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FI970968L - Pyrimido/5,4-d/pyrimidiinit, näitä yhdisteitä sisältävät lääkeaineet, niiden käyttö ja menetelmä niiden valmistamiseksi - Google Patents

Pyrimido/5,4-d/pyrimidiinit, näitä yhdisteitä sisältävät lääkeaineet, niiden käyttö ja menetelmä niiden valmistamiseksi Download PDF

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Publication number
FI970968L
FI970968L FI970968A FI970968A FI970968L FI 970968 L FI970968 L FI 970968L FI 970968 A FI970968 A FI 970968A FI 970968 A FI970968 A FI 970968A FI 970968 L FI970968 L FI 970968L
Authority
FI
Finland
Prior art keywords
pyrimido
pyrimidines
compounds
preparation
substances containing
Prior art date
Application number
FI970968A
Other languages
English (en)
Swedish (sv)
Other versions
FI970968A0 (fi
FI112947B (fi
Inventor
Frank Himmelsbach
Ruden Thomas Von
Georg Dahmann
Thomas Metz
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4431867A external-priority patent/DE4431867A1/de
Priority claimed from DE1995103151 external-priority patent/DE19503151A1/de
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of FI970968A0 publication Critical patent/FI970968A0/fi
Publication of FI970968L publication Critical patent/FI970968L/fi
Application granted granted Critical
Publication of FI112947B publication Critical patent/FI112947B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Detergent Compositions (AREA)
  • Luminescent Compositions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicinal Preparation (AREA)
FI970968A 1994-09-07 1997-03-07 Pyrimido[5,4-d]pyrimidiinejä, näitä yhdisteitä sisältävät lääkeaineet, niiden käyttö ja menetelmä niiden valmistamiseksi FI112947B (fi)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
DE4431867 1994-09-07
DE4431867A DE4431867A1 (de) 1994-09-07 1994-09-07 Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE1995103151 DE19503151A1 (de) 1995-02-01 1995-02-01 Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE19503151 1995-02-01
DE1995121386 DE19521386A1 (de) 1995-02-01 1995-06-13 Pyrimido/5,4-d/pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE19521386 1995-06-13
DE19528672 1995-08-04
DE1995128672 DE19528672A1 (de) 1995-02-01 1995-08-04 Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
PCT/EP1995/003482 WO1996007657A1 (de) 1994-09-07 1995-09-05 Pyrimido[5,4-d]pyrimidine, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
EP9503482 1995-09-05

Publications (3)

Publication Number Publication Date
FI970968A0 FI970968A0 (fi) 1997-03-07
FI970968L true FI970968L (fi) 1997-05-06
FI112947B FI112947B (fi) 2004-02-13

Family

ID=27436041

Family Applications (1)

Application Number Title Priority Date Filing Date
FI970968A FI112947B (fi) 1994-09-07 1997-03-07 Pyrimido[5,4-d]pyrimidiinejä, näitä yhdisteitä sisältävät lääkeaineet, niiden käyttö ja menetelmä niiden valmistamiseksi

Country Status (26)

Country Link
US (1) US5707989A (fi)
EP (1) EP0779888B1 (fi)
JP (1) JP3184533B2 (fi)
CN (1) CN1047778C (fi)
AT (1) ATE179420T1 (fi)
AU (1) AU688972B2 (fi)
BG (1) BG62969B1 (fi)
CA (1) CA2199401C (fi)
CZ (1) CZ295781B6 (fi)
DE (1) DE59505789D1 (fi)
DK (1) DK0779888T3 (fi)
EE (1) EE9700211A (fi)
ES (1) ES2133800T3 (fi)
FI (1) FI112947B (fi)
GR (1) GR3030589T3 (fi)
HK (1) HK1000837A1 (fi)
HU (1) HUT77744A (fi)
IL (1) IL115185A0 (fi)
MX (1) MX9701662A (fi)
NO (1) NO307833B1 (fi)
NZ (1) NZ292909A (fi)
PL (1) PL319042A1 (fi)
RO (1) RO120342B1 (fi)
SK (1) SK284277B6 (fi)
TW (1) TW414798B (fi)
WO (1) WO1996007657A1 (fi)

