FI954143L - Kiinteitä lipidihiukkasia, bioaktiivisten aineiden hiukkasia, menetelmiä niiden valmistamiseksi ja niiden käyttö - Google Patents
Kiinteitä lipidihiukkasia, bioaktiivisten aineiden hiukkasia, menetelmiä niiden valmistamiseksi ja niiden käyttö Download PDFInfo
- Publication number
- FI954143L FI954143L FI954143A FI954143A FI954143L FI 954143 L FI954143 L FI 954143L FI 954143 A FI954143 A FI 954143A FI 954143 A FI954143 A FI 954143A FI 954143 L FI954143 L FI 954143L
- Authority
- FI
- Finland
- Prior art keywords
- particles
- preparation
- methods
- solid lipid
- bioactive substances
- Prior art date
Links
- 239000002245 particle Substances 0.000 title 2
- 230000000975 bioactive effect Effects 0.000 title 1
- 150000002632 lipids Chemical class 0.000 title 1
- 239000007787 solid Substances 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/044—Suspensions
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
- A61K8/0245—Specific shapes or structures not provided for by any of the groups of A61K8/0241
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
- B01F23/4105—Methods of emulsifying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/48—Mixing liquids with liquids; Emulsifying characterised by the nature of the liquids
- B01F23/482—Mixing liquids with liquids; Emulsifying characterised by the nature of the liquids using molten solids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/50—Mixing liquids with solids
- B01F23/51—Methods thereof
- B01F23/511—Methods thereof characterised by the composition of the liquids or solids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nanotechnology (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Birds (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Optics & Photonics (AREA)
- Medical Informatics (AREA)
- Dermatology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Geometry (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- General Preparation And Processing Of Foods (AREA)
- Colloid Chemistry (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2750193A | 1993-03-05 | 1993-03-05 | |
| US2750193 | 1993-03-05 | ||
| CA2091152 | 1993-03-05 | ||
| CA002091152A CA2091152C (en) | 1993-03-05 | 1993-03-05 | Solid lipid particles, particles of bioactive agents and methods for the manfuacture and use thereof |
| SE9400185 | 1994-01-21 | ||
| PCT/SE1994/000185 WO1994020072A1 (en) | 1993-03-05 | 1994-03-04 | Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI954143A0 FI954143A0 (fi) | 1995-09-04 |
| FI954143L true FI954143L (fi) | 1995-10-19 |
| FI114006B FI114006B (fi) | 2004-07-30 |
Family
ID=25675967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI954143A FI114006B (fi) | 1993-03-05 | 1995-09-04 | Menetelmiä kiinteiden lipidihiukkasten ja bioaktiivisten aineiden hiukkasten valmistamiseksi |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0687172B1 (fi) |
| JP (2) | JP3916249B2 (fi) |
| AT (1) | ATE228821T1 (fi) |
| AU (1) | AU676279B2 (fi) |
| CA (1) | CA2091152C (fi) |
| DE (1) | DE69431831T2 (fi) |
| DK (1) | DK0687172T3 (fi) |
| ES (1) | ES2190439T3 (fi) |
| FI (1) | FI114006B (fi) |
| NO (1) | NO314285B1 (fi) |
| NZ (1) | NZ262541A (fi) |
| PT (1) | PT687172E (fi) |
| WO (1) | WO1994020072A1 (fi) |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5785976A (en) * | 1993-03-05 | 1998-07-28 | Pharmacia & Upjohn Ab | Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof |
| US5885486A (en) * | 1993-03-05 | 1999-03-23 | Pharmaciaand Upjohn Ab | Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof |
| PT101422B (pt) * | 1993-12-06 | 1997-06-30 | Ineti Inst Biotec Q F E Tecnol | Formulacoes lipossomicas contendo vidarabina e/ou derivados, com indice terapeutico elevado e processo para a sua preparacao |
| DE4440337A1 (de) * | 1994-11-11 | 1996-05-15 | Dds Drug Delivery Services Ges | Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit |
| US5747001A (en) * | 1995-02-24 | 1998-05-05 | Nanosystems, L.L.C. | Aerosols containing beclomethazone nanoparticle dispersions |
| JP4484247B2 (ja) * | 1995-02-24 | 2010-06-16 | エラン ファーマ インターナショナル,リミティド | ナノ粒子分散体を含有するエアロゾル |
