MX2010001079A - Derivados de 1-oxo-isoindolina-4-carboxamidas y de 1-oxo-1,2,3,4-tetrahidroisoquinoleina-5-carboxamidas, su preparacion y su aplicacion en terapeutica. - Google Patents
Derivados de 1-oxo-isoindolina-4-carboxamidas y de 1-oxo-1,2,3,4-tetrahidroisoquinoleina-5-carboxamidas, su preparacion y su aplicacion en terapeutica.Info
- Publication number
- MX2010001079A MX2010001079A MX2010001079A MX2010001079A MX2010001079A MX 2010001079 A MX2010001079 A MX 2010001079A MX 2010001079 A MX2010001079 A MX 2010001079A MX 2010001079 A MX2010001079 A MX 2010001079A MX 2010001079 A MX2010001079 A MX 2010001079A
- Authority
- MX
- Mexico
- Prior art keywords
- oxo
- alkyl
- carboxamide
- isoindoline
- nr7r8
- Prior art date
Links
- SYNWVHZFMKIQRS-UHFFFAOYSA-N 1-oxo-2,3-dihydroisoindole-4-carboxamide Chemical compound NC(=O)C1=CC=CC2=C1CNC2=O SYNWVHZFMKIQRS-UHFFFAOYSA-N 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 229910020008 S(O) Inorganic materials 0.000 abstract 4
- -1 C1-C6alkoxy Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 abstract 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000006728 (C1-C6) alkynyl group Chemical group 0.000 abstract 1
- ZLCXKZGIKAWAQY-UHFFFAOYSA-N 1-oxo-3,4-dihydro-2h-isoquinoline-5-carboxamide Chemical class O=C1NCCC2=C1C=CC=C2C(=O)N ZLCXKZGIKAWAQY-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
La invención se refiere a los derivados de 1-oxo-isoindolina-4-car boxamidas y de 1-oxo-1,2,3,4-tetrahidroisoquinoleina-5-carboxamida s, de fórmula general (I) en la que R1 representa un átomo de hidrógeno, un grupo alquilo(C1-C6), cicloalquilo(C3-C7) (CH2)n-alquenilo(C1-C6), (CH2)n-alquinilo(C1-C6), alquilo(C1-C6)-Z-alquilo(C1-C6) en el que Z representa un heteroátomo elegido entre O, N y S(O)m, o bien R1 representa un grupo COOR, S(O)mR, un arilo o un aralquilo; R2 representa uno o varios grupos elegidos entre un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo(C1-C6), cicloalquilo(C3-C7), alquenilo(C1-C6), alquinilo(C1-C5), alquilo(C1-C6)-Z-alquilo(C1-C6 ), en el que z representa un heteroátomo elegido entre O, N y S(O)m, o bien R2 representa un grupo haloalquilo(C1-C6), haloalcoxi(C1-C6), hidroxi, alcoxi(C1-C6), nitro, ciano, amino un grupo NR7R8, COOR, CONR7R8, OCOalquilo(C1-C6), S(O)mNR7R8, un grupo arilo, R3 representa un grupo trifluorometilo; R4 y R5 representan, independientemente uno del otro un átomo de hidrógeno, o bien R4 y R5 forman con el átomo de carbono que los llevan un ciclo saturado que contiene de 3 a 6 átomos de carbono y que contiene opcionalmente de O a 1 heteroátomos elegidos entre O, N o S; R6 representa un grupo elegido entre un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo(C1-C5), cicloalquilo(C3-C7), cicloalquilo(C3-C7)-alquilo(C3-C6), un grupo haloalquilo(C1-C6), nitro, amino, un grupo NR7R8, COOR, un grupo NR7(SO2)R8, CONR7R8, un grupo arilo o heterociclo; X representa