FI964004A0 - Serotoniiniantagonistien (5HT3) käyttö fibromyalgian hoitoon - Google Patents

Serotoniiniantagonistien (5HT3) käyttö fibromyalgian hoitoon

Info

Publication number: FI964004A0
Authority: FI; Finland
Prior art keywords: fibromyalgia; treatment; serotonin antagonists; antagonists; serotonin
Prior art date: 1994-04-07

Application number

FI964004A

Other languages

English (en)

Swedish (sv)

Other versions

FI964004L (fi

FI118034B (fi

Inventor

Wolfgang Muller

Thomas Stratz

Original Assignee

Sandoz Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-04-07

Filing date

1996-10-04

Publication date

1996-10-04

1996-10-04 Application filed by Sandoz Ltd filed Critical Sandoz Ltd

1996-10-04 Publication of FI964004A0 publication Critical patent/FI964004A0/fi

1996-11-29 Publication of FI964004L publication Critical patent/FI964004L/fi

2007-06-15 Application granted granted Critical

2007-06-15 Publication of FI118034B publication Critical patent/FI118034B/fi

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
- A—HUMAN NECESSITIES
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
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- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
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Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Physical Education & Sports Medicine (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Anesthesiology (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

FI964004A 1994-04-07 1996-10-04 Serotoniiniantagonistien (5HT3) käyttö fibromyalgian hoitoon FI118034B (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB9406857		1994-04-07
GB9406857A GB9406857D0 (en)	1994-04-07	1994-04-07	Improvements in or relating to organic compounds
EP9501264		1995-04-06
PCT/EP1995/001264 WO1995027490A1 (en)	1994-04-07	1995-04-06	Use of serotonin antagonists (5ht3) for treating fibromyalgia

Publications (3)

Publication Number	Publication Date
FI964004A0 true FI964004A0 (fi)	1996-10-04
FI964004L FI964004L (fi)	1996-11-29
FI118034B FI118034B (fi)	2007-06-15

Family

ID=10753131

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI964004A FI118034B (fi)	1994-04-07	1996-10-04	Serotoniiniantagonistien (5HT3) käyttö fibromyalgian hoitoon

Country Status (22)

Country	Link
US (2)	US5773436A (fi)
EP (1)	EP0804196B1 (fi)
JP (1)	JP2818303B2 (fi)
KR (1)	KR100415181B1 (fi)
CN (1)	CN1084618C (fi)
AT (1)	ATE225176T1 (fi)
AU (1)	AU706279B2 (fi)
CA (1)	CA2186844C (fi)
CZ (1)	CZ290359B6 (fi)
DE (1)	DE69528475T2 (fi)
DK (1)	DK0804196T3 (fi)
ES (1)	ES2184797T3 (fi)
FI (1)	FI118034B (fi)
GB (1)	GB9406857D0 (fi)
HU (1)	HU226892B1 (fi)
MX (1)	MX9604589A (fi)
NO (1)	NO312745B1 (fi)
PL (1)	PL316658A1 (fi)
PT (1)	PT804196E (fi)
RU (1)	RU2165760C2 (fi)
SK (1)	SK281603B6 (fi)
WO (1)	WO1995027490A1 (fi)

