GB1093355A - 2-carbamoylphenylbenzothiazoles - Google Patents
2-carbamoylphenylbenzothiazolesInfo
- Publication number
- GB1093355A GB1093355A GB3243865A GB3243865A GB1093355A GB 1093355 A GB1093355 A GB 1093355A GB 3243865 A GB3243865 A GB 3243865A GB 3243865 A GB3243865 A GB 3243865A GB 1093355 A GB1093355 A GB 1093355A
- Authority
- GB
- United Kingdom
- Prior art keywords
- halogen
- carbon atoms
- alkyl group
- alkoxy group
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- BFCAGYKRIZHKOV-UHFFFAOYSA-N 2-(1,3-benzothiazol-2-yl)benzamide Chemical class NC(=O)C1=CC=CC=C1C1=NC2=CC=CC=C2S1 BFCAGYKRIZHKOV-UHFFFAOYSA-N 0.000 title abstract 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- VRVRGVPWCUEOGV-UHFFFAOYSA-N 2-aminothiophenol Chemical compound NC1=CC=CC=C1S VRVRGVPWCUEOGV-UHFFFAOYSA-N 0.000 abstract 1
- STNAQENUCOFEKN-UHFFFAOYSA-N 2-cyanobenzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1C#N STNAQENUCOFEKN-UHFFFAOYSA-N 0.000 abstract 1
- QVTPWONEVZJCCS-UHFFFAOYSA-N 2-formylbenzonitrile Chemical compound O=CC1=CC=CC=C1C#N QVTPWONEVZJCCS-UHFFFAOYSA-N 0.000 abstract 1
- RUZTVLCSPAPBLN-UHFFFAOYSA-N 2-phenyl-1,3-benzothiazole-4-carbonitrile Chemical compound C(#N)C1=CC=CC2=C1N=C(S2)C2=CC=CC=C2 RUZTVLCSPAPBLN-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel compounds of formula <FORM:1093355/C2/1> where R is hydrogen, halogen, an alkyl group having not more than four carbon atoms, or an alkoxy group, and R1 is halogen, an alkyl group having not more than four carbon atoms or an alkoxy group, are prepared by condensing cyanobenzoyl chloride or cyanobenzaldehyde with a 2-aminobenzene thiol, and reacting the resulting cyanophenylbenzothiazole with hydrogen peroxide and an alkali metal hydroxide. Therapeutic compositions having anti-inflammatory activity comprise as active ingredient 2-carbamoylphenyl - benzothiazoles of the formula given above. Reference has been directed by the Comptroller to Specification 1,044,361.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3243865A GB1093355A (en) | 1965-07-29 | 1965-07-29 | 2-carbamoylphenylbenzothiazoles |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3243865A GB1093355A (en) | 1965-07-29 | 1965-07-29 | 2-carbamoylphenylbenzothiazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1093355A true GB1093355A (en) | 1967-11-29 |
Family
ID=10338609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3243865A Expired GB1093355A (en) | 1965-07-29 | 1965-07-29 | 2-carbamoylphenylbenzothiazoles |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1093355A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995006469A1 (en) * | 1993-08-28 | 1995-03-09 | Cancer Research Campaign Technology Limited | Benzazole compounds for use in therapy |
| US5874431A (en) * | 1993-08-28 | 1999-02-23 | Cancer Research Campaign Technology Limited | Benzazole compounds |
| AU2023200873B2 (en) * | 2016-05-12 | 2024-09-19 | The Regents Of The University Of Michigan | ASH1L inhibitors and methods of treatment therewith |
-
1965
- 1965-07-29 GB GB3243865A patent/GB1093355A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995006469A1 (en) * | 1993-08-28 | 1995-03-09 | Cancer Research Campaign Technology Limited | Benzazole compounds for use in therapy |
| US5874431A (en) * | 1993-08-28 | 1999-02-23 | Cancer Research Campaign Technology Limited | Benzazole compounds |
| AU2023200873B2 (en) * | 2016-05-12 | 2024-09-19 | The Regents Of The University Of Michigan | ASH1L inhibitors and methods of treatment therewith |
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