FI944822A0 - Galantaminderivat, förfarande för framställning av dessa och användning av dessa i läkemedel - Google Patents

Galantaminderivat, förfarande för framställning av dessa och användning av dessa i läkemedel

Info

Publication number: FI944822A0
Authority: FI; Finland
Prior art keywords: pharmaceuticals; processes; preparation; alkylaminocarbonyloxy; galantamine derivatives
Prior art date: 1993-10-15

Application number

FI944822A

Other languages

English (en)

Finnish (fi)

Other versions

FI108724B (sv

FI944822L (sv

Inventor

Raymond W Kosley Jr

Larry Davis

Veronica Taberna

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-15

Filing date

1994-10-13

Publication date

1994-10-13

1994-10-13 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1994-10-13 Publication of FI944822A0 publication Critical patent/FI944822A0/sv

1995-04-16 Publication of FI944822L publication Critical patent/FI944822L/sv

2002-03-15 Application granted granted Critical

2002-03-15 Publication of FI108724B publication Critical patent/FI108724B/sv

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Hospice & Palliative Care (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Psychiatry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

FI944822A 1993-10-15 1994-10-13 Förfarande för framställning av terapeutiskt användbara karbamoyloxiderivat av 4a,5,9,10,11,12-hexahydro-11-metyl-6H-bensofuro[3a,3,2-ef][2]bensazepin 3,6-diol och farmaceutiskt godtagbara syraadditionssalter därav FI108724B (sv)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US13744393		1993-10-15
US08/137,443 US6323196B1 (en)	1993-10-15	1993-10-15	Galanthamine derivatives as acetylcholinesterase inhibitors

Publications (3)

Publication Number	Publication Date
FI944822A0 true FI944822A0 (sv)	1994-10-13
FI944822L FI944822L (sv)	1995-04-16
FI108724B FI108724B (sv)	2002-03-15

Family

ID=22477457

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI944822A FI108724B (sv)	1993-10-15	1994-10-13	Förfarande för framställning av terapeutiskt användbara karbamoyloxiderivat av 4a,5,9,10,11,12-hexahydro-11-metyl-6H-bensofuro[3a,3,2-ef][2]bensazepin 3,6-diol och farmaceutiskt godtagbara syraadditionssalter därav

Country Status (24)

