FI916058A7 - Förfarande för framställning av terapeutiskt aktiva dihydrobensofurankarboxamider - Google Patents

Förfarande för framställning av terapeutiskt aktiva dihydrobensofurankarboxamider

Info

Publication number: FI916058A7
Authority: FI; Finland
Prior art keywords: dihydrobenzofurancarboxamides; therapeutically active; preparing therapeutically; preparing; active
Prior art date: 1990-12-27

Application number

FI916058A

Other languages

English (en)

Finnish (fi)

Other versions

FI97806C (sv

FI916058A0 (sv

FI97806B (sv

Inventor

Angelo Bedeschi

Walter Cabri

Ilaria Candiani

Bernardinis Silvia De

Marcello Marchi

Mario Varasi

Original Assignee

Erba Carlo Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-27

Filing date

1991-12-20

Publication date

1992-06-28

1990-12-27 Priority claimed from GB909028104A external-priority patent/GB9028104D0/en

1991-04-05 Priority claimed from GB919107140A external-priority patent/GB9107140D0/en

1991-12-20 Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa

1991-12-20 Publication of FI916058A0 publication Critical patent/FI916058A0/sv

1992-06-28 Publication of FI916058A7 publication Critical patent/FI916058A7/sv

1996-11-15 Application granted granted Critical

1996-11-15 Publication of FI97806B publication Critical patent/FI97806B/sv

1997-02-25 Publication of FI97806C publication Critical patent/FI97806C/sv

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Anesthesiology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Furan Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

FI916058A 1990-12-27 1991-12-20 Förfarande för framställning av terapeutiskt aktiva dihydrobensofurankarboxamider FI97806C (sv)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB9028104		1990-12-27
GB909028104A GB9028104D0 (en)	1990-12-27	1990-12-27	Dihydrobenzofuran carboxamides and process for their preparation
GB919107140A GB9107140D0 (en)	1991-04-05	1991-04-05	Dihydrobenzofuran carboxamides and process for their preparation
GB9107140		1991-04-05

Publications (4)

Publication Number	Publication Date
FI916058A0 FI916058A0 (sv)	1991-12-20
FI916058A7 true FI916058A7 (sv)	1992-06-28
FI97806B FI97806B (sv)	1996-11-15
FI97806C FI97806C (sv)	1997-02-25

Family

ID=26298184

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI916058A FI97806C (sv)	1990-12-27	1991-12-20	Förfarande för framställning av terapeutiskt aktiva dihydrobensofurankarboxamider

Country Status (19)