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IL112249A (en) 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
TW321649B (fi) * 1994-11-12 1997-12-01 Zeneca Ltd
GB9424233D0 (en) * 1994-11-30 1995-01-18 Zeneca Ltd Quinazoline derivatives
GB9508565D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
GB9508537D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
GB9508535D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivative
US5932574A (en) * 1995-04-27 1999-08-03 Zeneca Limited Quinazoline derivatives
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
AU719434B2 (en) 1996-02-13 2000-05-11 Astrazeneca Ab Quinazoline derivatives as VEGF inhibitors
GB9603095D0 (en) 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
GB9603097D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline compounds
ES2169355T3 (es) 1996-03-05 2002-07-01 Astrazeneca Ab Derivados de 4-anilinoquinazolina.
DE19608588A1 (de) * 1996-03-06 1997-09-11 Thomae Gmbh Dr K Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE19608653A1 (de) * 1996-03-06 1997-09-11 Thomae Gmbh Dr K Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE19613691A1 (de) 1996-04-05 1997-10-09 Boehringer Ingelheim Int Arzneimittel für die Behandlung von Tumorerkrankungen
DE69710712T3 (de) 1996-04-12 2010-12-23 Warner-Lambert Co. Llc Umkehrbare inhibitoren von tyrosin kinasen
GB9607729D0 (en) * 1996-04-13 1996-06-19 Zeneca Ltd Quinazoline derivatives
HRP970371A2 (en) 1996-07-13 1998-08-31 Kathryn Jane Smith Heterocyclic compounds
EP0912559B1 (en) 1996-07-13 2002-11-06 Glaxo Group Limited Fused heterocyclic compounds as protein tyrosine kinase inhibitors
JP3270834B2 (ja) * 1999-01-27 2002-04-02 ファイザー・プロダクツ・インク 抗がん剤として有用なヘテロ芳香族二環式誘導体
UA71945C2 (en) * 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
EP1676845B1 (en) 1999-11-05 2008-06-11 AstraZeneca AB New quinazoline derivatives
IL154034A0 (en) * 2000-08-09 2003-07-31 Astrazeneca Ab Indole, azaindole and indazole derivatives, processes for their preparation, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals
DE10115921A1 (de) * 2001-03-30 2002-10-02 Boehringer Ingelheim Pharma Verfahren zur Herstellung von 4,6-Diaminopyrimido[5,4-d]pyrimidinen
AU2004253967B2 (en) * 2003-07-03 2010-02-18 Cytovia, Inc. 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis
US8309562B2 (en) 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
NZ547794A (en) 2003-12-18 2009-11-27 Janssen Pharmaceutica Nv Pyrido- and pyrimidopyrimidine derivatives as anti-proliferative agents
NI200700147A (es) 2004-12-08 2019-05-10 Janssen Pharmaceutica Nv Derivados de quinazolina inhibidores de cinasas dirigidos a multip
US8258145B2 (en) 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
CA2592900A1 (en) 2005-01-03 2006-07-13 Myriad Genetics Inc. Nitrogen containing bicyclic compounds and therapeutical use thereof
JP2009523150A (ja) * 2006-01-13 2009-06-18 エフ．ホフマン−ラ ロシュ アーゲー シクロヘキシルピペラジニルメタノン誘導体及びｈ３受容体調節剤としてのそれらの使用
CA2654583C (en) 2006-07-13 2015-11-24 Janssen Pharmaceutica N.V. Mtki quinazoline derivatives
JP5536647B2 (ja) 2007-07-27 2014-07-02 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ピロロピリミジン
TW201014860A (en) * 2008-09-08 2010-04-16 Boehringer Ingelheim Int New chemical compounds
CA2752265A1 (en) 2009-02-17 2010-08-26 Boehringer Ingelheim International Gmbh Pyrimido [5,4-d] pyrimidine derivatives for the inhibition of tyrosine kinases
SG178592A1 (en) 2009-09-03 2012-04-27 Bristol Myers Squibb Co Quinazolines as potassium ion channel inhibitors
JP5868418B2 (ja) * 2010-12-01 2016-02-24 ヤンセン ファーマシューティカ エヌ．ベー． Ｃｃｒ２の４−置換シクロヘキシルアミノ−４−ピペリジニル−アセトアミドアンタゴニスト
US20130023531A1 (en) 2011-01-27 2013-01-24 Boehringer Ingelheim International Gmbh Pyrimido[5,4-d]pyrimidylamino phenyl sulfonamides as serine/threonine kinase inhibitors
US20130303507A1 (en) 2011-01-28 2013-11-14 Novartis Ag Substituted hetero-biaryl compounds and their uses
CA2836663A1 (en) 2011-05-20 2012-11-29 Janssen Pharmaceutica Nv Process for the preparation of compounds useful as inhibitors of sglt-2
WO2014175370A1 (ja) * 2013-04-25 2014-10-30 塩野義製薬株式会社 ピロリジン誘導体およびそれらを含有する医薬組成物
EP3247353A4 (en) 2015-01-23 2018-07-04 Confluence Life Sciences, Inc. Heterocyclic itk inhibitors for treating inflammation and cancer
CN111868058B (zh) * 2018-05-25 2023-06-13 上海和誉生物医药科技有限公司 一种fgfr抑制剂、其制备方法和在药学上的应用
US11608343B2 (en) * 2020-04-24 2023-03-21 Boehringer Ingelheim International Gmbh Substituted pyrimido[5,4-d]pyrimidines as HER2 inhibitors
WO2022221227A1 (en) 2021-04-13 2022-10-20 Nuvalent, Inc. Amino-substituted heterocycles for treating cancers with egfr mutations
WO2025240517A1 (en) * 2024-05-14 2025-11-20 Aleksia Therapeutics, Inc. Cdk4 inhibitor naphthyridine compounds

