[go: up one dir, main page]

FI970357L - Tyypin II diabeteksen hoitoon käyttökelpoisia bensoksatsoli- ja pyridiinijohdannaisia - Google Patents

Tyypin II diabeteksen hoitoon käyttökelpoisia bensoksatsoli- ja pyridiinijohdannaisia Download PDF

Info

Publication number
FI970357L
FI970357L FI970357A FI970357A FI970357L FI 970357 L FI970357 L FI 970357L FI 970357 A FI970357 A FI 970357A FI 970357 A FI970357 A FI 970357A FI 970357 L FI970357 L FI 970357L
Authority
FI
Finland
Prior art keywords
benzoxazole
diabetes
treatment
type
pyridine derivatives
Prior art date
Application number
FI970357A
Other languages
English (en)
Swedish (sv)
Other versions
FI970357A7 (fi
FI970357A0 (fi
Inventor
David Haigh
Harshad Kantilal Rami
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9415330A external-priority patent/GB9415330D0/en
Priority claimed from GBGB9425599.9A external-priority patent/GB9425599D0/en
Priority claimed from GBGB9509923.0A external-priority patent/GB9509923D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of FI970357A0 publication Critical patent/FI970357A0/fi
Publication of FI970357L publication Critical patent/FI970357L/fi
Publication of FI970357A7 publication Critical patent/FI970357A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
FI970357A 1994-07-29 1995-07-28 Tyypin II diabeteksen hoitoon käyttökelpoisia bensoksatsoli- ja pyridi inijohdannaisia FI970357A7 (fi)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9415330A GB9415330D0 (en) 1994-07-29 1994-07-29 Novel compounds
GBGB9425599.9A GB9425599D0 (en) 1994-12-19 1994-12-19 Novel compounds
GBGB9509923.0A GB9509923D0 (en) 1995-05-17 1995-05-17 Novel compounds
PCT/GB1995/001323 WO1996004261A1 (en) 1994-07-29 1995-06-07 Benzoxazoles and pryridine derivatives useful in the treatment of the type ii diabetes
PCT/EP1995/003038 WO1996004260A1 (en) 1994-07-29 1995-07-28 Benzoxazoles and pyridine derivatives useful in the treatment of the type ii diabetes

Publications (3)

Publication Number Publication Date
FI970357A0 FI970357A0 (fi) 1997-01-28
FI970357L true FI970357L (fi) 1997-03-26
FI970357A7 FI970357A7 (fi) 1997-03-26

Family

ID=27267309

Family Applications (1)

Application Number Title Priority Date Filing Date
FI970357A FI970357A7 (fi) 1994-07-29 1995-07-28 Tyypin II diabeteksen hoitoon käyttökelpoisia bensoksatsoli- ja pyridi inijohdannaisia

Country Status (16)

