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GB1546448A - Sustained-release formulations - Google Patents

Sustained-release formulations

Info

Publication number
GB1546448A
GB1546448A GB10482/76A GB1048276A GB1546448A GB 1546448 A GB1546448 A GB 1546448A GB 10482/76 A GB10482/76 A GB 10482/76A GB 1048276 A GB1048276 A GB 1048276A GB 1546448 A GB1546448 A GB 1546448A
Authority
GB
United Kingdom
Prior art keywords
mixture
weight
gastric juice
sustained
formulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB10482/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Priority claimed from KR7600645A external-priority patent/KR800001387B1/en
Publication of GB1546448A publication Critical patent/GB1546448A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus

Landscapes

  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Solid pharmaceutical formulations are described which have a sustained release effect and which are buoyant in gastric juice. The formulation is present in the form of a homogeneous mixture. This mixture contains at least one therapeutic active compound, up to 80% by weight of therapeutically inert, pharmaceutically acceptable auxiliary substances, up to 60% by weight of a fatty material having a specific weight less than 1 and such a proportion of a hydrocolloid or of a mixture of hydrocolloids, incorporated into the formulation essentially in the dry form, that, after contact with the gastric juice, a layer which is impermeable to water is generated on the surface of this homogeneous mixture.
GB10482/76A 1975-03-17 1976-03-16 Sustained-release formulations Expired GB1546448A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55910775A 1975-03-17 1975-03-17
US65800376A 1976-02-13 1976-02-13
KR7600645A KR800001387B1 (en) 1975-03-17 1976-03-16 Process for preparing sustained release formulation

Publications (1)

Publication Number Publication Date
GB1546448A true GB1546448A (en) 1979-05-23

Family

ID=27348140

Family Applications (1)

Application Number Title Priority Date Filing Date
GB10482/76A Expired GB1546448A (en) 1975-03-17 1976-03-16 Sustained-release formulations

Country Status (21)

Country Link
JP (1) JPS51115910A (en)
AR (1) AR222624A1 (en)
AT (1) AT353415B (en)
AU (1) AU505355B2 (en)
CA (1) CA1073358A (en)
CH (1) CH630257A5 (en)
DD (1) DD124102A5 (en)
DE (1) DE2611041A1 (en)
DK (1) DK148344C (en)
ES (1) ES446075A1 (en)
FR (1) FR2304354A1 (en)
GB (1) GB1546448A (en)
GR (1) GR60341B (en)
IE (1) IE43083B1 (en)
LU (1) LU74558A1 (en)
MC (1) MC1101A1 (en)
NL (1) NL190313C (en)
NZ (1) NZ180321A (en)
PH (1) PH14927A (en)
PT (1) PT64907B (en)
SE (1) SE433804B (en)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0095123A3 (en) * 1982-05-20 1984-12-12 Merrell Dow Pharmaceuticals Inc. Sustained release diethylpropion compositions
GB2154874A (en) * 1984-02-29 1985-09-18 Sandoz Ltd Bromocriptine compositions
GB2157169A (en) * 1984-03-21 1985-10-23 American Home Prod Sustained release pharmaceutical capsules
GB2163648A (en) * 1984-08-03 1986-03-05 Nippon Shinyaku Co Ltd Slow release preparations
EP0297978A3 (en) * 1987-07-01 1990-01-31 Forest Laboratories, Inc. Floating sustained release therapeutic compositions
GB2241168A (en) * 1990-02-26 1991-08-28 Int Medical Research Limited Controlled release product containing salicylate
US5498422A (en) * 1991-04-08 1996-03-12 Nippon Shinyaku Company Limited Sustained release capsule
US5556639A (en) * 1991-01-30 1996-09-17 Glaxo Wellcome Inc. Water-dispersible tablets
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
EP0759745A4 (en) * 1994-05-13 1997-11-19 Smithkline Beecham Corp Method and composition for increasing calcium uptake
US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
US5888540A (en) * 1993-10-29 1999-03-30 Sugden; Keith Pharmaceutical products
AU709413B2 (en) * 1994-12-01 1999-08-26 Amarin Development Ab Sustained-release drug delivery employing a powdered hydrocolloid gum obtainable from higher plants
EP1245227A1 (en) * 2001-03-31 2002-10-02 Jagotec Ag A pharmaceutical tablet system that floats in the stomach for programmed release of active substance and process of producing buoyant material contained in same
FR2874325A1 (en) * 2004-08-19 2006-02-24 Sanofi Synthelabo PHARMACEUTICAL COMPOSITION IN THE FORM OF A GASTRIC RESISTANCE COMPRESSOR CONTAINING ALFUZOSIN
WO2026022379A1 (en) * 2024-07-26 2026-01-29 Inkvivo Technologies Sa Gastroretentive formulations

