FR2919285B1 - Derives de 1-oxo-isoindoline-4-carboxamides et de 1-oxo- 1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur preparation et leur application en therapeutique. - Google Patents

Derives de 1-oxo-isoindoline-4-carboxamides et de 1-oxo- 1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur preparation et leur application en therapeutique.

Info

Publication number: FR2919285B1
Authority: FR; France
Prior art keywords: oxo; carboxamide; tetrahydroisoquinoleine; isoindoline; preparation
Prior art date: 2007-07-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

FR0705499A

Other languages

English (en)

Other versions

FR2919285A1 (fr

Inventor

Bernard Baudoin

Michel Evers

Borella Arielle Genevois

Andreas Karlsson

Jean Luc Malleron

Magali Mathieu

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi Aventis France

Original Assignee

Sanofi Aventis France

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-07-27

Filing date

2007-07-27

Publication date

2012-08-31

2007-07-27 Priority to FR0705499A priority Critical patent/FR2919285B1/fr

2007-07-27 Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France

2008-07-25 Priority to NZ582873A priority patent/NZ582873A/en

2008-07-25 Priority to CN2008801045290A priority patent/CN101790514B/zh

2008-07-25 Priority to PCT/FR2008/001110 priority patent/WO2009044019A2/fr

2008-07-25 Priority to MYPI20100428 priority patent/MY150436A/en

2008-07-25 Priority to CA2694322A priority patent/CA2694322A1/fr

2008-07-25 Priority to KR1020107004339A priority patent/KR20100051830A/ko

2008-07-25 Priority to BRPI0813624A priority patent/BRPI0813624A2/pt

2008-07-25 Priority to AU2008306763A priority patent/AU2008306763B2/en

2008-07-25 Priority to MX2010001079A priority patent/MX2010001079A/es

2008-07-25 Priority to SG2012055539A priority patent/SG183082A1/en

2008-07-25 Priority to EA201070197A priority patent/EA201070197A1/ru

2008-07-25 Priority to EP08835551A priority patent/EP2185511A2/fr

2008-07-25 Priority to HK10109764.3A priority patent/HK1143163B/xx

2008-07-25 Priority to JP2010517453A priority patent/JP5412428B2/ja

2009-01-30 Publication of FR2919285A1 publication Critical patent/FR2919285A1/fr

2010-01-26 Priority to ZA2010/00582A priority patent/ZA201000582B/en

2010-01-26 Priority to US12/693,597 priority patent/US8372864B2/en

2010-01-26 Priority to CO10007698A priority patent/CO6290678A2/es

2010-02-24 Priority to MA32652A priority patent/MA31635B1/fr

2012-08-31 Application granted granted Critical

2012-08-31 Publication of FR2919285B1 publication Critical patent/FR2919285B1/fr

Status Expired - Fee Related legal-status Critical Current

2027-07-27 Anticipated expiration legal-status Critical

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

FR0705499A 2007-07-27 2007-07-27 Derives de 1-oxo-isoindoline-4-carboxamides et de 1-oxo- 1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur preparation et leur application en therapeutique. Expired - Fee Related FR2919285B1 (fr)

Priority Applications (19)

