DK1181294T3 - Hidtil ukendte derivater og analoger af galanthamin - Google Patents

Hidtil ukendte derivater og analoger af galanthamin

Info

Publication number: DK1181294T3
Authority: DK; Denmark
Prior art keywords: galanthamine; analogs; novel derivatives; derivatives; novel
Prior art date: 2000-03-31

Application number

DK01914813T

Other languages

English (en)

Inventor

Ulrich Jordis

Johannes Froehlich

Matthias Treu

Manfred Hirnschall

Laszlo Czollner

Beate Kaelz

Stefan Welzig

Original Assignee

Sanochemia Pharmazeutika Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-03-31

Filing date

2001-03-22

Publication date

2004-08-02

2001-03-22 Application filed by Sanochemia Pharmazeutika Ag filed Critical Sanochemia Pharmazeutika Ag

2004-08-02 Application granted granted Critical

2004-08-02 Publication of DK1181294T3 publication Critical patent/DK1181294T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Psychology (AREA)
Hematology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Furan Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK01914813T 2000-03-31 2001-03-22 Hidtil ukendte derivater og analoger af galanthamin DK1181294T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
AT5462000		2000-03-31
AT2382001		2001-02-15
PCT/AT2001/000082 WO2001074820A1 (de)	2000-03-31	2001-03-22	Neue derivate und analoga von galanthamin

Publications (1)

Publication Number	Publication Date
DK1181294T3 true DK1181294T3 (da)	2004-08-02

Family

ID=25608130

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01914813T DK1181294T3 (da)	2000-03-31	2001-03-22	Hidtil ukendte derivater og analoger af galanthamin

Country Status (26)

Country	Link
US (2)	US7166588B2 (da)
EP (1)	EP1181294B1 (da)
JP (1)	JP2003529602A (da)
CN (1)	CN1380883A (da)
AT (1)	ATE263171T1 (da)
AU (1)	AU785385B2 (da)
BG (1)	BG65134B1 (da)
BR (1)	BR0105563A (da)
CA (1)	CA2368966A1 (da)
CZ (1)	CZ300160B6 (da)
DE (1)	DE50101827D1 (da)
DK (1)	DK1181294T3 (da)
ES (1)	ES2215885T3 (da)
HK (1)	HK1049832A1 (da)
HU (1)	HUP0202233A3 (da)
IS (1)	IS2287B (da)
MX (1)	MXPA01012275A (da)
NO (1)	NO326458B1 (da)
NZ (1)	NZ516302A (da)
PL (1)	PL202463B1 (da)
PT (1)	PT1181294E (da)
RU (1)	RU2241001C2 (da)
SI (1)	SI1181294T1 (da)
SK (1)	SK285909B6 (da)
TR (1)	TR200400857T4 (da)
WO (1)	WO2001074820A1 (da)