un grupo alquileno(C1-C2); m representa un número entero comprendido O y n representa un número entero comprendido entre 1y 6. La invención tiene igualmente por objeto un procedimiento de preparación y su aplicación en terapéutica como inhibidores de ß-secretasa para tratar los trastornos neurodegenerativos tales como Alzheimer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0705499A FR2919285B1 (fr) | 2007-07-27 | 2007-07-27 | Derives de 1-oxo-isoindoline-4-carboxamides et de 1-oxo- 1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur preparation et leur application en therapeutique. |
| PCT/FR2008/001110 WO2009044019A2 (fr) | 2007-07-27 | 2008-07-25 | Dérivés de 1-oxo-isoindoline-4-carboxamides et de 1-oxo-1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur préparation et leur application en thérapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010001079A true MX2010001079A (es) | 2010-03-24 |
Family
ID=39092246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010001079A MX2010001079A (es) | 2007-07-27 | 2008-07-25 | Derivados de 1-oxo-isoindolina-4-carboxamidas y de 1-oxo-1,2,3,4-tetrahidroisoquinoleina-5-carboxamidas, su preparacion y su aplicacion en terapeutica. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8372864B2 (es) |
| EP (1) | EP2185511A2 (es) |
| JP (1) | JP5412428B2 (es) |
| KR (1) | KR20100051830A (es) |
| CN (1) | CN101790514B (es) |
| AU (1) | AU2008306763B2 (es) |
| BR (1) | BRPI0813624A2 (es) |
| CA (1) | CA2694322A1 (es) |
| CO (1) | CO6290678A2 (es) |
| EA (1) | EA201070197A1 (es) |
| FR (1) | FR2919285B1 (es) |
| MA (1) | MA31635B1 (es) |
| MX (1) | MX2010001079A (es) |
| MY (1) | MY150436A (es) |
| NZ (1) | NZ582873A (es) |
| SG (1) | SG183082A1 (es) |
| WO (1) | WO2009044019A2 (es) |
| ZA (1) | ZA201000582B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014520776A (ja) | 2011-07-04 | 2014-08-25 | バイエル・インテレクチユアル・プロパテイー・ゲー・エム・ベー・ハー | 植物における非生物的ストレスに対する活性薬剤としての置換されているイソキノリノン類、イソキノリンジオン類、イソキノリントリオン類およびジヒドロイソキノリノン類または各場合でのそれらの塩の使用 |
| CN105254554B (zh) * | 2014-07-14 | 2018-01-30 | 南开大学 | 一种制备异吲哚啉酮类化合物的方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0846112A1 (en) * | 1995-08-25 | 1998-06-10 | E.I. Du Pont De Nemours And Company | Bicyclic herbicides |
| DE10018449A1 (de) | 2000-04-14 | 2001-11-22 | Top Caredent Ag Zuerich | Vorrichtung zum Darbieten von Gerätschaften der Dentalhygiene |
| IL161881A0 (en) * | 2001-11-08 | 2005-11-20 | Upjohn Co | N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives |
| GB0228410D0 (en) * | 2002-12-05 | 2003-01-08 | Glaxo Group Ltd | Novel Compounds |
| GB0305918D0 (en) * | 2003-03-14 | 2003-04-23 | Glaxo Group Ltd | Novel compounds |
| GB0309221D0 (en) | 2003-04-23 | 2003-06-04 | Glaxo Group Ltd | Novel compounds |
| GB0328900D0 (en) | 2003-12-12 | 2004-01-14 | Glaxo Group Ltd | Novel compounds |
| US7745470B2 (en) | 2005-03-10 | 2010-06-29 | Bristol-Myers Squibb Company | Isophthalates as beta-secretase inhibitors |
