GB1465223A - Decahydroisoquinoline derivatives processes for their prepa ration and their use in pharmaceutical compositions - Google Patents
Decahydroisoquinoline derivatives processes for their prepa ration and their use in pharmaceutical compositionsInfo
- Publication number
- GB1465223A GB1465223A GB3883675A GB3883675A GB1465223A GB 1465223 A GB1465223 A GB 1465223A GB 3883675 A GB3883675 A GB 3883675A GB 3883675 A GB3883675 A GB 3883675A GB 1465223 A GB1465223 A GB 1465223A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- och
- compound
- product
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NENLYAQPNATJSU-UHFFFAOYSA-N 1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline Chemical class C1NCCC2CCCCC21 NENLYAQPNATJSU-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- AGEZXYOZHKGVCM-UHFFFAOYSA-N benzyl bromide Chemical compound BrCC1=CC=CC=C1 AGEZXYOZHKGVCM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000012280 lithium aluminium hydride Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910000104 sodium hydride Inorganic materials 0.000 abstract 1
- 239000012312 sodium hydride Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50857774A | 1974-09-23 | 1974-09-23 | |
| US59838175A | 1975-07-29 | 1975-07-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1465223A true GB1465223A (en) | 1977-02-23 |
Family
ID=27056229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3883675A Expired GB1465223A (en) | 1974-09-23 | 1975-09-22 | Decahydroisoquinoline derivatives processes for their prepa ration and their use in pharmaceutical compositions |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS5159876A (es) |
| AR (1) | AR209936A1 (es) |
| AU (1) | AU506970B2 (es) |
| DD (1) | DD122973A5 (es) |
| DE (1) | DE2542152A1 (es) |
| DK (1) | DK424775A (es) |
| ES (2) | ES441207A1 (es) |
| FI (1) | FI752643A7 (es) |
| FR (1) | FR2285131A1 (es) |
| GB (1) | GB1465223A (es) |
| HU (1) | HU174285B (es) |
| IL (1) | IL48148A (es) |
| LU (1) | LU73435A1 (es) |
| NL (1) | NL7511199A (es) |
| NZ (1) | NZ178737A (es) |
| SE (1) | SE7509337L (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6075461A (ja) * | 1983-09-30 | 1985-04-27 | Nippon Steel Chem Co Ltd | Ν−アルキルデカヒドロイソキノリンの製造法 |
| US5939551A (en) * | 1996-05-15 | 1999-08-17 | Toray Industries, Inc. | Process for producing 4a-aryldecahydroisoquinoline derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2351599A1 (de) * | 1972-07-20 | 1974-01-31 | Du Pont | 4a-aryl-trans-decahydrochinoline und verfahren zu ihrer herstellung |
-
1975
- 1975-08-21 SE SE7509337A patent/SE7509337L/xx unknown
- 1975-09-22 LU LU73435A patent/LU73435A1/xx unknown
- 1975-09-22 FR FR7528988A patent/FR2285131A1/fr active Granted
- 1975-09-22 AU AU85041/75A patent/AU506970B2/en not_active Expired
- 1975-09-22 HU HU75DU241A patent/HU174285B/hu unknown
- 1975-09-22 NZ NZ178737A patent/NZ178737A/xx unknown
- 1975-09-22 IL IL48148A patent/IL48148A/xx unknown
- 1975-09-22 DE DE19752542152 patent/DE2542152A1/de not_active Withdrawn
- 1975-09-22 DD DD188475A patent/DD122973A5/xx unknown
- 1975-09-22 DK DK424775A patent/DK424775A/da not_active Application Discontinuation
- 1975-09-22 GB GB3883675A patent/GB1465223A/en not_active Expired
- 1975-09-22 FI FI752643A patent/FI752643A7/fi not_active Application Discontinuation
- 1975-09-23 NL NL7511199A patent/NL7511199A/xx unknown
- 1975-09-23 AR AR260493A patent/AR209936A1/es active
- 1975-09-23 JP JP50115442A patent/JPS5159876A/ja active Pending
- 1975-09-23 ES ES441207A patent/ES441207A1/es not_active Expired
-
1977
- 1977-02-16 ES ES456170A patent/ES456170A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU506970B2 (en) | 1980-01-31 |
| AU8504175A (en) | 1977-03-31 |
| DE2542152A1 (de) | 1976-04-01 |
| IL48148A (en) | 1979-12-30 |
| IL48148A0 (en) | 1975-11-25 |
| HU174285B (hu) | 1979-12-28 |
| DD122973A5 (de) | 1976-11-12 |
| NL7511199A (nl) | 1976-03-25 |
| FR2285131A1 (fr) | 1976-04-16 |
| ES441207A1 (es) | 1977-07-01 |
| FR2285131B1 (es) | 1978-11-10 |
| DK424775A (da) | 1976-03-24 |
| LU73435A1 (es) | 1976-08-13 |
| SE7509337L (sv) | 1976-03-24 |
| JPS5159876A (en) | 1976-05-25 |
| FI752643A7 (es) | 1976-03-24 |
| NZ178737A (en) | 1978-03-06 |
| ES456170A1 (es) | 1978-05-01 |
| AR209936A1 (es) | 1977-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |