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ZA9711129B - New analogues of camptothecin their medical application and the pharmaceutical substances that contain them - Google Patents

New analogues of camptothecin their medical application and the pharmaceutical substances that contain them

Info

Publication number
ZA9711129B
ZA9711129B ZA9711129A ZA9711129A ZA9711129B ZA 9711129 B ZA9711129 B ZA 9711129B ZA 9711129 A ZA9711129 A ZA 9711129A ZA 9711129 A ZA9711129 A ZA 9711129A ZA 9711129 B ZA9711129 B ZA 9711129B
Authority
ZA
South Africa
Prior art keywords
camptothecin
contain
medical application
pharmaceutical substances
new analogues
Prior art date
Application number
ZA9711129A
Inventor
Dennis Bigg
Francesc Pla Rodas
Gerard Ulibarri
Olivier Lavergne
Jacques Pommier
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Publication of ZA9711129B publication Critical patent/ZA9711129B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA9711129A 1996-12-20 1997-12-10 New analogues of camptothecin their medical application and the pharmaceutical substances that contain them ZA9711129B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9615774A FR2757514B1 (en) 1996-12-20 1996-12-20 NOVEL CAMPTOTHECIN ANALOGS, PREPARATION METHODS, USE THEREOF AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (1)

Publication Number Publication Date
ZA9711129B true ZA9711129B (en) 1999-05-03

Family

ID=9498938

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9711129A ZA9711129B (en) 1996-12-20 1997-12-10 New analogues of camptothecin their medical application and the pharmaceutical substances that contain them

Country Status (25)

Country Link
EP (1) EP0946567B1 (en)
JP (2) JP3576175B2 (en)
KR (1) KR100516874B1 (en)
CN (1) CN1097056C (en)
AR (1) AR008543A1 (en)
AT (1) ATE248177T1 (en)
AU (1) AU734485B2 (en)
BR (1) BR9714170A (en)
CA (1) CA2275351C (en)
CZ (1) CZ299795B6 (en)
DE (1) DE69724453T2 (en)
DK (1) DK0946567T3 (en)
ES (1) ES2206761T3 (en)
FR (1) FR2757514B1 (en)
HU (1) HUP9904210A3 (en)
MX (1) MXPA99005776A (en)
MY (1) MY119473A (en)
NO (1) NO326464B1 (en)
NZ (1) NZ335939A (en)
PL (1) PL188181B1 (en)
PT (1) PT946567E (en)
RU (1) RU2194051C2 (en)
UA (1) UA57758C2 (en)
WO (1) WO1998028305A1 (en)
ZA (1) ZA9711129B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790261B1 (en) * 1999-02-26 2004-09-10 Sod Conseils Rech Applic NOVEL OPTICALLY PURE CAMPTOTHECIN ANALOGS AND PROCESSES FOR THEIR PREPARATION
FR2768431B1 (en) * 1997-08-29 2000-03-24 Sod Conseils Rech Applic NOVEL OPTICALLY PURE CAMPTOTHECIN ANALOGS, A NEW OPTICALLY PURE SYNTHESIS INTERMEDIATE AND PROCESS FOR PREPARING THE SAME
US6291676B1 (en) * 1999-03-03 2001-09-18 University Of Kentucky Research Foundation Water-soluble derivatives of camptothecin/homocamptothecin
US6207832B1 (en) 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
AU3455100A (en) * 1999-05-28 2000-12-18 Nippon Chemiphar Co. Ltd. Process for the preparation of 2-halo-3-(3-quinolyl)propionic acid derivatives
US6372906B1 (en) 2001-04-12 2002-04-16 University Of Pittsburgh Synthesis of silyl camptothecins and silyl homocamptothecins
US6723853B2 (en) 2001-08-27 2004-04-20 University Of Pittsburgh Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
US20040077674A1 (en) * 2002-03-01 2004-04-22 Curran Dennis P. Mappicine analogs, intermediates in the synthesis of mappicine analogs and methods of synthesis of mappicine analogs
AR046579A1 (en) * 2003-11-12 2005-12-14 Smithkline Beecham Corp TOPOTECAN CRYSTAL COMPOSITE, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, PROCEDURE TO PREPARE IT AND ITS USE TO PREPARE SUCH PHARMACEUTICAL COMPOSITION
ITRM20040288A1 (en) * 2004-06-11 2004-09-11 Sigma Tau Ind Farmaceuti USE OF 7-T-BUTOXYIMINOMETHYL CAMPTOTECIN FOR THE PREPARATION OF A MEDICATION FOR THE TREATMENT OF UTERUS NEOPLASIES.
EP1794127A1 (en) * 2004-09-21 2007-06-13 Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) Novel processes for the production of useful intermediates
CN102746314B (en) * 2011-04-18 2016-07-06 华东师范大学 Containing stablizing the camptothecine compounds of 7 yuan of lactonic rings, preparation method and purposes
CN114539292B (en) * 2022-01-28 2023-08-29 遵义医药高等专科学校 A novel podophyllotoxin splicing anti-tumor active molecular compound and its preparation method and application
WO2023232145A1 (en) * 2022-06-02 2023-12-07 华东师范大学 Small molecule of homocamptothecins and use thereof
WO2024230752A1 (en) * 2023-05-08 2024-11-14 甘李药业股份有限公司 Camptothecin derivative, linker, ligand-drug conjugate and medical use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0615547B2 (en) * 1988-01-20 1994-03-02 株式会社ヤクルト本社 Novel camptothecin derivative
US5391745A (en) * 1992-07-23 1995-02-21 Sloan-Kettering Institute For Cancer Research Methods of preparation of camptothecin analogs
EP0835258B1 (en) * 1995-06-21 2002-09-25 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Novel camptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues

Also Published As

Publication number Publication date
CN1097056C (en) 2002-12-25
ATE248177T1 (en) 2003-09-15
HUP9904210A3 (en) 2000-09-28
ES2206761T3 (en) 2004-05-16
UA57758C2 (en) 2003-07-15
NZ335939A (en) 2000-04-28
JP2001505922A (en) 2001-05-08
EP0946567B1 (en) 2003-08-27
DE69724453T2 (en) 2004-06-09
HK1024695A1 (en) 2000-10-20
WO1998028305A1 (en) 1998-07-02
JP3576175B2 (en) 2004-10-13
CA2275351A1 (en) 1998-07-02
AU5326598A (en) 1998-07-17
DE69724453D1 (en) 2003-10-02
RU2194051C2 (en) 2002-12-10
MXPA99005776A (en) 2004-08-31
NO326464B1 (en) 2008-12-08
DK0946567T3 (en) 2003-12-22
CN1241191A (en) 2000-01-12
PL188181B1 (en) 2004-12-31
MY119473A (en) 2005-05-31
NO992998D0 (en) 1999-06-18
FR2757514A1 (en) 1998-06-26
CA2275351C (en) 2008-10-14
AU734485B2 (en) 2001-06-14
KR20000069608A (en) 2000-11-25
BR9714170A (en) 2000-02-29
HUP9904210A2 (en) 2000-05-28
FR2757514B1 (en) 1999-02-12
PT946567E (en) 2004-01-30
JP2004115535A (en) 2004-04-15
KR100516874B1 (en) 2005-09-26
NO992998L (en) 1999-08-18
CZ220599A3 (en) 1999-09-15
CZ299795B6 (en) 2008-11-26
AR008543A1 (en) 2000-01-19
EP0946567A1 (en) 1999-10-06
PL334125A1 (en) 2000-02-14

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