Country Link
EP (1) EP0772605A1 (fi)
AP (1) AP776A (fi)
BR (1) BR9508468A (fi)
CA (1) CA2196079A1 (fi)
CZ (1) CZ25497A3 (fi)
DZ (1) DZ1916A1 (fi)
FI (1) FI970357A7 (fi)
HU (1) HUT76637A (fi)
IL (3) IL125525A (fi)
MA (1) MA23632A1 (fi)
MX (1) MX9700763A (fi)
NO (1) NO307827B1 (fi)
OA (1) OA10470A (fi)
PL (1) PL318766A1 (fi)
SK (1) SK12297A3 (fi)
WO (2) WO1996004261A1 (fi)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9600464D0 (en) * 1996-01-09 1996-03-13 Smithkline Beecham Plc Novel method
ATE252074T1 (de) * 1996-04-04 2003-11-15 Sankyo Co Phenylalkylcarbonsäure-derivate
US6160000A (en) * 1996-12-23 2000-12-12 Merck & Co., Inc. Antidiabetic agents based on aryl and heteroarylacetic acids
US6090839A (en) * 1996-12-23 2000-07-18 Merck & Co., Inc. Antidiabetic agents
BR9813019A (pt) 1997-10-02 2000-09-05 Sankyo Co Derivados do ácido amidocarboxìlico, agentes para diminuir a glicose do sangue, redutor de lipìdio, para melhorar a resistência à insulina, anti-inflamatório, para imuno regulagem, para inibir a aldose reductase, para inibir a 5-lipoxigenase, para a geração de supressor de peróxido de lipìdio, para ativar a ppar, para minorar a osteoporose, e, composições para a terapia ou prevenção da diabete melito, da hiperlipemia, da obesidade, da tolerância à glicose prejudicada, da resistência à insulina que não a igt, do fìgado gorduroso, de complicações diabéticas, da arterioesclerose, da diabete melito gestacional, da sìndrome do ovário policìstico, da artroesteìte, da artrite reumática, de doenças alérgicas, da asma, do câncer, de doenças auto imunes, da pancreatite, e de cataratas
AU749505B2 (en) * 1997-10-27 2002-06-27 Dr. Reddy's Laboratories Limited Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them
US6265401B1 (en) * 1997-10-27 2001-07-24 Reddy-Cheminor, Inc. Bicyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
US6444816B1 (en) 1997-10-27 2002-09-03 Dr. Reddy's Research Foundation Fused 7-oxo-pyrimidinyl compounds, preparation, composition and use thereof
US6440961B1 (en) 1997-10-27 2002-08-27 Dr. Reddy's Research Foundation Tricyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
AU752059B2 (en) 1997-10-27 2002-09-05 Dr. Reddy's Laboratories Limited Bicyclic compounds, process for their preparation and pharmaceutical compositions containing them
US6369067B1 (en) 1997-10-27 2002-04-09 Dr. Reddy's Research Foundation Monocyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
WO1999016758A1 (en) * 1997-10-27 1999-04-08 Dr. Reddy's Research Foundation Novel heterocyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
WO1999019313A1 (en) * 1997-10-27 1999-04-22 Dr. Reddy's Research Foundation Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them
CN100357281C (zh) * 1998-05-27 2007-12-26 雷迪实验室有限公司 双环化合物、其制备方法和包含它们的药物组合物
CA2344309A1 (en) 1998-09-17 2000-03-23 Scott A. Biller Method for treating diabetes employing an ap2 inhibitor and combination
US6214820B1 (en) 1998-10-21 2001-04-10 Novo Nordisk A/S Compounds, their preparation and use
WO2000023425A1 (en) * 1998-10-21 2000-04-27 Novo Nordisk A/S New compounds, their preparation and use
US6300339B1 (en) 1998-10-21 2001-10-09 Novo Nordisk A/S Compounds, their preparation and use
US6353018B1 (en) 1998-10-21 2002-03-05 Novo Nordisk A/S Compounds, their preparation and use
US6248781B1 (en) 1998-10-21 2001-06-19 Novo Nordisk A/S Compounds useful in the treatment of conditions mediated by peroxisome proliferator-activated receptors (PPAR)
EP1123297A1 (en) * 1998-10-21 2001-08-16 Novo Nordisk A/S New compounds, their preparation and use
WO2000023416A1 (en) * 1998-10-21 2000-04-27 Novo Nordisk A/S New compounds, their preparation and use
EP1123269A1 (en) * 1998-10-21 2001-08-16 Novo Nordisk A/S New compounds, their preparation and use
AU6325599A (en) * 1998-10-21 2000-05-08 Dr. Reddy's Research Foundation New compounds, their preparation and use
US6365586B1 (en) 1998-10-21 2002-04-02 Novo Nordisk A/S Compounds, their preparation and use
US6468996B1 (en) 1998-10-21 2002-10-22 Novo Nordisk A/S Substituted hetero-polycyclic compounds as PPARα and PPARγ activators
US6531596B1 (en) 1998-10-29 2003-03-11 Dr. Reddy's Laboratories Ltd. Process for the preparation of new antidiabetic agents
JP2002528535A (ja) 1998-10-29 2002-09-03 ドクター・レディーズ・リサーチ・ファウンデーション 新規抗糖尿病剤製造の改良方法
WO2000063189A1 (en) * 1999-04-16 2000-10-26 Novo Nordisk A/S Crystalline r- guanidines, arginine or (l) -arginine (2s) -2- ethoxy -3-{4- [2-(10h -phenoxazin -10-yl)ethoxy]phenyl}propanoate