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ197543A (en) * 1980-07-02 1984-12-14 Commw Scient Ind Res Org Controlled release compositions for inclusion in intraruminal devices
CH649215A5 (en) * 1981-04-29 1985-05-15 Hoffmann La Roche PHARMACEUTICAL PREPARATIONS.
CH652025A5 (en) * 1981-09-14 1985-10-31 Hoffmann La Roche Pharmaceutical preparation.
CH666406A5 (en) * 1984-02-29 1988-07-29 Sandoz Ag METHOD FOR PRODUCING microcapsules BROMOKRIPTINMESYLAT AS PHARMACOLOGICAL ACTIVE INCLUDED.
HU195729B (en) * 1985-02-05 1988-07-28 Sandoz Ag Process for producing pharmaceutical compositions containing 9,10-dihydro-ergot-alkaloides
GB8524135D0 (en) * 1985-10-01 1985-11-06 Sandoz Ltd Darodipine compositions
NL194822C (en) * 1985-10-01 2003-04-03 Novartis Ag Preparation for oral administration with controlled release and method for its preparation.
US4786503A (en) * 1987-04-06 1988-11-22 Alza Corporation Dosage form comprising parallel lamine
US5133974A (en) * 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
ATE173159T1 (en) * 1992-03-25 1998-11-15 Depomed Systems Inc ORAL MEDICINAL DOSAGE FORMS BASED ON HYDROXYETHYL CELLULOSE WITH DELAYED RELEASE
WO1995011667A1 (en) * 1993-10-29 1995-05-04 R.P. Scherer Corporation Gelatin capsule fill able to foam
CA2174777A1 (en) * 1993-10-29 1995-05-04 Keith Sugden Gelatin capsule fill able to foam
FR2820319B3 (en) * 2001-02-08 2003-12-05 Ellipse Pharmaceuticals PROCESS FOR PRODUCING A FLOATING TABLET INCLUDING ALFUZOSINE AND TABLET OBTAINED
FR2820318B1 (en) * 2001-02-08 2005-12-23 Ellipse Pharmaceuticals METHOD FOR MANUFACTURING A FLOATING COMPRESSOR INCLUDING AN ACTIVE INGREDIENT AND A COMPRESS OBTAINED

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1059624B (en) * 1954-11-11 1959-06-18 Dr Knut Jacobus Sundman Process for the production of medicaments dispersed in a carrier substance in dosed form
JPS5512411B2 (en) * 1974-03-12 1980-04-02
DE2439538C3 (en) * 1974-08-17 1980-07-17 Ludwig Heumann & Co Gmbh, 8500 Nuernberg Process for the manufacture of orally administered drugs with delayed release of action