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JP4721386B2 (ja) *	2001-07-10	2011-07-13	第一三共株式会社	新規ガランタミン類縁体
US20060069251A1 (en) *	2002-03-25	2006-03-30	Ulrich Jordis	Methods for producing norgalanthamine, as well as isomers, salts and hydrates thereof
AT414125B (de) *	2003-09-29	2006-09-15	Sanochemia Pharmazeutika Ag	Neue derivate des 4a,5,9,10,11,12-hexahydro- benzofuro(3a,3,2)(2) benzazepin, verfahren zu deren herstellung sowie deren verwendung zur herstellung von arzneimitteln
AT500143A1 (de) *	2004-04-22	2005-11-15	Sanochemia Pharmazeutika Ag	Cholinesterase-inhibitoren in liposomen sowie deren herstellung und verwendung
US7877350B2 (en) *	2005-06-27	2011-01-25	Ab Initio Technology Llc	Managing metadata for graph-based computations
ATE473219T1 (de) *	2005-09-22	2010-07-15	Galantos Pharma Gmbh	Cholinerge enhancer mit verbesserter durchgängigkeit durch die blut-hirn-schranke zur behandlung von krankheiten, die mit kognitiven störungen einhergehen
US20090253654A1 (en)	2005-09-22	2009-10-08	Galantos Pharma Gmbh	Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
WO2008022365A2 (de) *	2006-08-24	2008-02-28	Sanochemia Ltd.	Mittel zum beeinflussen der wirkungen von organophosphorverbindungen und verwendung von galanthamin, dessen derivaten und analoga zum herstellen solcher mittel
CA2721007C (en)	2008-04-14	2014-04-29	Galantos Pharma Gmbh	Derivatives of galantamine as pro-drugs for the treatment of human brain diseases
BG110141A (en) *	2008-05-23	2009-12-31	"Софарма" Ад	GALANTAMINE DERIVATIVES, METHODS FOR THEIR PREPARATION AND USE
CN103069385B (zh)	2010-06-15	2016-12-28	起元技术有限责任公司	用于动态加载基于图的计算的系统和方法
WO2013160728A1 (en)	2012-04-26	2013-10-31	Alma Mater Studiorum - Universita' Di Bologna	Dual targeting compounds for the treatment of alzheimer's disease
US10108521B2 (en) *	2012-11-16	2018-10-23	Ab Initio Technology Llc	Dynamic component performance monitoring
WO2015085152A1 (en)	2013-12-05	2015-06-11	Ab Initio Technology Llc	Managing interfaces for dataflow graphs composed of sub-graphs
DE112015003587T5 (de)	2014-09-02	2017-05-11	Ab Initio Technology Llc	Spezifizieren von komponenten in graphbasierten programmen
WO2016036826A1 (en)	2014-09-02	2016-03-10	Ab Initio Technology Llc	Compiling graph-based program specifications
US10657134B2 (en)	2015-08-05	2020-05-19	Ab Initio Technology Llc	Selecting queries for execution on a stream of real-time data
US12006301B1 (en)	2021-05-13	2024-06-11	Florida A&M University	And synthesis of dual 5-HT1A and 5-HT7 receptor ligands
CN116082352A (zh) *	2023-02-16	2023-05-09	西南交通大学	一种加兰他敏衍生物及其制备方法和用途
CN118908968B (zh) *	2024-10-09	2025-03-04	威胜生物医药(苏州)股份有限公司	一种加兰他敏中间体衍生物及其催化氧化制备方法
CN119528922B (zh) *	2024-11-22	2025-12-09	泰安汉威集团有限公司	一种氢溴酸加兰他敏关键杂质-氢溴酸表加兰他敏的手性合成方法

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JP2755403B2 (ja) *	1987-05-04	1998-05-20	デイービス、ボニー	アルツハイマー病の治療のための化合物
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US6323195B1 (en)	1993-10-15	2001-11-27	Aventis Pharmaceuticals Inc.	Galanthamine derivatives as acetylcholinesterase inhibitors
US6323196B1 (en)	1993-10-15	2001-11-27	Aventis Pharmaceuticals Inc.	Galanthamine derivatives as acetylcholinesterase inhibitors
US5428159A (en)	1994-04-08	1995-06-27	Ciba-Geigy Corporation	Method of manufacture of (-)-galanthamine in high yield and purity substantially free of epigalanthamine
AU695352B2 (en) *	1994-10-21	1998-08-13	Sanochemia Pharmazeutika Ag	Process for producing derivatives of 4a,5,9,10,11,12,-hexahydro-6h-benzofuro{3a,3,2-ef}{2} benzazepine
AT401058B (de)	1994-10-21	1996-06-25	Waldheim Pharmazeutika Gmbh	Verfahren zum herstellen von derivaten des 4a,5, 9,10,11,12,-hexahydro-6h-benzofuro(3a,-3,2-ef) (2)benzazepins
US6407229B1 (en)	1994-10-21	2002-06-18	Sanochemia Pharmazeutika Ag	Processes for the preparation of derivatives of 4a,5,9,10,11,12-hexahydro-6H-benzofuro-[3a,3,2-ef][2] benzazapine
GB9514821D0 (en) *	1995-07-19	1995-09-20	Sod Conseils Rech Applic	Galanthamine derivatives
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AT403803B (de)	1996-04-19	1998-05-25	Sanochemia Ltd	Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
GB9716879D0 (en) *	1997-08-08	1997-10-15	Shire Int Licensing Bv	Treatment of attention deficit disorders
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AT414125B (de)	2003-09-29	2006-09-15	Sanochemia Pharmazeutika Ag	Neue derivate des 4a,5,9,10,11,12-hexahydro- benzofuro(3a,3,2)(2) benzazepin, verfahren zu deren herstellung sowie deren verwendung zur herstellung von arzneimitteln

