GB2097000B - Process for the preparation of 1,4-bis(2,2,2-trifluoroethoxy) benzene - Google Patents

Process for the preparation of 1,4-bis(2,2,2-trifluoroethoxy) benzene

Info

Publication number: GB2097000B
Authority: GB; United Kingdom
Prior art keywords: trifluoroethoxy; benzene; bis; preparation
Prior art date: 1979-03-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

GB8214964A

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Riker Laboratories Inc

Original Assignee

Riker Laboratories Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-03-19

Publication date

1983-11-30

1982-10-27 Publication of GB2097000A publication Critical patent/GB2097000A/en

1983-11-30 Application granted granted Critical

1983-11-30 Publication of GB2097000B publication Critical patent/GB2097000B/en

Status Expired legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Catalysts (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

GB8214964A 1979-03-19 Process for the preparation of 1,4-bis(2,2,2-trifluoroethoxy) benzene Expired GB2097000B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US2133179A	1979-03-19	1979-03-19
US2133279A	1979-03-19	1979-03-19

Publications (2)

Publication Number	Publication Date
GB2097000A GB2097000A (en)	1982-10-27
GB2097000B true GB2097000B (en)	1983-11-30

Family

ID=26694559

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
GB8214964A Expired GB2097000B (en)	1979-03-19		Process for the preparation of 1,4-bis(2,2,2-trifluoroethoxy) benzene
GB8009041A Expired GB2045760B (en)	1979-03-19	1980-03-18	Xy)-n-(2-piperidylmethyl) benzamide (flecanide) process for the preparation of 2,5-bis(2,2,2-trifluoroetho

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
GB8009041A Expired GB2045760B (en)	1979-03-19	1980-03-18	Xy)-n-(2-piperidylmethyl) benzamide (flecanide) process for the preparation of 2,5-bis(2,2,2-trifluoroetho

Country Status (14)

Country	Link
JP (8)	JPH01104044A (en)
CA (1)	CA1137486A (en)
CH (1)	CH643829A5 (en)
DE (1)	DE3010195A1 (en)
DK (3)	DK167062B1 (en)
ES (1)	ES8104227A1 (en)
FR (7)	FR2454438A1 (en)
GB (2)	GB2045760B (en)
IE (1)	IE49558B1 (en)
IL (1)	IL59623A (en)
IT (1)	IT1195262B (en)
NL (1)	NL191486C (en)
PT (1)	PT70967A (en)
SE (5)	SE447992B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2519980A1 (en) *	1982-01-21	1983-07-22	Rhone Poulenc Spec Chim	PROCESS FOR THE SULFONYLATION OF HALOGENO OR TRIHALOGENOMETHYLBENZENES
FR2519979A1 (en) *	1982-01-21	1983-07-22	Rhone Poulenc Spec Chim	PROCESS FOR THE PREPARATION OF TRIFLUOROMETHOXY OR TRIFLUOROMETHYLTHIOPHENYLSULFONES
FR2519975A1 (en) *	1982-01-21	1983-07-22	Rhone Poulenc Spec Chim	PROCESS FOR PREPARING TRIFLUOROMETHOXY OR TRIFLUOROMETHYLTHIOPHENYLCETONES
FR2519974A1 (en) *	1982-01-21	1983-07-22	Rhone Poulenc Spec Chim	PROCESS FOR THE ACYLATION OF HALOGENO OR TRIHALOGENOMETHYLBENZENES
FR2525589A1 (en)	1982-04-22	1983-10-28	Rhone Poulenc Spec Chim	PROCESS FOR PREPARING TRIFLUOROMETHOXY OR TRIFLUOROMETHYLTHIOPHENYLCETONES
FR2525588A1 (en) *	1982-04-22	1983-10-28	Rhone Poulenc Spec Chim	PROCESS FOR PREPARING PHENYLCETONES FROM HALOGENO OR TRIHALOGENOMETHYLBENZENES AND ALIPHATIC OR AROMATIC TRIHALOGENOMETHYL COMPOUNDS
EP0175188A1 (en) *	1984-09-11	1986-03-26	Nihon Tokushu Noyaku Seizo K.K.	Carbamoylimidazole derivatives
US4675448A (en) *	1985-02-13	1987-06-23	Ethyl Corporation	Chlorination process
FR2579591B1 (en) *	1985-03-29	1988-10-14	Rhone Poulenc Spec Chim	PROCESS FOR THE PREPARATION OF PENTAFLUOROETHOXY AND PENTAFLUOROETHYLTHIOBENZENIQUE DERIVATIVES
FR2579594B1 (en) *	1985-03-29	1987-06-05	Rhone Poulenc Spec Chim	PROCESS FOR THE PREPARATION OF TRIFLUOROETHOXY OR TRIFLUOROETHYLTHIOBENZENES
NZ219913A (en) *	1986-04-25	1990-08-28	Riker Laboratories Inc	Various flecainide derivatives and antibodies raised thereto
EP0242847B1 (en) *	1986-04-25	1993-06-02	Abbott Laboratories	Tracers for use in flecainide fluorescence polarization immunoassay
DE3644798A1 (en) *	1986-12-31	1988-07-14	Hoechst Ag	NEW NITROHALOALCOXYBENZOLS, METHOD FOR THEIR PRODUCTION AND THEIR USE
FR2640262B1 (en) *	1988-12-14	1991-05-31	Rhone Poulenc Chimie	PROCESS FOR THE PREPARATION OF TRIFLUOROETHOXYLATED ARYLIC KETONES
US6316627B1 (en) *	1997-04-21	2001-11-13	Fine Tech Ltd.	Process for the preparation of flecainide
IL121288A (en)	1997-07-11	2000-10-31	Finetech Ltd	Process and a novel intermediate for the preparation of flecainide
IL120715A (en)	1997-04-21	2000-07-16	Finetech Ltd	Process for the preparation of (2,2,2,-trifluoroethoxy)benzoic acids
US7196197B2 (en)	2003-09-17	2007-03-27	Apotex Pharmachem Inc.	Process for the preparation of Flecainide, its pharmaceutically acceptable salts and important intermediates thereof
JP4894226B2 (en) *	2005-10-31	2012-03-14	Ｄｉｃ株式会社	Method for producing fluorine-containing liquid crystal compound having hydroquinone skeleton
CN117326927A (en) *	2023-09-28	2024-01-02	清源创新实验室	Preparation method of 2,5-bis (2, 2-trifluoroethoxy) benzoic acid