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0095123A3 (en) * 1982-05-20 1984-12-12 Merrell Dow Pharmaceuticals Inc. Sustained release diethylpropion compositions
GB2154874A (en) * 1984-02-29 1985-09-18 Sandoz Ltd Bromocriptine compositions
GB2157169A (en) * 1984-03-21 1985-10-23 American Home Prod Sustained release pharmaceutical capsules
EP0156592A3 (en) * 1984-03-21 1987-03-11 American Home Products Corporation Substained release pharmaceutical capsules
GB2163648A (en) * 1984-08-03 1986-03-05 Nippon Shinyaku Co Ltd Slow release preparations
GB2163648B (en) * 1984-08-03 1989-06-01 Nippon Shinyaku Co Ltd Pharmaceutical preparation and a method of making the same
EP0297978A3 (en) * 1987-07-01 1990-01-31 Forest Laboratories, Inc. Floating sustained release therapeutic compositions
GB2241168A (en) * 1990-02-26 1991-08-28 Int Medical Research Limited Controlled release product containing salicylate
US5156849A (en) * 1990-02-26 1992-10-20 Byrne Rynne Holdings Limited Pharmaceutical composition
US5556639A (en) * 1991-01-30 1996-09-17 Glaxo Wellcome Inc. Water-dispersible tablets
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
US5660860A (en) * 1991-01-30 1997-08-26 Glaxo Wellcome Inc. Water-dispersible tablets
US5498422A (en) * 1991-04-08 1996-03-12 Nippon Shinyaku Company Limited Sustained release capsule
US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
US5888540A (en) * 1993-10-29 1999-03-30 Sugden; Keith Pharmaceutical products
EP0759745A4 (en) * 1994-05-13 1997-11-19 Smithkline Beecham Corp Method and composition for increasing calcium uptake
AU709413B2 (en) * 1994-12-01 1999-08-26 Amarin Development Ab Sustained-release drug delivery employing a powdered hydrocolloid gum obtainable from higher plants
EP1245227A1 (en) * 2001-03-31 2002-10-02 Jagotec Ag A pharmaceutical tablet system that floats in the stomach for programmed release of active substance and process of producing buoyant material contained in same
US7838028B2 (en) 2001-03-31 2010-11-23 Jagotec Ag Pharmaceutical tablet system that floats on gastric fluid for multipulse release of active substance, and respective processes of producing same and a cup-shaped envelope of same
FR2874325A1 (en) * 2004-08-19 2006-02-24 Sanofi Synthelabo PHARMACEUTICAL COMPOSITION IN THE FORM OF A GASTRIC RESISTANCE COMPRESSOR CONTAINING ALFUZOSIN
WO2006021692A1 (en) * 2004-08-19 2006-03-02 Sanofi-Aventis Pharmaceutical composition in the form of a gastric-resident tablet containing an active principle
EA012981B1 (en) * 2004-08-19 2010-02-26 Санофи-Авентис Pharmaceutical composition in the form ofa gastric-resident tablet containing an active principle
WO2026022379A1 (en) * 2024-07-26 2026-01-29 Inkvivo Technologies Sa Gastroretentive formulations

Also Published As

Publication number Publication date
DK113676A (en) 1976-09-18
PH14927A (en) 1982-01-29
LU74558A1 (en) 1977-09-27
NL190313C (en) 1994-01-17
DE2611041A1 (en) 1976-10-14
DE2611041C2 (en) 1988-06-09
DD124102A5 (en) 1977-02-02
MC1101A1 (en) 1977-02-04
PT64907A (en) 1976-04-01
CH630257A5 (en) 1982-06-15
AR222624A1 (en) 1981-06-15
GR60341B (en) 1978-05-17
AT353415B (en) 1979-11-12
ATA192276A (en) 1979-04-15
IE43083L (en) 1976-09-17
NL190313B (en) 1993-08-16
NZ180321A (en) 1978-06-20
JPS51115910A (en) 1976-10-13
DK148344B (en) 1985-06-17
FR2304354B1 (en) 1979-04-27
SE433804B (en) 1984-06-18
IE43083B1 (en) 1980-12-17
DK148344C (en) 1985-11-04
ES446075A1 (en) 1977-09-16
PT64907B (en) 1978-03-24
AU1204976A (en) 1977-09-22
CA1073358A (en) 1980-03-11
JPS638084B2 (en) 1988-02-19
SE7603325L (en) 1976-09-18
NL7602776A (en) 1976-09-21
FR2304354A1 (en) 1976-10-15
AU505355B2 (en) 1979-11-15

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PE20 Patent expired after termination of 20 years

Effective date: 19960315