Application Number	Priority Date	Filing Date	Title
FR0705499A FR2919285B1 (fr)	2007-07-27	2007-07-27	Derives de 1-oxo-isoindoline-4-carboxamides et de 1-oxo- 1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur preparation et leur application en therapeutique.
EA201070197A EA201070197A1 (ru)	2007-07-27	2008-07-25	Производные 1-оксо-изоиндолин-4-карбоксамидов и 1-оксо-1,2,3,4-тетрагидроизохинолин-5-карбоксамидов, способ их получения и применение в терапии
PCT/FR2008/001110 WO2009044019A2 (fr)	2007-07-27	2008-07-25	Dérivés de 1-oxo-isoindoline-4-carboxamides et de 1-oxo-1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur préparation et leur application en thérapeutique
MYPI20100428 MY150436A (en)	2007-07-27	2008-07-25	1-oxo-isoindoline-4-carboxamide and 1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide derivatives, preparation and therapeutic use thereof
CA2694322A CA2694322A1 (fr)	2007-07-27	2008-07-25	Derives de 1-oxo-isoindoline-4-carboxamides et de 1-oxo-1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur preparation et leur application en therapeutique
KR1020107004339A KR20100051830A (ko)	2007-07-27	2008-07-25	１-옥소-이소인돌린-４-카르복스아미드 및 １-옥소-１,２,３,４-테트라히드로이소퀴놀린-５-카르복스아미드 유도체, 그의 제조 및 치료적 용도
BRPI0813624A BRPI0813624A2 (pt)	2007-07-27	2008-07-25	derivados de 1-oxo-isoindolina-4-carboxamidas e de 1-oxo-1,2,3,4-tetra-hidroisoquinoleína-5-carboxamidas, o respectivo preparo e a respectiva aplicação em terapêutica.
HK10109764.3A HK1143163B (en)	2007-07-27	2008-07-25	1-oxo-isoindoline-4-carboxamide and 1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide derivatives, preparation and therapeutic use thereof
CN2008801045290A CN101790514B (zh)	2007-07-27	2008-07-25	1-氧代-异二氢吲哚-4-甲酰胺和1-氧代-1,2,3,4-四氢异喹啉-5-甲酰胺衍生物、其制备和治疗用途
SG2012055539A SG183082A1 (en)	2007-07-27	2008-07-25	1-oxo-isoindoline-4-carboxamide and 1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide derivatives, preparation and therapeutic use thereof
NZ582873A NZ582873A (en)	2007-07-27	2008-07-25	1-oxo-isoindoline-4-carboxamide and 1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide derivatives, preparation and therapeutic use thereof
MX2010001079A MX2010001079A (es)	2007-07-27	2008-07-25	Derivados de 1-oxo-isoindolina-4-carboxamidas y de 1-oxo-1,2,3,4-tetrahidroisoquinoleina-5-carboxamidas, su preparacion y su aplicacion en terapeutica.
AU2008306763A AU2008306763B2 (en)	2007-07-27	2008-07-25	1-oxo-isoindoline-4-carboxamide and 1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide derivatives, preparation and therapeutic use thereof
JP2010517453A JP5412428B2 (ja)	2007-07-27	2008-07-25	１−オキソ−イソインドリン−４−カルボキサミドおよび１−オキソ−１，２，３，４−テトラヒドロイソキノリン−５−カルボキサミド誘導体、それらの調製および治療上の使用
EP08835551A EP2185511A2 (fr)	2007-07-27	2008-07-25	Dérivés de 1-oxo-isoindoline-4-carboxamides et de 1-oxo-1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur préparation et leur application en thérapeutique
ZA2010/00582A ZA201000582B (en)	2007-07-27	2010-01-26	1-oxo-isoindoline-4-carboxamide and 1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide derivatives,preparation and therapeutic use thereof
US12/693,597 US8372864B2 (en)	2007-07-27	2010-01-26	1-oxo-isoindoline-4-carboxamide and 1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide derivatives, preparation and therapeutic use thereof
CO10007698A CO6290678A2 (es)	2007-07-27	2010-01-26	Derivados de 1-oxo-isoindolina-4-carboxamidas y de 1-oxo-1,2,3,4-tetrahidroisoquinoleina-5-carboxamidas su preparacion y su aplicacion en terapeutica
MA32652A MA31635B1 (fr)	2007-07-27	2010-02-24	Dérivés de 1-oxo-isoindoline-4-carboxamides et de 1-oxo-1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur préparation et leur application en thérapeutique

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0705499A FR2919285B1 (fr)	2007-07-27	2007-07-27	Derives de 1-oxo-isoindoline-4-carboxamides et de 1-oxo- 1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur preparation et leur application en therapeutique.

Publications (2)

Publication Number	Publication Date
FR2919285A1 FR2919285A1 (fr)	2009-01-30
FR2919285B1 true FR2919285B1 (fr)	2012-08-31

Family

ID=39092246

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR0705499A Expired - Fee Related FR2919285B1 (fr)	2007-07-27	2007-07-27	Derives de 1-oxo-isoindoline-4-carboxamides et de 1-oxo- 1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur preparation et leur application en therapeutique.

Country Status (18)

