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FI972194L - Nya benzylpyrimidiner - Google Patents

Nya benzylpyrimidiner Download PDF

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Publication number
FI972194L
FI972194L FI972194A FI972194A FI972194L FI 972194 L FI972194 L FI 972194L FI 972194 A FI972194 A FI 972194A FI 972194 A FI972194 A FI 972194A FI 972194 L FI972194 L FI 972194L
Authority
FI
Finland
Prior art keywords
benzylpyrimidines
new
new benzylpyrimidines
Prior art date
Application number
FI972194A
Other languages
English (en)
Finnish (fi)
Other versions
FI972194A7 (sv
FI972194A0 (sv
Inventor
Philippe Guerry
Synese Jolidon
Raffaello Masciadri
Henri Stalder
Rudolf Then
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI972194A7 publication Critical patent/FI972194A7/sv
Publication of FI972194L publication Critical patent/FI972194L/sv
Publication of FI972194A0 publication Critical patent/FI972194A0/sv

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48Two nitrogen atoms
    • C07D239/49Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509Six-membered rings
    • C07F9/6512Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Liquid Crystal Substances (AREA)
FI972194A 1994-11-24 1995-11-13 Nya benzylpyrimidiner FI972194A0 (sv)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH353694 1994-11-24
CH270495 1995-09-25
PCT/EP1995/004451 WO1996016046A2 (en) 1994-11-24 1995-11-13 Novel benzyl pyrimidines

Publications (3)

Publication Number Publication Date
FI972194A7 FI972194A7 (sv) 1997-05-22
FI972194L true FI972194L (sv) 1997-05-22
FI972194A0 FI972194A0 (sv) 1997-05-22

Family

ID=25691190

Family Applications (1)

Application Number Title Priority Date Filing Date
FI972194A FI972194A0 (sv) 1994-11-24 1995-11-13 Nya benzylpyrimidiner

Country Status (21)

