[go: up one dir, main page]

GT199800179A - Procedimiento de sintesis de pirrol amidas. - Google Patents

Procedimiento de sintesis de pirrol amidas.

Info

Publication number
GT199800179A
GT199800179A GT199800179A GT199800179A GT199800179A GT 199800179 A GT199800179 A GT 199800179A GT 199800179 A GT199800179 A GT 199800179A GT 199800179 A GT199800179 A GT 199800179A GT 199800179 A GT199800179 A GT 199800179A
Authority
GT
Guatemala
Prior art keywords
compounds
pirrol
amidas
synthesis
synthesis procedure
Prior art date
Application number
GT199800179A
Other languages
English (en)
Inventor
John Antony Ragan
Teresa Woodall Makowski
David John Am Ende
Pamela Jane Clifford
Gregory Randall Young
Alyson Kay Conrad
Shane Allen Eisenbeis
Douglas John Meldrum Allen
George Joseph Quallich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT199800179A publication Critical patent/GT199800179A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

ESTA INVENCION SE REFIERE A UN PROCEDIMIENTO PARA LA SINTESIS DE NUEVAS PIRROLCARBOXAMIDAS CONDENSADAS QUE SE UNEN SELECTIVAMENTE A RECEPTORES GABAA. ESTA INVENCION TAMBIEN SE REFIERE A INTERMEDIOS QUIMICOS PARA LA SINTESIS DE TALES COMPUESTOS. LOS COMPUESTOS QUE SE UNEN A LOS RECEPTORES GABAA SON UTILES EN EL TRATAMIENTO DE LA ANSIEDAD, DE TRASTORNOS DEL SUEÑO Y CRISIS CONVULSIVAS Y DE SOBREDOSIS DE FARMACOS DE TIPO BENZODIACEPINA, Y PARA AUMENTAR EL ESTADO DE VIGILANCIA. ESTOS COMPUESTOS TIENEN LA ESTRUCTURA I, EN LA QUE R1, R2 Y AR, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE.
GT199800179A 1997-11-13 1998-11-09 Procedimiento de sintesis de pirrol amidas. GT199800179A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6542297P 1997-11-13 1997-11-13

Publications (1)

Publication Number Publication Date
GT199800179A true GT199800179A (es) 2000-05-02

Family

ID=22062607

Family Applications (1)

Application Number Title Priority Date Filing Date
GT199800179A GT199800179A (es) 1997-11-13 1998-11-09 Procedimiento de sintesis de pirrol amidas.

Country Status (3)

Country Link
AP (1) AP948A (es)
GT (1) GT199800179A (es)
ZA (1) ZA9810350B (es)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5484944A (en) * 1993-10-27 1996-01-16 Neurogen Corporation Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands
US5804686A (en) * 1996-01-19 1998-09-08 Neurogen Corporation fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
AU2218997A (en) * 1996-03-22 1997-10-10 Neurogen Corporation Certain fused pyrrolecarboxamides as gaba brain receptor ligands

Also Published As

Publication number Publication date
ZA9810350B (en) 2000-05-12
AP9801391A0 (en) 1998-12-31
AP948A (en) 2001-03-15

Similar Documents

Publication Publication Date Title
GT199800200A (es) Compuestos azapoliciclicos condensados con arilo.
ES2164657T3 (es) Derivados aza-biciclicos puenteados como antagonistas de la sustancia p.
CU23535A3 (es) Compuestos de purina y usos de los mismos
GT200100041A (es) Acidos malonamicos y derivados de los mismos como ligandos de receptor tiroideo.
UY27259A1 (es) Derivados de dihidro-benzo b 1, 4- diazepin-2ona como antagonistas i de mglur2
UY28473A1 (es) Nuevos compuestos
UY27258A1 (es) Derivados de dihidro-benzo b 1, 4 diazepin-2-ona como antagonistas ii mglur2
PA8609701A1 (es) [1,8]naftiridin-2-onas y compuestos relacionados para el tratamiento de la esquizofrenia
ECSP077170A (es) Moduladores de receptores acetilcolina nicotinicos alfa 7 y sus usos terapeuticos
UY28482A1 (es) Nuevos compuestos
GT199800021A (es) Utilizacion de antagonistas de los receptores de canabinoides centrales para la preparacion de medicamentos.
CR9560A (es) Antagonistas y agonistas de piperazin-piperidina del receptor 5-ht1a
CO6351782A2 (es) COMPUESTOS NOVEDOSOS CON ACTIVIDAD ANTAGONISTA DEL RECEPTOR á 7 NICOTINICO DE ACETILCOLINA
PE20020970A1 (es) Derivados de imidazo-pirimidina como ligandos para los receptores de gaba
EA200100780A1 (ru) Антагонисты tweak и рецептора tweak и их использование для лечения иммунологических заболеваний
GT199900146A (es) Derivados de 4,4-biarilpiperidina.
GT200400081A (es) Ligandos de receptor cannabinoide y usos de los mismos.
BR9901279A (pt) Triciclicos substituìdos
EA200200766A1 (ru) Замещенные арилпиразины
ECSP034810A (es) Derivados heterociclilalcoxi-, -alquiltio- y - alquilaminobenzazol tales como ligandos 5-hidroxitriptamina-6
BR9701248A (pt) Novos pró-medicamentos para a terapia de tumores e distúrbios inflamatórios
AR030554A1 (es) Moleculas similares a receptores il-17 y usos de las mismas
GT199800068A (es) Procedimiento para la preparacion de nuevos derivados de triazole y los medicamentos que los contienen.
GT199800179A (es) Procedimiento de sintesis de pirrol amidas.
PA8514601A1 (es) Tratamiento de trastornos renales