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EP0914322A1 (en) *	1996-05-27	1999-05-12	Fujisawa Pharmaceutical Co., Ltd.	New indolyl and benzofuranyl carboxamides as inhibitors of nitric oxide production
US6696495B2 (en) *	1998-12-02	2004-02-24	Snowden Pharmaceuticals, Llc	Treatment of disorders secondary to organic impairments
US6323242B1 (en)	1998-12-02	2001-11-27	Peter Sterling Mueller	Treatment of disorders secondary to organic impairments
AU2672500A (en)	1999-02-18	2000-09-04	Novartis Ag	Systemic use of 5-ht3 receptor antagonists against rheumatic inflammatory processes
JP2002537245A (ja) *	1999-02-18	2002-11-05	ノバルティスアクチエンゲゼルシャフト	５−ｈｔ３レセプターアンタゴニストの使用
TW518218B (en) *	1999-05-27	2003-01-21	Merck Patent Gmbh	Pharmaceutical compositions comprising 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine or its physiologically acceptable salts for use in the treatment of sub-type anxiety disorders
GB9918425D0 (en) *	1999-08-04	1999-10-06	Novartis Ag	Organic compounds
GB0216027D0 (en) *	2002-07-10	2002-08-21	Arachnova Therapeutics Ltd	New therapeutic use
US20040048874A1 (en) *	2001-05-22	2004-03-11	Bardsley Hazel Judith	New therapeutic use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine
AR036040A1 (es)	2001-06-12	2004-08-04	Upjohn Co	Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
AR036041A1 (es)	2001-06-12	2004-08-04	Upjohn Co	Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen
ATE551340T1 (de)	2001-10-02	2012-04-15	Pharmacia & Upjohn Co Llc	Azabicyclisch- substituierte annelierte heteroaryl-verbinungen für die behandlung von krankheiten
AU2002339810A1 (en) *	2001-10-16	2003-04-28	Astrazeneca Ab	Azabicyclic compounds for the treatment of fibromyalgia syndrome
US6849620B2 (en)	2001-10-26	2005-02-01	Pfizer Inc	N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease
JP2005523287A (ja)	2002-02-19	2005-08-04	ファルマシア・アンド・アップジョン・カンパニー・エルエルシー	疾患治療用アザビシクロ化合物
AU2003219690A1 (en)	2002-02-19	2003-09-09	Pharmacia And Upjohn Company	Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease
WO2003100091A1 (en) *	2002-05-24	2003-12-04	Epidauros Biotechnologie Ag	Means and methods for improved treatment using 'setrones'
CZ2005252A3 (cs) *	2002-09-25	2005-11-16	Memory Pharmaceuticals Corporation	Indazoly, benzothiazoly a benzoisothiazoly jejich příprava a použití
CN100353946C (zh) *	2003-01-13	2007-12-12	戴诺吉药品有限公司	治疗功能性肠病的方法
MXPA05007379A (es) *	2003-01-13	2006-02-10	Dynogen Pharmaceuticals Inc	Metodo para tratar nauseas, vomito, esfuerzo por vomitar o cualquier combinacion de los mismos.
PT1697378E (pt)	2003-12-22	2008-02-28	Memory Pharm Corp	Indoles, 1h-indazoles, 1,2-benzisoxazoles e 1,2-benzisotiazoles, sua preparação e utilizações
TW200533348A (en) *	2004-02-18	2005-10-16	Theravance Inc	Indazole-carboxamide compounds as 5-ht4 receptor agonists
EP1735306A2 (en)	2004-03-25	2006-12-27	Memory Pharmaceuticals Corporation	Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof
US8309575B2 (en)	2004-04-07	2012-11-13	Theravance, Inc.	Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US7728006B2 (en) *	2004-04-07	2010-06-01	Theravance, Inc.	Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) *	2004-04-07	2011-11-01	Theravance Inc	Quinolinone-carboxamide compounds as 5-ht4 recepto
US7488737B2 (en) *	2004-04-22	2009-02-10	Memory Pharmaceutical Corporation	Indoles, 1H-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof
JP2007538011A (ja) *	2004-05-07	2007-12-27	メモリー・ファーマシューティカルズ・コーポレイション	１ｈ−インダゾール、ベンゾチアゾール、１，２−ベンゾイソキサゾール、１，２−ベンゾイソチアゾール、およびクロモン、ならびにそれらの調製および使用
JP5042028B2 (ja) *	2004-11-05	2012-10-03	セラヴァンス，インコーポレーテッド	キノリノン−カルボキサミド化合物
ATE441646T1 (de) *	2004-11-05	2009-09-15	Theravance Inc	5-ht4-rezeptoragonistenverbindungen
CA2588037A1 (en) *	2004-12-22	2006-06-29	Theravance, Inc.	Indazole-carboxamide compounds
RU2418797C2 (ru)	2004-12-22	2011-05-20	Мемори Фармасьютиклз Корпорейшн	Лиганды никотинового рецептора альфа-7, их получение и применение
US7446114B2 (en) *	2005-03-02	2008-11-04	Theravance, Inc.	Quinolinone compounds as 5-HT4 receptor agonists
US20060293309A1 (en) *	2005-03-28	2006-12-28	Dynogen Pharmaceuticals, Inc.	Method of treating disorders and conditions using peripherally-restricted antagonists and inhibitors
US8106066B2 (en)	2005-09-23	2012-01-31	Memory Pharmaceuticals Corporation	Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
EP2496227B1 (en)	2009-11-06	2019-05-22	SK Biopharmaceuticals Co., Ltd.	Methods for treating fibromyalgia syndrome
JOP20130213B1 (ar)	2012-07-17	2021-08-17	Takeda Pharmaceuticals Co	معارضات لمستقبلht3-5
MA40771B1 (fr)	2014-09-29	2021-09-30	Takeda Pharmaceuticals Co	Forme cristalline de 1-(1-méthyl-1h-pyrazol -4-yl)-n- ((1r,5s,7s) -9-méthyl-3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-1h-indole-3-carboxamide