Country	Link
US (1)	US5362740A (sv)
EP (1)	EP0493031B1 (sv)
JP (1)	JP3453394B2 (sv)
KR (1)	KR920012083A (sv)
AT (1)	ATE127119T1 (sv)
AU (1)	AU638665B2 (sv)
CA (1)	CA2058264C (sv)
DE (1)	DE69112594T2 (sv)
DK (1)	DK0493031T3 (sv)
ES (1)	ES2079590T3 (sv)
FI (1)	FI97806C (sv)
GR (1)	GR3017872T3 (sv)
HU (1)	HU208538B (sv)
IE (1)	IE914488A1 (sv)
IL (1)	IL100432A (sv)
MX (1)	MX9102686A (sv)
NZ (1)	NZ241067A (sv)
PT (1)	PT99886B (sv)
TW (1)	TW242624B (sv)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9028105D0 (en) *	1990-12-27	1991-02-13	Erba Carlo Spa	Process for the preparation of substituted benzofuran derivatives
JP2999669B2 (ja) *	1993-08-24	2000-01-17	株式会社三和化学研究所	ベンゾ［ｂ］フランカルボキサミド誘導体、その製法及び用途
JPH0820586A (ja)	1994-07-05	1996-01-23	Sanwa Kagaku Kenkyusho Co Ltd	１−アザビシクロ［３．３．０］オクタン誘導体、その塩及び製法並びに用途
JPH0873463A (ja)	1994-07-05	1996-03-19	Sanwa Kagaku Kenkyusho Co Ltd	ベンゾピランカルボキサミド誘導体、その塩及び製法並びに用途
AR036040A1 (es)	2001-06-12	2004-08-04	Upjohn Co	Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
AR036041A1 (es) *	2001-06-12	2004-08-04	Upjohn Co	Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen
WO2003022856A1 (en) *	2001-09-12	2003-03-20	Pharmacia & Upjohn Company	Substituted 7-aza[2.2.1] bicycloheptanes for the treatment of diseases
ATE551340T1 (de)	2001-10-02	2012-04-15	Pharmacia & Upjohn Co Llc	Azabicyclisch- substituierte annelierte heteroaryl-verbinungen für die behandlung von krankheiten
US6849620B2 (en)	2001-10-26	2005-02-01	Pfizer Inc	N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease
EP1442037A1 (en)	2001-11-09	2004-08-04	PHARMACIA & UPJOHN COMPANY	Azabicyclic-phenyl-fused-heterocyclic compounds and their use as alpha7 nachr ligands
AU2003219690A1 (en) *	2002-02-19	2003-09-09	Pharmacia And Upjohn Company	Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease
JP2005523287A (ja) *	2002-02-19	2005-08-04	ファルマシア・アンド・アップジョン・カンパニー・エルエルシー	疾患治療用アザビシクロ化合物
JP2006506395A (ja) *	2002-11-01	2006-02-23	ファルマシア・アンド・アップジョン・カンパニー・エルエルシー	ＣＮＳ疾患の治療のための、α７ニコチンアゴニスト活性及び５ＨＴ３アンタゴニスト活性を有する化合物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3705165A (en) *	1970-08-05	1972-12-05	Elmar Sturm	N-carbonyl derivatives of azabicyclooctanes
GB1593146A (en) *	1976-11-05	1981-07-15	Beecham Group Ltd	Octahydro-quinolizinyl benzamide derivatives
IL59004A0 (en) *	1978-12-30	1980-03-31	Beecham Group Ltd	Substituted benzamides their preparation and pharmaceutical compositions containing them
IL61642A0 (en) *	1979-12-20	1981-01-30	Beecham Group Ltd	Aniline derivatives,their preparation and pharmalceutical compositions containing them
EP0099194A3 (en) *	1982-07-03	1984-04-11	Beecham Group Plc	Novel benzamides
EP0135545A1 (en) *	1983-02-19	1985-04-03	Beecham Group Plc	Azabicycloalkyl benzamide and anilide derivatives
US4888353A (en) *	1986-02-28	1989-12-19	Erbamont, Inc.	Carboxamides useful as antiemetic or antipsychotic agents
GB8718345D0 (en) *	1987-08-03	1987-09-09	Fordonal Sa	N-substituted benzamides
US4997956A (en) *	1989-06-14	1991-03-05	Eli Lilly And Company	Certain 2,3-dihydro-2;2-dimethyl-benzothiophene carboxylic acids which are intermediates
US4921982A (en) *	1988-07-21	1990-05-01	Eli Lilly And Company	5-halo-2,3-dihydro-2,2-dimethylbenzofuran-7-carboxylic acids useful as intermediates for 5-HT3 antagonists
US4863921A (en) *	1988-04-27	1989-09-05	Rorer Pharmaceutical Corporation	Dibenzofurancarboxamides and their pharmaceutical compositions and methods
JPH0232077A (ja) *	1989-06-16	1990-02-01	Yoshitomi Pharmaceut Ind Ltd	ベンゾフランおよびベンゾピラン化合物
GB9028105D0 (en) *	1990-12-27	1991-02-13	Erba Carlo Spa	Process for the preparation of substituted benzofuran derivatives

1991
- 1991-12-19 IL IL10043291A patent/IL100432A/en not_active IP Right Cessation
- 1991-12-19 MX MX9102686A patent/MX9102686A/es not_active IP Right Cessation
- 1991-12-19 NZ NZ241067A patent/NZ241067A/en unknown
- 1991-12-20 AU AU89958/91A patent/AU638665B2/en not_active Ceased
- 1991-12-20 ES ES91311886T patent/ES2079590T3/es not_active Expired - Lifetime
- 1991-12-20 DK DK91311886.5T patent/DK0493031T3/da active
- 1991-12-20 CA CA002058264A patent/CA2058264C/en not_active Expired - Fee Related
- 1991-12-20 IE IE448891A patent/IE914488A1/en unknown
- 1991-12-20 AT AT91311886T patent/ATE127119T1/de not_active IP Right Cessation
- 1991-12-20 EP EP91311886A patent/EP0493031B1/en not_active Expired - Lifetime
- 1991-12-20 DE DE69112594T patent/DE69112594T2/de not_active Expired - Fee Related
- 1991-12-20 PT PT99886A patent/PT99886B/pt not_active IP Right Cessation
- 1991-12-20 HU HU914093A patent/HU208538B/hu not_active IP Right Cessation
- 1991-12-20 FI FI916058A patent/FI97806C/sv not_active IP Right Cessation
- 1991-12-20 TW TW080110003A patent/TW242624B/zh active
- 1991-12-23 KR KR1019910023918A patent/KR920012083A/ko not_active Ceased
- 1991-12-24 JP JP34146791A patent/JP3453394B2/ja not_active Expired - Fee Related
1992
- 1992-11-30 US US07/983,274 patent/US5362740A/en not_active Expired - Lifetime
1995
- 1995-10-25 GR GR950402976T patent/GR3017872T3/el unknown

