GB1046770A - Therapeutic composition containing mycelial matter - Google Patents
Therapeutic composition containing mycelial matterInfo
- Publication number
- GB1046770A GB1046770A GB1916863A GB1916863A GB1046770A GB 1046770 A GB1046770 A GB 1046770A GB 1916863 A GB1916863 A GB 1916863A GB 1916863 A GB1916863 A GB 1916863A GB 1046770 A GB1046770 A GB 1046770A
- Authority
- GB
- United Kingdom
- Prior art keywords
- protoplasm
- mycelium
- mycelial
- polynucleotide
- instructional
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- 210000000805 cytoplasm Anatomy 0.000 abstract 3
- 239000002157 polynucleotide Substances 0.000 abstract 3
- 102000040430 polynucleotide Human genes 0.000 abstract 3
- 108091033319 polynucleotide Proteins 0.000 abstract 3
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 241000228212 Aspergillus Species 0.000 abstract 1
- 241000235342 Saccharomycetes Species 0.000 abstract 1
- 241000187747 Streptomyces Species 0.000 abstract 1
- 241000221566 Ustilago Species 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 210000002421 cell wall Anatomy 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 238000009877 rendering Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/06—Lysis of microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
An acid-insoluble instructional oligopoly-nucleotide is obtained from the mycelium of Streptomyces, Pencillium, Aspergillus, Zygomycetes, Saccharomycetes or Ustilago by (a) rendering the mycelium non-viable (b) disrupting the cell walls of the non-viable mycelium to obtain access to the polynucleotide-containing mycelial protoplasm, and (c) effecting a partial depolymerization of the polynucleotide components contained in the mycelial protoplasm to give oligopolynucleotides having molecular weights in the range 600-1, 000, 000; the pH of the aqueous medium in which any of the steps (a), (b) and (c) may be carried out being in the range 2.7 to 11.3 to avoid disorganization of the instructional nucleotide sequence of the polynucleotide components contained in the protoplasm. Thereapeutical compositions for oral or parenteral administration to humans and animal comprises an acid-insoluble oligopolynucleotide as above.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1916863A GB1046770A (en) | 1963-05-14 | 1963-05-14 | Therapeutic composition containing mycelial matter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1916863A GB1046770A (en) | 1963-05-14 | 1963-05-14 | Therapeutic composition containing mycelial matter |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1046770A true GB1046770A (en) | 1966-10-26 |
Family
ID=10124885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1916863A Expired GB1046770A (en) | 1963-05-14 | 1963-05-14 | Therapeutic composition containing mycelial matter |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1046770A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1617659A1 (en) * | 1966-12-23 | 1971-04-01 | Merck & Co Inc | Polynucleotides which are effective as compounds inducing interferon production in living animal cells |
| US4154821A (en) * | 1977-01-27 | 1979-05-15 | Roussel Uclaf | Novel glycoproteins |
| US4157278A (en) * | 1977-03-22 | 1979-06-05 | Glaxo Laboratories Limited | Immunostimulatory agents |
| EP0107161A3 (en) * | 1982-10-26 | 1984-06-06 | Cta Finanz Ag | Device and process for optimising the tissue mass of organs within the genetic fluctuation range in humans and animals |
-
1963
- 1963-05-14 GB GB1916863A patent/GB1046770A/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1617659A1 (en) * | 1966-12-23 | 1971-04-01 | Merck & Co Inc | Polynucleotides which are effective as compounds inducing interferon production in living animal cells |
| US4154821A (en) * | 1977-01-27 | 1979-05-15 | Roussel Uclaf | Novel glycoproteins |
| US4157278A (en) * | 1977-03-22 | 1979-06-05 | Glaxo Laboratories Limited | Immunostimulatory agents |
| EP0107161A3 (en) * | 1982-10-26 | 1984-06-06 | Cta Finanz Ag | Device and process for optimising the tissue mass of organs within the genetic fluctuation range in humans and animals |
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