| DE19517147C2 (de) * | 1995-05-10 | 1999-07-01 | Hexal Pharmaforschung Gmbh | Aciclovir-Zubereitung |
| US6465016B2 (en) | 1996-08-22 | 2002-10-15 | Research Triangle Pharmaceuticals | Cyclosporiine particles |
| ES2252780T3 (es) * | 1996-08-22 | 2006-05-16 | Jagotec Ag | Composiciones que comprenden microparticulas de sustancias insolubles en agua y metodo para su preparacion. |
| US7255877B2 (en) | 1996-08-22 | 2007-08-14 | Jagotec Ag | Fenofibrate microparticles |
| DE19641259A1 (de) * | 1996-10-07 | 1998-04-16 | Kade Pharma Fab Gmbh | Arzneimittel auf Basis von Diclofenac |
| CA2269726A1 (en) | 1996-10-25 | 1998-04-30 | Monsanto Company | Composition and method for treating plants with exogenous chemicals |
| US6130186A (en) * | 1996-10-25 | 2000-10-10 | Monsanto Company | Composition and method for treating plants with exogenous chemicals |
| GB9624615D0 (en) * | 1996-11-26 | 1997-01-15 | Zeneca Ltd | Chrystallisation process |
| GB9625589D0 (en) * | 1996-12-10 | 1997-01-29 | Boots Co Plc | Therapeutic agents |
| IT1292142B1 (it) * | 1997-06-12 | 1999-01-25 | Maria Rosa Gasco | Composizione farmaceutica in forma di microparticelle lipidiche solide atte alla somministrazione parenterale |
| US6423363B1 (en) | 1997-08-22 | 2002-07-23 | Lipton, Division Of Conopco, Inc. | Aqueous dispersion |
| AU1809499A (en) * | 1997-12-10 | 1999-06-28 | Awadhesh K. Mishra | Self-emulsifying fenofibrate formulations |
| IT1298575B1 (it) * | 1998-02-06 | 2000-01-12 | Vectorpharma Int | Composizioni farmaceutiche in forma di nanoparticelle comprendenti sostanze lipidiche e sostanze antifiliche e relativo processo di |
| US6979456B1 (en) | 1998-04-01 | 2005-12-27 | Jagotec Ag | Anticancer compositions |
| SE512958C2 (sv) † | 1998-04-30 | 2000-06-12 | Triple Crown Ab | Kolesterolsänkande komposition innehållande beta-sitosterol och/eller beta-sitostanol samt förfarande för dess framställning |
| GB9810859D0 (en) | 1998-05-20 | 1998-07-22 | Zeneca Ltd | Crystallisation process |
| DK1087658T3 (da) * | 1998-06-17 | 2004-05-10 | Uniroyal Chem Co Inc | Biologisk aktiv mikrodispersionssammensætning |
| ITMI981528A1 (it) * | 1998-07-03 | 2000-01-03 | Recordati Ind Chimica E Farma | Formulazioni topiche di aciclovir |
| IL141095A0 (en) | 1998-08-19 | 2002-02-10 | Rtp Pharma Inc | Injectable aqueous dispersions of propofol |
| US7521068B2 (en) | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
| AU767154B2 (en) | 1998-11-20 | 2003-10-30 | Skyepharma Canada Inc. | Dispersible phospholipid stabilized microparticles |
| IT1303787B1 (it) | 1998-11-25 | 2001-02-23 | Maria Rosa Gasco | "nanosfere lipidiche solide atte ad una rapida internalizzazione nellecellule" |
| DE19919770A1 (de) * | 1999-04-30 | 2000-11-02 | Henkel Kgaa | Verwendung nanoskaliger antimikrobieller Wirkstoffe in der Mund- und/oder Zahnpflege |
| SE517769C2 (sv) | 1999-10-29 | 2002-07-16 | Triple Crown Ab | Kolesterol och blodfettsänkande komposition, innehållande fytosteroler, blandade med monoglycerider |
| KR20020026053A (ko) | 2000-09-30 | 2002-04-06 | 노승권 | 음료용 식물성 스테롤의 분산방법 및 이를 함유하는 음료 |
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| US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
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| US7193084B2 (en) | 2000-12-22 | 2007-03-20 | Baxter International Inc. | Polymorphic form of itraconazole |
| US6977085B2 (en) | 2000-12-22 | 2005-12-20 | Baxter International Inc. | Method for preparing submicron suspensions with polymorph control |
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| US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
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| LT1585548T (lt) | 2002-12-09 | 2018-09-25 | Abraxis Bioscience, Llc | Farmakologinių agentų kompozicijos ir įvedimo būdai |
| DE10312763A1 (de) * | 2003-03-21 | 2004-09-30 | IFAC Institut für angewandte Colloidtechnologie GmbH & Co. KG | Verfahren zur Herstellung einer SLN-Dispersion |
| FR2852843B1 (fr) | 2003-03-24 | 2008-05-23 | Karim Ioualalen | Systeme galenique permettant le masquage du gout |
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| US8741321B2 (en) | 2003-08-27 | 2014-06-03 | Beiersdorf Ag | Capsule whose envelope is separately imperceptible during the topical use thereof |
