GB850298A - ª‡,ª‡[(p-chlorophenyl)-(4-pyridyl)] carbinols and method of preparing same - Google Patents
ª‡,ª‡[(p-chlorophenyl)-(4-pyridyl)] carbinols and method of preparing sameInfo
- Publication number
- GB850298A GB850298A GB30950/57A GB3095057A GB850298A GB 850298 A GB850298 A GB 850298A GB 30950/57 A GB30950/57 A GB 30950/57A GB 3095057 A GB3095057 A GB 3095057A GB 850298 A GB850298 A GB 850298A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carbon atoms
- radical
- chlorobenzoylpyridine
- potentiating
- refluxing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- YMTFKKLFLLAFNI-UHFFFAOYSA-N (4-chlorophenyl)-pyridin-4-ylmethanone Chemical compound C1=CC(Cl)=CC=C1C(=O)C1=CC=NC=C1 YMTFKKLFLLAFNI-UHFFFAOYSA-N 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 abstract 2
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 230000003389 potentiating effect Effects 0.000 abstract 2
- 238000010992 reflux Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- BNTRVUUJBGBGLZ-UHFFFAOYSA-N hydron;pyridine-4-carbonyl chloride;chloride Chemical compound Cl.ClC(=O)C1=CC=NC=C1 BNTRVUUJBGBGLZ-UHFFFAOYSA-N 0.000 abstract 1
- 230000000147 hypnotic effect Effects 0.000 abstract 1
- 229910052740 iodine Chemical group 0.000 abstract 1
- 239000011630 iodine Chemical group 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compounds of the general formula: <FORM:0850298/IV(b)/1> (wherein R represents an alkyl radical of not more than 5 carbon atoms, or phenyl radical or a phenylalkyl radical of not more than 11 carbon atoms) are prepared by refluxing 4-p-chlorobenzoylpyridine with an organomagnesinium halide of the formula X-Mg.-R (wherein X represents chlorine, bromine or iodine). Acid addition salts of the bases are also described. The products are useful for potentiating or prolonging the action of centrally acting drugs (see Group VI). 4-p-Chlorobenzoylpyridine is prepared by refluxing isonicotinic acid chloride hydrochloride with chlorobenzene in the presence of aluminium chloride.ALSO:Pharmaceutical preparations comprise a centrally acting drug of the analgesic, ataraxic, hypnotic or sedative class and, as a potentiating or prolonging agent therefor, a base of the general formula: <FORM:0850298/VI/1> (wherein R represents an alkyl radical of not more than 5 carbon atoms, a phenyl radical, or a phenylalkyl radical of not more than 11 carbon atoms), or a non-toxic pharmaceutically acceptable acid addition salt thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT850298X | 1956-10-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB850298A true GB850298A (en) | 1960-10-05 |
Family
ID=11326941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB30950/57A Expired GB850298A (en) | 1956-10-30 | 1957-10-03 | ª‡,ª‡[(p-chlorophenyl)-(4-pyridyl)] carbinols and method of preparing same |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB850298A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1979000024A1 (en) * | 1977-07-04 | 1979-01-25 | Astra Laekemedel Ab | A novel intermediate for preparation of therapeutically active pyridine compounds |
| US4418065A (en) | 1979-11-16 | 1983-11-29 | Astra Lakemedel Aktiebolag | Halophenyl-pyridyl-allylamine derivatives and use |
| EP1584335A3 (en) * | 2004-04-05 | 2006-02-22 | Laboratorios Del Dr. Esteve, S.A. | Active substance combination comprising a carbinol composition and an opioid |
| WO2005097192A3 (en) * | 2004-04-05 | 2006-03-30 | Esteve Labor Dr | Active substance combination of a carbinol compound and an opioid |
-
1957
- 1957-10-03 GB GB30950/57A patent/GB850298A/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1979000024A1 (en) * | 1977-07-04 | 1979-01-25 | Astra Laekemedel Ab | A novel intermediate for preparation of therapeutically active pyridine compounds |
| US4418065A (en) | 1979-11-16 | 1983-11-29 | Astra Lakemedel Aktiebolag | Halophenyl-pyridyl-allylamine derivatives and use |
| EP1584335A3 (en) * | 2004-04-05 | 2006-02-22 | Laboratorios Del Dr. Esteve, S.A. | Active substance combination comprising a carbinol composition and an opioid |
| WO2005097192A3 (en) * | 2004-04-05 | 2006-03-30 | Esteve Labor Dr | Active substance combination of a carbinol compound and an opioid |
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