Country Link
US (1) US5763450A (sv)
EP (1) EP0793656B1 (sv)
JP (1) JP3117721B2 (sv)
KR (1) KR100417508B1 (sv)
CN (1) CN1136198C (sv)
AT (1) ATE235471T1 (sv)
AU (1) AU704911B2 (sv)
BR (1) BR9509768A (sv)
CA (1) CA2205406C (sv)
CZ (1) CZ157597A3 (sv)
DE (1) DE69530104T2 (sv)
DK (1) DK0793656T3 (sv)
ES (1) ES2193205T3 (sv)
FI (1) FI972194A0 (sv)
HU (1) HUT77372A (sv)
MX (1) MX9703687A (sv)
NO (1) NO308845B1 (sv)
NZ (1) NZ296532A (sv)
PL (1) PL320458A1 (sv)
PT (1) PT793656E (sv)
WO (1) WO1996016046A2 (sv)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
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TW438796B (en) * 1996-05-15 2001-06-07 Hoffmann La Roche 2,4-diaminopyrimidine derivatives, the manufacture process thereof, and the antibiotically-active pharmaceutical composition containing the same
CA2281642C (en) * 1997-03-03 2008-02-05 F. Hoffmann-La Roche Ag Substituted 2,4-diaminopyrimidines
EP0966464B1 (en) * 1997-03-03 2003-05-28 Basilea Pharmaceutica AG Substituted 2,4-diaminopyrimidines
EP1000932B9 (en) * 1997-06-27 2005-12-28 Fujisawa Pharmaceutical Co., Ltd. Aromatic ring derivatives
US6893815B1 (en) * 1997-06-30 2005-05-17 Isis Pharmaceuticals, Inc. Nucleobase heterocyclic combinatorialization
WO1999007682A1 (en) * 1997-08-08 1999-02-18 Toyama Chemical Co., Ltd. Quinolonecarboxylic acid derivatives or salts thereof
ES2248923T3 (es) * 1997-12-22 2006-03-16 PHARMACIA & UPJOHN COMPANY LLC 4-hydroxiquinolin-3-carboxamidas y hidrazidas como agentes antivirales.
PT1070713E (pt) * 1998-04-06 2006-12-29 Toyama Chemical Co Ltd Derivados de ácido quinolonocarboxílico ou seus sais
DE60041763D1 (de) * 1999-04-23 2009-04-23 Vertex Pharma Inhibitoren von c-jun n-terminal kinasen (jnk)
DE50009143D1 (de) * 1999-11-04 2005-02-03 Basilea Pharmaceutica Ag Basel Substituierte 5-benzyl-2,4-diaminopyrimidine
US7612065B2 (en) 2000-04-21 2009-11-03 Vertex Pharmaceuticals Incorporated Inhibitors of c-JUN N-terminal kinases (JNK)
PE20011349A1 (es) 2000-06-16 2002-01-19 Upjohn Co 1-aril-4-oxo-1,4-dihidro-3-quinolincarboxamidas como agentes antivirales
HUP0301189A3 (en) * 2000-07-24 2003-11-28 Bayer Cropscience Ag Pyrazolyl biphenyl carboxamides, intermediates, preparation and use thereof for controlling undesired microorganisms
CN1252055C (zh) * 2000-07-24 2006-04-19 拜尔农作物科学股份公司 联苯甲酰胺类化合物
WO2003032999A1 (en) * 2001-10-12 2003-04-24 Warner-Lambert Company Llc Alkyne matrix metalloproteinase inhibitors
US6962922B2 (en) 2001-10-12 2005-11-08 Warner-Lambert Company Llc Alkynylated quinazoline compounds
US6747147B2 (en) 2002-03-08 2004-06-08 Warner-Lambert Company Oxo-azabicyclic compounds
US6894057B2 (en) 2002-03-08 2005-05-17 Warner-Lambert Company Oxo-azabicyclic compounds
SI1403271T1 (sl) * 2002-09-25 2006-04-30 Degussa Postopek za pripravo 5-formil-2-furilborove kisline
US7144911B2 (en) 2002-12-31 2006-12-05 Deciphera Pharmaceuticals Llc Anti-inflammatory medicaments
US7279576B2 (en) 2002-12-31 2007-10-09 Deciphera Pharmaceuticals, Llc Anti-cancer medicaments
US7202257B2 (en) 2003-12-24 2007-04-10 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
EP1924564B1 (en) * 2005-09-01 2016-11-09 F.Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p2x2/3 modulators
US8268825B2 (en) 2005-09-26 2012-09-18 The Board Of Regents For Oklahoma State University Method for the treatment of anthrax infections
ES2466667T3 (es) * 2006-10-04 2014-06-10 F. Hoffmann-La Roche Ag Proceso para síntesis de derivados de fenoxi diaminopirimidina
EP2146716A4 (en) 2007-04-20 2010-08-11 Deciphera Pharmaceuticals Llc KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYELOPROLIFERATIVE SYNDROME AND OTHER PROLIFERATIVE DISEASES
US8853228B2 (en) * 2007-06-04 2014-10-07 University Of Connecticut Heterocyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase
CN103351390A (zh) * 2007-11-21 2013-10-16 解码遗传Ehf公司 用于治疗肺部和心血管病症的联芳基pde4 抑制剂
JP5305704B2 (ja) * 2008-03-24 2013-10-02 富士フイルム株式会社 新規化合物、光重合性組成物、カラーフィルタ用光重合性組成物、カラーフィルタ、及びその製造方法、固体撮像素子、並びに、平版印刷版原版
GB0815962D0 (en) * 2008-09-02 2008-10-08 Merlion Pharmaceuticals Pte Ltd Hybrid antibacterial compounds and their use
MX2011004535A (es) 2008-10-29 2011-11-18 Deciphera Pharmaceuticals Llc Ciclopropanamidas y analogos que exhiben actividades anti-cancer y anti-proliferativas.
US9950062B2 (en) 2009-09-02 2018-04-24 Glaxosmithkline Biologicals Sa Compounds and compositions as TLR activity modulators
CN102040591B (zh) * 2009-10-15 2013-12-11 山东轩竹医药科技有限公司 7-苯基喹诺酮类化合物
CN103313725B (zh) * 2010-09-01 2016-06-29 诺华有限公司 免疫增强剂吸附不溶性金属离子
CA2828844C (en) 2011-03-02 2020-07-14 Novartis Ag Combination vaccines with lower doses of antigen and/or adjuvant
MX372965B (es) 2012-03-08 2020-04-01 Glaxosmithkline Biologicals Sa Formulaciones adyuvadas de vacunas de difteria, tetanos y tos ferina (dtp) de refuerzo.
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
CA3089630A1 (en) 2018-01-31 2019-08-08 Deciphera Pharmaceuticals, Llc Combination therapy for the treatment of mastocytosis
SG11202007198WA (en) 2018-01-31 2020-08-28 Deciphera Pharmaceuticals Llc Combination therapy for the treatment of gastrointestinal stromal tumors
WO2020185812A1 (en) 2019-03-11 2020-09-17 Teva Pharmaceuticals International Gmbh Solid state forms of ripretinib
KR20220045189A (ko) 2019-08-12 2022-04-12 데시페라 파마슈티칼스, 엘엘씨. 위장관 기질 종양을 치료하는 방법
TWI878335B (zh) 2019-08-12 2025-04-01 美商迪賽孚爾製藥有限公司 治療胃腸道基質瘤方法
SMT202300467T1 (it) 2019-12-30 2024-01-10 Deciphera Pharmaceuticals Llc Formulazioni di inibitori di chinasi amorfi e loro procedimenti d’uso
SMT202400484T1 (it) 2019-12-30 2025-01-14 Deciphera Pharmaceuticals Llc Composizioni di 1-(4-bromo-5-(1-etil-7-(metilammino)-2-osso-1,2-diidro-1,6-naftiridin-3-il)-2-fluorofenil)-3-fenilurea
US11779572B1 (en) 2022-09-02 2023-10-10 Deciphera Pharmaceuticals, Llc Methods of treating gastrointestinal stromal tumors
TW202448872A (zh) * 2023-05-25 2024-12-16 美商安銳生物醫藥公司 Egfr抑制劑及其使用方法
CN117285511A (zh) * 2023-09-21 2023-12-26 西南大学 吲哚杂化的喹诺酮类化合物及其制备方法和应用

