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FR2693195B1 - Dérivés de 2-amino-N-[[[(4-aminocarbonyl)pyrimidin-2-yl]amino]alkyl] pyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique. - Google Patents

Dérivés de 2-amino-N-[[[(4-aminocarbonyl)pyrimidin-2-yl]amino]alkyl] pyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique.

Info

Publication number
FR2693195B1
FR2693195B1 FR9208199A FR9208199A FR2693195B1 FR 2693195 B1 FR2693195 B1 FR 2693195B1 FR 9208199 A FR9208199 A FR 9208199A FR 9208199 A FR9208199 A FR 9208199A FR 2693195 B1 FR2693195 B1 FR 2693195B1
Authority
FR
France
Prior art keywords
amino
aminocarbonyl
pyrimidin
pyrimidine
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9208199A
Other languages
English (en)
Other versions
FR2693195A1 (fr
Inventor
Pascal George
Benoit Marabout
Jacques Froissant
Jean-Pierre Merly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR9208199A priority Critical patent/FR2693195B1/fr
Priority to DE69300162T priority patent/DE69300162T2/de
Priority to AT93401594T priority patent/ATE123025T1/de
Priority to DK93401594.2T priority patent/DK0577470T3/da
Priority to EP93401594A priority patent/EP0577470B1/fr
Priority to ES93401594T priority patent/ES2073951T3/es
Priority to IL106213A priority patent/IL106213A/en
Priority to PL93299541A priority patent/PL172583B1/pl
Priority to US08/084,493 priority patent/US5330985A/en
Priority to MX9303976A priority patent/MX9303976A/es
Priority to RU93033697A priority patent/RU2111963C1/ru
Priority to KR1019930012427A priority patent/KR940005619A/ko
Priority to FI933064A priority patent/FI933064A7/fi
Priority to NO932418A priority patent/NO932418L/no
Priority to CA002099556A priority patent/CA2099556A1/fr
Priority to SK699-93A priority patent/SK69993A3/sk
Priority to CN93108413A priority patent/CN1100416A/zh
Priority to ZA934775A priority patent/ZA934775B/xx
Priority to CZ931351A priority patent/CZ282079B6/cs
Priority to HU9301937A priority patent/HUT65533A/hu
Priority to JP16454493A priority patent/JP3285421B2/ja
Priority to NZ248051A priority patent/NZ248051A/en
Priority to AU41712/93A priority patent/AU660815B2/en
Publication of FR2693195A1 publication Critical patent/FR2693195A1/fr
Application granted granted Critical
Publication of FR2693195B1 publication Critical patent/FR2693195B1/fr
Priority to HU95P/P00445P priority patent/HU211462A9/hu
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR9208199A 1992-07-03 1992-07-03 Dérivés de 2-amino-N-[[[(4-aminocarbonyl)pyrimidin-2-yl]amino]alkyl] pyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique. Expired - Fee Related FR2693195B1 (fr)

Priority Applications (24)

