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BR9701248A - Novos pró-medicamentos para a terapia de tumores e distúrbios inflamatórios - Google Patents

Novos pró-medicamentos para a terapia de tumores e distúrbios inflamatórios

Info

Publication number
BR9701248A
BR9701248A BR9701248-3A BR9701248A BR9701248A BR 9701248 A BR9701248 A BR 9701248A BR 9701248 A BR9701248 A BR 9701248A BR 9701248 A BR9701248 A BR 9701248A
Authority
BR
Brazil
Prior art keywords
therapy
inflammatory disorders
tumors
new
new prodrugs
Prior art date
Application number
BR9701248-3A
Other languages
English (en)
Other versions
BRPI9701248B1 (pt
BR9701248A8 (pt
Inventor
Klaus Bosslet
Joerg Czech
Manfred Gerken
Rainer Straub
Jean-Claude Florent
Felix Schmidt
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8222555&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9701248(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of BR9701248A publication Critical patent/BR9701248A/pt
Publication of BR9701248A8 publication Critical patent/BR9701248A8/pt
Publication of BRPI9701248B1 publication Critical patent/BRPI9701248B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

Patente de Invenção:<B>"NOVOS PRó-MEDICAMENTOS PARA A TERAPIA DE TUMORES E DISTúRBIOS INFLAMATóRIOS"<D>. Novos pró-medicamentos para a terapia de tumores e distúrbios inflamatórios. São descritos compostos da fórmula I: glocosil-Y[-C(=Y)X-]~ p~-W(R)~ n~-Z-C(=Y)-composto ativo que são adequados para o tratamento de doenças carcinomatosas, doenças auto-imunes e doenças inflamatórias crónicas, tais como a artrite reumatóide.
BRPI9701248A 1996-03-12 1997-03-11 Compostos para a terapia de tumores e distúrbios inflamatórios, produto farmacêutico e formulação farmacêutica dos mesmos BRPI9701248B1 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96103866 1996-03-12

Publications (3)

Publication Number Publication Date
BR9701248A true BR9701248A (pt) 1999-10-13
BR9701248A8 BR9701248A8 (pt) 2013-06-18
BRPI9701248B1 BRPI9701248B1 (pt) 2022-01-18

Family

ID=8222555

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9701248A BRPI9701248B1 (pt) 1996-03-12 1997-03-11 Compostos para a terapia de tumores e distúrbios inflamatórios, produto farmacêutico e formulação farmacêutica dos mesmos

Country Status (24)

Country Link
US (1) US5935995A (pt)
EP (1) EP0795334B1 (pt)
JP (1) JP4392065B2 (pt)
KR (1) KR100466467B1 (pt)
CN (1) CN1168733C (pt)
AT (1) ATE316799T1 (pt)
AU (1) AU708202B2 (pt)
BG (1) BG61900B1 (pt)
BR (1) BRPI9701248B1 (pt)
CA (1) CA2199664C (pt)
CZ (1) CZ297994B6 (pt)
DE (1) DE59712561D1 (pt)
DK (1) DK0795334T3 (pt)
ES (1) ES2257756T3 (pt)
HU (1) HU228764B1 (pt)
NO (1) NO320322B1 (pt)
NZ (1) NZ314368A (pt)
PL (1) PL189604B1 (pt)
RO (1) RO120951B1 (pt)
RU (1) RU2191021C2 (pt)
SG (1) SG50011A1 (pt)
SI (1) SI0795334T1 (pt)
TR (1) TR199700178A2 (pt)
UA (1) UA50719C2 (pt)