Country	Link
US (1)	US8372864B2 (fr)
EP (1)	EP2185511A2 (fr)
JP (1)	JP5412428B2 (fr)
KR (1)	KR20100051830A (fr)
CN (1)	CN101790514B (fr)
AU (1)	AU2008306763B2 (fr)
BR (1)	BRPI0813624A2 (fr)
CA (1)	CA2694322A1 (fr)
CO (1)	CO6290678A2 (fr)
EA (1)	EA201070197A1 (fr)
FR (1)	FR2919285B1 (fr)
MA (1)	MA31635B1 (fr)
MX (1)	MX2010001079A (fr)
MY (1)	MY150436A (fr)
NZ (1)	NZ582873A (fr)
SG (1)	SG183082A1 (fr)
WO (1)	WO2009044019A2 (fr)
ZA (1)	ZA201000582B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2014520776A (ja)	2011-07-04	2014-08-25	バイエル・インテレクチユアル・プロパテイー・ゲー・エム・ベー・ハー	植物における非生物的ストレスに対する活性薬剤としての置換されているイソキノリノン類、イソキノリンジオン類、イソキノリントリオン類およびジヒドロイソキノリノン類または各場合でのそれらの塩の使用
CN105254554B (zh) *	2014-07-14	2018-01-30	南开大学	一种制备异吲哚啉酮类化合物的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0846112A1 (fr) *	1995-08-25	1998-06-10	E.I. Du Pont De Nemours And Company	Herbicides bicycliques
DE10018449A1 (de)	2000-04-14	2001-11-22	Top Caredent Ag Zuerich	Vorrichtung zum Darbieten von Gerätschaften der Dentalhygiene
IL161881A0 (en) *	2001-11-08	2005-11-20	Upjohn Co	N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives
GB0228410D0 (en) *	2002-12-05	2003-01-08	Glaxo Group Ltd	Novel Compounds
GB0305918D0 (en) *	2003-03-14	2003-04-23	Glaxo Group Ltd	Novel compounds
GB0309221D0 (en)	2003-04-23	2003-06-04	Glaxo Group Ltd	Novel compounds
GB0328900D0 (en)	2003-12-12	2004-01-14	Glaxo Group Ltd	Novel compounds
US7745470B2 (en)	2005-03-10	2010-06-29	Bristol-Myers Squibb Company	Isophthalates as beta-secretase inhibitors
GB0506562D0 (en)	2005-03-31	2005-05-04	Glaxo Group Ltd	Novel compounds
FR2919286A1 (fr) *	2007-07-27	2009-01-30	Sanofi Aventis Sa	Derives de derives de 1-oxo-1,2-dihydroisoquinoleine-5- carboxamides et de 4-oxo-3,4-dihydroquinazoline-8- carboxamides,leur preparation et leur application en therapeutique.
RS51912B (sr) *	2007-07-27	2012-02-29	Sanofi	DERIVATI 1,2,3,4-TETRAHIDROPIROLO(1,2-a)PIRAZIN-6-KARBOKSAMIDA I 2,3,4,5-TETRAHIDROPIROLO(1,2-a)(1,4)-DIAZEPIN-7-KARBOKSAMIDA NJIHOVO DOBIJANJE I TERAPEUTSKA PRIMENA

2007
- 2007-07-27 FR FR0705499A patent/FR2919285B1/fr not_active Expired - Fee Related
2008
- 2008-07-25 CN CN2008801045290A patent/CN101790514B/zh not_active Expired - Fee Related
- 2008-07-25 WO PCT/FR2008/001110 patent/WO2009044019A2/fr not_active Ceased
- 2008-07-25 NZ NZ582873A patent/NZ582873A/en not_active IP Right Cessation
- 2008-07-25 CA CA2694322A patent/CA2694322A1/fr not_active Abandoned
- 2008-07-25 JP JP2010517453A patent/JP5412428B2/ja not_active Expired - Fee Related
- 2008-07-25 AU AU2008306763A patent/AU2008306763B2/en not_active Ceased
- 2008-07-25 MX MX2010001079A patent/MX2010001079A/es active IP Right Grant
- 2008-07-25 EP EP08835551A patent/EP2185511A2/fr not_active Ceased
- 2008-07-25 KR KR1020107004339A patent/KR20100051830A/ko not_active Ceased
- 2008-07-25 MY MYPI20100428 patent/MY150436A/en unknown
- 2008-07-25 SG SG2012055539A patent/SG183082A1/en unknown
- 2008-07-25 EA EA201070197A patent/EA201070197A1/ru unknown
- 2008-07-25 BR BRPI0813624A patent/BRPI0813624A2/pt not_active IP Right Cessation
2010
- 2010-01-26 US US12/693,597 patent/US8372864B2/en not_active Expired - Fee Related
- 2010-01-26 ZA ZA2010/00582A patent/ZA201000582B/en unknown
- 2010-01-26 CO CO10007698A patent/CO6290678A2/es not_active Application Discontinuation
- 2010-02-24 MA MA32652A patent/MA31635B1/fr unknown

Also Published As

Publication number	Publication date
MY150436A (en)	2014-01-30
EP2185511A2 (fr)	2010-05-19
WO2009044019A3 (fr)	2009-06-18
AU2008306763A1 (en)	2009-04-09
CN101790514A (zh)	2010-07-28
JP5412428B2 (ja)	2014-02-12
KR20100051830A (ko)	2010-05-18
BRPI0813624A2 (pt)	2019-09-24
US20100197725A1 (en)	2010-08-05
WO2009044019A9 (fr)	2010-10-14
MA31635B1 (fr)	2010-08-02
AU2008306763B2 (en)	2013-08-29
CA2694322A1 (fr)	2009-04-09
FR2919285A1 (fr)	2009-01-30
WO2009044019A2 (fr)	2009-04-09
SG183082A1 (en)	2012-08-30
HK1143163A1 (en)	2010-12-24
CO6290678A2 (es)	2011-06-20
CN101790514B (zh)	2012-12-19
NZ582873A (en)	2012-07-27
US8372864B2 (en)	2013-02-12
JP2010534641A (ja)	2010-11-11
MX2010001079A (es)	2010-03-24
EA201070197A1 (ru)	2010-08-30
ZA201000582B (en)	2011-04-28

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