2001
- 2001-03-22 DK DK01914813T patent/DK1181294T3/da active
- 2001-03-22 TR TR2004/00857T patent/TR200400857T4/xx unknown
- 2001-03-22 PL PL352638A patent/PL202463B1/pl not_active IP Right Cessation
- 2001-03-22 NZ NZ516302A patent/NZ516302A/xx unknown
- 2001-03-22 SK SK1702-2001A patent/SK285909B6/sk not_active IP Right Cessation
- 2001-03-22 MX MXPA01012275A patent/MXPA01012275A/es active IP Right Grant
- 2001-03-22 PT PT01914813T patent/PT1181294E/pt unknown
- 2001-03-22 ES ES01914813T patent/ES2215885T3/es not_active Expired - Lifetime
- 2001-03-22 JP JP2001572510A patent/JP2003529602A/ja active Pending
- 2001-03-22 CN CN01801342A patent/CN1380883A/zh active Pending
- 2001-03-22 DE DE50101827T patent/DE50101827D1/de not_active Expired - Lifetime
- 2001-03-22 EP EP01914813A patent/EP1181294B1/de not_active Expired - Lifetime
- 2001-03-22 AT AT01914813T patent/ATE263171T1/de not_active IP Right Cessation
- 2001-03-22 CA CA002368966A patent/CA2368966A1/en not_active Abandoned
- 2001-03-22 BR BR0105563-1A patent/BR0105563A/pt not_active IP Right Cessation
- 2001-03-22 CZ CZ20014178A patent/CZ300160B6/cs not_active IP Right Cessation
- 2001-03-22 AU AU42085/01A patent/AU785385B2/en not_active Ceased
- 2001-03-22 WO PCT/AT2001/000082 patent/WO2001074820A1/de not_active Ceased
- 2001-03-22 HU HU0202233A patent/HUP0202233A3/hu unknown
- 2001-03-22 HK HK03101873.7A patent/HK1049832A1/zh unknown
- 2001-03-22 RU RU2001135839/04A patent/RU2241001C2/ru not_active IP Right Cessation
- 2001-03-22 SI SI200130081T patent/SI1181294T1/xx unknown
- 2001-05-22 US US09/980,025 patent/US7166588B2/en not_active Expired - Fee Related
- 2001-11-23 IS IS6174A patent/IS2287B/is unknown
- 2001-11-28 BG BG106155A patent/BG65134B1/bg unknown
- 2001-11-30 NO NO20015857A patent/NO326458B1/no not_active IP Right Cessation
2006
- 2006-06-28 US US11/478,170 patent/US20070027138A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20070027138A1 (en)	2007-02-01
MXPA01012275A (es)	2003-06-24
SK17022001A3 (sk)	2003-02-04
EP1181294B1 (de)	2004-03-31
IS2287B (is)	2007-10-15
CZ20014178A3 (cs)	2002-11-13
HK1045990A1 (en)	2002-12-20
HUP0202233A3 (en)	2004-12-28
JP2003529602A (ja)	2003-10-07
PL352638A1 (en)	2003-09-08
ATE263171T1 (de)	2004-04-15
SK285909B6 (sk)	2007-10-04
BR0105563A (pt)	2002-04-02
BG65134B1 (bg)	2007-03-30
PT1181294E (pt)	2004-07-30
IS6174A (is)	2001-11-23
US7166588B2 (en)	2007-01-23
RU2241001C2 (ru)	2004-11-27
CZ300160B6 (cs)	2009-02-25
SI1181294T1 (en)	2004-08-31
NZ516302A (en)	2004-02-27
PL202463B1 (pl)	2009-06-30
AU785385B2 (en)	2007-03-29
HUP0202233A2 (hu)	2002-11-28
AU4208501A (en)	2001-10-15
CA2368966A1 (en)	2001-10-11
DE50101827D1 (de)	2004-05-06
HK1049832A1 (zh)	2003-05-30
NO326458B1 (no)	2008-12-08
NO20015857L (no)	2002-01-29
TR200400857T4 (tr)	2004-06-21
EP1181294A1 (de)	2002-02-27
ES2215885T3 (es)	2004-10-16
NO20015857D0 (no)	2001-11-30
CN1380883A (zh)	2002-11-20
US20030199493A1 (en)	2003-10-23
WO2001074820A1 (de)	2001-10-11
BG106155A (en)	2002-08-30