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DE3587151T2 (de) *	1984-12-20	1993-07-15	Sandoz Ag	Behandlung von gastrointestinalkrankheiten durch anwendung von 5-ht3-antagonisten.
DE3650772T2 (de) *	1985-04-27	2003-04-03	F. Hoffmann-La Roche Ag, Basel	Derivate von Indazole-3-carboxamide und -3-carboxylsäure
GB8623142D0 (en) *	1986-09-26	1986-10-29	Beecham Group Plc	Compounds
US5246942A (en) *	1988-04-27	1993-09-21	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Pharmaceutically useful dibenzofurancarboxamides of specific stereo-configuration
US4963689A (en) *	1989-05-19	1990-10-16	Pfizer Inc.	Heterocyclicguanidines as 5HT3 antagonists
GB8928208D0 (en) *	1989-12-13	1990-02-14	Glaxo Group Ltd	Medicaments
EP0517984A1 (en) *	1991-06-11	1992-12-16	Merrell Dow Pharmaceuticals Inc.	Derivatives of amide analogs of certain methano bridged quinolizines

1994
- 1994-04-07 GB GB9406857A patent/GB9406857D0/en active Pending
1995
- 1995-04-06 SK SK1278-96A patent/SK281603B6/sk not_active IP Right Cessation
- 1995-04-06 MX MX9604589A patent/MX9604589A/es not_active IP Right Cessation
- 1995-04-06 AT AT95916611T patent/ATE225176T1/de not_active IP Right Cessation
- 1995-04-06 PT PT95916611T patent/PT804196E/pt unknown
- 1995-04-06 WO PCT/EP1995/001264 patent/WO1995027490A1/en not_active Ceased
- 1995-04-06 ES ES95916611T patent/ES2184797T3/es not_active Expired - Lifetime
- 1995-04-06 US US08/721,988 patent/US5773436A/en not_active Expired - Lifetime
- 1995-04-06 DE DE69528475T patent/DE69528475T2/de not_active Expired - Lifetime
- 1995-04-06 DK DK95916611T patent/DK0804196T3/da active
- 1995-04-06 CZ CZ19962915A patent/CZ290359B6/cs not_active IP Right Cessation
- 1995-04-06 RU RU96121561/14A patent/RU2165760C2/ru not_active IP Right Cessation
- 1995-04-06 CN CN95192946A patent/CN1084618C/zh not_active Expired - Fee Related
- 1995-04-06 JP JP7526064A patent/JP2818303B2/ja not_active Expired - Fee Related
- 1995-04-06 CA CA002186844A patent/CA2186844C/en not_active Expired - Fee Related
- 1995-04-06 AU AU23052/95A patent/AU706279B2/en not_active Ceased
- 1995-04-06 PL PL95316658A patent/PL316658A1/xx unknown
- 1995-04-06 EP EP95916611A patent/EP0804196B1/en not_active Expired - Lifetime
- 1995-04-06 HU HU9602721A patent/HU226892B1/hu not_active IP Right Cessation
- 1995-04-06 KR KR1019960705579A patent/KR100415181B1/ko not_active Expired - Fee Related
1996
- 1996-10-04 NO NO19964236A patent/NO312745B1/no not_active IP Right Cessation
- 1996-10-04 FI FI964004A patent/FI118034B/fi not_active IP Right Cessation
1998
- 1998-05-18 US US09/080,605 patent/US5985866A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
RU2165760C2 (ru)	2001-04-27
DE69528475T2 (de)	2003-02-20
SK127896A3 (en)	1997-12-10
NO964236D0 (no)	1996-10-04
NO312745B1 (no)	2002-07-01
EP0804196A1 (en)	1997-11-05
US5773436A (en)	1998-06-30
FI964004L (fi)	1996-11-29
NO964236L (no)	1996-10-04
WO1995027490A1 (en)	1995-10-19
CN1084618C (zh)	2002-05-15
JPH09511739A (ja)	1997-11-25
MX9604589A (es)	1997-11-29
CN1147767A (zh)	1997-04-16
ES2184797T3 (es)	2003-04-16
US5985866A (en)	1999-11-16
DE69528475D1 (de)	2002-11-07
DK0804196T3 (da)	2003-01-27
FI118034B (fi)	2007-06-15
CZ291596A3 (en)	1997-03-12
ATE225176T1 (de)	2002-10-15
CA2186844A1 (en)	1995-10-19
CZ290359B6 (cs)	2002-07-17
SK281603B6 (sk)	2001-05-10
AU2305295A (en)	1995-10-30
AU706279B2 (en)	1999-06-10
PL316658A1 (en)	1997-02-03
HU9602721D0 (en)	1996-11-28
PT804196E (pt)	2003-01-31
EP0804196B1 (en)	2002-10-02
HU226892B1 (en)	2010-01-28
GB9406857D0 (en)	1994-06-01
KR100415181B1 (ko)	2004-07-30
CA2186844C (en)	2007-01-09
JP2818303B2 (ja)	1998-10-30
HUT74992A (en)	1997-03-28

