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DK164857C - METHOD FOR PREPARING 2,5-BIS (2,2,2-TRIFLUORETHOXY) -N- (2-PIPERIDYLMETHYL) BENZAMIDE - Google Patents

METHOD FOR PREPARING 2,5-BIS (2,2,2-TRIFLUORETHOXY) -N- (2-PIPERIDYLMETHYL) BENZAMIDE

Info

Publication number
DK164857C
DK164857C DK122290A DK122290A DK164857C DK 164857 C DK164857 C DK 164857C DK 122290 A DK122290 A DK 122290A DK 122290 A DK122290 A DK 122290A DK 164857 C DK164857 C DK 164857C
Authority
DK
Denmark
Prior art keywords
trifluorethoxy
piperidylmethyl
benzamide
bis
preparing
Prior art date
Application number
DK122290A
Other languages
Danish (da)
Other versions
DK122290D0 (en
DK122290A (en
DK164857B (en
Inventor
Charles Martin Leir
Original Assignee
Riker Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riker Laboratories Inc filed Critical Riker Laboratories Inc
Publication of DK122290D0 publication Critical patent/DK122290D0/en
Publication of DK122290A publication Critical patent/DK122290A/en
Publication of DK164857B publication Critical patent/DK164857B/en
Application granted granted Critical
Publication of DK164857C publication Critical patent/DK164857C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK122290A 1979-03-19 1990-05-17 METHOD FOR PREPARING 2,5-BIS (2,2,2-TRIFLUORETHOXY) -N- (2-PIPERIDYLMETHYL) BENZAMIDE DK164857C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2133179A 1979-03-19 1979-03-19
US2133279A 1979-03-19 1979-03-19
US2133279 1979-03-19
US2133179 1979-03-19

Publications (4)

Publication Number Publication Date
DK122290D0 DK122290D0 (en) 1990-05-17
DK122290A DK122290A (en) 1990-05-17
DK164857B DK164857B (en) 1992-08-31
DK164857C true DK164857C (en) 1993-01-18

Family

ID=26694559

Family Applications (3)

Application Number Title Priority Date Filing Date
DK112180A DK167062B1 (en) 1979-03-19 1980-03-14 METHOD FOR PREPARING 1,4-BIS (2,2,2-TRIFLUORETHOXY) BENZEN
DK122290A DK164857C (en) 1979-03-19 1990-05-17 METHOD FOR PREPARING 2,5-BIS (2,2,2-TRIFLUORETHOXY) -N- (2-PIPERIDYLMETHYL) BENZAMIDE
DK079891A DK79891A (en) 1979-03-19 1991-04-30 2,5-BIS (2,2,2-TRIFLUORETHOXY) ACETOPHENONS USED AS INTERMEDIATES AND PROCEDURES FOR PRODUCING THEREOF

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK112180A DK167062B1 (en) 1979-03-19 1980-03-14 METHOD FOR PREPARING 1,4-BIS (2,2,2-TRIFLUORETHOXY) BENZEN

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK079891A DK79891A (en) 1979-03-19 1991-04-30 2,5-BIS (2,2,2-TRIFLUORETHOXY) ACETOPHENONS USED AS INTERMEDIATES AND PROCEDURES FOR PRODUCING THEREOF

Country Status (14)