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3539642A (en) *	1967-07-19	1970-11-10	Geigy Chem Corp	2-phenyl-2-(1-naphthyl)acetamides
US3772304A (en) *	1969-10-30	1973-11-13	Hoffmann La Roche	4-hydroxy-isoquinolines and processes for their preparation
US3719687A (en) *	1970-07-22	1973-03-06	Riker Laboratories Inc	N-(2-dialkylaminoalkylene)amides of 1,1-dihydroperfluoroalkoxy-substituted aryl acids and salts thereof
US3655728A (en)	1970-07-22	1972-04-11	Riker Laboratories Inc	N-(2 - dialkylaminoalkylene)-esters of fluoroalkoxy-substituted aryl carboxylic acid and salts thereof
US3967949A (en) *	1973-06-18	1976-07-06	Eli Lilly And Company	Fluoroalkoxyphenyl-substituted nitrogen heterocycles as plant stunting agents
US4169108A (en) *	1973-08-16	1979-09-25	Sterling Drug Inc.	5(OR 6)-[(Substituted-amino)alkyl]-2,3-naphthalenediols
US4005209A (en) *	1974-04-01	1977-01-25	Riker Laboratories, Inc.	Antiarrhythmic method utilizing fluoroalkoxy-N-piperidyl and pyridyl benzamides
US4013670A (en) *	1974-04-01	1977-03-22	Riker Laboratories, Inc.	Derivatives of pyrrolidine and piperidine
US3900481A (en) *	1974-04-01	1975-08-19	Riker Laboratories Inc	Derivatives of pyrrolidine and piperidine
IL49803A (en) *	1975-06-28	1979-11-30	Fisons Ltd	Preparation of pyrogallol
DE2616478C2 (en) *	1976-04-14	1986-05-22	Brickl, Rolf, Dr., 7951 Warthausen	Medicines, biocides and cosmetics containing fluoroacylresorcins
JPS6023656B2 (en) *	1976-09-02	1985-06-08	川研フアインケミカル株式会社	Method for producing alkoxy aromatic compounds
US4071524A (en) *	1976-11-08	1978-01-31	Riker Laboratories, Inc.	Derivatives of urea
US4097481A (en) *	1976-11-08	1978-06-27	Riker Laboratories, Inc.	Tertiary amide derivatives of pyrrolidine and piperidine