Country	Link
US (1)	US6323196B1 (sv)
EP (2)	EP1020469A3 (sv)
JP (1)	JP2718637B2 (sv)
KR (1)	KR100189043B1 (sv)
CN (1)	CN1039011C (sv)
AT (1)	ATE201687T1 (sv)
AU (1)	AU679560B2 (sv)
CA (1)	CA2118171C (sv)
CZ (1)	CZ283561B6 (sv)
DE (1)	DE69427332T2 (sv)
DK (1)	DK0648771T3 (sv)
EG (1)	EG20747A (sv)
ES (1)	ES2158876T3 (sv)
FI (1)	FI108724B (sv)
GR (1)	GR3036068T3 (sv)
IL (1)	IL111273A (sv)
NO (1)	NO307463B1 (sv)
NZ (1)	NZ264681A (sv)
PL (1)	PL177754B1 (sv)
PT (1)	PT648771E (sv)
RO (1)	RO114132B1 (sv)
RU (1)	RU2113438C1 (sv)
TW (1)	TW375615B (sv)
ZA (1)	ZA948060B (sv)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT403803B (de)	1996-04-19	1998-05-25	Sanochemia Ltd	Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
CA2351347A1 (en) *	1998-11-23	2000-06-02	Bonnie Davis	Dosage formulations for acetylcholinesterase inhibitors
EE04996B1 (et)	1998-12-24	2008-04-15	Janssen Pharmaceutica N.V.	Reguleeritud vabanemisega galantamiinipreparaat, meetod selle valmistamiseks, seda sisaldav doseerimisvorm ning farmatseutiline pakend
EP1237524A4 (en) *	1999-12-10	2004-06-30	Bonnie M Davis	GALANTHAMINE AND LYCORAMINE ANALOGS FOR USE AS MODULATORS OF NICOTINIC RECEPTORS
DK1181294T3 (da)	2000-03-31	2004-08-02	Sanochemia Pharmazeutika Ag	Hidtil ukendte derivater og analoger af galanthamin
US20030162770A1 (en) *	2002-02-22	2003-08-28	Davis Bonnie M.	Use of modulators of nicotinic receptors for treatment of cognitive dysfunction
US20040142970A1 (en) *	2002-11-01	2004-07-22	Kathryn Chung	Treatment of hyperkinetic movement disorder with donepezil
US20050048543A1 (en) *	2003-07-11	2005-03-03	Jeroen Aerssens	CHRNA2 genetic markers associated with galantamine response
WO2005042762A2 (en) *	2003-10-28	2005-05-12	Genaissance Pharmaceuticals, Inc.	Lrpap1 genetic markers associated with galantamine response
US20050143350A1 (en) *	2003-11-19	2005-06-30	Seed John C.	Combination drug therapy to treat obesity
US7250258B2 (en) *	2003-12-15	2007-07-31	Pgxhealth Llc	CDK5 genetic markers associated with galantamine response
WO2005065662A1 (en) *	2003-12-31	2005-07-21	Actavis Group Hf	Solid dosage formulations of galantamine
EP1763337A2 (en) *	2003-12-31	2007-03-21	Actavis Group HF	Immediate, controlled and sustained release formulations of galanthamine
EP1779867A4 (en) *	2004-07-01	2009-12-02	Eisai R&D Man Co Ltd	MEANS FOR PROMOTING NERVE REVENERATION
PT1895994E (pt) *	2005-05-13	2010-12-03	Alza Corp	Sistema de administração de medicamentos de camada múltipla com barreira contra o fluxo de material do reservatório
US20080188510A1 (en) *	2005-05-23	2008-08-07	Eisai R & D Management Co., Ltd.	Novel methods using zonisamide
US20090253654A1 (en)	2005-09-22	2009-10-08	Galantos Pharma Gmbh	Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
EP1777222A1 (en) *	2005-09-22	2007-04-25	Galantos Pharma GmbH	Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
US20070104771A1 (en) *	2005-09-23	2007-05-10	Jay Audett	Transdermal galantamine delivery system
KR100786371B1 (ko) *	2006-12-07	2007-12-17	한국화학연구원	갈란타민의 제조방법
CA2721007C (en)	2008-04-14	2014-04-29	Galantos Pharma Gmbh	Derivatives of galantamine as pro-drugs for the treatment of human brain diseases
EP2456434A1 (en) *	2009-07-23	2012-05-30	Shire LLC	Galantamine amino acid and peptide prodrugs and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL122665B1 (en)	1978-11-21	1982-08-31	Edinen Zentar Chim	Process for preparing novel dienones of narvedine type and their derivatives
US4663318A (en)	1986-01-15	1987-05-05	Bonnie Davis	Method of treating Alzheimer's disease
US6150354A (en) *	1987-01-15	2000-11-21	Bonnie Davis	Compounds for the treatment of Alzheimer's disease
JP2755403B2 (ja) *	1987-05-04	1998-05-20	デイービス、ボニー	アルツハイマー病の治療のための化合物
NL8800350A (nl)	1988-02-12	1989-09-01	Stichting Biomedical Research	Synthetische galanthamine-derivaten, werkwijze voor het bereiden daarvan, en farmaceutische samenstellingen.
EP0515301A3 (en) *	1991-05-14	1993-06-16	Ernir Snorrason	Improvements in benzodiazepine treatment by cholinesterterase inhibitors
US5336675A (en) *	1991-05-14	1994-08-09	Ernir Snorrason	Method of treating mania in humans
US5231093A (en) *	1991-10-01	1993-07-27	Hoechst-Roussel Pharmaceuticals Incorporated	Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs
US5153193A (en)	1991-10-01	1992-10-06	Hoechst-Roussel Pharmaceuticals Incorporated	Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs

1993
- 1993-10-15 US US08/137,443 patent/US6323196B1/en not_active Expired - Lifetime
1994
- 1994-10-10 AT AT94115960T patent/ATE201687T1/de active
- 1994-10-10 EP EP00107569A patent/EP1020469A3/en not_active Withdrawn
- 1994-10-10 PT PT94115960T patent/PT648771E/pt unknown
- 1994-10-10 ES ES94115960T patent/ES2158876T3/es not_active Expired - Lifetime
- 1994-10-10 DE DE69427332T patent/DE69427332T2/de not_active Expired - Lifetime
- 1994-10-10 EP EP94115960A patent/EP0648771B1/en not_active Expired - Lifetime
- 1994-10-10 DK DK94115960T patent/DK0648771T3/da active
- 1994-10-12 EG EG63794A patent/EG20747A/xx active
- 1994-10-13 FI FI944822A patent/FI108724B/sv not_active IP Right Cessation
- 1994-10-13 NZ NZ264681A patent/NZ264681A/en not_active IP Right Cessation
- 1994-10-13 RU RU94036761A patent/RU2113438C1/ru active
- 1994-10-13 IL IL111273A patent/IL111273A/en not_active IP Right Cessation
- 1994-10-14 AU AU75812/94A patent/AU679560B2/en not_active Expired
- 1994-10-14 ZA ZA948060A patent/ZA948060B/xx unknown
- 1994-10-14 NO NO943894A patent/NO307463B1/no not_active IP Right Cessation
- 1994-10-14 TW TW083109528A patent/TW375615B/zh not_active IP Right Cessation
- 1994-10-14 CZ CZ942547A patent/CZ283561B6/cs not_active IP Right Cessation
- 1994-10-14 CA CA002118171A patent/CA2118171C/en not_active Expired - Lifetime
- 1994-10-14 CN CN94117061A patent/CN1039011C/zh not_active Expired - Lifetime
- 1994-10-14 RO RO94-01668A patent/RO114132B1/ro unknown
- 1994-10-14 PL PL94305455A patent/PL177754B1/pl unknown
- 1994-10-14 KR KR1019940026304A patent/KR100189043B1/ko not_active Expired - Lifetime
- 1994-10-17 JP JP6250776A patent/JP2718637B2/ja not_active Expired - Fee Related
2001
- 2001-06-19 GR GR20010400911T patent/GR3036068T3/el unknown

