1)

Publication Number Publication Date
GT200000011A true GT200000011A (en) 2001-07-27

Family

ID=7896332

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200000011A GT200000011A (en) 1999-02-04 2000-02-03 USE OF SUBSTITUTED AND DERIVATIVE ISOXAZOLCARBOXILIC ACIDS AND NEW MATERIALS.

Country Status (5)

Country Link
AR (1) AR022469A1 (en)
AU (1) AU2110000A (en)
DE (1) DE19904389A1 (en)
GT (1) GT200000011A (en)
WO (1) WO2000045799A2 (en)

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WO1998037068A1 (en) 1997-02-21 1998-08-27 Bristol-Myers Squibb Company Benzoic acid derivatives and related compounds as antiarrhythmic agents
MY151199A (en) 2001-11-02 2014-04-30 Rigel Pharmaceuticals Inc Substituted diphenyl heterocycles useful for treating hcv infection
JP2006501312A (en) 2002-08-23 2006-01-12 ライジェル ファーマシューティカルズ， インコーポレイテッド Pyridyl-substituted heterocycles useful for treating or preventing HCV infection
US7115642B2 (en) 2003-05-02 2006-10-03 Rigel Pharmaceuticals, Inc. Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating HCV infection
US7326790B2 (en) 2003-05-02 2008-02-05 Rigel Pharmaceuticals, Inc. Diphenylisoxazole compounds and hydro isomers thereof
US7220745B2 (en) 2003-05-15 2007-05-22 Rigel Pharmaceuticals Heterocyclic compounds useful to treat HCV
US8580842B2 (en) 2003-09-30 2013-11-12 Abbott Gmbh & Co. Kg Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US7410979B2 (en) 2003-11-19 2008-08-12 Rigel Pharmaceuticals, Inc. Synergistically effective combinations of dihaloacetamide compounds and interferon or ribavirin against HCV infections
US7514434B2 (en) 2004-02-23 2009-04-07 Rigel Pharmaceuticals, Inc. Heterocyclic compounds having an oxadiazole moiety and hydro isomers thereof
WO2006044456A1 (en) 2004-10-13 2006-04-27 Ptc Therapeutics, Inc. Compounds for nonsense suppression, and methods for their use
CN101203498A (en) 2005-05-02 2008-06-18 里格尔药品股份有限公司 Heterocyclic antiviral compounds including metabolizable moieties and uses thereof
EP1893591A1 (en) * 2005-06-08 2008-03-05 Novartis AG POLYCYCLIC OXADIAZOLES OR I SOXAZOLES AND THEIR USE AS SlP RECEPTOR LIGANDS
GB0601744D0 (en) * 2006-01-27 2006-03-08 Novartis Ag Organic compounds
AR062683A1 (en) 2006-09-07 2008-11-26 Actelion Pharmaceuticals Ltd COMPOUNDS DERIVED FROM PIRIDIN-4-ILO, PHARMACEUTICAL COMPOSITION CONTAINING THEM, AND USE OF THE SAME IN THE PREPARATION OF MEDICINES
DK2069335T3 (en) * 2006-09-08 2013-02-18 Actelion Pharmaceuticals Ltd PYRIDIN-3-YLD DERIVATIVES AS IMMUNO MODULATORS
US20080167286A1 (en) 2006-12-12 2008-07-10 Abbott Laboratories Pharmaceutical compositions and their methods of use
US8486979B2 (en) 2006-12-12 2013-07-16 Abbvie Inc. 1,2,4 oxadiazole compounds and methods of use thereof
UY30846A1 (en) 2006-12-30 2008-07-31 Abbott Gmbh & Amp OXINDOL DERIVATIVES REPLACED, MEDICINES THAT UNDERSTAND AND USE THEMSELVES
EP2125797B1 (en) 2007-03-16 2014-01-15 Actelion Pharmaceuticals Ltd. Amino- pyridine derivatives as s1p1 /edg1 receptor agonists
WO2009029632A1 (en) 2007-08-27 2009-03-05 Helicon Therapeutics, Inc. Therapeutic isoxazole compounds
MX2010006202A (en) 2007-12-07 2011-03-04 Abbott Gmbh & Co Kg Amidomethyl-substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses.
WO2010009775A1 (en) 2007-12-07 2010-01-28 Abbott Gmbh & Co. Kg Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases
CA2707669C (en) 2007-12-07 2016-07-05 Wilfried Braje 5-halogen-substituted oxindole derivatives and use thereof for treating vasopressine-dependent diseases
WO2009071690A2 (en) 2007-12-07 2009-06-11 Abbott Gmbh & Co. Kg 5,6-disubstituted oxindole-derivatives and use thereof for treating vasopressine-dependent diseases
WO2010138600A2 (en) 2009-05-29 2010-12-02 Abbott Laboratories Pharmaceutical compositions for the treatment of pain
WO2011005660A1 (en) 2009-07-08 2011-01-13 Valocor Therapeutics, Inc. Tofa analogs useful in treating dermatological disorders or conditions
SG178042A1 (en) 2009-07-16 2012-03-29 Actelion Pharmaceuticals Ltd Pyridin-4-yl derivatives
SI2665720T1 (en) 2011-01-19 2015-08-31 Actelion Pharmaceuticals Ltd. 2-methoxy-pyridin-4-yl derivatives
CN102329277B (en) * 2011-10-24 2013-08-07 海南霞迪药业有限公司 Method for preparing Parecoxib
US10385043B2 (en) 2015-05-20 2019-08-20 Idorsia Pharmaceuticals Ltd Crystalline form of the compound (S)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol
CN116535399B (en) * 2022-01-25 2024-02-27 中国药科大学 3-hydroxy-5- (isoxazol-5-yl) pyridine formyl glycine compound, preparation method, pharmaceutical composition and application
WO2024029638A1 (en) * 2022-08-01 2024-02-08 한국과학기술연구원 Novel heterocyclyl-phenyl-methylamine derivative, preparation method therefor, and use thereof for prevention, alleviation, or treatment of multiple sclerosis

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GB149877A (en) * 1919-11-22 1920-08-26 Arthur William Wells Improvements in and in connection with safety razors
ES488768A0 (en) * 1979-02-22 1981-02-16 Monsanto Co A PROCEDURE FOR PREPARING ACID 2- (3-ARIL-5-ISOXAZOLIL) -BENZOIC
US5330994A (en) * 1992-03-24 1994-07-19 Warner-Lambert Company Tetrahydropyridine isoxazoline derivatives
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WO1997019039A1 (en) * 1995-11-17 1997-05-29 Novartis Ag Solid phase synthesis of heterocyclic compounds and combinatorial compound library
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EP0994101A4 (en) * 1997-06-18 2002-05-02 Fujisawa Pharmaceutical Co New production process

Also Published As

Publication number Publication date
WO2000045799A3 (en) 2002-01-24
WO2000045799A2 (en) 2000-08-10
AU2110000A (en) 2000-08-25
AR022469A1 (en) 2002-09-04
DE19904389A1 (en) 2000-08-10

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