US6274608B1 (en) 1999-04-20 2001-08-14 Novo Nordisk A/S Compounds, their preparation and use
US6369055B1 (en) 1999-04-20 2002-04-09 Novo Nordisk A/S Compounds, their preparation and use
EP1171431A1 (en) * 1999-04-20 2002-01-16 Novo Nordisk A/S Compounds, their preparation and use
US7414128B2 (en) 1999-04-20 2008-08-19 Dr. Reddy's Laboratories, Limited Crystalline R-guanidines, Arginine or (L)-Arginine (2S)-2-Ethoxy-3-{4-[2-(10H -phenoxazin-10-yl)ethoxy]phenyl}propanoate
US6972294B1 (en) 1999-04-20 2005-12-06 Novo Nordisk, A/S Compounds, their preparation and use
PL351312A1 (en) * 1999-04-20 2003-04-07 Novo Nordisk As New compounds, their preparation and use
WO2000063209A1 (en) * 1999-04-20 2000-10-26 Novo Nordisk A/S New compounds, their preparation and use
CZ20013832A3 (cs) * 1999-04-28 2002-04-17 Dr. Reddy's Research Foundation Substituované bicyklické heterocyklické sloučeniny, způsob jejich přípravy a jejich pouľití jako antiobezitních a hypocholesterolemických činidel
DK1206457T3 (da) 1999-08-27 2004-02-16 Lilly Co Eli Biaryl-oxa(thia)zolderivater og deres anvendelse som modulatorer PPAP'ER
CZ304346B6 (cs) * 2000-01-19 2014-03-19 Cadila Healthcare Ltd. Substituovaný pyrrolový derivát s hypolipidemickou hypocholesteremickou aktivitou, způsob jeho přípravy a farmaceutický přípravek obsahující tyto sloučeniny
US6569901B2 (en) 2000-01-28 2003-05-27 Novo Nordisk A/S Alkynyl-substituted propionic acid derivatives, their preparation and use
US6555577B1 (en) 2000-01-28 2003-04-29 Novo Nordisk A/S Compounds, their preparation and use
IL150259A0 (en) * 2000-01-28 2002-12-01 Novo Nordisk As Alkylnyl-substituted propionic acid derivatives and their use against diabetes and obesity
US6509374B2 (en) 2000-04-17 2003-01-21 Novo Nordisk A/S Compounds, their preparation and use
WO2001087861A2 (en) * 2000-05-12 2001-11-22 Ortho-Mcneil Pharmaceutical, Inc. Methods of treatment using benzoxazinones as peroxisome proliferator activated receptor gamma modulators
AU2001263083A1 (en) * 2000-05-12 2001-11-26 Ortho-Mcneil Pharmaceutical, Inc. Biologically active 4h-benzo(1,4)oxazin-3-ones
US6908908B2 (en) 2000-05-12 2005-06-21 Ortho-Mcneil Pharmaceutical, Inc. Biologically active 4H-benzo [1,4] oxazin-3-ones
US6599899B2 (en) 2000-05-12 2003-07-29 Ortho-Mcneil Pharmaceutical, Inc. Benzoxazinones as peroxisome proliferator activated receptor gamma modulators and method of treatment
US6987123B2 (en) 2001-07-26 2006-01-17 Cadila Healthcare Limited Heterocyclic compounds, their preparation, pharmaceutical compositions containing them and their use in medicine
US7067530B2 (en) 2001-07-30 2006-06-27 Novo Nordisk A/S Compounds, their preparation and use
US6869967B2 (en) 2001-07-30 2005-03-22 Novo Nordisk A/S Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives
US7220877B2 (en) 2001-10-17 2007-05-22 Novo Nordisk A/S Compounds, their preparation and use
WO2003059378A2 (en) 2001-12-29 2003-07-24 Novo Nordisk A/S Combined use of a glp-1 compound and another drug for treating dyslipidemia
US7015345B2 (en) 2002-02-21 2006-03-21 Asahi Kasei Pharma Corporation Propionic acid derivatives
US7816385B2 (en) 2002-12-20 2010-10-19 High Point Pharmaceuticals, Llc Dimeric dicarboxylic acid derivatives, their preparation and use
US6653334B1 (en) 2002-12-27 2003-11-25 Kowa Co., Ltd. Benzoxazole compound and pharmaceutical composition containing the same
JPWO2008139879A1 (ja) * 2007-04-26 2010-07-29 ファルマフロンティア株式会社 Ｇ蛋白質共役型レセプター抑制剤および医薬
KR101733414B1 (ko) 2011-01-31 2017-05-10 카딜라 핼쓰캐어 리미티드 지방이상증의 치료
WO2014174524A1 (en) 2013-04-22 2014-10-30 Cadila Healthcare Limited A novel composition for nonalcoholic fatty liver disease (nafld)
MX2015016403A (es) 2013-05-30 2016-04-11 Cadila Healthcare Ltd Proceso para la preparacion de pirroles que tienen actividad hipolipidemica e hipocolesterolemica.
TW201636015A (zh) 2013-07-05 2016-10-16 卡地拉保健有限公司 協同性組成物
IN2013MU02470A (fi) 2013-07-25 2015-06-26 Cadila Healthcare Ltd
WO2015033357A2 (en) 2013-09-06 2015-03-12 Cadila Healthcare Limited An improved process for the preparation of pyrrole derivatives
WO2017064635A2 (en) 2015-10-14 2017-04-20 Cadila Healthcare Limited Pyrrole compound, compositions and process for preparation thereof
MX382765B (es) 2016-12-09 2025-03-13 Zydus Lifesciences Ltd Tratamiento para la colangitis biliar primaria.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089514A (en) * 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
KR950702545A (ko) * 1992-07-03 1995-07-29 데이빗 로버츠 약제로서의 헤테로시클릭 화합물(Heterocyclic compounds as pharmaceutical)