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Publication number Priority date Publication date Assignee Title
US3031450A (en) * 1959-04-30 1962-04-24 Thomae Gmbh Dr K Substituted pyrimido-[5, 4-d]-pyrimidines
EP0023559B1 (de) * 1979-07-03 1984-09-19 Dr. Karl Thomae GmbH 2-(Perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidine, ihre Herstellung und diese Verbindungen enthaltenden Arzneimittel
DE3049207A1 (de) * 1980-12-27 1982-07-29 Dr. Karl Thomae Gmbh, 7950 Biberach Neue trisubstituierte pyrimido (5,4-d) pyrimidine, ihre herstellung und ihre verwendung als arzneimittel
DE3423092A1 (de) * 1984-06-22 1986-01-02 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 8-alkylthio-2-piperazino-pyrimido(5,4-d) pyrimidine, ihre herstellung und diese verbindungen enthaltende arzneimittel
US5034393A (en) * 1989-07-27 1991-07-23 Dowelanco Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives
DE4325900A1 (de) * 1993-08-02 1995-02-09 Thomae Gmbh Dr K Trisubstituierte Pyrimido [5,4-d] pyrimidine zur Modulation der Multidrugresistenz, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
CZ295781B6 (cs) 2005-11-16
CA2199401A1 (en) 1996-03-04
EP0779888B1 (de) 1999-04-28
AU688972B2 (en) 1998-03-19
NZ292909A (en) 1998-09-24
AU3521895A (en) 1996-03-27
DE59505789D1 (de) 1999-06-02
ATE179420T1 (de) 1999-05-15
BG62969B1 (bg) 2000-12-29
DK0779888T3 (da) 1999-10-25
HK1000837A1 (en) 2000-11-03
SK30297A3 (en) 1997-10-08
IL115185A0 (en) 1995-12-31
NO971038L (no) 1997-05-06
NO971038D0 (no) 1997-03-06
GR3030589T3 (en) 1999-10-29
BG101289A (en) 1997-08-29
ES2133800T3 (es) 1999-09-16
SK284277B6 (sk) 2004-12-01
MX9701662A (es) 1998-02-28
HUT77744A (hu) 1998-07-28
FI970968A0 (fi) 1997-03-07
EP0779888A1 (de) 1997-06-25
TW414798B (en) 2000-12-11
JP3184533B2 (ja) 2001-07-09
CN1047778C (zh) 1999-12-29
CA2199401C (en) 2007-07-10
FI112947B (fi) 2004-02-13
RO120342B1 (ro) 2005-12-30
JPH10505078A (ja) 1998-05-19
US5707989A (en) 1998-01-13
CN1157619A (zh) 1997-08-20
EE9700211A (et) 1998-04-15
WO1996007657A1 (de) 1996-03-14
NO307833B1 (no) 2000-06-05
PL319042A1 (en) 1997-07-21
CZ69197A3 (en) 1997-10-15

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