GB925407A - Dermatological preparations containing corticosteroids - Google Patents
Dermatological preparations containing corticosteroidsInfo
- Publication number
- GB925407A GB925407A GB26990/61A GB2699061A GB925407A GB 925407 A GB925407 A GB 925407A GB 26990/61 A GB26990/61 A GB 26990/61A GB 2699061 A GB2699061 A GB 2699061A GB 925407 A GB925407 A GB 925407A
- Authority
- GB
- United Kingdom
- Prior art keywords
- corticosteroids
- toluidide
- liquids
- ethyl
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003246 corticosteroid Substances 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 4
- 229960001334 corticosteroids Drugs 0.000 title abstract 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
- 239000000839 emulsion Substances 0.000 abstract 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 239000003921 oil Substances 0.000 abstract 2
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 abstract 1
- YYVFXSYQSOZCOQ-UHFFFAOYSA-N Oxyquinoline sulfate Chemical compound [O-]S([O-])(=O)=O.C1=C[NH+]=C2C(O)=CC=CC2=C1.C1=C[NH+]=C2C(O)=CC=CC2=C1 YYVFXSYQSOZCOQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000000443 aerosol Substances 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001857 anti-mycotic effect Effects 0.000 abstract 1
- 239000002543 antimycotic Substances 0.000 abstract 1
- 239000003899 bactericide agent Substances 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- GPTXWRGISTZRIO-UHFFFAOYSA-N chlorquinaldol Chemical compound ClC1=CC(Cl)=C(O)C2=NC(C)=CC=C21 GPTXWRGISTZRIO-UHFFFAOYSA-N 0.000 abstract 1
- ALEXXDVDDISNDU-JZYPGELDSA-N cortisol 21-acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O ALEXXDVDDISNDU-JZYPGELDSA-N 0.000 abstract 1
- LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical compound C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000003995 emulsifying agent Substances 0.000 abstract 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 abstract 1
- 229960000890 hydrocortisone Drugs 0.000 abstract 1
- 229960001067 hydrocortisone acetate Drugs 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000006210 lotion Substances 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 235000010755 mineral Nutrition 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 229960005205 prednisolone Drugs 0.000 abstract 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 239000003380 propellant Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 229940075582 sorbic acid Drugs 0.000 abstract 1
- 235000010199 sorbic acid Nutrition 0.000 abstract 1
- 239000004334 sorbic acid Substances 0.000 abstract 1
- LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 abstract 1
- 235000015112 vegetable and seed oil Nutrition 0.000 abstract 1
- 235000019871 vegetable fat Nutrition 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
A dermatological preparation for anti-inflammatory skin conditions comprises one or more corticosteroids and crotonic acid N-ethyl-o-toluidide in admixture with a pharmaceutical carrier. The preparations contain 0.1 to 1.0% of the corticosteroid and 2-10% of the crotonic acid-N-ethyl-o-toluidide. Specified corticosteroids are hydrocortisone, hydrocortisone acetate and prednisolone. The preparations may be solids, liquids or semi-liquids; ointments and lotions being the preferred form and these may be water-in-oil emulsions or oil-in-water emulsions. Aerosols in which the active ingredients are dissolved in a solvent such as isopropanol and packaged with a propellant, e.g. dichloromethane, may be used. Many carriers, e.g. alcohols, polyethylene glycols, mineral and vegetable fats and oils, and emulsifiers are exemplified. Optional ingredients are (a) preserving agents, e.g. p-hydroxybenzoic acid alkyl esters, 8-hydroxyquinoline sulphate or sorbic acid, and (b) bactericides and antimycotics, e.g. 5,7 - dichloro - 8 - hydroxyquinaldine.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH877160 | 1960-08-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB925407A true GB925407A (en) | 1963-05-08 |
Family
ID=4344541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB26990/61A Expired GB925407A (en) | 1960-08-02 | 1961-07-26 | Dermatological preparations containing corticosteroids |
Country Status (2)
| Country | Link |
|---|---|
| FR (1) | FR1443M (en) |
| GB (1) | GB925407A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4267169A (en) * | 1978-07-22 | 1981-05-12 | Toko Yakuhin Kogyo Kabushiki Kaisha | Novel preparation of clotrimazole |
| DE2964471D1 (en) * | 1979-06-08 | 1983-02-17 | Toko Yakuhin Kogyo Kk | Creamy preparation containing steroid and process for the preparation thereof |
| JPS5798209A (en) * | 1980-12-09 | 1982-06-18 | Kowa Co | Remedy for dermatopathy for external use |
| JPS5815909A (en) * | 1981-07-22 | 1983-01-29 | Toko Yakuhin Kogyo Kk | Antimycotic agent for external use |
-
1961
- 1961-07-26 GB GB26990/61A patent/GB925407A/en not_active Expired
- 1961-08-01 FR FR869748A patent/FR1443M/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| FR1443M (en) | 1962-08-13 |
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