| GB0506562D0 (en) | 2005-03-31 | 2005-05-04 | Glaxo Group Ltd | Novel compounds |
| FR2919286A1 (fr) * | 2007-07-27 | 2009-01-30 | Sanofi Aventis Sa | Derives de derives de 1-oxo-1,2-dihydroisoquinoleine-5- carboxamides et de 4-oxo-3,4-dihydroquinazoline-8- carboxamides,leur preparation et leur application en therapeutique. |
| RS51912B (sr) * | 2007-07-27 | 2012-02-29 | Sanofi | DERIVATI 1,2,3,4-TETRAHIDROPIROLO(1,2-a)PIRAZIN-6-KARBOKSAMIDA I 2,3,4,5-TETRAHIDROPIROLO(1,2-a)(1,4)-DIAZEPIN-7-KARBOKSAMIDA NJIHOVO DOBIJANJE I TERAPEUTSKA PRIMENA |
-
2007
- 2007-07-27 FR FR0705499A patent/FR2919285B1/fr not_active Expired - Fee Related
-
2008
- 2008-07-25 CN CN2008801045290A patent/CN101790514B/zh not_active Expired - Fee Related
- 2008-07-25 WO PCT/FR2008/001110 patent/WO2009044019A2/fr not_active Ceased
- 2008-07-25 NZ NZ582873A patent/NZ582873A/en not_active IP Right Cessation
- 2008-07-25 CA CA2694322A patent/CA2694322A1/fr not_active Abandoned
- 2008-07-25 JP JP2010517453A patent/JP5412428B2/ja not_active Expired - Fee Related
- 2008-07-25 AU AU2008306763A patent/AU2008306763B2/en not_active Ceased
- 2008-07-25 MX MX2010001079A patent/MX2010001079A/es active IP Right Grant
- 2008-07-25 EP EP08835551A patent/EP2185511A2/fr not_active Ceased
- 2008-07-25 KR KR1020107004339A patent/KR20100051830A/ko not_active Ceased
- 2008-07-25 MY MYPI20100428 patent/MY150436A/en unknown
- 2008-07-25 SG SG2012055539A patent/SG183082A1/en unknown
- 2008-07-25 EA EA201070197A patent/EA201070197A1/ru unknown
- 2008-07-25 BR BRPI0813624A patent/BRPI0813624A2/pt not_active IP Right Cessation
-
2010
- 2010-01-26 US US12/693,597 patent/US8372864B2/en not_active Expired - Fee Related
- 2010-01-26 ZA ZA2010/00582A patent/ZA201000582B/en unknown
- 2010-01-26 CO CO10007698A patent/CO6290678A2/es not_active Application Discontinuation
- 2010-02-24 MA MA32652A patent/MA31635B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MY150436A (en) | 2014-01-30 |
| EP2185511A2 (fr) | 2010-05-19 |
| WO2009044019A3 (fr) | 2009-06-18 |
| AU2008306763A1 (en) | 2009-04-09 |
| CN101790514A (zh) | 2010-07-28 |
| JP5412428B2 (ja) | 2014-02-12 |
| KR20100051830A (ko) | 2010-05-18 |
| BRPI0813624A2 (pt) | 2019-09-24 |
| US20100197725A1 (en) | 2010-08-05 |
| WO2009044019A9 (fr) | 2010-10-14 |
| MA31635B1 (fr) | 2010-08-02 |
| AU2008306763B2 (en) | 2013-08-29 |
| CA2694322A1 (fr) | 2009-04-09 |
| FR2919285A1 (fr) | 2009-01-30 |
| WO2009044019A2 (fr) | 2009-04-09 |
| SG183082A1 (en) | 2012-08-30 |
| HK1143163A1 (en) | 2010-12-24 |
| CO6290678A2 (es) | 2011-06-20 |
| CN101790514B (zh) | 2012-12-19 |
| NZ582873A (en) | 2012-07-27 |
| US8372864B2 (en) | 2013-02-12 |
| JP2010534641A (ja) | 2010-11-11 |
| EA201070197A1 (ru) | 2010-08-30 |
| ZA201000582B (en) | 2011-04-28 |
| FR2919285B1 (fr) | 2012-08-31 |
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