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FI883603A7 - Menetelmä terapeuttisesti käyttökelpoisten 1,4-dihydropyridiinijohdannaisten valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten 1,4-dihydropyridiinijohdannaisten valmistamiseksi

Info

Publication number
FI883603A7
FI883603A7 FI883603A FI883603A FI883603A7 FI 883603 A7 FI883603 A7 FI 883603A7 FI 883603 A FI883603 A FI 883603A FI 883603 A FI883603 A FI 883603A FI 883603 A7 FI883603 A7 FI 883603A7
Authority
FI
Finland
Prior art keywords
therapeutically useful
dihydropyridine derivatives
preparing therapeutically
preparing
dihydropyridine
Prior art date
Application number
FI883603A
Other languages
English (en)
Swedish (sv)
Other versions
FI91406C (fi
FI91406B (fi
FI883603A0 (fi
Inventor
Torija Carlos Fernandez
Ramos Joaquin Alvaro Galiano
Original Assignee
Delagrange Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delagrange Lab filed Critical Delagrange Lab
Publication of FI883603A0 publication Critical patent/FI883603A0/fi
Publication of FI883603A7 publication Critical patent/FI883603A7/fi
Application granted granted Critical
Publication of FI91406B publication Critical patent/FI91406B/fi
Publication of FI91406C publication Critical patent/FI91406C/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FI883603A 1987-08-03 1988-08-01 Menetelmä terapeuttisesti käyttökelpoisten 1,4-dihydropyridiinijohdannaisten valmistamiseksi FI91406C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP87401799A EP0302980B1 (fr) 1987-08-03 1987-08-03 1,4-Dihydropyridines, leur procédé de préparation et leur application comme médicaments
EP87401799 1987-08-03

Publications (4)

Publication Number Publication Date
FI883603A0 FI883603A0 (fi) 1988-08-01
FI883603A7 true FI883603A7 (fi) 1989-02-04
FI91406B FI91406B (fi) 1994-03-15
FI91406C FI91406C (fi) 1994-06-27

Family

ID=8198243

Family Applications (1)

Application Number Title Priority Date Filing Date
FI883603A FI91406C (fi) 1987-08-03 1988-08-01 Menetelmä terapeuttisesti käyttökelpoisten 1,4-dihydropyridiinijohdannaisten valmistamiseksi

Country Status (34)

Country Link
US (1) US4952592A (fi)
EP (1) EP0302980B1 (fi)
JP (1) JPH0733383B2 (fi)
KR (1) KR960001724B1 (fi)
CN (1) CN1038587C (fi)
AT (1) ATE61588T1 (fi)
BE (1) BE1001055A4 (fi)
CA (2) CA1306261C (fi)
CH (1) CH675999A5 (fi)
CZ (1) CZ282077B6 (fi)
DD (1) DD282008A5 (fi)
DE (2) DE3768658D1 (fi)
DK (1) DK430288A (fi)
ES (1) ES2007543A6 (fi)
FI (1) FI91406C (fi)
GB (1) GB2208861B (fi)
GR (2) GR880100507A (fi)
HU (1) HU204523B (fi)
IE (1) IE60358B1 (fi)
IL (1) IL87321A (fi)
IN (1) IN167550B (fi)
IS (1) IS1549B (fi)
IT (1) IT1235013B (fi)
LU (1) LU87297A1 (fi)
MA (1) MA21344A1 (fi)
NO (1) NO170934C (fi)
NZ (1) NZ225661A (fi)
PH (1) PH25645A (fi)
PT (1) PT88173B (fi)
RU (1) RU2036922C1 (fi)
SK (1) SK541388A3 (fi)
TN (1) TNSN88081A1 (fi)
YU (1) YU46547B (fi)
ZA (1) ZA885684B (fi)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242933A (en) * 1990-07-10 1993-09-07 Adir Et Compagnie Piperidine, tetrahydropyridine and pyrrolidine compounds
EP0854721B1 (en) * 1995-08-02 2001-10-24 Smithkline Beecham Corporation Endothelin receptor antagonists
RU2168987C2 (ru) * 1997-04-15 2001-06-20 Санкт-Петербургская Государственная Химико-Фармацевтическая Академия Гипотензивное средство
RU2155036C2 (ru) * 1998-11-11 2000-08-27 Азад Зияд Оглы Абышев Средство для лечения ишемической болезни сердца
IT1304513B1 (it) * 1998-12-30 2001-03-19 Endura Spa Processo per la sintesi di 5-(alfa-idrossialchil)benzo(1,3)diossoli.
BR0109991A (pt) * 2000-04-11 2003-05-27 Sankyo Co Composição farmacêutica
RU2187303C2 (ru) * 2000-10-12 2002-08-20 Азад Зияд Оглы Абышев Способ получения таблеток диуманкала - forte по 0,01 г
BR0313593A (pt) 2002-08-19 2005-07-12 Pfizer Prod Inc Terapia de combinação para doenças hiperproliferativas
KR20070054644A (ko) * 2004-07-26 2007-05-29 액테리온 파마슈티칼 리미티드 미립자 제형으로 흡입된 일로프로스트에 의한 폐고혈압의치료
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP2111863B1 (en) 2005-10-26 2012-03-28 Asahi Kasei Pharma Corporation Fasudil in combination with bosentan for the treament of pulmonary arterial hypertension
EP2351569B1 (en) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
TW200736245A (en) * 2005-11-29 2007-10-01 Sankyo Co Acid addition salts of optically active dihydropyridine derivatives
TW200806648A (en) * 2005-11-29 2008-02-01 Sankyo Co Acid addition salts of dihydropyridine derivatives
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
ATE547394T1 (de) 2006-12-01 2012-03-15 Bristol Myers Squibb Co N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen
WO2012037665A1 (en) 2010-09-24 2012-03-29 Oral Delivery Technology Ltd. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
CA2909442A1 (en) 2013-04-17 2014-10-23 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
HUE069590T2 (hu) 2019-01-18 2025-03-28 Astrazeneca Ab PCSK9-gátló 6'-[[(1s,3s)-3-[[5-(difluormetoxi)-2-pirimidinil]amino]ciklopentil]amino][1(2h ),3'-bipiridin]-2-on és alkalmazására szolgáló eljárások