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DE19720312A1 (de) * 1997-05-15 1998-11-19 Hoechst Ag Zubereitung mit erhöhter in vivo Verträglichkeit
US6395299B1 (en) 1999-02-12 2002-05-28 Biostream, Inc. Matrices for drug delivery and methods for making and using the same
US6716452B1 (en) * 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
IL146284A0 (en) 1999-05-04 2002-07-25 Strakan Ltd Androgen glycosides and pharmaceutical compositions containing the same
US6191119B1 (en) * 1999-10-15 2001-02-20 Supergen, Inc. Combination therapy including 9-nitro-20(S)-camptothecin
US8394813B2 (en) 2000-11-14 2013-03-12 Shire Llc Active agent delivery systems and methods for protecting and administering active agents
DE10058596A1 (de) * 2000-11-25 2002-06-06 Aventis Pharma Gmbh Verfahren zum Screening von chemischen Verbindungen zur Modulierung der Wechselwirkung einer EVH1-Domäne oder eines Proteins mit einer EVH1-Domäne mit einer EVH1-Bindedomäne oder einem Protein mit einer EVH1-Bindedomäne sowie ein Verfahren zum Nachweis besagter Wechselwirkung
US20060014697A1 (en) 2001-08-22 2006-01-19 Travis Mickle Pharmaceutical compositions for prevention of overdose or abuse
US7169752B2 (en) 2003-09-30 2007-01-30 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
EP1429771B1 (en) * 2001-08-30 2009-08-12 ChemoCentryx Inc Bicyclic compounds as inhibitors of chemokine binding to us28
US20050203061A1 (en) * 2002-06-20 2005-09-15 Shinya Yamashita Prodrug, medicinal utilization thereof and process for producing the same
US8133881B2 (en) 2003-01-13 2012-03-13 Shire Llc Carbohydrate conjugates to prevent abuse of controlled substances
US7160867B2 (en) 2003-05-16 2007-01-09 Isotechnika, Inc. Rapamycin carbohydrate derivatives
JP2007530664A (ja) * 2004-03-30 2007-11-01 ペインセプター ファーマ コーポレーション ゲートイオンチャンネルを調節するための組成物及び方法
US7825096B2 (en) * 2004-09-08 2010-11-02 The United States Of America As Represented By The Department Of Health And Human Services O6-alkylguanine-DNA alkyltransferase inactivators and beta-glucuronidase cleavable prodrugs
CA2613312C (en) * 2005-06-29 2014-10-14 Threshold Pharmaceuticals, Inc. Phosphoramidate alkylator prodrugs
KR101505415B1 (ko) * 2007-04-06 2015-03-25 지오팜 온콜로지 인코포레이티드 이소포스포르아미드 머스타드의 염 및 이의 동족체
GB0907551D0 (en) * 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
MX336332B (es) * 2009-09-02 2016-01-15 Auckland Uniservices Ltd Inhibidores de cinasa, formas de profarmaco de los mismos y su uso en terapia.
KR101253399B1 (ko) 2010-10-26 2013-04-11 영남대학교 산학협력단 아포지단백질 ａ－ｉ 및 그 변이체를 포함한 재조합 고밀도지단백질을 이용한 라파마이신 제형
KR101628872B1 (ko) 2014-05-28 2016-06-09 주식회사 레고켐 바이오사이언스 자가-희생 기를 포함하는 화합물
CN107847606A (zh) 2015-11-25 2018-03-27 乐高化学生物科学股份有限公司 包含自降解基团的缀合物及其相关方法
US11167040B2 (en) 2015-11-25 2021-11-09 Legochem Biosciences, Inc. Conjugates comprising peptide groups and methods related thereto
CN113599533A (zh) 2015-11-25 2021-11-05 乐高化学生物科学股份有限公司 包含分支接头的抗体-药物缀合物及其相关方法
KR20180090290A (ko) 2015-12-04 2018-08-10 시애틀 지네틱스, 인크. 사차화 튜불리신 화합물들의 컨쥬게이트들
US11793880B2 (en) 2015-12-04 2023-10-24 Seagen Inc. Conjugates of quaternized tubulysin compounds
MX2019011655A (es) 2017-03-29 2019-12-19 Legochem Biosciences Inc Profarmaco de dimero de pirrolobenzodiazepina y compuesto conjugado ligando-conector de este.
MX2020008188A (es) 2018-02-02 2020-11-18 Maverix Oncology Inc Conjugados de fármacos de molécula pequeña de monofosfato de gemcitabina.
KR20210023839A (ko) 2018-05-09 2021-03-04 주식회사 레고켐 바이오사이언스 항-cd19 항체 약물 접합체 관련 조성물 및 방법
KR20210028544A (ko) 2019-09-04 2021-03-12 주식회사 레고켐 바이오사이언스 인간 ror1에 대한 항체를 포함하는 항체 약물 접합체 및 이의 용도

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Also Published As

Publication number Publication date
TR199700178A2 (tr) 1997-09-21
DK0795334T3 (da) 2006-06-06
KR100466467B1 (ko) 2005-06-29
NO320322B1 (no) 2005-11-21
SG50011A1 (en) 1998-06-15
ES2257756T3 (es) 2006-08-01
RU2191021C2 (ru) 2002-10-20
AU708202B2 (en) 1999-07-29
DE59712561D1 (de) 2006-04-13
HUP9700579A2 (en) 1997-12-29
EP0795334A3 (de) 1997-09-24
PL318878A1 (en) 1997-09-15
NO971116D0 (no) 1997-03-11
EP0795334A2 (de) 1997-09-17
BG61900B1 (bg) 1998-09-30
NO971116L (no) 1997-09-15
BRPI9701248B1 (pt) 2022-01-18
MX9701832A (es) 1998-07-31
CZ297994B6 (cs) 2007-05-16
CN1168733C (zh) 2004-09-29
ATE316799T1 (de) 2006-02-15
HU228764B1 (en) 2013-05-28
HU9700579D0 (en) 1997-04-28
CN1163895A (zh) 1997-11-05
AU1620597A (en) 1997-09-18
CA2199664A1 (en) 1997-09-12
SI0795334T1 (sl) 2006-06-30
CZ74297A3 (en) 1997-09-17
BG101290A (en) 1997-09-30
CA2199664C (en) 2008-05-20
EP0795334B1 (de) 2006-02-01
HUP9700579A3 (en) 1999-05-28
KR970065550A (ko) 1997-10-13
PL189604B1 (pl) 2005-08-31
US5935995A (en) 1999-08-10
JP4392065B2 (ja) 2009-12-24
BR9701248A8 (pt) 2013-06-18
JPH101495A (ja) 1998-01-06
UA50719C2 (uk) 2002-11-15
NZ314368A (en) 1998-10-28
RO120951B1 (ro) 2006-10-30

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