Application Number Priority Date Filing Date Title
FR9208199A FR2693195B1 (fr) 1992-07-03 1992-07-03 Dérivés de 2-amino-N-[[[(4-aminocarbonyl)pyrimidin-2-yl]amino]alkyl] pyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique.
DE69300162T DE69300162T2 (de) 1992-07-03 1993-06-22 2-Amino-N-[[[4-(aminocarbonyl)pyrimidin-2-yl]amino]alkyl]-pyrimidin-4-carbonsäureamidderivate, ihre Herstellung und ihre Anwendung in der Therapeutica.
AT93401594T ATE123025T1 (de) 1992-07-03 1993-06-22 2-amino-n-(((4-(aminocarbonyl)pyrimidin-2- yl>amino>alkyl>-pyrimidin-4- carbonsäureamidderivate, ihre herstellung und ihre anwendung in der therapeutica.
DK93401594.2T DK0577470T3 (da) 1992-07-03 1993-06-22 2-amino-N(((4-(aminocarbonyl)pyrimidin-2-yl)amino)alkyl) pyrimidin-4-carboxamid-derivater, deres fremstilling og deres anvendelse i terapi
EP93401594A EP0577470B1 (fr) 1992-07-03 1993-06-22 Dérivés de 2-amino-N-[[[4-(aminocarbonyl)pyrimidin-2-yl]-amino]alkyl]pyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique
ES93401594T ES2073951T3 (es) 1992-07-03 1993-06-22 Derivados de 2-amino-n-(((4-(aminocarbonil)pirimidin-2-il)amino)alquil)pirimidina-4-carboxamida, su preparacion y su aplicacion en terapeutica.
PL93299541A PL172583B1 (pl) 1992-07-03 1993-07-01 Nowe pochodne N-[(4-aminokarbonylopirymidylo-2)-aminoalkilo] -2-aminopirymidynokarbonamidu-4 i sposób ich wytwarzaniaP L 172583 B1 PL PL PL
US08/084,493 US5330985A (en) 1992-07-03 1993-07-01 2-amino-N-[[4-(aminocarbonyl)pyrimidin-2-yl]amino]-alkyl]pyrimidine-4-carboxamide derivatives, their preparation and pharmaceutical compositions containing them
MX9303976A MX9303976A (es) 1992-07-03 1993-07-01 Derivados de 2-amino-n-{{((4-(aminocarbonil)-pirimidin-2-il-amino)-alquil}-pirimidi n-4-carboxamida, su preparacion y su aplicacion en terapeutica.
IL106213A IL106213A (en) 1992-07-03 1993-07-01 2-amino-n- £££4-(aminocarbonyl) pyrimidin-2-yl| amino| alkyl| pyrimidine- 4-carboxamide derivatives, preparation thereof and pharmaceutical compositions containing them
HU9301937A HUT65533A (en) 1992-07-03 1993-07-02 Process for producing 2-amino-pyrimidine-4-carboxamide derivatives and pharmaceutical preparations containing them
FI933064A FI933064A7 (fi) 1992-07-03 1993-07-02 2-amino-N-(((4-(aminokarbonyyli)pyrimidin2-yyli)amino)alkyyli)pyrimidin-4-karboksamidijohdannaiset, niiden valmistus ja terapeuttinen käyttö
RU93033697A RU2111963C1 (ru) 1992-07-03 1993-07-02 Производные 2-амино-n-[[[4-(аминокарбонил)-пиримидин-2-ил]-амино]алкил]пиримидин-4-карбоксамида или их кислотно-аддитивные соли, способ их получения, фармацевтическая композиция
CA002099556A CA2099556A1 (fr) 1992-07-03 1993-07-02 Derives de 2-amino-n-({¬4-(aminocarbonyl)pyrimidin-2-yl|amino}alkyl)pyrimidine-4-carboxamide; methode de preparation; utilisation comme agent therapeutique
SK699-93A SK69993A3 (en) 1992-07-03 1993-07-02 2-amino-n-[[[4-(aminocarbonyl)pyrimidine-2- -yl]amino]alkyl]pyrimidine-4-carboxamide derivatives, process for their preparation and their pharmaceutical compositions
CN93108413A CN1100416A (zh) 1992-07-03 1993-07-02 嘧啶酰胺衍生物,其制备及其在药物中的应用
ZA934775A ZA934775B (en) 1992-07-03 1993-07-02 2-amino-N-[[[4-(aminocarbonyl) pyrimidin-2-y]amino]alkyl] pyrimidine-4-carboxamide derivatives, preparation thereof and therapeutical application thereof.
CZ931351A CZ282079B6 (cs) 1992-07-03 1993-07-02 Deriváty 2-amino-N-///4-(aminokarbonyl)pyrimidin-2-yl/amino/alkyl/pyrimidin-4-karboxamidu, způsob jejich přípravy a farmaceutické kompozice tyto deriváty obsahující
KR1019930012427A KR940005619A (ko) 1992-07-03 1993-07-02 2-아미노-n-[[[4-(아미노카르보닐)피리미딘-2-일]아미노]알킬]피리미딘-4-카르복시아미드 유도체, 이것의 제법 및 치료에의 이용
JP16454493A JP3285421B2 (ja) 1992-07-03 1993-07-02 ２−アミノ−ｎ−［［［４−（アミノカルボニル）ピリミジン−２−イル］アミノ］アルキル］ピリミジン−４−カルボキシアミド誘導体、その製造および医薬への応用
NZ248051A NZ248051A (en) 1992-07-03 1993-07-02 2-(substituted amino)-n-[[4-(aminocarbonyl) pyrimidin-2-yl]alkyl]pyrimidine-4-carboxamide derivatives; medicaments and preparatory processes
AU41712/93A AU660815B2 (en) 1992-07-03 1993-07-02 2-amino-N-(((4-(aminocarbonyl)pyrimidin-2-yl)amino)alkyl) pyrimidine-4-carboxamide derivatives preparation thereof and therapeutical application thereof
NO932418A NO932418L (no) 1992-07-03 1993-07-02 Pyrimidinderivater, fremgangsmaate for deres fremstilling og terapeutiske anvendelse derav
HU95P/P00445P HU211462A9 (en) 1992-07-03 1995-06-27 2-amino-n-[[[4-(amino-carbonyl)-pyrimidin-2-yl]-amino]-alkyl]-pyrimidine-4-carboxamide derivatives, process for producing them, and pharmaceutical use of them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9208199A FR2693195B1 (fr) 1992-07-03 1992-07-03 Dérivés de 2-amino-N-[[[(4-aminocarbonyl)pyrimidin-2-yl]amino]alkyl] pyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique.

Publications (2)

Publication Number Publication Date
FR2693195A1 FR2693195A1 (fr) 1994-01-07
FR2693195B1 true FR2693195B1 (fr) 1994-09-23

Family

ID=9431485

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9208199A Expired - Fee Related FR2693195B1 (fr) 1992-07-03 1992-07-03 Dérivés de 2-amino-N-[[[(4-aminocarbonyl)pyrimidin-2-yl]amino]alkyl] pyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique.

Country Status (2)

Country Link
FR (1) FR2693195B1 (fr)
ZA (1) ZA934775B (fr)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0696561B2 (ja) * 1985-08-30 1994-11-30 正幸 石川 新規な２−（４−フエニル−１−ピペラジニルアルキル）アミノピリミジン誘導体及びその酸付加塩
JP2814600B2 (ja) * 1989-08-31 1998-10-22 正幸 石川 排尿障害治療剤
CA2024428A1 (fr) * 1989-09-06 1991-03-07 Masayuki Ishikawa Agent pour le traitement de l'obstruction des voies urinaires
FR2656609B1 (fr) * 1989-12-28 1992-03-27 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
FR2667317B1 (fr) * 1990-10-02 1992-12-04 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
FR2693195A1 (fr) 1994-01-07
ZA934775B (en) 1994-01-20

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