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3441648A (en) * 1967-02-07 1969-04-29 Smithkline Corp Compositions and methods for lowering blood pressure with 1,4-dihydropyridines
US4031104A (en) * 1972-04-18 1977-06-21 Bayer Aktiengesellschaft 1,4-Dihydropyridine carboxylic acid esters
JPS5978186A (ja) * 1982-10-27 1984-05-04 Yoshitomi Pharmaceut Ind Ltd 1,4−ジヒドロピリジン−3,5−ジカルボン酸エステル誘導体
ES531033A0 (es) * 1984-03-27 1985-09-01 Inst Investigacion Desarrollo Un procedimiento para la preparacion de nuevas 1,4-dihidropirinas-4-(polioxialquilfenil)-sustituidas
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
JPH068294B2 (ja) * 1985-02-26 1994-02-02 富山化学工業株式会社 新規な1,4−ジヒドロピリジン誘導体およびその塩
EP0174131A3 (en) * 1984-09-01 1989-06-07 FISONS plc Dihydropyridines, processes and intermediates for their production, and pharmaceutical formulations containing them
JPH01207267A (ja) * 1987-03-05 1989-08-21 Yamanouchi Pharmaceut Co Ltd ピリジン誘導体及び該化合物を含有する肝疾患治療剤

Also Published As

Publication number Publication date
GB2208861B (en) 1991-07-17
FI91406C (fi) 1994-06-27
JPH0733383B2 (ja) 1995-04-12
TNSN88081A1 (fr) 1990-07-10
GB8818356D0 (en) 1988-09-07
ES2007543A6 (es) 1989-06-16
KR890003743A (ko) 1989-04-17
KR960001724B1 (ko) 1996-02-03
NZ225661A (en) 1990-08-28
BE1001055A4 (fr) 1989-06-20
EP0302980B1 (fr) 1991-03-13
NO883406L (no) 1989-02-06
AU606441B2 (en) 1991-02-07
SK278775B6 (sk) 1998-02-04
DE3768658D1 (de) 1991-04-18
IE60358B1 (en) 1994-06-29
IE882364L (en) 1989-02-03
FI91406B (fi) 1994-03-15
PT88173B (pt) 1995-03-01
RU2036922C1 (ru) 1995-06-09
CN1031531A (zh) 1989-03-08
IN167550B (fi) 1990-11-10
ZA885684B (en) 1989-04-26
US4952592A (en) 1990-08-28
LU87297A1 (fr) 1989-02-02
CZ282077B6 (cs) 1997-05-14
JPH01294675A (ja) 1989-11-28
IS1549B (is) 1994-06-08
FI883603A0 (fi) 1988-08-01
YU46547B (sh) 1993-11-16
IS3378A7 (is) 1989-02-04
CA1306261C (fr) 1992-08-11
CN1038587C (zh) 1998-06-03
GR880100507A (el) 1989-05-25
DE3825962A1 (de) 1989-02-16
MA21344A1 (fr) 1989-04-01
GB2208861A (en) 1989-04-19
NO883406D0 (no) 1988-08-01
HUT54142A (en) 1991-01-28
IT8848259A0 (it) 1988-08-02
NO170934B (no) 1992-09-21
CZ541388A3 (en) 1997-01-15
DK430288A (da) 1989-02-03
IL87321A (en) 1993-04-04
SK541388A3 (en) 1998-02-04
AU2033088A (en) 1989-02-09
PT88173A (pt) 1989-06-30
IL87321A0 (en) 1989-01-31
YU147088A (en) 1990-04-30
DD282008A5 (de) 1990-08-29
GR3001984T3 (en) 1992-11-23
HU204523B (en) 1992-01-28
IT1235013B (it) 1992-06-16
CH675999A5 (en) 1990-11-30
ATE61588T1 (de) 1991-03-15
PH25645A (en) 1991-08-21
NO170934C (no) 1992-12-30
CA1306262C (fr) 1992-08-11
DK430288D0 (da) 1988-08-02
EP0302980A1 (fr) 1989-02-15

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Legal Events

Date Code Title Description
BB Publication of examined application
PC Transfer of assignment of patent

Owner name: ALMIRALL-PRODESFARMA S.A.

TC Name/ company changed in patent

Owner name: ALMIRALL-PRODESFARMA S.A.

MM Patent lapsed

Owner name: ALMIRALL-PRODESFARMA S.A.