Country Link
JP (8) JPH01104045A (en)
CA (1) CA1137486A (en)
CH (1) CH643829A5 (en)
DE (1) DE3010195A1 (en)
DK (3) DK167062B1 (en)
ES (1) ES8104227A1 (en)
FR (7) FR2454438A1 (en)
GB (2) GB2045760B (en)
IE (1) IE49558B1 (en)
IL (1) IL59623A (en)
IT (1) IT1195262B (en)
NL (1) NL191486C (en)
PT (1) PT70967A (en)
SE (5) SE447992B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2519979A1 (en) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim PROCESS FOR THE PREPARATION OF TRIFLUOROMETHOXY OR TRIFLUOROMETHYLTHIOPHENYLSULFONES
FR2519974A1 (en) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim PROCESS FOR THE ACYLATION OF HALOGENO OR TRIHALOGENOMETHYLBENZENES
FR2519975A1 (en) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim PROCESS FOR PREPARING TRIFLUOROMETHOXY OR TRIFLUOROMETHYLTHIOPHENYLCETONES
FR2519980A1 (en) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim PROCESS FOR THE SULFONYLATION OF HALOGENO OR TRIHALOGENOMETHYLBENZENES
FR2525588A1 (en) * 1982-04-22 1983-10-28 Rhone Poulenc Spec Chim PROCESS FOR PREPARING PHENYLCETONES FROM HALOGENO OR TRIHALOGENOMETHYLBENZENES AND ALIPHATIC OR AROMATIC TRIHALOGENOMETHYL COMPOUNDS
FR2525589A1 (en) 1982-04-22 1983-10-28 Rhone Poulenc Spec Chim PROCESS FOR PREPARING TRIFLUOROMETHOXY OR TRIFLUOROMETHYLTHIOPHENYLCETONES
EP0175188A1 (en) * 1984-09-11 1986-03-26 Nihon Tokushu Noyaku Seizo K.K. Carbamoylimidazole derivatives
US4675448A (en) * 1985-02-13 1987-06-23 Ethyl Corporation Chlorination process
FR2579594B1 (en) * 1985-03-29 1987-06-05 Rhone Poulenc Spec Chim PROCESS FOR THE PREPARATION OF TRIFLUOROETHOXY OR TRIFLUOROETHYLTHIOBENZENES
FR2579591B1 (en) * 1985-03-29 1988-10-14 Rhone Poulenc Spec Chim PROCESS FOR THE PREPARATION OF PENTAFLUOROETHOXY AND PENTAFLUOROETHYLTHIOBENZENIQUE DERIVATIVES
NZ219913A (en) * 1986-04-25 1990-08-28 Riker Laboratories Inc Various flecainide derivatives and antibodies raised thereto
DE3786037T2 (en) * 1986-04-25 1993-11-25 Abbott Lab Tracer for use in immunological fluorescence polarization methods for the detection of flecainide.
DE3644798A1 (en) * 1986-12-31 1988-07-14 Hoechst Ag NEW NITROHALOALCOXYBENZOLS, METHOD FOR THEIR PRODUCTION AND THEIR USE
FR2640262B1 (en) * 1988-12-14 1991-05-31 Rhone Poulenc Chimie PROCESS FOR THE PREPARATION OF TRIFLUOROETHOXYLATED ARYLIC KETONES
IL121288A (en) 1997-07-11 2000-10-31 Finetech Ltd Process and a novel intermediate for the preparation of flecainide
US6316627B1 (en) 1997-04-21 2001-11-13 Fine Tech Ltd. Process for the preparation of flecainide
IL120715A (en) 1997-04-21 2000-07-16 Finetech Ltd Process for the preparation of (2,2,2,-trifluoroethoxy)benzoic acids
US7196197B2 (en) 2003-09-17 2007-03-27 Apotex Pharmachem Inc. Process for the preparation of Flecainide, its pharmaceutically acceptable salts and important intermediates thereof
JP4894226B2 (en) * 2005-10-31 2012-03-14 Ｄｉｃ株式会社 Method for producing fluorine-containing liquid crystal compound having hydroquinone skeleton
CN117326927A (en) * 2023-09-28 2024-01-02 清源创新实验室 Preparation method of 2,5-bis (2, 2-trifluoroethoxy) benzoic acid

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3539642A (en) * 1967-07-19 1970-11-10 Geigy Chem Corp 2-phenyl-2-(1-naphthyl)acetamides
US3772304A (en) * 1969-10-30 1973-11-13 Hoffmann La Roche 4-hydroxy-isoquinolines and processes for their preparation
US3719687A (en) * 1970-07-22 1973-03-06 Riker Laboratories Inc N-(2-dialkylaminoalkylene)amides of 1,1-dihydroperfluoroalkoxy-substituted aryl acids and salts thereof
US3655728A (en) 1970-07-22 1972-04-11 Riker Laboratories Inc N-(2 - dialkylaminoalkylene)-esters of fluoroalkoxy-substituted aryl carboxylic acid and salts thereof
US3967949A (en) * 1973-06-18 1976-07-06 Eli Lilly And Company Fluoroalkoxyphenyl-substituted nitrogen heterocycles as plant stunting agents
US4169108A (en) * 1973-08-16 1979-09-25 Sterling Drug Inc. 5(OR 6)-[(Substituted-amino)alkyl]-2,3-naphthalenediols
US3900481A (en) * 1974-04-01 1975-08-19 Riker Laboratories Inc Derivatives of pyrrolidine and piperidine
US4013670A (en) * 1974-04-01 1977-03-22 Riker Laboratories, Inc. Derivatives of pyrrolidine and piperidine
US4005209A (en) * 1974-04-01 1977-01-25 Riker Laboratories, Inc. Antiarrhythmic method utilizing fluoroalkoxy-N-piperidyl and pyridyl benzamides
IL49803A (en) * 1975-06-28 1979-11-30 Fisons Ltd Preparation of pyrogallol
DE2616478C2 (en) * 1976-04-14 1986-05-22 Brickl, Rolf, Dr., 7951 Warthausen Medicines, biocides and cosmetics containing fluoroacylresorcins
JPS6023656B2 (en) * 1976-09-02 1985-06-08 川研フアインケミカル株式会社 Method for producing alkoxy aromatic compounds
US4097481A (en) * 1976-11-08 1978-06-27 Riker Laboratories, Inc. Tertiary amide derivatives of pyrrolidine and piperidine
US4071524A (en) * 1976-11-08 1978-01-31 Riker Laboratories, Inc. Derivatives of urea