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| AU2006346369B2 (en) * | 2005-07-18 | 2013-02-21 | University Of Massachusetts Lowell | Compositions and methods for making and using nanoemulsions |
| US9486408B2 (en) | 2005-12-01 | 2016-11-08 | University Of Massachusetts Lowell | Botulinum nanoemulsions |
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| JO3685B1 (ar) | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
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| AU2013351934B2 (en) * | 2012-11-30 | 2018-03-29 | Insmed Incorporated | Prostacylin compositions and methods for using the same |
| EP2823811A1 (en) * | 2013-07-09 | 2015-01-14 | OTC GmbH | Targeted active release system comprising solid lipid nano-particles |
| CA2927788C (en) | 2013-10-25 | 2022-09-06 | Insmed Incorporated | Prostacyclin compounds, compositions and methods of use thereof |
| AU2015246030B2 (en) | 2014-04-09 | 2020-03-12 | Pulse Pharmaceuticals Pvt Ltd | Composition and method of producing nanoformulation of water insoluble bioactives in aqueous base |
| EP3904326A1 (en) | 2014-11-18 | 2021-11-03 | Insmed Incorporated | Methods of manufacturing treprostinil and treprostinil derivative prodrugs |
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| CN114867363A (zh) * | 2019-12-10 | 2022-08-05 | 比利时胶囊公司 | 含脂质基质核心和活性成分的颗粒 |
| WO2021168362A1 (en) | 2020-02-21 | 2021-08-26 | Akouos, Inc. | Compositions and methods for treating non-age-associated hearing impairment in a human subject |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3421468A1 (de) * | 1984-06-08 | 1985-12-19 | Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim | Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung |
| DE3702029A1 (de) * | 1987-01-24 | 1988-08-04 | Basf Ag | Waessriges oder pulverfoermiges, wasserdispergierbares praeparat eines in wasser schwerloeslichen pharmazeutischen wirkstoffs und verfahren zu seiner herstellung |
| ES2085465T3 (es) * | 1989-11-13 | 1996-06-01 | Abraham J Domb | Lipoesferas para la administracion controlada de sustancias. |
| AU658608B2 (en) * | 1991-03-25 | 1995-04-27 | Astellas Pharma Europe B.V. | Topical preparation containing a suspension of solid lipid particles |
-
1993
- 1993-03-05 CA CA002091152A patent/CA2091152C/en not_active Expired - Fee Related
-
1994
- 1994-03-04 NZ NZ262541A patent/NZ262541A/en unknown
- 1994-03-04 AU AU62253/94A patent/AU676279B2/en not_active Ceased
- 1994-03-04 DE DE69431831T patent/DE69431831T2/de not_active Expired - Fee Related
- 1994-03-04 AT AT94909393T patent/ATE228821T1/de not_active IP Right Cessation
- 1994-03-04 WO PCT/SE1994/000185 patent/WO1994020072A1/en not_active Ceased
- 1994-03-04 DK DK94909393T patent/DK0687172T3/da active
- 1994-03-04 EP EP94909393A patent/EP0687172B1/en not_active Expired - Lifetime
- 1994-03-04 ES ES94909393T patent/ES2190439T3/es not_active Expired - Lifetime
- 1994-03-04 JP JP51988794A patent/JP3916249B2/ja not_active Expired - Fee Related
- 1994-03-04 PT PT94909393T patent/PT687172E/pt unknown
-
1995
- 1995-09-04 NO NO19953461A patent/NO314285B1/no unknown
- 1995-09-04 FI FI954143A patent/FI114006B/fi not_active IP Right Cessation
-
2006
- 2006-09-27 JP JP2006261728A patent/JP2007023051A/ja not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE69431831D1 (de) | 2003-01-16 |
| JP2007023051A (ja) | 2007-02-01 |
| PT687172E (pt) | 2003-04-30 |
| EP0687172A1 (en) | 1995-12-20 |
| EP0687172B1 (en) | 2002-12-04 |
| NO953461D0 (no) | 1995-09-04 |
| ES2190439T3 (es) | 2003-08-01 |
| ATE228821T1 (de) | 2002-12-15 |
| NO314285B1 (no) | 2003-03-03 |
| NO953461L (no) | 1995-11-06 |
| JPH08507515A (ja) | 1996-08-13 |
| DE69431831T2 (de) | 2003-04-10 |
| CA2091152A1 (en) | 1994-09-06 |
| DK0687172T3 (da) | 2003-03-17 |
| FI114006B (fi) | 2004-07-30 |
| CA2091152C (en) | 2005-05-03 |
| FI954143A0 (fi) | 1995-09-04 |
| WO1994020072A1 (en) | 1994-09-15 |
| AU6225394A (en) | 1994-09-26 |
| AU676279B2 (en) | 1997-03-06 |
| JP3916249B2 (ja) | 2007-05-16 |
| NZ262541A (en) | 1997-04-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |