GB1056045A - 5-aminoalkyl dibenzodiazepines - Google Patents
5-aminoalkyl dibenzodiazepinesInfo
- Publication number
- GB1056045A GB1056045A GB27502/66A GB2750266A GB1056045A GB 1056045 A GB1056045 A GB 1056045A GB 27502/66 A GB27502/66 A GB 27502/66A GB 2750266 A GB2750266 A GB 2750266A GB 1056045 A GB1056045 A GB 1056045A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydrogen
- alkylene
- alkyl
- compound
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 102000021944 Butyrylcholinesterase Human genes 0.000 abstract 1
- 108010053652 Butyrylcholinesterase Proteins 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002269 analeptic agent Substances 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- -1 dimethylaminopropyl Chemical group 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000012280 lithium aluminium hydride Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/38—[b, e]- or [b, f]-condensed with six-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Agronomy & Crop Science (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
The invention comprises compounds of the formula <FORM:1056045/C2/1> wherein R1 and R2 taken separately are hydrogen or C1- 8 alkyl, or taken together with the nitrogen atom to which they are attached constitute a saturated heterocyclic amino radical -NZ of 5 to 7 nuclear atoms, wherein Z is alkylene, oxaalkylene or thiaalkylene, -CnH2nis alkylene having at least two carbon atoms between the valences, n is 2 to 4 and Y is hydrogen, chlorine, fluorine, trifluoromethyl, C1- 8 alkyl or C1- 8 alkoxy, provided that when Y represents hydrogen, <FORM:1056045/C2/2> does not represent dimethylaminopropyl; acid addition salts thereof; and a process for their preparation comprising reducing a compound of the formula <FORM:1056045/C2/3> with lithium aluminium hydride. Pharmaceutical compositions, active as central nervous system stimulants and pseudocholinesterase inhibitors, for oral or parenteral administration, comprise a compound of the invention together with a pharmaceutical carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22005062A | 1962-08-28 | 1962-08-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1056045A true GB1056045A (en) | 1967-01-25 |
Family
ID=22821844
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB27502/66A Expired GB1056045A (en) | 1962-08-28 | 1963-07-17 | 5-aminoalkyl dibenzodiazepines |
| GB27501/66A Expired GB1056044A (en) | 1962-08-28 | 1963-07-17 | 5,10-disubstituted dibenzodiazepinones |
| GB28318/63A Expired GB1056043A (en) | 1962-08-28 | 1963-07-17 | 5-aminoalkyl dibenzodiazepinones |
| GB27503/66A Expired GB1056046A (en) | 1962-08-28 | 1963-07-17 | Hydrocarbyl n-(aminoalkyl)-n-(2-aminophenyl) anthranilates |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB27501/66A Expired GB1056044A (en) | 1962-08-28 | 1963-07-17 | 5,10-disubstituted dibenzodiazepinones |
| GB28318/63A Expired GB1056043A (en) | 1962-08-28 | 1963-07-17 | 5-aminoalkyl dibenzodiazepinones |
| GB27503/66A Expired GB1056046A (en) | 1962-08-28 | 1963-07-17 | Hydrocarbyl n-(aminoalkyl)-n-(2-aminophenyl) anthranilates |
Country Status (3)
| Country | Link |
|---|---|
| CH (1) | CH441343A (en) |
| FR (1) | FR3073M (en) |
| GB (4) | GB1056045A (en) |
-
1963
- 1963-07-17 GB GB27502/66A patent/GB1056045A/en not_active Expired
- 1963-07-17 GB GB27501/66A patent/GB1056044A/en not_active Expired
- 1963-07-17 GB GB28318/63A patent/GB1056043A/en not_active Expired
- 1963-07-17 GB GB27503/66A patent/GB1056046A/en not_active Expired
- 1963-08-15 CH CH1007863A patent/CH441343A/en unknown
- 1963-11-26 FR FR955056A patent/FR3073M/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| GB1056046A (en) | 1967-01-25 |
| FR3073M (en) | 1965-01-18 |
| GB1056044A (en) | 1967-01-25 |
| CH441343A (en) | 1967-08-15 |
| GB1056043A (en) | 1967-01-25 |
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