Also Published As

Publication number Publication date
GB2097000A (en) 1982-10-27
SE8002003L (en) 1980-09-20
FR2468571B1 (en) 1983-03-11
NL8001551A (en) 1980-09-23
FR2468590A1 (en) 1981-05-08
IL59623A0 (en) 1980-06-30
FR2468576A1 (en) 1981-05-08
JPH01104045A (en) 1989-04-21
FR2454438A1 (en) 1980-11-14
GB2045760A (en) 1980-11-05
SE463418B (en) 1990-11-19
SE8901533D0 (en) 1989-04-27
IL59623A (en) 1983-07-31
JPH01104044A (en) 1989-04-21
SE8401554D0 (en) 1984-03-21
CH643829A5 (en) 1984-06-29
JPH01125341A (en) 1989-05-17
FR2468591B1 (en) 1983-07-22
IE49558B1 (en) 1985-10-30
ES489629A0 (en) 1981-04-01
DK79891D0 (en) 1991-04-30
JPH01125339A (en) 1989-05-17
JPH0251908B2 (en) 1990-11-08
DE3010195A1 (en) 1980-10-02
SE447992B (en) 1987-01-12
FR2468591A1 (en) 1981-05-08
IT8020746A0 (en) 1980-03-18
FR2468570B1 (en) 1983-03-11
DK112180A (en) 1980-09-20
JPH0251906B2 (en) 1990-11-08
SE8901532L (en) 1989-04-27
DK122290D0 (en) 1990-05-17
SE463419B (en) 1990-11-19
IE800549L (en) 1980-09-19
ES8104227A1 (en) 1981-04-01
JPH01125343A (en) 1989-05-17
FR2468569B1 (en) 1983-03-11
DK122290A (en) 1990-05-17
IT1195262B (en) 1988-10-12
JPH022870B2 (en) 1990-01-19
SE463260B (en) 1990-10-29
JPH0339498B2 (en) 1991-06-14
SE8401555D0 (en) 1984-03-21
NL191486B (en) 1995-04-03
SE8401555L (en) 1984-03-21
SE8401554L (en) 1984-03-21
FR2454438B1 (en) 1982-07-23
JPH0251907B2 (en) 1990-11-08
FR2468571A1 (en) 1981-05-08
FR2468570A1 (en) 1981-05-08
JPH01125342A (en) 1989-05-17
DK164857B (en) 1992-08-31
NL191486C (en) 1995-08-04
FR2468590B1 (en) 1983-09-23
GB2097000B (en) 1983-11-30
CA1137486A (en) 1982-12-14
JPH022869B2 (en) 1990-01-19
FR2468569A1 (en) 1981-05-08
DK167062B1 (en) 1993-08-23
PT70967A (en) 1980-04-01
DE3010195C2 (en) 1990-10-25
SE8901533L (en) 1989-04-27
JPH0372212B2 (en) 1991-11-18
JPH0149695B2 (en) 1989-10-25
JPH01104043A (en) 1989-04-21
GB2045760B (en) 1983-05-11
JPH01125344A (en) 1989-05-17
SE8901532D0 (en) 1989-04-27
SE447993B (en) 1987-01-12
FR2468576B1 (en) 1983-01-21
DK79891A (en) 1991-04-30

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