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GB1112334A - Improvements in or relating to isoquinolo[2,1-d]benzo[1,4]diazepine derivatives - Google Patents

Improvements in or relating to isoquinolo[2,1-d]benzo[1,4]diazepine derivatives

Info

Publication number
GB1112334A
GB1112334A GB36070/65A GB3607065A GB1112334A GB 1112334 A GB1112334 A GB 1112334A GB 36070/65 A GB36070/65 A GB 36070/65A GB 3607065 A GB3607065 A GB 3607065A GB 1112334 A GB1112334 A GB 1112334A
Authority
GB
United Kingdom
Prior art keywords
formula
chloro
optically active
dihydroisoquinoline
nitrophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB36070/65A
Inventor
Hans Ott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US388237A external-priority patent/US3369290A/en
Priority claimed from US478351A external-priority patent/US3383760A/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB1112334A publication Critical patent/GB1112334A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10D—INORGANIC ELECTRIC SEMICONDUCTOR DEVICES
    • H10D99/00—Subject matter not provided for in other groups of this subclass
    • H10P10/12—
    • H10P54/00—
    • H10P95/00—
    • H10W10/011—
    • H10W10/014—
    • H10W10/019—
    • H10W10/10—
    • H10W10/17—
    • H10W20/40—
    • H10W20/497—
    • H10W74/131—
    • H10W74/43—
    • H10W90/00—
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Die Bonding (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Rectifiers (AREA)
  • Thyristors (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Racemic and optically active compounds of the general formula <FORM:1112334/C2/1> (in which R represents a hydrogen atom or C1- 4 alkyl radical) and their acid addition salts are prepared by subjecting a compound of the formula <FORM:1112334/C2/2> to intramolecular ring closure, optionally followed by salt formation and/or resolution. The racemic and optically active starting materials are prepared by autoclaving I-(21 - chloro - 51 - nitrophenyl) - 3,4 - dihydroisoquinoline with RNH2 in the presence of cuprous chloride and copper powder, reducing the resulting compound of the formula <FORM:1112334/C2/3> with sodium borohydride and, if desired, resolving the product of the formula <FORM:1112334/C2/4> heating the racemate or optically active isomer with a C1- 4 alkyl bromoacetate or chloroacetate and saponifying the resulting compound of the formula <FORM:1112334/C2/5> (in which R1 represents a C1- 4 alkyl radical). The preparation of N-(b -phenethyl)-2-chloro-5-nitrobenzamide and 1-(21-chloro-51-nitrophenyl) -3,4-dihydroisoquinoline is described. Some of the compounds of the invention may be used as sedatives, sedative-hypnotics, tranquillizers, muscle relaxants, anticonvulsants and for the relief of anxiety, some are hypotensive agents and some are anti-inflammatory agents. They may be administered in the form of pharmaceutical preparations containing them together with a carrier.
GB36070/65A 1964-08-07 1965-08-23 Improvements in or relating to isoquinolo[2,1-d]benzo[1,4]diazepine derivatives Expired GB1112334A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US388237A US3369290A (en) 1964-08-07 1964-08-07 Method of making passivated semiconductor devices
US39173264A 1964-08-24 1964-08-24
US46255765A 1965-06-09 1965-06-09
US47797665A 1965-08-06 1965-08-06
US478351A US3383760A (en) 1965-08-09 1965-08-09 Method of making semiconductor devices

Publications (1)

Publication Number Publication Date
GB1112334A true GB1112334A (en) 1968-05-01

Family

ID=27541415

Family Applications (7)

Application Number Title Priority Date Filing Date
GB32673/65A Expired GB1084598A (en) 1964-08-07 1965-07-30 A method of making passivated semiconductor devices
GB3327/68A Expired GB1126353A (en) 1964-08-07 1965-08-13 Isoquinolinobenzodiazepine derivatives
GB34751/65A Expired GB1126352A (en) 1964-08-07 1965-08-13 Isoquinolinobenzodiazepine derivatives
GB3328/68A Expired GB1126354A (en) 1964-08-07 1965-08-13 Novel tetrahydroisoquinoline derivatives
GB36070/65A Expired GB1112334A (en) 1964-08-07 1965-08-23 Improvements in or relating to isoquinolo[2,1-d]benzo[1,4]diazepine derivatives
GB22856/66A Expired GB1133376A (en) 1964-08-07 1966-05-23 Semiconductor device and method of making same
GB30882/66A Expired GB1120488A (en) 1964-08-07 1966-07-08 A method of making semiconductor devices

Family Applications Before (4)