Also Published As

Publication number Publication date
IL125525A0 (en) 1999-03-12
HUT76637A (en) 1997-10-28
IL114759A (en) 1999-10-28
NO970373D0 (no) 1997-01-28
EP0772605A1 (en) 1997-05-14
WO1996004260A1 (en) 1996-02-15
AP776A (en) 1999-10-28
OA10470A (en) 2002-04-08
AP9700918A0 (en) 1997-01-31
PL318766A1 (en) 1997-07-07
DZ1916A1 (fr) 2002-02-17
NO970373L (no) 1997-03-18
SK12297A3 (en) 1997-08-06
CA2196079A1 (en) 1996-02-15
NO307827B1 (no) 2000-06-05
FI970357A7 (fi) 1997-03-26
MX9700763A (es) 1997-05-31
WO1996004261A1 (en) 1996-02-15
MA23632A1 (fr) 1996-04-01
BR9508468A (pt) 1997-11-25
IL114759A0 (en) 1995-12-31
FI970357A0 (fi) 1997-01-28
CZ25497A3 (en) 1997-09-17
IL125525A (en) 2000-02-29

Similar Documents

Publication Publication Date Title
FI970357L (fi) Tyypin II diabeteksen hoitoon käyttökelpoisia bensoksatsoli- ja pyridiinijohdannaisia
NO952573D0 (no) Blandinger for behandling av diabetiske komplikasjoner
FI954718L (fi) Heterosykliset johdannaiset iskeemian ja vastaavien sairauksien hoitamiseksi
FI963238A7 (fi) Heteroaromaattisia oksatsoli yhdisteitä ja niiden käyttö
FI964314A7 (fi) Substituoidut sulfonamidit selektiivisinä beta3-agonisteina diabeteksen ja liikalihavuuden hoitoon
FI970967A7 (fi) Heterosyklinen johdannainen ja lääkeaine
FI955051L (fi) Heterosyklisiä yhdisteitä ja niiden valmistus ja käyttö
DE59501319D1 (de) Benzyliden-Norcampher-Derivate
FI951370A7 (fi) Tiatsolidinin ja oksatsolidinin johdannaiset, niiden valmistus ja lääkinnällinen käyttö
DE69521645D1 (de) Pyridinderivate
BR9507179A (pt) Derivados de 3-aril-4-hidróxi-delta3-dihidrotiofena
FI971268A7 (fi) Menetelmä 1,3-alkaanidiolien ja 3-hydroksialdehydien valmistamiseksi
NO985227L (no) Alkylaminobenzothiazol og -benzoksazol - derivater
FI961184L (fi) Menetelmä norborneenin ja substituoitujen norborneenijohdannaisten valmistamiseksi
FI964482A7 (fi) Amidijohdannaisia ja niiden käyttö lääkkeenä
FI970110A0 (fi) Helico-bakteerin vastaisia heterosyklisiä atsolonijohdannaisia
ATE366577T1 (de) Behandlung der diabetes mit thiazolidindione und sulphonylurea
ATE353654T1 (de) Behandlung der diabetes mit thiazolidindione und sulphonylurea
FI971267L (fi) Menetelmä 1,3-alkaanidiolien ja 3-hydroksialdehydien valmistamiseksi
FI963130L (fi) Heterosykliset yhdisteet sekä niiden valmistus ja käyttö
DE69507727D1 (de) Hexendiin-Derivate und Flüssigkristallzusammensetzung
FI974609A7 (fi) Uusia heterosyklisiä yhdisteitä kivun hoitoon ja niiden käyttö
FI971459A7 (fi) Antosyanidiinin ja sen johdannaisten käyttö retroviraalisten infektioiden hoitoon
BR9508669A (pt) Novos derivados de taizoloÚ3,2-a¾quinolina e naftirina
KR950026706U (ko) 치료용 발열기