GB1086192A - Phenylcyclopropane derivatives - Google Patents
Phenylcyclopropane derivativesInfo
- Publication number
- GB1086192A GB1086192A GB49345/66A GB4934566A GB1086192A GB 1086192 A GB1086192 A GB 1086192A GB 49345/66 A GB49345/66 A GB 49345/66A GB 4934566 A GB4934566 A GB 4934566A GB 1086192 A GB1086192 A GB 1086192A
- Authority
- GB
- United Kingdom
- Prior art keywords
- cis
- cyclopropane
- phenyl
- carboxylic acid
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Novel compounds of formula <FORM:1086192/C2/1> in which R is hydrogen, hydroxyl, halogen, nitro, amino or alkoxy, R1 is a straight or branched alkyl radical having at least 2 carbon atoms, or a cycloalkyl, aralkyl, arylcycloalkyl-alkyl, or hydroxy-alkyl radical, and R2 is hydrogen, or a straight or branched alkyl radical or a hydroxyalkyl radical, or the grouping -NR1R2 represents a heterocyclic ring, which exist in the form of the separated cis- and trans-isomers as well as the cis-trans mixture, are prepared by reacting a 2-phenyl-cyclopropane-1-carboxylic acid chloride or bromide or a methyl or ethyl ester of a 2-phenyl-cyclopropane-1-carboxylic acid with an amine of formula HNR1R2. Cis - 2 - phenylcyclopropane - 1 - carbonyl chloride is prepared by treating cis-2-phenyl-cyclopropane-1-carboxylic acid with thionyl chloride. Therapeutic compositions having antispasmodic activity, and/or activity as central nervous system depressants, which may be administered orally, subcutaneously or intravenously, contain as active ingredient, compounds of Formula I above.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB43626/63A GB1086191A (en) | 1963-11-05 | 1963-11-05 | Phenylcyclopropane derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1086192A true GB1086192A (en) | 1967-10-04 |
Family
ID=10429612
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB49345/66A Expired GB1086192A (en) | 1963-11-05 | 1963-11-05 | Phenylcyclopropane derivatives |
| GB43626/63A Expired GB1086191A (en) | 1963-11-05 | 1963-11-05 | Phenylcyclopropane derivatives |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB43626/63A Expired GB1086191A (en) | 1963-11-05 | 1963-11-05 | Phenylcyclopropane derivatives |
Country Status (15)
| Country | Link |
|---|---|
| JP (2) | JPS4821102B1 (en) |
| AT (3) | AT269832B (en) |
| BE (1) | BE655245A (en) |
| BR (1) | BR6464004D0 (en) |
| CH (1) | CH482648A (en) |
| DE (1) | DE1518207B1 (en) |
| DK (1) | DK127726B (en) |
| ES (1) | ES305661A1 (en) |
| FI (1) | FI43069B (en) |
| FR (4) | FR4554M (en) |
| GB (2) | GB1086192A (en) |
| IL (1) | IL22302A (en) |
| LU (1) | LU47291A1 (en) |
| NL (3) | NL6412766A (en) |
| SE (1) | SE317669B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0015604A1 (en) * | 1979-03-05 | 1980-09-17 | Shell Internationale Researchmaatschappij B.V. | Compounds and compositions for use in inhibition of lipogenesis in mammals |
| US7622589B2 (en) | 2005-03-17 | 2009-11-24 | Pfizer Inc. | Substituted sulfonylaminoarylmethyl cyclopropanecarboxamide as VR1 receptor antagonists |
| US8063215B2 (en) | 2007-08-22 | 2011-11-22 | Astrazeneca Ab | Cyclopropyl amide derivatives |
| US8993577B2 (en) | 2009-02-20 | 2015-03-31 | Astrazeneca Ab | Cyclopropyl amide derivatives |
| US9012452B2 (en) | 2010-02-18 | 2015-04-21 | Astrazeneca Ab | Processes for making cyclopropyl amide derivatives and intermediates associated therewith |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4103030A (en) * | 1974-12-11 | 1978-07-25 | Sumitomo Chemical Company, Limited | Novel cyclopropylmethylamine derivatives |
| DE3582728D1 (en) * | 1985-01-17 | 1991-06-06 | Ici Plc | TERTIAL AMINO CONNECTIONS. |
| GB2170197B (en) * | 1985-01-17 | 1988-08-24 | Ici Plc | Tertiary amine compounds |
| GB8617377D0 (en) * | 1986-07-16 | 1986-08-20 | Ici Plc | Tertiary amine compounds |
| WO1992001447A1 (en) * | 1990-07-18 | 1992-02-06 | Sandoz Ltd. | 2-cyclopropylacetic acid derivatives |
| US20090203750A1 (en) * | 2005-08-24 | 2009-08-13 | Alan Kozikowski | 5-HT2C Receptor Agonists as Anorectic Agents |
| US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| RU2449989C2 (en) | 2006-06-23 | 2012-05-10 | Эбботт Лэборетриз | Cyclopropylamide derivatives as n3-histamine receptor modulators |
| US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| WO2012037258A1 (en) | 2010-09-16 | 2012-03-22 | Abbott Laboratories | Processes for preparing 1,2-substituted cyclopropyl derivatives |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3081336A (en) * | 1963-03-12 | Carbamates | ||
| US3050559A (en) * | 1962-08-21 | Substituted phenylcyclopropylamjnes | ||
| US2997422A (en) * | 1959-01-09 | 1961-08-22 | Smith Kline French Lab | Monoamine oxidase inhibition |
| US3106578A (en) * | 1960-09-16 | 1963-10-08 | Smith Kline French Lab | Nu-phenethyl-2-phenylcyclopropylamine derivatives |
| US3079403A (en) * | 1960-09-19 | 1963-02-26 | Smith Kline French Lab | Process for preparing amines |
-
0
- NL NL128365D patent/NL128365C/xx active
-
1963
- 1963-11-05 GB GB49345/66A patent/GB1086192A/en not_active Expired
- 1963-11-05 GB GB43626/63A patent/GB1086191A/en not_active Expired
-
1964
- 1964-10-21 IL IL22302A patent/IL22302A/en unknown
- 1964-11-03 NL NL6412766A patent/NL6412766A/xx unknown
- 1964-11-04 ES ES0305661A patent/ES305661A1/en not_active Expired
- 1964-11-04 CH CH1426464A patent/CH482648A/en not_active IP Right Cessation
- 1964-11-04 BE BE655245D patent/BE655245A/xx unknown
- 1964-11-04 DE DE19641518207 patent/DE1518207B1/en active Pending
- 1964-11-05 SE SE13334/64A patent/SE317669B/xx unknown
- 1964-11-05 AT AT938664A patent/AT269832B/en active
- 1964-11-05 DK DK546064AA patent/DK127726B/en unknown
- 1964-11-05 JP JP39062253A patent/JPS4821102B1/ja active Pending
- 1964-11-05 AT AT586167A patent/AT273066B/en active
- 1964-11-05 AT AT586267A patent/AT266812B/en active
- 1964-11-05 BR BR164004/64A patent/BR6464004D0/en unknown
- 1964-11-05 FI FI2317/64A patent/FI43069B/fi active
- 1964-11-05 LU LU47291D patent/LU47291A1/xx unknown
-
1965
- 1965-02-04 FR FR4378A patent/FR4554M/fr not_active Expired
- 1965-02-04 FR FR4380A patent/FR4555M/fr not_active Expired
- 1965-02-04 FR FR4379A patent/FR4217M/fr not_active Expired
- 1965-02-04 FR FR4377A patent/FR4282M/fr not_active Expired
-
1967
- 1967-03-02 JP JP42012912A patent/JPS507598B1/ja active Pending
-
1969
- 1969-01-23 NL NL6901128A patent/NL6901128A/xx unknown
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0015604A1 (en) * | 1979-03-05 | 1980-09-17 | Shell Internationale Researchmaatschappij B.V. | Compounds and compositions for use in inhibition of lipogenesis in mammals |
| US7622589B2 (en) | 2005-03-17 | 2009-11-24 | Pfizer Inc. | Substituted sulfonylaminoarylmethyl cyclopropanecarboxamide as VR1 receptor antagonists |
| US7915448B2 (en) * | 2005-03-17 | 2011-03-29 | Pfizer Inc. | Substituted sulfonylaminoarylmethyl cyclopropanecarboxamide as VR1 receptor antagonists |
| US8063215B2 (en) | 2007-08-22 | 2011-11-22 | Astrazeneca Ab | Cyclopropyl amide derivatives |
| US9029381B2 (en) | 2007-08-22 | 2015-05-12 | Astrazeneca Ab | Cyclopropyl amide derivatives |
| US8993577B2 (en) | 2009-02-20 | 2015-03-31 | Astrazeneca Ab | Cyclopropyl amide derivatives |
| US9012452B2 (en) | 2010-02-18 | 2015-04-21 | Astrazeneca Ab | Processes for making cyclopropyl amide derivatives and intermediates associated therewith |
Also Published As
| Publication number | Publication date |
|---|---|
| FR4555M (en) | 1966-11-02 |
| CH482648A (en) | 1969-12-15 |
| NL6901128A (en) | 1969-04-25 |
| DK127726B (en) | 1973-12-24 |
| FR4217M (en) | 1966-06-13 |
| NL128365C (en) | |
| AT266812B (en) | 1968-12-10 |
| ES305661A1 (en) | 1965-05-01 |
| FR4554M (en) | 1966-11-02 |
| AT269832B (en) | 1969-04-10 |
| LU47291A1 (en) | 1965-11-05 |
| FI43069B (en) | 1970-10-01 |
| SE317669B (en) | 1969-11-24 |
| JPS4821102B1 (en) | 1973-06-26 |
| AT273066B (en) | 1969-07-25 |
| BR6464004D0 (en) | 1973-08-09 |
| NL6412766A (en) | 1965-05-06 |
| GB1086191A (en) | 1967-10-04 |
| BE655245A (en) | 1965-05-04 |
| FR4282M (en) | 1966-07-11 |
| JPS507598B1 (en) | 1975-03-27 |
| IL22302A (en) | 1968-10-24 |
| DE1518207B1 (en) | 1971-07-01 |
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