Publication	Publication Date	Title
DK1181294T3 (da)	2004-08-02	Hidtil ukendte derivater og analoger af galanthamin
SE0000540D0 (sv)	2000-02-18	New compounds
CY1107634T1 (el)	2013-04-18	Φαρμακευτικη συνθεση
DOP2001000151A (es)	2002-05-15	Derivados de imidazopirimidina y derivados de triazolopimidina.
CY1113648T1 (el)	2016-06-22	Παραγωγα πυριδινονης για θεραπεια αθηροσκληρωσης
ATE409189T1 (de)	2008-10-15	Farnesyl transferase-hemmende 6- heterocyclylmethyl-chinolin und chinazol-derivate
ATE491703T1 (de)	2011-01-15	Phthalazinonderivate
CY1111648T1 (el)	2015-10-07	Πολυαρυλκαρβοξαμιδια χρησιμα ως παραγοντες μειωσης λιπιδιων
ATE506354T1 (de)	2011-05-15	Substituierte arylcyclopropylacetamide als glucokinaseaktivatoren
TW200510368A (en)	2005-03-16	Pharmaceutical compositions and combinations of novel non-imidazole compounds
NO20042534L (no)	2004-08-23	Forbedringer vedrorende optiske lysgjoringsmidler
CY1113657T1 (el)	2016-06-22	Νεα παραγωγα βενζοφαινονης ή αλατα αυτων
ECSP056130A (es)	2006-03-01	Compuestos farmacéuticos novedosos
UY28625A1 (es)	2005-06-30	Nuevos compuestos farmacéuticos
YU25497A (sh)	1998-12-23	Postupak za dobijanje sildenafila
CY1106132T1 (el)	2011-06-08	Παραγωγα πιπepιδινης ως αναστολεις καναλιου καλιου
MX9700557A (es)	1997-12-31	Dihidrobenzofuranos.
AR028567A1 (es)	2003-05-14	Nuevos derivados de fenil-propargileter
UY26899A1 (es)	2002-03-22	Derivados de pirazol fusionados
BR0213981A (pt)	2004-08-31	Fotoiniciadores difuncionais
CY2004011I1 (el)	2010-07-28	Aσυμμετρη συνθεση της πρεγαβαλινης
AR028596A1 (es)	2003-05-14	Nuevos derivados de fenilglicina
CO5580821A2 (es)	2005-11-30	4-cetolactamas y -lactonas 3-fenil-3-substituidas, espirociclicas
DE60121587D1 (de)	2006-08-31	Zyklische gmp-spezifische phosphodiesteraseinhibitoren
DE60041001D1 (de)	2009-01-15	Substituierte homopiperidylbenzimidazolanaloga als fundusrelaxantien