GB1235540A - Oral preparations containing proteolytic enzymes suitable for pediatric use - Google Patents
Oral preparations containing proteolytic enzymes suitable for pediatric useInfo
- Publication number
- GB1235540A GB1235540A GB5701768A GB5701768A GB1235540A GB 1235540 A GB1235540 A GB 1235540A GB 5701768 A GB5701768 A GB 5701768A GB 5701768 A GB5701768 A GB 5701768A GB 1235540 A GB1235540 A GB 1235540A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compositions
- proteolytic enzymes
- preparations containing
- oral preparations
- enzymes suitable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- 102000035195 Peptidases Human genes 0.000 title 1
- 108091005804 Peptidases Proteins 0.000 title 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940088598 enzyme Drugs 0.000 abstract 2
- 108090000317 Chymotrypsin Proteins 0.000 abstract 1
- 229930182555 Penicillin Natural products 0.000 abstract 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 1
- NHUHCSRWZMLRLA-UHFFFAOYSA-N Sulfisoxazole Chemical compound CC1=NOC(NS(=O)(=O)C=2C=CC(N)=CC=2)=C1C NHUHCSRWZMLRLA-UHFFFAOYSA-N 0.000 abstract 1
- 108090000631 Trypsin Proteins 0.000 abstract 1
- 102000004142 Trypsin Human genes 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- XMEVHPAGJVLHIG-FMZCEJRJSA-N chembl454950 Chemical compound [Cl-].C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H]([NH+](C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O XMEVHPAGJVLHIG-FMZCEJRJSA-N 0.000 abstract 1
- 229960005091 chloramphenicol Drugs 0.000 abstract 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 abstract 1
- 229960002376 chymotrypsin Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000019634 flavors Nutrition 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 229940049954 penicillin Drugs 0.000 abstract 1
- 235000020183 skimmed milk Nutrition 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 abstract 1
- 239000006188 syrup Substances 0.000 abstract 1
- 235000020357 syrup Nutrition 0.000 abstract 1
- 229960004989 tetracycline hydrochloride Drugs 0.000 abstract 1
- 239000012588 trypsin Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Botany (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
Abstract
1,235,540. Medicines containing enzymes. ARMOUR PHARMACEUTICAL CO. 2 Dec., 1968, No. 57017/68. Heading A5B. Orally administrable compositions comprise trypsin and/or chymotrypsin in intimate admixture with powdered skim milk, the preparation having a protein content of not more than 1.0 gram per 50,000 AU of enzyme activity. The compositions may contain flavours and may comprise additional medicaments, e.g. penicillin, chloramphenicol tetracycline hydrochloride, sulphisoxazole or sulphaniloamide, which are readily soluble in a pharmaceutically acceptable solvent especially water. The compositions may be dissolved in pharmaceutical liquid carriers for administration, e.g. as a syrup.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5701768A GB1235540A (en) | 1968-12-02 | 1968-12-02 | Oral preparations containing proteolytic enzymes suitable for pediatric use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5701768A GB1235540A (en) | 1968-12-02 | 1968-12-02 | Oral preparations containing proteolytic enzymes suitable for pediatric use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1235540A true GB1235540A (en) | 1971-06-16 |
Family
ID=10478146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5701768A Expired GB1235540A (en) | 1968-12-02 | 1968-12-02 | Oral preparations containing proteolytic enzymes suitable for pediatric use |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1235540A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3991180A (en) * | 1972-03-06 | 1976-11-09 | Rohm And Haas Company | Stabilization of internally administered pancreatic lipase |
| EP0196434A1 (en) * | 1985-03-20 | 1986-10-08 | Societe Des Produits Nestle S.A. | Process for the preparation of a composition based on a divided substance with a slight hydrosolubility |
| GB2261372A (en) * | 1991-11-15 | 1993-05-19 | Gregor Reid | Lactobacillus and skim milk compositions for prevention of urogenital infection |
| WO2009068301A1 (en) * | 2007-11-30 | 2009-06-04 | Pharmathen S.A | Pharmaceutical formulation containing lipophilic drugs and milk as a solubilizing/dispersing agent and method for the preparation thereof |
-
1968
- 1968-12-02 GB GB5701768A patent/GB1235540A/en not_active Expired
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3991180A (en) * | 1972-03-06 | 1976-11-09 | Rohm And Haas Company | Stabilization of internally administered pancreatic lipase |
| EP0196434A1 (en) * | 1985-03-20 | 1986-10-08 | Societe Des Produits Nestle S.A. | Process for the preparation of a composition based on a divided substance with a slight hydrosolubility |
| CH663899A5 (en) * | 1985-03-20 | 1988-01-29 | Nestle Sa | PROCESS FOR THE PREPARATION OF A COMPOSITION BASED ON A FINELY DIVIDED LOW HYDROSOLUBILITY ACTIVE INGREDIENT. |
| GB2261372A (en) * | 1991-11-15 | 1993-05-19 | Gregor Reid | Lactobacillus and skim milk compositions for prevention of urogenital infection |
| WO2009068301A1 (en) * | 2007-11-30 | 2009-06-04 | Pharmathen S.A | Pharmaceutical formulation containing lipophilic drugs and milk as a solubilizing/dispersing agent and method for the preparation thereof |
| US8435982B2 (en) | 2007-11-30 | 2013-05-07 | Pharmathen S.A. | Pharmaceutical formulation containing lipophilic drugs and milk as a solubilizing/dispensing agent and method for the preparation thereof |
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