Also Published As

Publication number	Publication date
US5362740A (en)	1994-11-08
DE69112594D1 (de)	1995-10-05
PT99886B (pt)	1999-06-30
MX9102686A (es)	1994-01-31
IL100432A0 (en)	1992-09-06
DE69112594T2 (de)	1996-02-01
FI97806C (sv)	1997-02-25
TW242624B (sv)	1995-03-11
HUT59678A (en)	1992-06-29
CA2058264C (en)	1999-03-16
EP0493031B1 (en)	1995-08-30
KR920012083A (ko)	1992-07-25
HU914093D0 (en)	1992-03-30
NZ241067A (en)	1993-03-26
GR3017872T3 (en)	1996-01-31
ATE127119T1 (de)	1995-09-15
CA2058264A1 (en)	1992-06-28
IE914488A1 (en)	1992-07-01
ES2079590T3 (es)	1996-01-16
JP3453394B2 (ja)	2003-10-06
EP0493031A1 (en)	1992-07-01
HU208538B (en)	1993-11-29
AU638665B2 (en)	1993-07-01
PT99886A (pt)	1992-12-31
AU8995891A (en)	1992-07-02
IL100432A (en)	1996-01-19
FI916058A0 (sv)	1991-12-20
DK0493031T3 (da)	1995-09-25
JPH04295476A (ja)	1992-10-20
FI97806B (sv)	1996-11-15

Publication	Publication Date	Title
FI870903L (sv)	1987-09-08	Förfarande för framställning av terapeutiskt aktiva med alfa-heterocykler substituerade tolunitriler
FI883050L (sv)	1988-12-25	Förfarande för framställning av terapeutiskt aktiva pyranoindolizinokinolinderivat
FI963424L (sv)	1996-09-02	Förfarande för framställning av terapeutiskt aktiva tiofensulfonamider
FI890652A7 (sv)	1989-08-11	Förfarande för framställning av terapeutiskt aktiva substituerade indolylpyrrolderivat
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NO176759C (no)	1995-05-24	Analogifremgangsmåte for fremstilling av terapeutisk aktive 3-substituerte-2-oksindol-derivater
FI20000343L (sv)	2000-02-16	Förfarande för framställning av terapeutiskt användbara pyrrolopyrimidiner
FI913446L (sv)	1992-01-19	Förfarande för framställning av terapeutiskt aktiva 3-(2-substituerad-3-oxo-2,3-dihydropyridazin-6-yl)-2-fenylpyrazolo/1,5-a/pyridiner
FI892497L (sv)	1989-11-25	Förfarande för framställning av terapeutiskt aktiva bensamidderivat
DK0535034T3 (da)	2002-12-09	Farmaceutisk aktive benzoquinazolinforbindelser
FI930150L (sv)	1993-01-14	Förfarande för framställning av terapeutiskt aktiva indolderivat
FI880869A7 (sv)	1988-08-26	Förfarande för framställning av terapeutiskt aktiva tetrazolderivat
FI890123L (sv)	1989-07-15	Förfarande för framställning av terapeutiskt verksamma indolylpiperidinderivat
FI924642L (sv)	1992-10-14	Förfarande för framställning av terapeutiskt aktiva 3-indolyltioacetatderivat
FI916058A7 (sv)	1992-06-28	Förfarande för framställning av terapeutiskt aktiva dihydrobensofurankarboxamider
FI893936A7 (sv)	1989-08-22	Förfarande för framställning av terapeutiskt aktiva föreningar samt mellanprodukter
NO173784C (no)	1994-02-02	Anaslogifremgangsmaate for fremstilling av terapeutisk aktive tieno-tri-azolo-diazepinderivater
FI884660L (sv)	1989-04-13	Förfarande för framställning av terapeutiskt aktiva 2,2-dimetylkromenderivat
FI911420L (sv)	1991-09-27	Förfarande för framställning av terapeutiskt användbara föreningar
FI911701L (sv)	1991-10-11	Förfarande för framställning av terapeutiskt användbara 2-substituerade-3-karboxikarbapenemer
NO174200C (no)	1994-04-06	Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-imino-6-polyfluoralkoksybenzotiazol-forbindelser
FI880103L (sv)	1988-01-11	Förfarande för framställning av terapeutiskt aktiv sialosylkolesterol
FI880190L (sv)	1988-07-28	Förfarande för framställning av terapeutiskt verksamma tetrahydrofuranderivat
FI911812A7 (sv)	1991-11-09	Förfarande för framställning av xylanas
FI910366L (sv)	1991-07-27	Förfarande för framställning av deoximulundokandin

Legal Events

Date	Code	Title	Description
1996-10-16	BB	Publication of examined application
1997-01-20	GB	Transfer or assigment of application	Owner name: PHARMACIA & UPJOHN S.P.A.
1998-12-20	MM	Patent lapsed