0
- GB GB8214964A patent/GB2097000B/en not_active Expired
1980
- 1980-03-04 CA CA000346919A patent/CA1137486A/en not_active Expired
- 1980-03-14 IL IL59623A patent/IL59623A/en unknown
- 1980-03-14 DK DK112180A patent/DK167062B1/en not_active IP Right Cessation
- 1980-03-14 SE SE8002003A patent/SE447992B/en not_active IP Right Cessation
- 1980-03-16 NL NL8001551A patent/NL191486C/en not_active IP Right Cessation
- 1980-03-17 DE DE19803010195 patent/DE3010195A1/en active Granted
- 1980-03-17 ES ES489629A patent/ES8104227A1/en not_active Expired
- 1980-03-18 GB GB8009041A patent/GB2045760B/en not_active Expired
- 1980-03-18 IE IE549/80A patent/IE49558B1/en not_active IP Right Cessation
- 1980-03-18 IT IT20746/80A patent/IT1195262B/en active Protection Beyond IP Right Term
- 1980-03-18 CH CH212880A patent/CH643829A5/en not_active IP Right Cessation
- 1980-03-18 PT PT70967A patent/PT70967A/en active IP Right Revival
- 1980-03-18 FR FR8006019A patent/FR2454438A1/en active Granted
1981
- 1981-01-07 FR FR8100144A patent/FR2468590A1/en active Granted
- 1981-01-07 FR FR8100141A patent/FR2468570A1/en active Granted
- 1981-01-07 FR FR8100142A patent/FR2468571A1/en active Granted
- 1981-01-07 FR FR8100145A patent/FR2468591A1/en active Granted
- 1981-01-07 FR FR8100140A patent/FR2468569A1/en active Granted
- 1981-01-07 FR FR8100143A patent/FR2468576A1/en active Granted
1984
- 1984-03-21 SE SE8401555A patent/SE463260B/en not_active IP Right Cessation
- 1984-03-21 SE SE8401554A patent/SE447993B/en not_active IP Right Cessation
1988
- 1988-06-01 JP JP63135365A patent/JPH01104044A/en active Granted
- 1988-06-01 JP JP63135366A patent/JPH01125339A/en active Granted
- 1988-06-01 JP JP63135368A patent/JPH01125342A/en active Granted
- 1988-06-01 JP JP63135369A patent/JPH01125343A/en active Granted
- 1988-06-01 JP JP63135367A patent/JPH01125341A/en active Granted
- 1988-06-01 JP JP63135370A patent/JPH01125344A/en active Granted
- 1988-06-01 JP JP63135363A patent/JPH01104045A/en active Granted
- 1988-06-01 JP JP63135364A patent/JPH01104043A/en active Granted
1989
- 1989-04-27 SE SE8901532A patent/SE463418B/en not_active IP Right Cessation
- 1989-04-27 SE SE8901533A patent/SE463419B/en not_active IP Right Cessation
1990
- 1990-05-17 DK DK122290A patent/DK164857C/en not_active IP Right Cessation
1991
- 1991-04-30 DK DK079891A patent/DK79891A/en unknown

Also Published As

Publication number	Publication date
JPH022869B2 (en)	1990-01-19
FR2468590B1 (en)	1983-09-23
FR2468576B1 (en)	1983-01-21
JPH0372212B2 (en)	1991-11-18
FR2468591A1 (en)	1981-05-08
GB2097000A (en)	1982-10-27
DK112180A (en)	1980-09-20
FR2468570B1 (en)	1983-03-11
JPH0251906B2 (en)	1990-11-08
IE49558B1 (en)	1985-10-30
FR2468591B1 (en)	1983-07-22
IE800549L (en)	1980-09-19
SE8901532L (en)	1989-04-27
JPH01125339A (en)	1989-05-17
DE3010195A1 (en)	1980-10-02
DK167062B1 (en)	1993-08-23
JPH01125344A (en)	1989-05-17
JPH01125342A (en)	1989-05-17
FR2468590A1 (en)	1981-05-08
GB2045760A (en)	1980-11-05
FR2468571B1 (en)	1983-03-11
DK122290A (en)	1990-05-17
GB2045760B (en)	1983-05-11
JPH0339498B2 (en)	1991-06-14
SE8401555D0 (en)	1984-03-21
FR2454438B1 (en)	1982-07-23
ES489629A0 (en)	1981-04-01
NL8001551A (en)	1980-09-23
IL59623A (en)	1983-07-31
SE8901533D0 (en)	1989-04-27
DK122290D0 (en)	1990-05-17
FR2468576A1 (en)	1981-05-08
SE8002003L (en)	1980-09-20
SE463418B (en)	1990-11-19
SE8901532D0 (en)	1989-04-27
IT1195262B (en)	1988-10-12
FR2454438A1 (en)	1980-11-14
IL59623A0 (en)	1980-06-30
SE447992B (en)	1987-01-12
DK164857B (en)	1992-08-31
DE3010195C2 (en)	1990-10-25
FR2468569A1 (en)	1981-05-08
JPH022870B2 (en)	1990-01-19
JPH0149695B2 (en)	1989-10-25
SE8901533L (en)	1989-04-27
JPH0251907B2 (en)	1990-11-08
JPH01104043A (en)	1989-04-21
DK164857C (en)	1993-01-18
FR2468569B1 (en)	1983-03-11
JPH01125341A (en)	1989-05-17
SE447993B (en)	1987-01-12
FR2468571A1 (en)	1981-05-08
SE8401554D0 (en)	1984-03-21
DK79891D0 (en)	1991-04-30
NL191486C (en)	1995-08-04
SE463260B (en)	1990-10-29
CH643829A5 (en)	1984-06-29
SE8401555L (en)	1984-03-21
SE463419B (en)	1990-11-19
ES8104227A1 (en)	1981-04-01
JPH0251908B2 (en)	1990-11-08
CA1137486A (en)	1982-12-14
JPH01104045A (en)	1989-04-21
IT8020746A0 (en)	1980-03-18
JPH01104044A (en)	1989-04-21
JPH01125343A (en)	1989-05-17
PT70967A (en)	1980-04-01
NL191486B (en)	1995-04-03
SE8401554L (en)	1984-03-21
FR2468570A1 (en)	1981-05-08
DK79891A (en)	1991-04-30