Application Number Title Priority Date Filing Date
GB32673/65A Expired GB1084598A (en) 1964-08-07 1965-07-30 A method of making passivated semiconductor devices
GB3327/68A Expired GB1126353A (en) 1964-08-07 1965-08-13 Isoquinolinobenzodiazepine derivatives
GB34751/65A Expired GB1126352A (en) 1964-08-07 1965-08-13 Isoquinolinobenzodiazepine derivatives
GB3328/68A Expired GB1126354A (en) 1964-08-07 1965-08-13 Novel tetrahydroisoquinoline derivatives

Family Applications After (2)

Application Number Title Priority Date Filing Date
GB22856/66A Expired GB1133376A (en) 1964-08-07 1966-05-23 Semiconductor device and method of making same
GB30882/66A Expired GB1120488A (en) 1964-08-07 1966-07-08 A method of making semiconductor devices

Country Status (17)

Country Link
BE (1) BE668687A (en)
BG (1) BG17566A3 (en)
BR (4) BR6572393D0 (en)
CA (1) CA953297A (en)
CH (5) CH460033A (en)
CY (1) CY613A (en)
DE (3) DE1514363B1 (en)
ES (1) ES337005A1 (en)
FI (1) FI46968C (en)
FR (2) FR4985M (en)
GB (7) GB1084598A (en)
IL (1) IL24214A (en)
MC (1) MC542A1 (en)
MY (1) MY7100223A (en)
NL (4) NL6510287A (en)
NO (1) NO120580B (en)
SE (5) SE312863B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5116264B2 (en) 1971-10-01 1976-05-22
FR2328286A1 (en) 1975-10-14 1977-05-13 Thomson Csf PROCESS FOR MANUFACTURING SEMICONDUCTOR DEVICES WITH VERY LOW THERMAL RESISTANCE, AND DEVICES OBTAINED BY THIS PROCEDURE
EP0603971A3 (en) * 1992-12-23 1995-06-28 Koninkl Philips Electronics Nv Semiconductor device with passivated sides and method for manufacturing it.
EP0603973A3 (en) * 1992-12-23 1995-06-28 Philips Electronics Nv Semiconductor component having p-n junctions separated by trenches and its manufacturing process.
US5401690A (en) * 1993-07-08 1995-03-28 Goodark Electronic Corp. Method for making circular diode chips through glass passivation
GB201111217D0 (en) 2011-07-01 2011-08-17 Ash Gaming Ltd A system and method
US9570542B2 (en) * 2014-04-01 2017-02-14 Infineon Technologies Ag Semiconductor device including a vertical edge termination structure and method of manufacturing

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2865082A (en) * 1953-07-16 1958-12-23 Sylvania Electric Prod Semiconductor mount and method
NL255453A (en) * 1960-02-04
NL284599A (en) * 1961-05-26 1900-01-01

Also Published As

Publication number Publication date
NO120580B (en) 1970-11-09
GB1126353A (en) 1968-09-05
GB1126352A (en) 1968-09-05
GB1126354A (en) 1968-09-05
MY7100223A (en) 1971-12-31
CH460008A (en) 1968-07-31
NL6611133A (en) 1967-02-10
BG17566A3 (en) 1973-11-10
DE1620295C3 (en) 1975-05-22
SE350500B (en) 1972-10-30
NL6607936A (en) 1966-12-12
CH460007A (en) 1968-07-31
BR6572393D0 (en) 1973-08-14
DE1620295B2 (en) 1974-10-03
GB1084598A (en) 1967-09-27
SE345040B (en) 1972-05-08
DE1564537B2 (en) 1973-01-25
ES337005A1 (en) 1968-01-16
BR6681707D0 (en) 1973-09-06
FI46968C (en) 1973-08-10
DE1564537A1 (en) 1970-07-30
CH466298A (en) 1968-12-15
CY613A (en) 1971-10-01
SE312863B (en) 1969-07-28
BR6680263D0 (en) 1973-03-01
DE1514363B1 (en) 1970-06-18
CA953297A (en) 1974-08-20
FI46968B (en) 1973-05-02
GB1133376A (en) 1968-11-13
CH460031A (en) 1968-07-31
NL129867C (en) 1900-01-01
BE668687A (en) 1966-02-23
SE322227B (en) 1970-04-06
NL6510287A (en) 1966-02-08
GB1120488A (en) 1968-07-17
DE1620294A1 (en) 1970-02-05
FR4985M (en) 1967-04-10
CH460033A (en) 1968-07-31
IL24214A (en) 1969-06-25
BR6572394D0 (en) 1973-08-14
FR5364M (en) 1967-09-11
SE351641B (en) 1972-12-04
MC542A1 (en) 1966-04-06
DE1620295A1 (en) 1970-02-19

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