Also Published As

Publication number	Publication date
AU679560B2 (en)	1997-07-03
JP2718637B2 (ja)	1998-02-25
RU94036761A (ru)	1996-09-10
NO943894D0 (no)	1994-10-14
KR100189043B1 (ko)	1999-06-01
GR3036068T3 (en)	2001-09-28
NO943894L (no)	1995-04-18
EG20747A (en)	2000-01-31
DE69427332D1 (de)	2001-07-05
ES2158876T3 (es)	2001-09-16
CZ283561B6 (cs)	1998-05-13
EP0648771A1 (en)	1995-04-19
EP1020469A3 (en)	2000-07-26
IL111273A (en)	1998-04-05
CZ254794A3 (en)	1995-05-17
NZ264681A (en)	1997-12-19
IL111273A0 (en)	1994-12-29
RU2113438C1 (ru)	1998-06-20
DK0648771T3 (da)	2001-08-27
PT648771E (pt)	2001-09-28
NO307463B1 (no)	2000-04-10
FI108724B (sv)	2002-03-15
AU7581294A (en)	1995-05-04
KR950011444A (ko)	1995-05-15
JPH07188238A (ja)	1995-07-25
CA2118171C (en)	1999-12-28
RO114132B1 (ro)	1999-01-29
TW375615B (en)	1999-12-01
CN1108658A (zh)	1995-09-20
FI944822L (sv)	1995-04-16
CN1039011C (zh)	1998-07-08
PL177754B1 (pl)	2000-01-31
EP1020469A2 (en)	2000-07-19
EP0648771B1 (en)	2001-05-30
ATE201687T1 (de)	2001-06-15
PL305455A1 (en)	1995-04-18
CA2118171A1 (en)	1995-04-16
DE69427332T2 (de)	2001-10-11
ZA948060B (en)	1995-06-09
US6323196B1 (en)	2001-11-27

Publication	Publication Date	Title
FI944822A0 (sv)	1994-10-13	Galantaminderivat, förfarande för framställning av dessa och användning av dessa i läkemedel
LU91210I2 (fr)	2006-11-06	Emodepside & Praziquantel ainsi que leurs dérivés pharmaceutiqement acceptables (PROFENDER)
FI863917A0 (sv)	1986-09-29	Förfarande för framställning av farmakologiskt användbara kinazolinderivat
WO2001009103A3 (en)	2001-05-31	Imidazole antiproliferative agents
IL107426A0 (en)	1994-01-25	Heterocyclic compounds, processes for the preparation thereof, and pharmaceutical compositions containing the same
IE880960L (en)	1988-10-03	Organic salts of physostigmine derivatives
EP0322738A3 (en)	1991-05-08	Benzylidene-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells
DK0695755T3 (da)	1999-06-28	Pyrrolocarbazoler
ES2150613T3 (es)	2000-12-01	Compuestos benzo-condensados de acepinona y piperidinona, utiles como inhibidores de ace y nep.
AU7452791A (en)	1992-10-06	Novel diphenylthyazole derivative
MX9206930A (es)	1993-06-01	Nuevos compuestos
PT89098A (pt)	1988-12-01	Processo para a preparacao de derivados de guanina
EP0555479A4 (sv)	1994-02-09
ES2149180T3 (es)	2000-11-01	Derivado de pirazolotiazolopirimidina.

Legal Events

Date	Code	Title	Description
1997-06-13	GB	Transfer or assigment of application	Owner name: HOECHST MARION ROUSSEL, INC.
2010-06-09	PC	Transfer of assignment of patent	Owner name: AVENTISUB II INC. Free format text: AVENTISUB II INC.
2014-11-19	MA	Patent expired

Date

Code

Title

Description

1997-06-13

Transfer or assigment of application

Owner name: HOECHST MARION ROUSSEL, INC.

2010-06-09

Transfer of assignment of patent

Owner name: AVENTISUB II INC.

Free format text: AVENTISUB II INC.

2014-11-19

Patent expired