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FI964004A0 (fi)	1996-10-04	Serotoniiniantagonistien (5HT3) käyttö fibromyalgian hoitoon
YU48666B (sh)	1999-06-15	Mometason furoat monohidrat i postupak za njegovo dobijanje
EA199800667A1 (ru)	1999-02-25	Новые фенантридины
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FI954944A7 (fi)	1995-10-17	Indolijohdannaisia 5-HT1-kaltaisina agonisteina käytettäväksi migreenin hoitoon
EA199700061A1 (ru)	1997-12-30	Способ получения силденафила
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FI925211A0 (fi)	1992-11-17	Isoxazol-4-karboxylsyraamider och hydroxialkylidencyanaettiksyraamider,laekemedel innehaollande dessa och anvaendning av dessa
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FI960727A0 (fi)	1996-02-16	Neurokiniiniantagonisteina käyttökelpoiset heterosyklit
IT1240078B (it)	1993-11-27	Procedimento di trattamento di polveri inorganiche.
ES2184077T3 (es)	2003-04-01	Nuevas fenantridinas sustituidas en la posicion 6.
IT1285770B1 (it)	1998-06-18	Composti corticoidei
DE59100670D1 (de)	1994-01-13	Bausatz zur herstellung von büro-arbeitstischen.
IS4367A (is)	1996-09-30	CCK eða gastrín temprandi 5-heterósýklísk-1,5-bensódíazepín
DE69110713D1 (de)	1995-08-03	7-Oxabicycloheptan-imidazol-prostaglandin-Analoge, verwendbar bei der Behandlung von thrombotischen und vasospastischen Erkrankungen.
TR200001102T2 (tr)	2000-08-21	İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları.
FI844645A0 (fi)	1984-11-27	1,7-difenyl-3-metylaza-7-cyan-8 -metyl-nonan foer anvaendning vid bekaempning av sjukdomar.
DE3873278D1 (de)	1992-09-03	Aryl-substituierte thiophen-3-ole, ihre derivate und analoge als lipoxygenase-inhibitoren.
DK207086A (da)	1986-11-07	Anvendelse af dopaminagonister
TR26931A (tr)	1994-08-24	Lak koagülasyonunda molipten bilesiklerinin kullanilmasi.
FI824155A0 (fi)	1982-12-02	Foerfarande foer framstaellning av 3,7a-diazacyklohepta/j,k/fluoren
FI832828L (fi)	1985-02-06	Kolv foer anvaendning i formen pao en horisontell straenggjutningsmaskin foer framstaellning av runda tackor.
YU48719B (sh)	1999-07-28	Lizin so 6-hloro-5-fluoro-3-(2-tenoil)-2-oksindol-1-karboksamida

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