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MX9303976A - Derivados de 2-amino-n-{{((4-(aminocarbonil)-pirimidin-2-il-amino)-alquil}-pirimidi n-4-carboxamida, su preparacion y su aplicacion en terapeutica. - Google Patents

Derivados de 2-amino-n-{{((4-(aminocarbonil)-pirimidin-2-il-amino)-alquil}-pirimidi n-4-carboxamida, su preparacion y su aplicacion en terapeutica.

Info

Publication number
MX9303976A
MX9303976A MX9303976A MX9303976A MX9303976A MX 9303976 A MX9303976 A MX 9303976A MX 9303976 A MX9303976 A MX 9303976A MX 9303976 A MX9303976 A MX 9303976A MX 9303976 A MX9303976 A MX 9303976A
Authority
MX
Mexico
Prior art keywords
amino
group
therapeutics
alkyl
pirimidi
Prior art date
Application number
MX9303976A
Other languages
English (en)
Inventor
Pascal George
Benoit Marabout
Jacques Froissant
Jean-Pierre Merly
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9208199A external-priority patent/FR2693195B1/fr
Priority claimed from FR9215037A external-priority patent/FR2699171B1/fr
Application filed by Synthelabo filed Critical Synthelabo
Publication of MX9303976A publication Critical patent/MX9303976A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Compuestos de fórmula general (I): (Ver Fórmula I); en la cual m representa el entero 0 ó 1, R1, representa un grupo metilo, en cuyo caso R2 representa un grupo fenoxi (C1-C4)-alquilo, o entonces R1 y R2 forman juntos, y con el átomo de nitrógeno que los lleva, un grupo 4-fenoxipiperidin-1-ilo, un grupo fenoximetilpiperidin-1-ilo, o un grupo 4-fenilpiperazin-1-ilo, y R3 representa un átomo de hidrógeno o, cuando n es igual a 1, un grupo hidroxi o un grupo metoxi. Se aplica en terapéutica.
MX9303976A 1992-07-03 1993-07-01 Derivados de 2-amino-n-{{((4-(aminocarbonil)-pirimidin-2-il-amino)-alquil}-pirimidi n-4-carboxamida, su preparacion y su aplicacion en terapeutica. MX9303976A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9208199A FR2693195B1 (fr) 1992-07-03 1992-07-03 Dérivés de 2-amino-N-[[[(4-aminocarbonyl)pyrimidin-2-yl]amino]alkyl] pyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique.
FR9215037A FR2699171B1 (fr) 1992-12-14 1992-12-14 Dérivés de 2-amino-N[[[4-aminocarbonyl) pyrimidin-2-yl]amino]alkyl]pyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique.

Publications (1)

Publication Number Publication Date
MX9303976A true MX9303976A (es) 1994-02-28

Family

ID=26229565

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9303976A MX9303976A (es) 1992-07-03 1993-07-01 Derivados de 2-amino-n-{{((4-(aminocarbonil)-pirimidin-2-il-amino)-alquil}-pirimidi n-4-carboxamida, su preparacion y su aplicacion en terapeutica.

Country Status (21)

Country Link
US (1) US5330985A (es)
EP (1) EP0577470B1 (es)
JP (1) JP3285421B2 (es)
KR (1) KR940005619A (es)
CN (1) CN1100416A (es)
AT (1) ATE123025T1 (es)
AU (1) AU660815B2 (es)
CA (1) CA2099556A1 (es)
CZ (1) CZ282079B6 (es)
DE (1) DE69300162T2 (es)
DK (1) DK0577470T3 (es)
ES (1) ES2073951T3 (es)
FI (1) FI933064L (es)
HU (2) HUT65533A (es)
IL (1) IL106213A (es)
MX (1) MX9303976A (es)
NO (1) NO932418L (es)
NZ (1) NZ248051A (es)
PL (1) PL172583B1 (es)
RU (1) RU2111963C1 (es)
SK (1) SK69993A3 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4425143A1 (de) * 1994-07-15 1996-01-18 Basf Ag Substituierte Pyrimidinverbindungen und deren Verwendung
FR2744722B1 (fr) * 1996-02-14 1998-03-13 Synthelabo Devires de 2-((3-(piperazin-1-yl)propyl)amino)pyrimidine-4- carboxamide et leur application en therapeutique
AU3883099A (en) * 1998-05-06 1999-11-23 Duke University Method of treating bladder and lower urinary tract syndromes
AU2005266459A1 (en) * 2004-07-29 2006-02-02 Sanofi-Aventis Pharmaceutical multilayer tablet for controlled release of active ingredients with highly pH-dependent solubility
US9113629B2 (en) * 2013-03-15 2015-08-25 Dow Agrosciences Llc 4-amino-6-(4-substituted-phenyl)-picolinates and 6-amino-2-(4-substituted-phenyl)-pyrimidine-4-carboxylates and their use as herbicides

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2618436B1 (fr) * 1987-07-23 1989-10-27 Synthelabo Derives de piperidine, leur preparation et leur application en therapeutique
JP2814600B2 (ja) * 1989-08-31 1998-10-22 正幸 石川 排尿障害治療剤
JPH078795B2 (ja) * 1989-09-06 1995-02-01 日立化成工業株式会社 排尿障害治療剤
FR2656609B1 (fr) * 1989-12-28 1992-03-27 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
FR2667317B1 (fr) * 1990-10-02 1992-12-04 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
FR2675799B1 (fr) * 1991-04-24 1993-12-24 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
FR2678271B1 (fr) * 1991-06-27 1995-01-13 Synthelabo Derives de pyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
FR2678272B1 (fr) * 1991-06-27 1994-01-14 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
DE69300162T2 (de) 1995-11-02
EP0577470A1 (fr) 1994-01-05
FI933064A0 (fi) 1993-07-02
ATE123025T1 (de) 1995-06-15
HUT65533A (en) 1994-06-28
KR940005619A (ko) 1994-03-21
JP3285421B2 (ja) 2002-05-27
FI933064A7 (fi) 1994-01-04
US5330985A (en) 1994-07-19
DK0577470T3 (da) 1995-10-02
AU660815B2 (en) 1995-07-06
IL106213A0 (en) 1993-11-15
SK69993A3 (en) 1994-04-06
HU9301937D0 (en) 1993-09-28
JPH06100545A (ja) 1994-04-12
NO932418L (no) 1994-01-04
DE69300162D1 (de) 1995-06-29
RU2111963C1 (ru) 1998-05-27
NO932418D0 (no) 1993-07-02
CA2099556A1 (en) 1994-01-04
PL172583B1 (pl) 1997-10-31
IL106213A (en) 1998-02-22
FI933064L (fi) 1994-01-04
NZ248051A (en) 1994-10-26
ES2073951T3 (es) 1995-08-16
CN1100416A (zh) 1995-03-22
CZ135193A3 (en) 1994-02-16
AU4171293A (en) 1994-01-06
PL299541A1 (en) 1994-01-10
EP0577470B1 (fr) 1995-05-24
CZ282079B6 (cs) 1997-05-14
HU211462A9 (en) 1995-11-28

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Legal Events

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MM Annulment or lapse due to non-payment of fees