Family Cites Families (4)

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US4515948A (en) * 1973-09-12 1985-05-07 Hoffmann-La Roche Inc. 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines
US4039543A (en) * 1974-12-24 1977-08-02 Hoffmann-La Roche Inc. Benzylpyrimidines
JPH07509215A (ja) * 1990-11-14 1995-10-12 カイロン コーポレイション ジヒドロ葉酸還元酵素の特異的阻害およびそのための化合物
NO304832B1 (no) * 1992-05-27 1999-02-22 Ube Industries Aminokinolonderivater samt middel mot HIV

Also Published As

Publication number Publication date
DE69530104D1 (de) 2003-04-30
BR9509768A (pt) 1998-07-07
EP0793656A1 (en) 1997-09-10
DE69530104T2 (de) 2003-12-24
US5763450A (en) 1998-06-09
PT793656E (pt) 2003-07-31
FI972194A7 (sv) 1997-05-22
ES2193205T3 (es) 2003-11-01
JPH11507009A (ja) 1999-06-22
NZ296532A (en) 2000-02-28
HUT77372A (hu) 1998-03-30
NO972393L (no) 1997-05-29
CN1136198C (zh) 2004-01-28
WO1996016046A3 (en) 1996-07-25
CA2205406C (en) 2008-02-05
JP3117721B2 (ja) 2000-12-18
NO308845B1 (no) 2000-11-06
DK0793656T3 (da) 2003-07-21
PL320458A1 (en) 1997-09-29
KR100417508B1 (ko) 2004-03-18
AU704911B2 (en) 1999-05-06
CN1166831A (zh) 1997-12-03
MX9703687A (es) 1997-08-30
CA2205406A1 (en) 1996-05-30
ATE235471T1 (de) 2003-04-15
CZ157597A3 (en) 1997-09-17
FI972194A0 (sv) 1997-05-22
EP0793656B1 (en) 2003-03-26
NO972393D0 (no) 1997-05-26
AU4116196A (en) 1996-06-17
WO1996016046A2 (en) 1996-05-30

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MA Patent expired