Publication	Publication Date	Title
GB2097000B (en)	1983-11-30	Process for the preparation of 1,4-bis(2,2,2-trifluoroethoxy) benzene
DE3361803D1 (en)	1986-02-20	Process for the preparation of (2,2)-paracyclophane
DE2960436D1 (en)	1981-10-08	Process for the preparation of 2,4-oxazolidine diones
DE2962315D1 (en)	1982-04-29	Process for the preparation of 2,2,6,6-tetramethyl-piperidone-(4)
DE2962943D1 (en)	1982-07-15	Process for the preparation of 2,6-dialkyl-n-alkylanilines
ZA804178B (en)	1981-08-26	Process for the preparation of 2,6-dialkylcyclohexylamines
DE3060705D1 (en)	1982-09-16	Process for the preparation of 1,4-diamino-2,3-dicyanoanthraquinones
IL62842A0 (en)	1981-07-31	Process for the preparation of n-di-n-propyl-2,6-dinitro-4-trifluoro-methylaniline
DE2960770D1 (en)	1981-11-26	Process for the preparation of 2,2,4-trimethyl-3-hydroxypentyl-isobutyrate
PT70537A (en)	1980-01-01	Process for the preparation of 2',6'-dialkyl-n-alkoxymethyl-2-chloro-acetanilides
DE3162242D1 (en)	1984-03-22	Process for the preparation of 2,3,5-trichloropyridine
ZA807964B (en)	1982-01-27	Process for the preparation of 4,1,6-trichloro -4,1'6-trideoxy galactosucrose
DE3360040D1 (en)	1985-02-14	Process for the preparation of 2,3-dichlorobutadiene-1,3
DE3361151D1 (en)	1985-12-12	Process for the preparation of 2,3,5-trimethyl-p-benzoquinone
GB2028314B (en)	1982-10-06	Process for the preparation of dicyclopentylene (2,2-bis(4-alkyl-6-t-butylphenols
DE3160035D1 (en)	1983-03-03	Process for the preparation of 1,4-diamino-2,3-dicyano-anthraquinone
DE3060617D1 (en)	1982-08-19	Process for the preparation of 1,3,5-trichlorobenzene
GB2039904B (en)	1983-05-11	Process for the preparation of 1-chloro-2-methyl-3,3a-dihydro-2h,9h-isoxazolo(3,2-b)(1.3)-benzoxazin-9-one
DE3160815D1 (en)	1983-10-06	Process for the preparation of 2,6-dichlorobenzoxazole or 2,6-dichlorobenzthiazole
DE3262022D1 (en)	1985-03-07	Process for the synthesis of trialkyl-tris(3,5-dialkyl-4-hydroxybenzyl) benzene
DE2962222D1 (en)	1982-04-01	Process for the preparation of 2.4-difluoro-5-chloro-6-methylpyrimidine
IL67486A0 (en)	1983-05-15	Process for the preparation of 1,4-bis(2,2,2-trifluoroethoxy)benzene
DE3160037D1 (en)	1983-03-03	Process for the preparation of 2,4,6-trifluorotriazine-(1,3,5)
DE3061368D1 (en)	1983-01-20	Process for the preparation of 1,2,4-triazolidin-3,5-dione
DE2962366D1 (en)	1982-04-29	Process for the preparation of 2,3-dihydro-2,2-dimethyl-7-hydroxy-benzofurane

Legal Events

Date	Code	Title	Description
2000-04-12	PE20	Patent expired after termination of 20 years	Effective date: 20000317